Abstract:
PURPOSE OF REVIEW:The new pandemic of coronavirus disease-2019 (COVID-19) has produced a global tumult and has overburdened national health systems. We herein discuss the cardiovascular implications and complications of this pandemic analyzing the most recent data clustered over the last several months. RECENT FINDINGS:COVID-19 afflicts the cardiovascular system producing acute cardiac injury in 10-20% of cases with mild disease but in greater than 50-60% in severe cases, contributing to patients' demise. Other cardiovascular complications include arrhythmias, heart failure, pulmonary embolism and shock. Off-label therapies are being trialed with their own inherent cardiovascular risks, while supportive therapies currently dominate, until more specific and effective antiviral therapies and vaccinations become available. A controversial issue relates to the safety of drugs blocking the renin--angiotensin system as an angiotensin-converting enzyme (ACE) homologue, ACE2, serves as the receptor for viral entry into host cells. However, to-date, no harm has been proven for these drugs. SUMMARY:In the cardiovascular system, COVID-19 can induce acute cardiac injury, arrhythmias, heart failure, pulmonary embolism, shock and death, whereas anti-COVID therapies also confer serious cardiovascular side-effects. Ongoing extensive efforts focus on specific vaccines and antivirals. Meanwhile, cardiovascular risk factors and diseases should be jointly controlled according to current evidence-based guidelines.
journal_name
Curr Opin Cardioljournal_title
Current opinion in cardiologyauthors
Manolis AS,Manolis TA,Manolis AA,Melita Hdoi
10.1097/HCO.0000000000000838subject
Has Abstractpub_date
2020-12-30 00:00:00eissn
0268-4705issn
1531-7080pii
00001573-900000000-98931journal_volume
Publish Ahead of Printpub_type
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/01.hco.0000198980.40390.e4
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journal_title:Current opinion in cardiology
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journal_title:Current opinion in cardiology
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cardiology
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journal_title:Current opinion in cardiology
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journal_title:Current opinion in cardiology
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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更新日期:2009-07-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-200207000-00007
更新日期:2002-07-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199907000-00005
更新日期:1999-07-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0b013e32831217ed
更新日期:2008-11-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章
doi:10.1097/HCO.0000000000000741
更新日期:2020-07-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cardiology
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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更新日期:1996-07-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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更新日期:1994-03-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
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journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-07-01 00:00:00