Abstract:
:For patients with recurrent implantation failure in IVF, histologic or transcriptomic testing of the endometrium during the mid-secretory phase is often considered. Histological dating of endometrial biopsies (Noyes criteria) can determine if endometrial morphology is consistent with the period of receptivity. Alternatively, endometrial tissue can be sent for a commercial Endometrial Receptivity Array (ERA) test which characterizes the gene expression of the endometrium using a panel of 238 genes that have been implicated in endometrial receptivity. This study aimed to compare the two tests to assess their concordance and to examine the ability of the ERA to successfully predict implantation and pregnancy in a subsequent personalized embryo transfer. A retrospective review was done of 97 patients with a history of implantation failure who underwent an ERA, 35 of whom had histologic dating on the same sample. ERA and histology were classified as 'concordant' when samples were receptive by both tests or non-receptive by both tests. The ERA result was then used to personalize the embryo transfer day, and pregnancy rates from the first subsequent frozen transfer cycle were analyzed. The results indicated that there is poor concordance between ERA and histological dating with only 40.0% agreement and a kappa (95%CI) = -0.18 (-0.50, 0.14). According to the ERA, 48.5% of biopsies were receptive, 47.4% were non-receptive and 2.01% were insufficient tissue for analysis. The clinical pregnancy rate in patients shown to be receptive by ERA was 26.7% and non-receptive was 22.5% following the subsequent personalized ET (p = 0.66). This study concludes that there is a high degree of discordance between histological dating of the endometrium and molecular analysis by ERA. There was no evidence of clinical benefit when embryo transfer was personalized according to ERA in patients with a history of implantation failure.
journal_name
Syst Biol Reprod Medjournal_title
Systems biology in reproductive medicineauthors
Cohen AM,Ye XY,Colgan TJ,Greenblatt EM,Chan Cdoi
10.1080/19396368.2020.1824032subject
Has Abstractpub_date
2020-12-01 00:00:00pages
347-354issue
6eissn
1939-6368issn
1939-6376journal_volume
66pub_type
杂志文章abstract::Establishing specific biomarkers for the assessment of human male fertility status is an important goal to ensure the fitness of the male contribution so as to support the birth of a healthy child. Spermatozoa are considered an optimal surrogate tissue for the evaluation of spermatogenic function. Unlike the cells of ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2011.637152
更新日期:2012-02-01 00:00:00
abstract::The aim of this study was to evaluate the predictive value of the anti-Mullerian hormone (AMH) level for early pregnancy loss and to compare the significance of AMH level to age as prognostic factors of pregnancy loss in subfertile women. The outcome of 848 subfertile patients confirmed with intrauterine pregnancies b...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2020.1806944
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abstract::The understanding of the early mammalian development is a prerequisite for the advancement of in vitro fertilization and improvement of derivation and culturing of embryonic stem cells. While, whole genome transcriptomic analysis on bovine blastocysts has identified genes active in early development, little informatio...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.894152
更新日期:2014-06-01 00:00:00
abstract::In this retrospective study the outcomes of two protocols of controlled ovarian hyperstimulation and natural cycle in poor ovarian responders defined according to the Bologna criteria were compared to elucidate which approach is more suitable for the treatment of these patients. We comparatively analyzed 142 cycles of...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2016.1170229
更新日期:2016-08-01 00:00:00
abstract::In order to identify unreliable data in a dataset of motility parameters obtained from a pilot study acquired by a veterinarian with experience in boar semen handling, but without experience in the operation of a computer assisted sperm analysis (CASA) system, a multivariate graphical and statistical analysis was perf...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2013.766281
更新日期:2013-06-01 00:00:00
abstract::A very common conception about the function of the spermatozoon is that its unique role is to transmit the paternal genome to the next generation. Most of the sperm genome is known to be condensed in many species by protamines, which are small and extremely positively charged proteins (50-70% arginine) with the functi...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2018.1482383
更新日期:2018-12-01 00:00:00
abstract::We aimed to assess the possible presence of a seasonal pattern in three parameters of semen analysis: sperm concentration, morphology, and motility as a function of the time of ejaculation and sperm production (spermatogenesis) in normal and oligozoospermic men. This retrospective study included a consecutive series o...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2016.1225322
更新日期:2016-12-01 00:00:00
abstract::Assisted reproductive technology has evolved tremendously since the emergence of in vitro fertilization (IVF). In the course of the recent decade, there have been significant efforts in order to minimize multiple gestations, while improving percentages of singleton pregnancies and offering individualized services in I...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1080/19396368.2018.1504347
更新日期:2018-10-01 00:00:00
abstract::Complete deletions in the AZF (a, b, and c) sub-regions of the Y-chromosome have been shown to contribute to unexplained male infertility. However, the role of partial AZFc deletions in male infertility remains to be verified. Three types of partial AZFc deletions have been identified. They are gr/gr, b1/b3, and b2/b3...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2012.748851
更新日期:2013-04-01 00:00:00
abstract::Although intracytoplasmic sperm injection (ICSI) is now a widely-used technique, it is still of interest to improve our knowledge as to which is the best spermatozoon to be selected for ICSI. Infertile men have increased risks of producing aneuploid spermatozoa. Using hyaluronic acid (HA)-binding sperm selection may r...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.948102
更新日期:2014-12-01 00:00:00
abstract::To date we have yet to examine whether amino acid (AA) transport in human ovarian follicles is affected by competitive inhibition. In contrast, transplacental transfer of AAs in late-gestation sheep is characterized by reciprocal competition. This phenomenon has been described by algebraic equations of umbilical uptak...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1341962
更新日期:2017-10-01 00:00:00
