Clinical outcome of cycles with oocyte degeneration after intracytoplasmic sperm injection.

abstract：:At least in mammals, retinoic acid is a pivotal factor in maintaining the functionality of the testis, in particular, for the progression of germ cells from mitosis to meiosis. Removal of dietary vitamin A or a targeted deletion of retinoic acid receptor alpha gene (Rara), the receptor for retinoic acid, in mice, led ...

journal_title：Systems biology in reproductive medicine

authors： Doyle TJ,Oudes AJ,Kim KH

更新日期：2009-08-01 00:00:00

abstract：:Spermatogenesis is a highly sophisticated process involved in the transmission of genetic heritage. It includes halving ploidy, repackaging of the chromatin for transport, and the equipment of developing spermatids and eventually spermatozoa with the advanced apparatus (e.g., tightly packed mitochondrial sheat in the ...

journal_title：Systems biology in reproductive medicine

authors： Chocu S,Calvel P,Rolland AD,Pineau C

更新日期：2012-08-01 00:00:00

abstract：:We explored the molecular mechanisms of obesity and insulin resistance in patients with polycystic ovary syndrome (PCOS) using a human embryonic stem cell model (hESCs). Three PCOS-derived and one non-PCOS-derived hESC lines were induced into adipocytes, and then total RNA was extracted. The differentially expressed P...

journal_title：Systems biology in reproductive medicine

authors： Wang F,Liu WW,Chen XM,Kong HJ,Li J,Sun YP

更新日期：2014-06-01 00:00:00

abstract：:One of the major causes of defective sperm function is oxidative stress, which limits the fertilizing potential of these cells as the result of collateral damage to proteins and lipids in the sperm plasma membrane. On this point, a derangement of both generation and neutralization of reactive oxygen species (ROS) is a...

journal_title：Systems biology in reproductive medicine

authors： Signorini C,Moretti E,Collodel G

更新日期：2020-10-01 00:00:00

abstract：:For patients with recurrent implantation failure in IVF, histologic or transcriptomic testing of the endometrium during the mid-secretory phase is often considered. Histological dating of endometrial biopsies (Noyes criteria) can determine if endometrial morphology is consistent with the period of receptivity. Alterna...

journal_title：Systems biology in reproductive medicine

authors： Cohen AM,Ye XY,Colgan TJ,Greenblatt EM,Chan C

更新日期：2020-12-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF), a major angiogenic factor, is known to play an important role in the development of endometriosis. The aim of this study was to investigate the association of three VEGF (-460 C/T, +405 G/C, and +936 C/T) polymorphisms with the risk of endometriosis in the Tunisian popula...

journal_title：Systems biology in reproductive medicine

authors： Henidi B,Kaabachi W,Naouali A,Kaabachi S,Zhioua A,Haj Sassi F,Hamzaoui K

更新日期：2015-01-01 00:00:00

abstract：:Although intracytoplasmic sperm injection (ICSI) is now a widely-used technique, it is still of interest to improve our knowledge as to which is the best spermatozoon to be selected for ICSI. Infertile men have increased risks of producing aneuploid spermatozoa. Using hyaluronic acid (HA)-binding sperm selection may r...

journal_title：Systems biology in reproductive medicine

authors： Mokánszki A,Tóthné EV,Bodnár B,Tándor Z,Molnár Z,Jakab A,Ujfalusi A,Oláh É

更新日期：2014-12-01 00:00:00

abstract：:Increased trophoblast apoptosis has been implicated in pregnancies complicated by fetal growth restriction and preeclampsia (EC). We investigated placenta growth factor (PLGF) signaling during trophoblast apoptosis in culture and X-linked inhibitor of apoptosis protein (XIAP) and apoptosis inducible factor (AIF) in th...

journal_title：Systems biology in reproductive medicine

authors： Arroyo J,Price M,Straszewski-Chavez S,Torry RJ,Mor G,Torry DS

更新日期：2014-10-01 00:00:00

abstract：:Sperm progressive motility has been reported to be one of the key factors influencing in vitro fertilization rates. However, recent studies have shown that sperm DNA fragmentation is a more robust predictor of assisted reproductive outcomes including reduced fertilization rates, embryo quality, and pregnancy rates. Th...

journal_title：Systems biology in reproductive medicine

authors： Simon L,Lewis SE

更新日期：2011-06-01 00:00:00

abstract：:Spermatozoa contain a complex population of RNAs including messenger RNAs (mRNAs) and small RNAs such as microRNAs (miRNA). It has been reported that these RNAs can be used to understand the mechanisms by which toxicological exposure affects spermatogenesis. The aim of our study was to compare mRNA and miRNA profiles ...

journal_title：Systems biology in reproductive medicine

authors： Metzler-Guillemain C,Victorero G,Lepoivre C,Bergon A,Yammine M,Perrin J,Sari-Minodier I,Boulanger N,Rihet P,Nguyen C

