Cause-specific treatment in patients with high sperm DNA damage resulted in significant DNA improvement.

abstract：:The GIRK2-containing inward-rectifying K(+) ion channels have been implicated in mammalian spermatogenesis. While the Girk2 null mice are fertile, the male weaver transgenic mice carrying a gain-of-function mutation in the Girk2 gene are infertile. To establish the exact period of spermatogenesis affected by this muta...

journal_title：Systems biology in reproductive medicine

authors： Yi YJ,Sung DY,Millette C,Sutovsky M,Kennedy C,Sutovsky P,Thompson W,Thomas K

更新日期：2011-12-01 00:00:00

abstract：:FSH in infertile patients may be measured in the normal range and abnormal semen analysis findings may be observed in patients with normal FSH values. A recent study predicts that the sperm morphology and concentration may be impaired if the FSH value is above 4.5 IU/L. Therefore, this study aimed to define a clinical...

journal_title：Systems biology in reproductive medicine

authors： Ozkaya M,Oztekin U,Caniklioglu M,Ekmekcioglu O

更新日期：2020-10-01 00:00:00

abstract：:The aim of this study was to evaluate the predictive value of the anti-Mullerian hormone (AMH) level for early pregnancy loss and to compare the significance of AMH level to age as prognostic factors of pregnancy loss in subfertile women. The outcome of 848 subfertile patients confirmed with intrauterine pregnancies b...

journal_title：Systems biology in reproductive medicine

authors： Hong S,Chang E,Han EJ,Min SG,Kim S,Kang MK,Cha DH,Shim SH,Park HJ

更新日期：2020-12-01 00:00:00

abstract：:Maternal obesity can cause complications for both women and their offspring for generations. Therefore, we intended to verify the repercussions of induction of transgenerational obesity on biochemical parameters, reproductive performance, and congenital anomaly frequency in Wistar rats. Female rats were used from succ...

journal_title：Systems biology in reproductive medicine

authors： Soares TS,Andreolla AP,Miranda CA,Klöppel E,Rodrigues LS,Moraes-Souza RQ,Damasceno DC,Volpato GT,Campos KE

更新日期：2018-02-01 00:00:00

abstract：:Short gamete co-incubation (SGCO) consists in decreasing the duration of contact between oocytes and sperm from the standard overnight insemination (SOI) toward 2 hours. However, the effectiveness of this technique to improve in vitro fertilization and embryo transfer (IVF-ET) outcomes remains controversial. Our study...

journal_title：Systems biology in reproductive medicine

authors： Le Bras A,Hesters L,Gallot V,Tallet C,Tachdjian G,Frydman N

更新日期：2017-10-01 00:00:00

abstract：:Sexual dysfunction is one of the diabetic complications in males. The present study aimed to evaluate the antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin (STZ) induced diabetic male rats. Male Wistar rats were divided as control, diabetic control, diabetic rats admini...

journal_title：Systems biology in reproductive medicine

authors： Nelli GB,K AS,Kilari EK

更新日期：2013-12-01 00:00:00

abstract：:We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent...

journal_title：Systems biology in reproductive medicine

authors： Nagaraja MR,Gubbala SP,Delphine Silvia CRW,Amanchy R

更新日期：2019-04-01 00:00:00

abstract：:The object of this study was to investigate the effect of molybdenum on the development of mouse preimplantation embryos cultured in vitro. Zygotes were flushed from one outbred mouse strain (Kunming), and then were cultured in potassium simplex optimized medium (KSOM) containing 0, 5, 10, 20, 40, 80, 120, and 160 µg/...

journal_title：Systems biology in reproductive medicine

authors： Bi CM,Zhang YL,Liu FJ,Zhou TZ,Yang ZJ,Gao SY,Wang SD,Chen XL,Zhai XW,Ma XG,Jin LJ,Wang S

更新日期：2013-04-01 00:00:00

abstract：:Reproductive biology is considered a specialty field, however, an argument can be made that it is instead generally applicable to many fields of biology. The one-cell embryo is presented here as a model system for the study of eukaryotic DNA replication, apoptotic DNA degradation, and signaling mechanisms between the ...

journal_title：Systems biology in reproductive medicine

authors： Ortega MA,Sil P,Ward WS

更新日期：2011-02-01 00:00:00

abstract：:Varicocele is currently the most common irregularity identified in males that is associated with impaired spermatogenesis. It primarily presents in the form of decreased sperm count and motility, abnormal morphology, and significantly increased sperm DNA fragmentation. Several studies have shown that surgical repair i...