abstract::Sexual dysfunction is one of the diabetic complications in males. The present study aimed to evaluate the antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin (STZ) induced diabetic male rats. Male Wistar rats were divided as control, diabetic control, diabetic rats admini...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2013.820369
更新日期:2013-12-01 00:00:00
abstract::The ICSI procedure was invented to treat severe male infertility but is often used even if the sperm quality parameters are normal. This practice has recently been called into question, but there is still no clear answer especially in terms of sperm morphology, regarding when it is necessary to perform ICSI and when c...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2019.1666436
更新日期:2019-12-01 00:00:00
abstract::Multiple prevention therapy has gained importance for the prevention and treatment of sexually transmitted diseases, especially HIV/AIDS. Antiretroviral drugs encapsulated in nanoparticles have been developed for efficient delivery of the drugs to the vaginal surface. Lactoferrin nanoparticles (LFNPs) encapsulating an...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2018.1519047
更新日期:2019-06-01 00:00:00
abstract::Increased trophoblast apoptosis has been implicated in pregnancies complicated by fetal growth restriction and preeclampsia (EC). We investigated placenta growth factor (PLGF) signaling during trophoblast apoptosis in culture and X-linked inhibitor of apoptosis protein (XIAP) and apoptosis inducible factor (AIF) in th...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.927540
更新日期:2014-10-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396360903244598
更新日期:2010-04-01 00:00:00
abstract::At least in mammals, retinoic acid is a pivotal factor in maintaining the functionality of the testis, in particular, for the progression of germ cells from mitosis to meiosis. Removal of dietary vitamin A or a targeted deletion of retinoic acid receptor alpha gene (Rara), the receptor for retinoic acid, in mice, led ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396360902896844
更新日期:2009-08-01 00:00:00
abstract::Thymoquinone (TQ) is a phytochemical compound found in the plant Nigella sativa. It has antioxidant and anti-cancer effects. This study investigated the effects of TQ on obesity and testicular structure of high-fat-diet (HFD) fed rats. Obese control (OC) and obese thymoquinone (OT) groups were fed a special diet conta...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2015.1044135
更新日期:2015-01-01 00:00:00
abstract::There are variant rates of oocyte degeneration after intracytoplasmic sperm injection (ICSI) among different patients. Oocyte degeneration after ICSI may reflect the cohort of oocyte quality and subsequent embryo development capacity and clinical outcome. This retrospective study analyzed 255 cycles with at least one ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2016.1272648
更新日期:2017-04-01 00:00:00
abstract::We explored the molecular mechanisms of obesity and insulin resistance in patients with polycystic ovary syndrome (PCOS) using a human embryonic stem cell model (hESCs). Three PCOS-derived and one non-PCOS-derived hESC lines were induced into adipocytes, and then total RNA was extracted. The differentially expressed P...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.889774
更新日期:2014-06-01 00:00:00
abstract::We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1080/19396368.2018.1549619
更新日期:2019-04-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2010.527427
更新日期:2011-02-01 00:00:00
abstract::Spermatogenesis is a highly sophisticated process involved in the transmission of genetic heritage. It includes halving ploidy, repackaging of the chromatin for transport, and the equipment of developing spermatids and eventually spermatozoa with the advanced apparatus (e.g., tightly packed mitochondrial sheat in the ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2012.691943
更新日期:2012-08-01 00:00:00
abstract::Varicocele is currently the most common irregularity identified in males that is associated with impaired spermatogenesis. It primarily presents in the form of decreased sperm count and motility, abnormal morphology, and significantly increased sperm DNA fragmentation. Several studies have shown that surgical repair i...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2012.692431
更新日期:2012-10-01 00:00:00
abstract::The aim of this study is to compare the expression patterns of tyrosine kinases and their ligand activators between matched myometrium and leiomyoma tissues. Total RNA extracted from 42 pairs of matched leiomyomal and adjacent myometrial tissues were hybridized to a set of 840 customized oligonucleotide microarrays to...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396361003646109
更新日期:2010-08-01 00:00:00
abstract::Short gamete co-incubation (SGCO) consists in decreasing the duration of contact between oocytes and sperm from the standard overnight insemination (SOI) toward 2 hours. However, the effectiveness of this technique to improve in vitro fertilization and embryo transfer (IVF-ET) outcomes remains controversial. Our study...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1336581
更新日期:2017-10-01 00:00:00
abstract::We have earlier shown that cobalt chloride (CoCl2)-induced hypoxia and second messenger 8-bromoadenosine 3', 5'-cyclic adenosine monophosphate (8-Br-cAMP) stimulates vascular endothelial growth factor (VEGF) production in Leydig tumor cell derived MA-10 cells. Both stimuli follow common signal transduction pathways in...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2013.861034
更新日期:2014-04-01 00:00:00
abstract::Maternal obesity can cause complications for both women and their offspring for generations. Therefore, we intended to verify the repercussions of induction of transgenerational obesity on biochemical parameters, reproductive performance, and congenital anomaly frequency in Wistar rats. Female rats were used from succ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1410866
更新日期:2018-02-01 00:00:00
abstract::Artificial insemination has achieved a dynamic increase in genetic progress, and this is due to the improvement of sperm preservation technology. In recent years, a lot of attention has been paid to optimizing bull sperm storage environment and objectifying methods of sperm quality analysis. This review presents bull ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2020.1795432
更新日期:2020-10-01 00:00:00
abstract::One of the major causes of defective sperm function is oxidative stress, which limits the fertilizing potential of these cells as the result of collateral damage to proteins and lipids in the sperm plasma membrane. On this point, a derangement of both generation and neutralization of reactive oxygen species (ROS) is a...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2020.1793032
更新日期:2020-10-01 00:00:00