更新日期：2015-06-01 00:00:00

abstract：:Reproductive biology is considered a specialty field, however, an argument can be made that it is instead generally applicable to many fields of biology. The one-cell embryo is presented here as a model system for the study of eukaryotic DNA replication, apoptotic DNA degradation, and signaling mechanisms between the ...

journal_title：Systems biology in reproductive medicine

authors： Ortega MA,Sil P,Ward WS

更新日期：2011-02-01 00:00:00

abstract：:Thymoquinone (TQ) is a phytochemical compound found in the plant Nigella sativa. It has antioxidant and anti-cancer effects. This study investigated the effects of TQ on obesity and testicular structure of high-fat-diet (HFD) fed rats. Obese control (OC) and obese thymoquinone (OT) groups were fed a special diet conta...

journal_title：Systems biology in reproductive medicine

authors： Tüfek NH,Altunkaynak ME,Altunkaynak BZ,Kaplan S

更新日期：2015-01-01 00:00:00

abstract：:The etiology of adverse pregnancy outcomes is not well understood. Wildlife observations provide considerable evidence that environmental contaminants can play a critical role in reproductive and developmental dysfunction. Early evidence leading to a widespread awareness of the impact of environmental chemicals on sur...

journal_title：Systems biology in reproductive medicine

authors： Hamlin HJ,Guillette LJ Jr

更新日期：2010-04-01 00:00:00

abstract：:The aim of this study was to evaluate the predictive value of the anti-Mullerian hormone (AMH) level for early pregnancy loss and to compare the significance of AMH level to age as prognostic factors of pregnancy loss in subfertile women. The outcome of 848 subfertile patients confirmed with intrauterine pregnancies b...

journal_title：Systems biology in reproductive medicine

authors： Hong S,Chang E,Han EJ,Min SG,Kim S,Kang MK,Cha DH,Shim SH,Park HJ

更新日期：2020-12-01 00:00:00

abstract：:The understanding of the early mammalian development is a prerequisite for the advancement of in vitro fertilization and improvement of derivation and culturing of embryonic stem cells. While, whole genome transcriptomic analysis on bovine blastocysts has identified genes active in early development, little informatio...

journal_title：Systems biology in reproductive medicine

authors： Jensen PL,Grøndahl ML,Beck HC,Petersen J,Stroebech L,Christensen ST,Yding Andersen C

更新日期：2014-06-01 00:00:00

abstract：:Assisted reproductive technology has evolved tremendously since the emergence of in vitro fertilization (IVF). In the course of the recent decade, there have been significant efforts in order to minimize multiple gestations, while improving percentages of singleton pregnancies and offering individualized services in I...

journal_title：Systems biology in reproductive medicine

authors： Simopoulou M,Sfakianoudis K,Antoniou N,Maziotis E,Rapani A,Bakas P,Anifandis G,Kalampokas T,Bolaris S,Pantou A,Pantos K,Koutsilieris M

更新日期：2018-10-01 00:00:00

abstract：:In order to identify unreliable data in a dataset of motility parameters obtained from a pilot study acquired by a veterinarian with experience in boar semen handling, but without experience in the operation of a computer assisted sperm analysis (CASA) system, a multivariate graphical and statistical analysis was perf...

journal_title：Systems biology in reproductive medicine

authors： Martínez LB,Crispín RH,Mendoza MM,Gallegos OH,Martínez AA

更新日期：2013-06-01 00:00:00

abstract：:Assessment of sperm DNA damage has been suggested as a negative predictor of fertility potential. Multiple pathological factors acting at both the intra-testicular and post-testicular levels may contribute to sperm DNA damage. The relative contribution of each of these factors in an individual with high DNA damage (>3...

journal_title：Systems biology in reproductive medicine

authors： Moskovtsev SI,Lecker I,Mullen JB,Jarvi K,Willis J,White J,Lo KC

更新日期：2009-03-01 00:00:00

abstract：:What is the impact of intentional weight loss and regain on serum androgens in women? We conducted an ancillary analysis of prospectively collected samples from a randomized controlled trial. The trial involved supervised 10% weight loss (8.5 kg on average) with diet and exercise over 4-6 months followed by supervised...

journal_title：Systems biology in reproductive medicine

authors： Aubuchon M,Liu Y,Petroski GF,Thomas TR,Polotsky AJ

更新日期：2016-08-01 00:00:00

abstract：:The object of this study was to investigate the effect of molybdenum on the development of mouse preimplantation embryos cultured in vitro. Zygotes were flushed from one outbred mouse strain (Kunming), and then were cultured in potassium simplex optimized medium (KSOM) containing 0, 5, 10, 20, 40, 80, 120, and 160 µg/...

