Significant improvement of sperm DNA quality after microsurgical repair of varicocele.

abstract：:Primary ovarian insufficiency (POI) affects ~1% of women in the general population. Despite numerous attempts at identifying POI genetic aetiology, coding mutations in only a few genes have been functionally related to POI pathogenesis. It has been suggested that mutant BMPR2 might contribute towards the phenotype. Se...

journal_title：Systems biology in reproductive medicine

authors： Patiño LC,Silgado D,Laissue P

更新日期：2017-06-01 00:00:00

abstract：:In order to identify unreliable data in a dataset of motility parameters obtained from a pilot study acquired by a veterinarian with experience in boar semen handling, but without experience in the operation of a computer assisted sperm analysis (CASA) system, a multivariate graphical and statistical analysis was perf...

journal_title：Systems biology in reproductive medicine

authors： Martínez LB,Crispín RH,Mendoza MM,Gallegos OH,Martínez AA

更新日期：2013-06-01 00:00:00

abstract：:The aim of this study was to evaluate the feasibility and efficiency of using a sucrose gradient-based warming protocol as a universal warming approach on human cleavage stage embryos. Between January 2013 and November 2014, a total of 118 warming cycles were performed on 705 embryos which had previously been cryopres...

journal_title：Systems biology in reproductive medicine

authors： Serdarogullari M,Coban O,Boynukalin FK,Bilgin EM,Findikli N,Bahceci M

更新日期：2019-02-01 00:00:00

abstract：:A very common conception about the function of the spermatozoon is that its unique role is to transmit the paternal genome to the next generation. Most of the sperm genome is known to be condensed in many species by protamines, which are small and extremely positively charged proteins (50-70% arginine) with the functi...

journal_title：Systems biology in reproductive medicine

authors： Barrachina F,Anastasiadi D,Jodar M,Castillo J,Estanyol JM,Piferrer F,Oliva R

更新日期：2018-12-01 00:00:00

abstract：:There are variant rates of oocyte degeneration after intracytoplasmic sperm injection (ICSI) among different patients. Oocyte degeneration after ICSI may reflect the cohort of oocyte quality and subsequent embryo development capacity and clinical outcome. This retrospective study analyzed 255 cycles with at least one ...

journal_title：Systems biology in reproductive medicine

authors： Liu L,Cai J,Li P,Jiang X,Ren J

更新日期：2017-04-01 00:00:00

abstract：:Assisted reproductive technology has evolved tremendously since the emergence of in vitro fertilization (IVF). In the course of the recent decade, there have been significant efforts in order to minimize multiple gestations, while improving percentages of singleton pregnancies and offering individualized services in I...

journal_title：Systems biology in reproductive medicine

authors： Simopoulou M,Sfakianoudis K,Antoniou N,Maziotis E,Rapani A,Bakas P,Anifandis G,Kalampokas T,Bolaris S,Pantou A,Pantos K,Koutsilieris M

更新日期：2018-10-01 00:00:00

abstract：:Both microdrop and open methods are commonly used for in vitro fertilization (IVF) protocols for embryo culture as well as oocyte insemination. However, few comparative studies evaluating the microdrop or open method of insemination on the fertilization outcome and subsequent embryo development have been performed. A ...

journal_title：Systems biology in reproductive medicine

authors： Li Y,Li T,Mai Q,Long L,Ou J

更新日期：2014-06-01 00:00:00

abstract：:We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent...

journal_title：Systems biology in reproductive medicine

authors： Nagaraja MR,Gubbala SP,Delphine Silvia CRW,Amanchy R

更新日期：2019-04-01 00:00:00

abstract：:We explored the molecular mechanisms of obesity and insulin resistance in patients with polycystic ovary syndrome (PCOS) using a human embryonic stem cell model (hESCs). Three PCOS-derived and one non-PCOS-derived hESC lines were induced into adipocytes, and then total RNA was extracted. The differentially expressed P...

journal_title：Systems biology in reproductive medicine

authors： Wang F,Liu WW,Chen XM,Kong HJ,Li J,Sun YP

更新日期：2014-06-01 00:00:00

abstract：:Complete deletions in the AZF (a, b, and c) sub-regions of the Y-chromosome have been shown to contribute to unexplained male infertility. However, the role of partial AZFc deletions in male infertility remains to be verified. Three types of partial AZFc deletions have been identified. They are gr/gr, b1/b3, and b2/b3...

