Role of isoprostanes in human male infertility.

abstract：:At least in mammals, retinoic acid is a pivotal factor in maintaining the functionality of the testis, in particular, for the progression of germ cells from mitosis to meiosis. Removal of dietary vitamin A or a targeted deletion of retinoic acid receptor alpha gene (Rara), the receptor for retinoic acid, in mice, led ...

journal_title：Systems biology in reproductive medicine

authors： Doyle TJ,Oudes AJ,Kim KH

更新日期：2009-08-01 00:00:00

abstract：:Assessment of sperm DNA damage has been suggested as a negative predictor of fertility potential. Multiple pathological factors acting at both the intra-testicular and post-testicular levels may contribute to sperm DNA damage. The relative contribution of each of these factors in an individual with high DNA damage (>3...

journal_title：Systems biology in reproductive medicine

authors： Moskovtsev SI,Lecker I,Mullen JB,Jarvi K,Willis J,White J,Lo KC

更新日期：2009-03-01 00:00:00

abstract：:There are variant rates of oocyte degeneration after intracytoplasmic sperm injection (ICSI) among different patients. Oocyte degeneration after ICSI may reflect the cohort of oocyte quality and subsequent embryo development capacity and clinical outcome. This retrospective study analyzed 255 cycles with at least one ...

journal_title：Systems biology in reproductive medicine

authors： Liu L,Cai J,Li P,Jiang X,Ren J

更新日期：2017-04-01 00:00:00

abstract：:We aimed to assess the possible presence of a seasonal pattern in three parameters of semen analysis: sperm concentration, morphology, and motility as a function of the time of ejaculation and sperm production (spermatogenesis) in normal and oligozoospermic men. This retrospective study included a consecutive series o...

journal_title：Systems biology in reproductive medicine

authors： Ozelci R,Yılmaz S,Dilbaz B,Akpınar F,Akdag Cırık D,Dilbaz S,Ocal A

更新日期：2016-12-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF), a major angiogenic factor, is known to play an important role in the development of endometriosis. The aim of this study was to investigate the association of three VEGF (-460 C/T, +405 G/C, and +936 C/T) polymorphisms with the risk of endometriosis in the Tunisian popula...

journal_title：Systems biology in reproductive medicine

authors： Henidi B,Kaabachi W,Naouali A,Kaabachi S,Zhioua A,Haj Sassi F,Hamzaoui K

更新日期：2015-01-01 00:00:00

abstract：:To date we have yet to examine whether amino acid (AA) transport in human ovarian follicles is affected by competitive inhibition. In contrast, transplacental transfer of AAs in late-gestation sheep is characterized by reciprocal competition. This phenomenon has been described by algebraic equations of umbilical uptak...

journal_title：Systems biology in reproductive medicine

authors： Jóźwik M,Jóźwik M,Milewska AJ,Battaglia FC,Jóźwik M

更新日期：2017-10-01 00:00:00

abstract：:We have earlier shown that cobalt chloride (CoCl2)-induced hypoxia and second messenger 8-bromoadenosine 3', 5'-cyclic adenosine monophosphate (8-Br-cAMP) stimulates vascular endothelial growth factor (VEGF) production in Leydig tumor cell derived MA-10 cells. Both stimuli follow common signal transduction pathways in...

journal_title：Systems biology in reproductive medicine

authors： Kumar A,Rani L,Dhole B

更新日期：2014-04-01 00:00:00

abstract：:The ICSI procedure was invented to treat severe male infertility but is often used even if the sperm quality parameters are normal. This practice has recently been called into question, but there is still no clear answer especially in terms of sperm morphology, regarding when it is necessary to perform ICSI and when c...

journal_title：Systems biology in reproductive medicine

authors： Stimpfel M,Jancar N,Vrtacnik-Bokal E,Virant-Klun I

更新日期：2019-12-01 00:00:00

abstract：:During spermatogenesis, changes in sperm nuclear morphology are associated with the replacement of core somatic histones by protamines. Although protamines are the major nucleoproteins of mature sperm, not all species totally replace the histones. Histone H1, along with protamines, mediates chromatin condensation into...

journal_title：Systems biology in reproductive medicine

authors： Sánchez-Vázquez ML,Flores-Alonso JC,Merchant-Larios H,Reyes R

更新日期：2008-11-01 00:00:00

abstract：:The object of this study was to investigate the effect of molybdenum on the development of mouse preimplantation embryos cultured in vitro. Zygotes were flushed from one outbred mouse strain (Kunming), and then were cultured in potassium simplex optimized medium (KSOM) containing 0, 5, 10, 20, 40, 80, 120, and 160 µg/...