journal_title：Systems biology in reproductive medicine

authors： Li F,Yamaguchi K,Okada K,Matsushita K,Ando M,Chiba K,Yue H,Fujisawa M

更新日期：2012-10-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF), a major angiogenic factor, is known to play an important role in the development of endometriosis. The aim of this study was to investigate the association of three VEGF (-460 C/T, +405 G/C, and +936 C/T) polymorphisms with the risk of endometriosis in the Tunisian popula...

journal_title：Systems biology in reproductive medicine

authors： Henidi B,Kaabachi W,Naouali A,Kaabachi S,Zhioua A,Haj Sassi F,Hamzaoui K

更新日期：2015-01-01 00:00:00

abstract：:In order to identify unreliable data in a dataset of motility parameters obtained from a pilot study acquired by a veterinarian with experience in boar semen handling, but without experience in the operation of a computer assisted sperm analysis (CASA) system, a multivariate graphical and statistical analysis was perf...

journal_title：Systems biology in reproductive medicine

authors： Martínez LB,Crispín RH,Mendoza MM,Gallegos OH,Martínez AA

更新日期：2013-06-01 00:00:00

abstract：:Assisted reproductive technology has evolved tremendously since the emergence of in vitro fertilization (IVF). In the course of the recent decade, there have been significant efforts in order to minimize multiple gestations, while improving percentages of singleton pregnancies and offering individualized services in I...

journal_title：Systems biology in reproductive medicine

authors： Simopoulou M,Sfakianoudis K,Antoniou N,Maziotis E,Rapani A,Bakas P,Anifandis G,Kalampokas T,Bolaris S,Pantou A,Pantos K,Koutsilieris M

更新日期：2018-10-01 00:00:00

abstract：:At least in mammals, retinoic acid is a pivotal factor in maintaining the functionality of the testis, in particular, for the progression of germ cells from mitosis to meiosis. Removal of dietary vitamin A or a targeted deletion of retinoic acid receptor alpha gene (Rara), the receptor for retinoic acid, in mice, led ...

journal_title：Systems biology in reproductive medicine

authors： Doyle TJ,Oudes AJ,Kim KH

更新日期：2009-08-01 00:00:00

abstract：:The understanding of the early mammalian development is a prerequisite for the advancement of in vitro fertilization and improvement of derivation and culturing of embryonic stem cells. While, whole genome transcriptomic analysis on bovine blastocysts has identified genes active in early development, little informatio...

journal_title：Systems biology in reproductive medicine

authors： Jensen PL,Grøndahl ML,Beck HC,Petersen J,Stroebech L,Christensen ST,Yding Andersen C

更新日期：2014-06-01 00:00:00

abstract：:The aim of this study is to compare the expression patterns of tyrosine kinases and their ligand activators between matched myometrium and leiomyoma tissues. Total RNA extracted from 42 pairs of matched leiomyomal and adjacent myometrial tissues were hybridized to a set of 840 customized oligonucleotide microarrays to...

journal_title：Systems biology in reproductive medicine

authors： Jiang Y,Suo G,Sadarangani A,Cowan B,Wang JY

更新日期：2010-08-01 00:00:00

abstract：:One of the major causes of defective sperm function is oxidative stress, which limits the fertilizing potential of these cells as the result of collateral damage to proteins and lipids in the sperm plasma membrane. On this point, a derangement of both generation and neutralization of reactive oxygen species (ROS) is a...

journal_title：Systems biology in reproductive medicine

authors： Signorini C,Moretti E,Collodel G

更新日期：2020-10-01 00:00:00

abstract：:We explored the molecular mechanisms of obesity and insulin resistance in patients with polycystic ovary syndrome (PCOS) using a human embryonic stem cell model (hESCs). Three PCOS-derived and one non-PCOS-derived hESC lines were induced into adipocytes, and then total RNA was extracted. The differentially expressed P...

journal_title：Systems biology in reproductive medicine

authors： Wang F,Liu WW,Chen XM,Kong HJ,Li J,Sun YP

更新日期：2014-06-01 00:00:00

abstract：:To date we have yet to examine whether amino acid (AA) transport in human ovarian follicles is affected by competitive inhibition. In contrast, transplacental transfer of AAs in late-gestation sheep is characterized by reciprocal competition. This phenomenon has been described by algebraic equations of umbilical uptak...

journal_title：Systems biology in reproductive medicine

authors： Jóźwik M,Jóźwik M,Milewska AJ,Battaglia FC,Jóźwik M

更新日期：2017-10-01 00:00:00

abstract：:There are variant rates of oocyte degeneration after intracytoplasmic sperm injection (ICSI) among different patients. Oocyte degeneration after ICSI may reflect the cohort of oocyte quality and subsequent embryo development capacity and clinical outcome. This retrospective study analyzed 255 cycles with at least one ...

