Trends in protein evolution inferred from sequence and structure analysis.

Abstract:

:Complementary developments in comparative genomics, protein structure determination and in-depth comparison of protein sequences and structures have provided a better understanding of the prevailing trends in the emergence and diversification of protein domains. The investigation of deep relationships among different classes of proteins involved in key cellular functions, such as nucleic acid polymerases and other nucleotide-dependent enzymes, indicates that a substantial set of diverse protein domains evolved within the primordial, ribozyme-dominated RNA world.

journal_name

Curr Opin Struct Biol

authors

Aravind L,Mazumder R,Vasudevan S,Koonin EV

doi

10.1016/s0959-440x(02)00334-2

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

392-9

issue

3

eissn

0959-440X

issn

1879-033X

pii

S0959440X02003342

journal_volume

12

pub_type

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