journal_title：Systems biology in reproductive medicine

authors： Bi CM,Zhang YL,Liu FJ,Zhou TZ,Yang ZJ,Gao SY,Wang SD,Chen XL,Zhai XW,Ma XG,Jin LJ,Wang S

更新日期：2013-04-01 00:00:00

abstract：:In many species, extended semen can be stored at low temperatures to slow bacterial growth. However, boar semen performs poorly at temperatures below 15 °C and this poses unique challenges, as it is not easy to maintain a constant 15-19 °C during shipment. Some extenders have been formulated with egg yolk for storage ...

journal_title：Systems biology in reproductive medicine

authors： Casas I,Miller-Lux Y,Osborne B,Bonet S,Althouse GC

更新日期：2015-01-01 00:00:00

abstract：:Multiple prevention therapy has gained importance for the prevention and treatment of sexually transmitted diseases, especially HIV/AIDS. Antiretroviral drugs encapsulated in nanoparticles have been developed for efficient delivery of the drugs to the vaginal surface. Lactoferrin nanoparticles (LFNPs) encapsulating an...

journal_title：Systems biology in reproductive medicine

authors： Madugulla L,Ravula AR,Kondapi AK,Yenugu S

更新日期：2019-06-01 00:00:00

abstract：:Preimplantation embryos may have an increased risk of having mismatches due to the rates of cell proliferation and DNA replication. Elimination of mismatches in human gametes and embryos has not been investigated. In this study we developed a sensitive functional assay to examine the repair or elimination of mismatche...

journal_title：Systems biology in reproductive medicine

authors： Tulay P,Jaroudi S,Doshi A,SenGupta SB

更新日期：2016-12-01 00:00:00

abstract：:Genomic disorders are defined as diseases caused by rearrangements of the genome incited by a genomic architecture that conveys instability. Y-chromosome related dysfunctions such as male infertility are frequently associated with gross DNA rearrangements resulting from its peculiar genomic architecture. The Y-chromos...

journal_title：Systems biology in reproductive medicine

authors： Carvalho CM,Zhang F,Lupski JR

更新日期：2011-02-01 00:00:00

abstract：:Both microdrop and open methods are commonly used for in vitro fertilization (IVF) protocols for embryo culture as well as oocyte insemination. However, few comparative studies evaluating the microdrop or open method of insemination on the fertilization outcome and subsequent embryo development have been performed. A ...

journal_title：Systems biology in reproductive medicine

authors： Li Y,Li T,Mai Q,Long L,Ou J

更新日期：2014-06-01 00:00:00

abstract：:A very common conception about the function of the spermatozoon is that its unique role is to transmit the paternal genome to the next generation. Most of the sperm genome is known to be condensed in many species by protamines, which are small and extremely positively charged proteins (50-70% arginine) with the functi...

journal_title：Systems biology in reproductive medicine

authors： Barrachina F,Anastasiadi D,Jodar M,Castillo J,Estanyol JM,Piferrer F,Oliva R

更新日期：2018-12-01 00:00:00

abstract：:The objective of this study is to compare the pregnancy and live birth rates of a natural cycle in vitro fertilization (IVF) combined with in vitro maturation (IVM) treatment (natural cycle IVF/M) by the presence or absence of mature oocytes retrieved. Infertile women were divided into two groups: (A) patients with ma...

journal_title：Systems biology in reproductive medicine

authors： Yang SH,Patrizio P,Yoon SH,Lim JH,Chian RC

更新日期：2012-06-01 00:00:00

abstract：:In the human, canonical histones are largely replaced by protamine 1 (P1) and protamine 2 (P2) during late spermatogenesis. Recent studies have demonstrated that abnormal replacement of the histones is associated with severe male infertility and has profound implications for early embryogenesis. In this review the his...

journal_title：Systems biology in reproductive medicine

authors： Nanassy L,Griffin J,Emery BR,Carrell DT

更新日期：2010-06-01 00:00:00

abstract：:In this retrospective study the outcomes of two protocols of controlled ovarian hyperstimulation and natural cycle in poor ovarian responders defined according to the Bologna criteria were compared to elucidate which approach is more suitable for the treatment of these patients. We comparatively analyzed 142 cycles of...

journal_title：Systems biology in reproductive medicine

authors： Stimpfel M,Vrtačnik-Bokal E,Pozlep B,Kmecl J,Virant-Klun I

更新日期：2016-08-01 00:00:00

abstract：:We explored the molecular mechanisms of obesity and insulin resistance in patients with polycystic ovary syndrome (PCOS) using a human embryonic stem cell model (hESCs). Three PCOS-derived and one non-PCOS-derived hESC lines were induced into adipocytes, and then total RNA was extracted. The differentially expressed P...

