Abstract:
:Both microdrop and open methods are commonly used for in vitro fertilization (IVF) protocols for embryo culture as well as oocyte insemination. However, few comparative studies evaluating the microdrop or open method of insemination on the fertilization outcome and subsequent embryo development have been performed. A randomized study was conducted to compare microdrop and open fertilization with respect to fertilization rate and embryo development among non-male factor patients undergoing in vitro fertilization and embryo transfer (IVF-ET). The results presented in this study demonstrate that the fertilization failure rate [total fertilization failure rate (TFF) plus low fertilization rate (<25% oocytes fertilized)] in the microdrop insemination group was higher than in the open insemination group (11.9% versus 3.3%, p < 0.001), while the good quality embryo rate and pregnancy rate did not differ significantly between the groups. As a highly complicated process involving many extrinsic and intrinsic factors, further studies are needed to confirm the effects of these insemination methods on the rate of fertilization failure.
journal_name
Syst Biol Reprod Medjournal_title
Systems biology in reproductive medicineauthors
Li Y,Li T,Mai Q,Long L,Ou Jdoi
10.3109/19396368.2013.872707subject
Has Abstractpub_date
2014-06-01 00:00:00pages
165-70issue
3eissn
1939-6368issn
1939-6376journal_volume
60pub_type
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