Abstract:
:The vascular endothelial growth factor (VEGF), a major angiogenic factor, is known to play an important role in the development of endometriosis. The aim of this study was to investigate the association of three VEGF (-460 C/T, +405 G/C, and +936 C/T) polymorphisms with the risk of endometriosis in the Tunisian population. This study includes 105 women with endometriosis and 150 women with no laparoscopic evidence of disease. Genotyping of the VEGF -460 C/T, +405 G/C, and +936 C/T polymorphisms were performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The distribution of genotypes (P = 0.006) and allele (P = 0.0009) frequencies of the +936 C/T polymorphism was significantly different between patients and controls. Patients with stages III-IV endometriosis showed a higher VEGF + 936T allele frequency than controls (P = 0.0001). However, the distribution of genotypes and allele frequencies of the VEGF -460 C/T and +405 G/C polymorphisms did not differ significantly between endometriosis patients and controls. These findings suggest that the VEGF +936 C/T polymorphism may be a risk factor for endometriosis development and the VEGF +936 T allele is associated with an increased risk of stages III-IV endometriosis in the Tunisian population.
journal_name
Syst Biol Reprod Medjournal_title
Systems biology in reproductive medicineauthors
Henidi B,Kaabachi W,Naouali A,Kaabachi S,Zhioua A,Haj Sassi F,Hamzaoui Kdoi
10.3109/19396368.2015.1041622subject
Has Abstractpub_date
2015-01-01 00:00:00pages
238-44issue
4eissn
1939-6368issn
1939-6376journal_volume
61pub_type
杂志文章abstract::Although intracytoplasmic sperm injection (ICSI) is now a widely-used technique, it is still of interest to improve our knowledge as to which is the best spermatozoon to be selected for ICSI. Infertile men have increased risks of producing aneuploid spermatozoa. Using hyaluronic acid (HA)-binding sperm selection may r...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.948102
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abstract::We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396360801935644
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abstract::Assessment of sperm DNA damage has been suggested as a negative predictor of fertility potential. Multiple pathological factors acting at both the intra-testicular and post-testicular levels may contribute to sperm DNA damage. The relative contribution of each of these factors in an individual with high DNA damage (>3...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396360902787944
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2016.1177619
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abstract::For natural fertilization to occur successfully, millions of spermatozoa must be deposited in the lower end of the female genital tract during mating. Considerably fewer spermatozoa are required for fertilization when spermatozoa are deposited in the upper region of the female tract. The extreme case of assisted ferti...
journal_title:Systems biology in reproductive medicine
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doi:10.3109/19396368.2010.507860
更新日期:2011-02-01 00:00:00
abstract::The ICSI procedure was invented to treat severe male infertility but is often used even if the sperm quality parameters are normal. This practice has recently been called into question, but there is still no clear answer especially in terms of sperm morphology, regarding when it is necessary to perform ICSI and when c...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2019.1666436
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2010.505679
更新日期:2011-02-01 00:00:00
abstract::Establishing specific biomarkers for the assessment of human male fertility status is an important goal to ensure the fitness of the male contribution so as to support the birth of a healthy child. Spermatozoa are considered an optimal surrogate tissue for the evaluation of spermatogenic function. Unlike the cells of ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2011.637152
更新日期:2012-02-01 00:00:00
abstract::Short gamete co-incubation (SGCO) consists in decreasing the duration of contact between oocytes and sperm from the standard overnight insemination (SOI) toward 2 hours. However, the effectiveness of this technique to improve in vitro fertilization and embryo transfer (IVF-ET) outcomes remains controversial. Our study...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1336581
更新日期:2017-10-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2013.861034
更新日期:2014-04-01 00:00:00
abstract::Spermatogenesis is a highly sophisticated process involved in the transmission of genetic heritage. It includes halving ploidy, repackaging of the chromatin for transport, and the equipment of developing spermatids and eventually spermatozoa with the advanced apparatus (e.g., tightly packed mitochondrial sheat in the ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2012.691943
更新日期:2012-08-01 00:00:00
abstract::Both microdrop and open methods are commonly used for in vitro fertilization (IVF) protocols for embryo culture as well as oocyte insemination. However, few comparative studies evaluating the microdrop or open method of insemination on the fertilization outcome and subsequent embryo development have been performed. A ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,随机对照试验
doi:10.3109/19396368.2013.872707
更新日期:2014-06-01 00:00:00
abstract::Varicocele is currently the most common irregularity identified in males that is associated with impaired spermatogenesis. It primarily presents in the form of decreased sperm count and motility, abnormal morphology, and significantly increased sperm DNA fragmentation. Several studies have shown that surgical repair i...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2012.692431
更新日期:2012-10-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2020.1758834
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1341962
更新日期:2017-10-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2018.1482383
更新日期:2018-12-01 00:00:00
abstract::Primary ovarian insufficiency (POI) affects ~1% of women in the general population. Despite numerous attempts at identifying POI genetic aetiology, coding mutations in only a few genes have been functionally related to POI pathogenesis. It has been suggested that mutant BMPR2 might contribute towards the phenotype. Se...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1291767
更新日期:2017-06-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.927540
更新日期:2014-10-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2015.1022835
更新日期:2015-06-01 00:00:00
abstract::Complete deletions in the AZF (a, b, and c) sub-regions of the Y-chromosome have been shown to contribute to unexplained male infertility. However, the role of partial AZFc deletions in male infertility remains to be verified. Three types of partial AZFc deletions have been identified. They are gr/gr, b1/b3, and b2/b3...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2012.748851
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.894152
更新日期:2014-06-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2013.820369
更新日期:2013-12-01 00:00:00
abstract::The aim of this study is to compare the expression patterns of tyrosine kinases and their ligand activators between matched myometrium and leiomyoma tissues. Total RNA extracted from 42 pairs of matched leiomyomal and adjacent myometrial tissues were hybridized to a set of 840 customized oligonucleotide microarrays to...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396361003646109
更新日期:2010-08-01 00:00:00
abstract::In the human, canonical histones are largely replaced by protamine 1 (P1) and protamine 2 (P2) during late spermatogenesis. Recent studies have demonstrated that abnormal replacement of the histones is associated with severe male infertility and has profound implications for early embryogenesis. In this review the his...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396361003653311
更新日期:2010-06-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2012.655403
更新日期:2012-06-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2020.1824032
更新日期:2020-12-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396360802055921
更新日期:2008-05-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1080/19396368.2018.1504347
更新日期:2018-10-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
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