Physical and molecular bases of protein thermal stability and cold adaptation.

Abstract:

:The molecular bases of thermal and cold stability and adaptation, which allow proteins to remain folded and functional in the temperature ranges in which their host organisms live and grow, are still only partially elucidated. Indeed, both experimental and computational studies fail to yield a fully precise and global physical picture, essentially because all effects are context-dependent and thus quite intricate to unravel. We present a snapshot of the current state of knowledge of this highly complex and challenging issue, whose resolution would enable large-scale rational protein design.

journal_name

Curr Opin Struct Biol

authors

Pucci F,Rooman M

doi

10.1016/j.sbi.2016.12.007

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

117-128

eissn

0959-440X

issn

1879-033X

pii

S0959-440X(16)30235-4

journal_volume

42

pub_type

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