Abstract：
:The anaphase-promoting complex/cyclosome (APC/C) is a large multi-subunit complex that functions as a RING domain E3 ubiquitin ligase to regulate transitions through the cell cycle, achieved by controlling the defined ubiquitin-dependent degradation of specific cell cycle regulators. APC/C activity and substrate selection are controlled at various levels to ensure that specific cell cycle events occur in the correct order and time. Structural and mechanistic studies over the past two decades have complemented functional studies to provide comprehensive insights that explain APC/C molecular mechanisms. This review discusses how modifications of the core APC/C are responsible for the APC/C's interconversion between different structural and functional states that govern its capacity to control transitions between specific cell cycle phases. A unifying theme is that these structural interconversions involve competition between short linear sequence motifs (SLIMs), shared between substrates, coactivators, inhibitors and E2s, for their common binding sites on the APC/C.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
Barford Ddoi
10.1016/j.sbi.2019.11.010subject
Has Abstractpub_date
2020-04-01 00:00:00pages
86-97eissn
0959-440Xissn
1879-033Xpii
S0959-440X(19)30136-8journal_volume
61pub_type
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