journal_title：Systems biology in reproductive medicine

authors： Almeamar HA,Ramachandran V,Ismail P,Nadkarni P,Fawzi N

更新日期：2013-04-01 00:00:00

abstract：:We have earlier shown that cobalt chloride (CoCl2)-induced hypoxia and second messenger 8-bromoadenosine 3', 5'-cyclic adenosine monophosphate (8-Br-cAMP) stimulates vascular endothelial growth factor (VEGF) production in Leydig tumor cell derived MA-10 cells. Both stimuli follow common signal transduction pathways in...

journal_title：Systems biology in reproductive medicine

authors： Kumar A,Rani L,Dhole B

更新日期：2014-04-01 00:00:00

abstract：:The aim of this study was to evaluate the predictive value of the anti-Mullerian hormone (AMH) level for early pregnancy loss and to compare the significance of AMH level to age as prognostic factors of pregnancy loss in subfertile women. The outcome of 848 subfertile patients confirmed with intrauterine pregnancies b...

journal_title：Systems biology in reproductive medicine

authors： Hong S,Chang E,Han EJ,Min SG,Kim S,Kang MK,Cha DH,Shim SH,Park HJ

更新日期：2020-12-01 00:00:00

abstract：:At least in mammals, retinoic acid is a pivotal factor in maintaining the functionality of the testis, in particular, for the progression of germ cells from mitosis to meiosis. Removal of dietary vitamin A or a targeted deletion of retinoic acid receptor alpha gene (Rara), the receptor for retinoic acid, in mice, led ...

journal_title：Systems biology in reproductive medicine

authors： Doyle TJ,Oudes AJ,Kim KH

更新日期：2009-08-01 00:00:00

abstract：:The understanding of the early mammalian development is a prerequisite for the advancement of in vitro fertilization and improvement of derivation and culturing of embryonic stem cells. While, whole genome transcriptomic analysis on bovine blastocysts has identified genes active in early development, little informatio...

journal_title：Systems biology in reproductive medicine

authors： Jensen PL,Grøndahl ML,Beck HC,Petersen J,Stroebech L,Christensen ST,Yding Andersen C

更新日期：2014-06-01 00:00:00

abstract：:Assessment of sperm DNA damage has been suggested as a negative predictor of fertility potential. Multiple pathological factors acting at both the intra-testicular and post-testicular levels may contribute to sperm DNA damage. The relative contribution of each of these factors in an individual with high DNA damage (>3...

journal_title：Systems biology in reproductive medicine

authors： Moskovtsev SI,Lecker I,Mullen JB,Jarvi K,Willis J,White J,Lo KC

更新日期：2009-03-01 00:00:00

abstract：:Pulsatile secretion of hormones in the hypothalamic-pituitary-gonadal axis is critical for normal functioning of the reproductive system. Thus, appropriate characterization of pulsatile secretion is important for identifying the (patho)physiology of reproductive conditions. Existing analysis methods often fail to adeq...

journal_title：Systems biology in reproductive medicine

authors： Liu H,Polotsky AJ,Grunwald GK,Carlson NE

更新日期：2018-02-01 00:00:00

abstract：:The etiology of adverse pregnancy outcomes is not well understood. Wildlife observations provide considerable evidence that environmental contaminants can play a critical role in reproductive and developmental dysfunction. Early evidence leading to a widespread awareness of the impact of environmental chemicals on sur...

journal_title：Systems biology in reproductive medicine

authors： Hamlin HJ,Guillette LJ Jr

更新日期：2010-04-01 00:00:00

abstract：:Establishing specific biomarkers for the assessment of human male fertility status is an important goal to ensure the fitness of the male contribution so as to support the birth of a healthy child. Spermatozoa are considered an optimal surrogate tissue for the evaluation of spermatogenic function. Unlike the cells of ...

journal_title：Systems biology in reproductive medicine

authors： Anton E,Krawetz SA

更新日期：2012-02-01 00:00:00

abstract：:Spermatozoa contain a complex population of RNAs including messenger RNAs (mRNAs) and small RNAs such as microRNAs (miRNA). It has been reported that these RNAs can be used to understand the mechanisms by which toxicological exposure affects spermatogenesis. The aim of our study was to compare mRNA and miRNA profiles ...

journal_title：Systems biology in reproductive medicine

authors： Metzler-Guillemain C,Victorero G,Lepoivre C,Bergon A,Yammine M,Perrin J,Sari-Minodier I,Boulanger N,Rihet P,Nguyen C

更新日期：2015-06-01 00:00:00

abstract：:Although intracytoplasmic sperm injection (ICSI) is now a widely-used technique, it is still of interest to improve our knowledge as to which is the best spermatozoon to be selected for ICSI. Infertile men have increased risks of producing aneuploid spermatozoa. Using hyaluronic acid (HA)-binding sperm selection may r...