journal_title：Systems biology in reproductive medicine

authors： Liu L,Cai J,Li P,Jiang X,Ren J

更新日期：2017-04-01 00:00:00

abstract：:Genomic disorders are defined as diseases caused by rearrangements of the genome incited by a genomic architecture that conveys instability. Y-chromosome related dysfunctions such as male infertility are frequently associated with gross DNA rearrangements resulting from its peculiar genomic architecture. The Y-chromos...

journal_title：Systems biology in reproductive medicine

authors： Carvalho CM,Zhang F,Lupski JR

更新日期：2011-02-01 00:00:00

abstract：:Preimplantation embryos may have an increased risk of having mismatches due to the rates of cell proliferation and DNA replication. Elimination of mismatches in human gametes and embryos has not been investigated. In this study we developed a sensitive functional assay to examine the repair or elimination of mismatche...

journal_title：Systems biology in reproductive medicine

authors： Tulay P,Jaroudi S,Doshi A,SenGupta SB

更新日期：2016-12-01 00:00:00

abstract：:The etiology of adverse pregnancy outcomes is not well understood. Wildlife observations provide considerable evidence that environmental contaminants can play a critical role in reproductive and developmental dysfunction. Early evidence leading to a widespread awareness of the impact of environmental chemicals on sur...

journal_title：Systems biology in reproductive medicine

authors： Hamlin HJ,Guillette LJ Jr

更新日期：2010-04-01 00:00:00

abstract：:The study of embryos with the tools and mindset of physics, started by Wilhelm His in the 1880s, has resumed after a hiatus of a century. The Embryo Physics Course convenes online allowing interested researchers and students, who are scattered around the world, to gather weekly in one place, the virtual world of Secon...

journal_title：Systems biology in reproductive medicine

authors： Gordon R

更新日期：2013-06-01 00:00:00

abstract：:Multiple prevention therapy has gained importance for the prevention and treatment of sexually transmitted diseases, especially HIV/AIDS. Antiretroviral drugs encapsulated in nanoparticles have been developed for efficient delivery of the drugs to the vaginal surface. Lactoferrin nanoparticles (LFNPs) encapsulating an...

journal_title：Systems biology in reproductive medicine

authors： Madugulla L,Ravula AR,Kondapi AK,Yenugu S

更新日期：2019-06-01 00:00:00

abstract：:Sperm progressive motility has been reported to be one of the key factors influencing in vitro fertilization rates. However, recent studies have shown that sperm DNA fragmentation is a more robust predictor of assisted reproductive outcomes including reduced fertilization rates, embryo quality, and pregnancy rates. Th...

journal_title：Systems biology in reproductive medicine

authors： Simon L,Lewis SE

更新日期：2011-06-01 00:00:00

abstract：:Although intracytoplasmic sperm injection (ICSI) is now a widely-used technique, it is still of interest to improve our knowledge as to which is the best spermatozoon to be selected for ICSI. Infertile men have increased risks of producing aneuploid spermatozoa. Using hyaluronic acid (HA)-binding sperm selection may r...

journal_title：Systems biology in reproductive medicine

authors： Mokánszki A,Tóthné EV,Bodnár B,Tándor Z,Molnár Z,Jakab A,Ujfalusi A,Oláh É

更新日期：2014-12-01 00:00:00

abstract：:What is the impact of intentional weight loss and regain on serum androgens in women? We conducted an ancillary analysis of prospectively collected samples from a randomized controlled trial. The trial involved supervised 10% weight loss (8.5 kg on average) with diet and exercise over 4-6 months followed by supervised...

journal_title：Systems biology in reproductive medicine

authors： Aubuchon M,Liu Y,Petroski GF,Thomas TR,Polotsky AJ

更新日期：2016-08-01 00:00:00

abstract：:We have earlier shown that cobalt chloride (CoCl2)-induced hypoxia and second messenger 8-bromoadenosine 3', 5'-cyclic adenosine monophosphate (8-Br-cAMP) stimulates vascular endothelial growth factor (VEGF) production in Leydig tumor cell derived MA-10 cells. Both stimuli follow common signal transduction pathways in...

journal_title：Systems biology in reproductive medicine

authors： Kumar A,Rani L,Dhole B

更新日期：2014-04-01 00:00:00

abstract：:Pulsatile secretion of hormones in the hypothalamic-pituitary-gonadal axis is critical for normal functioning of the reproductive system. Thus, appropriate characterization of pulsatile secretion is important for identifying the (patho)physiology of reproductive conditions. Existing analysis methods often fail to adeq...

journal_title：Systems biology in reproductive medicine

authors： Liu H,Polotsky AJ,Grunwald GK,Carlson NE

更新日期：2018-02-01 00:00:00