Abstract:
:The aim of this study is to compare the expression patterns of tyrosine kinases and their ligand activators between matched myometrium and leiomyoma tissues. Total RNA extracted from 42 pairs of matched leiomyomal and adjacent myometrial tissues were hybridized to a set of 840 customized oligonucleotide microarrays to compare the expression profiles of 244 selected human genes including 90 tyrosine kinases and 103 ligands. Among the 244 genes surveyed, 38 were found to exhibit differential expression between pairs of myometrium and leiomyoma tissues. Clustering analysis of the expression ratios of these 38 genes from 42 pairs of samples led to the subdivision of fibroid samples into three groups, based in principle on the expression ratios of two peptide ligands, CYR61 and EFNA4. Real-time quantitative RT-PCR measurements of an additional 32 pairs of samples further confirmed the three subgroups. The altered expression of ligand activators between myometrium and leiomyoma suggest that tyrosine kinases regulated by CYR61 and EFNA4 may be exploited as therapeutic targets to develop non-surgical treatments of symptomatic leiomyomas.
journal_name
Syst Biol Reprod Medjournal_title
Systems biology in reproductive medicineauthors
Jiang Y,Suo G,Sadarangani A,Cowan B,Wang JYdoi
10.3109/19396361003646109subject
Has Abstractpub_date
2010-08-01 00:00:00pages
318-26issue
4eissn
1939-6368issn
1939-6376journal_volume
56pub_type
杂志文章abstract::The aim of this study was to evaluate the feasibility and efficiency of using a sucrose gradient-based warming protocol as a universal warming approach on human cleavage stage embryos. Between January 2013 and November 2014, a total of 118 warming cycles were performed on 705 embryos which had previously been cryopres...
journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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doi:10.1080/19396368.2017.1291767
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2012.743198
更新日期:2013-04-01 00:00:00
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
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journal_title:Systems biology in reproductive medicine
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journal_title:Systems biology in reproductive medicine
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