journal_title：Systems biology in reproductive medicine

authors： Mokánszki A,Tóthné EV,Bodnár B,Tándor Z,Molnár Z,Jakab A,Ujfalusi A,Oláh É

更新日期：2014-12-01 00:00:00

abstract：:The aim of this study is to compare the expression patterns of tyrosine kinases and their ligand activators between matched myometrium and leiomyoma tissues. Total RNA extracted from 42 pairs of matched leiomyomal and adjacent myometrial tissues were hybridized to a set of 840 customized oligonucleotide microarrays to...

journal_title：Systems biology in reproductive medicine

authors： Jiang Y,Suo G,Sadarangani A,Cowan B,Wang JY

更新日期：2010-08-01 00:00:00

abstract：:One of the major causes of defective sperm function is oxidative stress, which limits the fertilizing potential of these cells as the result of collateral damage to proteins and lipids in the sperm plasma membrane. On this point, a derangement of both generation and neutralization of reactive oxygen species (ROS) is a...

journal_title：Systems biology in reproductive medicine

authors： Signorini C,Moretti E,Collodel G

更新日期：2020-10-01 00:00:00

abstract：:To date we have yet to examine whether amino acid (AA) transport in human ovarian follicles is affected by competitive inhibition. In contrast, transplacental transfer of AAs in late-gestation sheep is characterized by reciprocal competition. This phenomenon has been described by algebraic equations of umbilical uptak...

journal_title：Systems biology in reproductive medicine

authors： Jóźwik M,Jóźwik M,Milewska AJ,Battaglia FC,Jóźwik M

更新日期：2017-10-01 00:00:00

abstract：:Sexual dysfunction is one of the diabetic complications in males. The present study aimed to evaluate the antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin (STZ) induced diabetic male rats. Male Wistar rats were divided as control, diabetic control, diabetic rats admini...

journal_title：Systems biology in reproductive medicine

authors： Nelli GB,K AS,Kilari EK

更新日期：2013-12-01 00:00:00

abstract：:Preimplantation embryos may have an increased risk of having mismatches due to the rates of cell proliferation and DNA replication. Elimination of mismatches in human gametes and embryos has not been investigated. In this study we developed a sensitive functional assay to examine the repair or elimination of mismatche...

journal_title：Systems biology in reproductive medicine

authors： Tulay P,Jaroudi S,Doshi A,SenGupta SB

更新日期：2016-12-01 00:00:00

abstract：:In the human, canonical histones are largely replaced by protamine 1 (P1) and protamine 2 (P2) during late spermatogenesis. Recent studies have demonstrated that abnormal replacement of the histones is associated with severe male infertility and has profound implications for early embryogenesis. In this review the his...

journal_title：Systems biology in reproductive medicine

authors： Nanassy L,Griffin J,Emery BR,Carrell DT

更新日期：2010-06-01 00:00:00

abstract：:FSH in infertile patients may be measured in the normal range and abnormal semen analysis findings may be observed in patients with normal FSH values. A recent study predicts that the sperm morphology and concentration may be impaired if the FSH value is above 4.5 IU/L. Therefore, this study aimed to define a clinical...

journal_title：Systems biology in reproductive medicine

authors： Ozkaya M,Oztekin U,Caniklioglu M,Ekmekcioglu O

更新日期：2020-10-01 00:00:00

abstract：:During spermatogenesis, changes in sperm nuclear morphology are associated with the replacement of core somatic histones by protamines. Although protamines are the major nucleoproteins of mature sperm, not all species totally replace the histones. Histone H1, along with protamines, mediates chromatin condensation into...

journal_title：Systems biology in reproductive medicine

authors： Sánchez-Vázquez ML,Flores-Alonso JC,Merchant-Larios H,Reyes R

更新日期：2008-11-01 00:00:00

abstract：:Multiple prevention therapy has gained importance for the prevention and treatment of sexually transmitted diseases, especially HIV/AIDS. Antiretroviral drugs encapsulated in nanoparticles have been developed for efficient delivery of the drugs to the vaginal surface. Lactoferrin nanoparticles (LFNPs) encapsulating an...

journal_title：Systems biology in reproductive medicine

authors： Madugulla L,Ravula AR,Kondapi AK,Yenugu S

更新日期：2019-06-01 00:00:00

abstract：:For natural fertilization to occur successfully, millions of spermatozoa must be deposited in the lower end of the female genital tract during mating. Considerably fewer spermatozoa are required for fertilization when spermatozoa are deposited in the upper region of the female tract. The extreme case of assisted ferti...

journal_title：Systems biology in reproductive medicine

authors： Yanagimachi R

更新日期：2011-02-01 00:00:00