journal_title：Systems biology in reproductive medicine

authors： Wang F,Liu WW,Chen XM,Kong HJ,Li J,Sun YP

更新日期：2014-06-01 00:00:00

abstract：:For patients with recurrent implantation failure in IVF, histologic or transcriptomic testing of the endometrium during the mid-secretory phase is often considered. Histological dating of endometrial biopsies (Noyes criteria) can determine if endometrial morphology is consistent with the period of receptivity. Alterna...

journal_title：Systems biology in reproductive medicine

authors： Cohen AM,Ye XY,Colgan TJ,Greenblatt EM,Chan C

更新日期：2020-12-01 00:00:00

abstract：:Reproductive biology is considered a specialty field, however, an argument can be made that it is instead generally applicable to many fields of biology. The one-cell embryo is presented here as a model system for the study of eukaryotic DNA replication, apoptotic DNA degradation, and signaling mechanisms between the ...

journal_title：Systems biology in reproductive medicine

authors： Ortega MA,Sil P,Ward WS

更新日期：2011-02-01 00:00:00

abstract：:What is the impact of intentional weight loss and regain on serum androgens in women? We conducted an ancillary analysis of prospectively collected samples from a randomized controlled trial. The trial involved supervised 10% weight loss (8.5 kg on average) with diet and exercise over 4-6 months followed by supervised...

journal_title：Systems biology in reproductive medicine

authors： Aubuchon M,Liu Y,Petroski GF,Thomas TR,Polotsky AJ

更新日期：2016-08-01 00:00:00

abstract：:Maternal obesity can cause complications for both women and their offspring for generations. Therefore, we intended to verify the repercussions of induction of transgenerational obesity on biochemical parameters, reproductive performance, and congenital anomaly frequency in Wistar rats. Female rats were used from succ...

journal_title：Systems biology in reproductive medicine

authors： Soares TS,Andreolla AP,Miranda CA,Klöppel E,Rodrigues LS,Moraes-Souza RQ,Damasceno DC,Volpato GT,Campos KE

更新日期：2018-02-01 00:00:00

abstract：:Pulsatile secretion of hormones in the hypothalamic-pituitary-gonadal axis is critical for normal functioning of the reproductive system. Thus, appropriate characterization of pulsatile secretion is important for identifying the (patho)physiology of reproductive conditions. Existing analysis methods often fail to adeq...

journal_title：Systems biology in reproductive medicine

authors： Liu H,Polotsky AJ,Grunwald GK,Carlson NE

更新日期：2018-02-01 00:00:00

abstract：:Systems biology presents a new paradigm for elucidating the processes required to organize and sustain life. We now have access to whole genome sequences, gene expression data for multiple cell types, and databases for regulatory elements governing these genes. These resources make it feasible to identify conserved ge...

journal_title：Systems biology in reproductive medicine

authors： Naismith L,Lalancette C,Platts AE,Krawetz SA

更新日期：2008-03-01 00:00:00

abstract：:Sperm progressive motility has been reported to be one of the key factors influencing in vitro fertilization rates. However, recent studies have shown that sperm DNA fragmentation is a more robust predictor of assisted reproductive outcomes including reduced fertilization rates, embryo quality, and pregnancy rates. Th...

journal_title：Systems biology in reproductive medicine

authors： Simon L,Lewis SE

更新日期：2011-06-01 00:00:00

abstract：:Phthalates are ubiquitous industrial chemicals that are reported to adversely affect human reproductive outcomes. Divergent effects on semen quality have been reported in a limited number of studies. To assess the possible contribution of regional differences in phthalate exposure to these results, we wished to determ...

journal_title：Systems biology in reproductive medicine

authors： Wirth JJ,Rossano MG,Potter R,Puscheck E,Daly DC,Paneth N,Krawetz SA,Protas BM,Diamond MP

更新日期：2008-05-01 00:00:00

abstract：:Sexual dysfunction is one of the diabetic complications in males. The present study aimed to evaluate the antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin (STZ) induced diabetic male rats. Male Wistar rats were divided as control, diabetic control, diabetic rats admini...

journal_title：Systems biology in reproductive medicine

authors： Nelli GB,K AS,Kilari EK

更新日期：2013-12-01 00:00:00

abstract：:Short gamete co-incubation (SGCO) consists in decreasing the duration of contact between oocytes and sperm from the standard overnight insemination (SOI) toward 2 hours. However, the effectiveness of this technique to improve in vitro fertilization and embryo transfer (IVF-ET) outcomes remains controversial. Our study...

journal_title：Systems biology in reproductive medicine

authors： Le Bras A,Hesters L,Gallot V,Tallet C,Tachdjian G,Frydman N

更新日期：2017-10-01 00:00:00