Abstract：
:The computational evaluation of protein-protein interactions will play an important role in organising the wealth of data being generated by high-throughput initiatives. Here we discuss future applications, report recent developments and identify areas requiring further investigation. Many functions have been developed to quantify the structural and energetic properties of interacting proteins, finding use in interrelated challenges revolving around the relationship between sequence, structure and binding free energy. These include loop modelling, side-chain refinement, docking, multimer assembly, affinity prediction, affinity change upon mutation, hotspots location and interface design. Information derived from models optimised for one of these challenges can be used to benefit the others, and can be unified within the theoretical frameworks of multi-task learning and Pareto-optimal multi-objective learning.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
Moal IH,Moretti R,Baker D,Fernández-Recio Jdoi
10.1016/j.sbi.2013.06.017subject
Has Abstractpub_date
2013-12-01 00:00:00pages
862-7issue
6eissn
0959-440Xissn
1879-033Xpii
S0959-440X(13)00120-6journal_volume
23pub_type
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journal_title：Current opinion in structural biology
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journal_title：Current opinion in structural biology
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journal_title：Current opinion in structural biology
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journal_title：Current opinion in structural biology
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journal_title：Current opinion in structural biology
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journal_title：Current opinion in structural biology
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journal_title：Current opinion in structural biology
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journal_title：Current opinion in structural biology
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