journal_title：Systems biology in reproductive medicine

authors： Bi CM,Zhang YL,Liu FJ,Zhou TZ,Yang ZJ,Gao SY,Wang SD,Chen XL,Zhai XW,Ma XG,Jin LJ,Wang S

更新日期：2013-04-01 00:00:00

abstract：:To date we have yet to examine whether amino acid (AA) transport in human ovarian follicles is affected by competitive inhibition. In contrast, transplacental transfer of AAs in late-gestation sheep is characterized by reciprocal competition. This phenomenon has been described by algebraic equations of umbilical uptak...

journal_title：Systems biology in reproductive medicine

authors： Jóźwik M,Jóźwik M,Milewska AJ,Battaglia FC,Jóźwik M

更新日期：2017-10-01 00:00:00

abstract：:We have earlier shown that cobalt chloride (CoCl2)-induced hypoxia and second messenger 8-bromoadenosine 3', 5'-cyclic adenosine monophosphate (8-Br-cAMP) stimulates vascular endothelial growth factor (VEGF) production in Leydig tumor cell derived MA-10 cells. Both stimuli follow common signal transduction pathways in...

journal_title：Systems biology in reproductive medicine

authors： Kumar A,Rani L,Dhole B

更新日期：2014-04-01 00:00:00

abstract：:In the human, canonical histones are largely replaced by protamine 1 (P1) and protamine 2 (P2) during late spermatogenesis. Recent studies have demonstrated that abnormal replacement of the histones is associated with severe male infertility and has profound implications for early embryogenesis. In this review the his...

journal_title：Systems biology in reproductive medicine

authors： Nanassy L,Griffin J,Emery BR,Carrell DT

更新日期：2010-06-01 00:00:00

abstract：:Varicocele is currently the most common irregularity identified in males that is associated with impaired spermatogenesis. It primarily presents in the form of decreased sperm count and motility, abnormal morphology, and significantly increased sperm DNA fragmentation. Several studies have shown that surgical repair i...

journal_title：Systems biology in reproductive medicine

authors： Li F,Yamaguchi K,Okada K,Matsushita K,Ando M,Chiba K,Yue H,Fujisawa M

更新日期：2012-10-01 00:00:00

abstract：:Preimplantation embryos may have an increased risk of having mismatches due to the rates of cell proliferation and DNA replication. Elimination of mismatches in human gametes and embryos has not been investigated. In this study we developed a sensitive functional assay to examine the repair or elimination of mismatche...

journal_title：Systems biology in reproductive medicine

authors： Tulay P,Jaroudi S,Doshi A,SenGupta SB

更新日期：2016-12-01 00:00:00

abstract：:A very common conception about the function of the spermatozoon is that its unique role is to transmit the paternal genome to the next generation. Most of the sperm genome is known to be condensed in many species by protamines, which are small and extremely positively charged proteins (50-70% arginine) with the functi...

journal_title：Systems biology in reproductive medicine

authors： Barrachina F,Anastasiadi D,Jodar M,Castillo J,Estanyol JM,Piferrer F,Oliva R

更新日期：2018-12-01 00:00:00

abstract：:For natural fertilization to occur successfully, millions of spermatozoa must be deposited in the lower end of the female genital tract during mating. Considerably fewer spermatozoa are required for fertilization when spermatozoa are deposited in the upper region of the female tract. The extreme case of assisted ferti...

journal_title：Systems biology in reproductive medicine

authors： Yanagimachi R

更新日期：2011-02-01 00:00:00

abstract：:The ICSI procedure was invented to treat severe male infertility but is often used even if the sperm quality parameters are normal. This practice has recently been called into question, but there is still no clear answer especially in terms of sperm morphology, regarding when it is necessary to perform ICSI and when c...

journal_title：Systems biology in reproductive medicine

authors： Stimpfel M,Jancar N,Vrtacnik-Bokal E,Virant-Klun I

更新日期：2019-12-01 00:00:00

abstract：:Both microdrop and open methods are commonly used for in vitro fertilization (IVF) protocols for embryo culture as well as oocyte insemination. However, few comparative studies evaluating the microdrop or open method of insemination on the fertilization outcome and subsequent embryo development have been performed. A ...

journal_title：Systems biology in reproductive medicine

authors： Li Y,Li T,Mai Q,Long L,Ou J

更新日期：2014-06-01 00:00:00

abstract：:Primary ovarian insufficiency (POI) affects ~1% of women in the general population. Despite numerous attempts at identifying POI genetic aetiology, coding mutations in only a few genes have been functionally related to POI pathogenesis. It has been suggested that mutant BMPR2 might contribute towards the phenotype. Se...

journal_title：Systems biology in reproductive medicine

authors： Patiño LC,Silgado D,Laissue P

更新日期：2017-06-01 00:00:00