Resolution-recovery for EPR imaging of free radical molecules in mice.

Abstract:

:A method of post-processing to enhance the image resolution of the distribution of free radical molecules obtained with continuous-wave electron paramagnetic resonance (CW-EPR) imaging is reported. The low spatial resolution of EPR imaging, which has created difficulties in biomedical applications, was overcome by the method of resolution-recovery for EPR imaging. High spatial resolution images for the distribution of free radical molecules with a very short relaxation time were obtained with this method. The method's two-step postprocessing consists of conventional deconvolution and filtered back-projection and a process of iterative deconvolution. The resolution-recovery method was demonstrated with three-dimensional (3D) imaging of stable nitroxyl radicals in mouse head. In phantom experiments with a solution of triarylmethyl (TAM) radicals, the spatial resolution was improved by a factor of 7 with the resolution-recovery method.

journal_name

Magn Reson Med

authors

Ikebata Y,Sato-Akaba H,Aoyama T,Fujii H,Itoh K,Hirata H

doi

10.1002/mrm.22029

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

788-95

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

62

pub_type

杂志文章
  • Counter rotating current local coils for high-resolution magnetic resonance imaging.

    abstract::A type of local coil (or surface coil) for magnetic resonance imaging and spectroscopy is described in which two circular loops of the same diameter are disposed axially with respect to each other and in which counter rotating currents (CRC) are supported in the two loops. This type of coil has been used for localized...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910030412

    authors: Froncisz W,Jesmanowicz A,Kneeland JB,Hyde JS

    更新日期:1986-08-01 00:00:00

  • Efficient sample density estimation by combining gridding and an optimized kernel.

    abstract::The reconstruction of non-Cartesian k-space trajectories often requires the estimation of nonuniform sampling density. Particularly for 3D, this calculation can be computationally expensive. The method proposed in this work combines an iterative algorithm previously proposed by Pipe and Menon (Magn Reson Med 1999;41:1...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23041

    authors: Zwart NR,Johnson KO,Pipe JG

    更新日期:2012-03-01 00:00:00

  • Water in tendon: orientational analysis of the free induction decay.

    abstract::The orientation dependence of the free induction decay (FID) of 1H NMR water signal in ex vivo bovine digital flexor tendon at the native level of hydration is reported. Residual dipolar coupling due to the overall tissue anisotropy produces a 6:1 change in the signal intensity as an angle between the long axis of a s...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20540

    authors: Krasnosselskaia LV,Fullerton GD,Dodd SJ,Cameron IL

    更新日期:2005-08-01 00:00:00

  • Effect of distortion corrections on the tractography quality in spinal cord diffusion-weighted imaging.

    abstract:PURPOSE:To assess the impact of a different distortion correction (DC) method and patient geometry (sagittal balance) on the quality of spinal cord tractography rendering according to different tractography approaches. METHODS:Forty-four adults free of spinal cord diseases underwent cervical diffusion-weighted imaging...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28665

    authors: Dauleac C,Bannier E,Cotton F,Frindel C

    更新日期:2021-01-21 00:00:00

  • A new steady-state imaging sequence for simultaneous acquisition of two MR images with clearly different contrasts.

    abstract::We present a new steady-state imaging sequence, which simultaneously allows in a single acquisition the formation of two MR images with clearly different contrasts. The contrast of the first image is FISP-like, whereas the second image is strongly T2-weighted. In principle the T2 values in the image can be calculated ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910070105

    authors: Bruder H,Fischer H,Graumann R,Deimling M

    更新日期:1988-05-01 00:00:00

  • High-frequency subband compressed sensing MRI using quadruplet sampling.

    abstract:PURPOSE:To present and validate a new method that formalizes a direct link between k-space and wavelet domains to apply separate undersampling and reconstruction for high- and low-spatial-frequency k-space data. THEORY AND METHODS:High- and low-spatial-frequency regions are defined in k-space based on the separation o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24592

    authors: Sung K,Hargreaves BA

    更新日期:2013-11-01 00:00:00

  • Phase-labeled reference EPI for frequency-segmented inhomogeneity corrections (PREFICS).

    abstract:PURPOSE:To develop a method to correct for geometric distortions in non-Cartesian echo planar imaging using data acquired in a fast prescan. METHODS:Echo planar images were obtained using a non-Cartesian density weighted k-space trajectory. In contrast to linear Cartesian acquisition, distortions arising in non-Cartes...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24737

    authors: Zeller M,Müller A,Hahn D,Köstler H

    更新日期:2014-03-01 00:00:00

  • Time-resolved flow measurement in the isolated rat heart: characterization of left coronary artery stenosis.

    abstract::The investigation of flow behavior in coronary arteries is of great importance for an understanding of heart failure and heart regulation mechanisms. The purpose of the present study was to demonstrate that flow velocity can be quantified in the coronary arteries of the isolated rat heart with high-resolution phase co...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10563

    authors: Köhler S,Hiller KH,Jakob PM,Bauer WR,Haase A

    更新日期:2003-09-01 00:00:00

  • Selective excitation of two-dimensional arbitrarily shaped voxels with parallel excitation in spectroscopy.

    abstract::Parallel excitation is being studied intensively for applications in MR imaging and in particular for selecting arbitrary shapes as regions of interest. In this work, parallel excitation was applied to arbitrarily shaped voxel selection in spectroscopy and investigated for different excitation k-space trajectories (ra...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23018

    authors: Snyder J,Haas M,Hennig J,Zaitsev M

    更新日期:2012-02-01 00:00:00

  • Potential degradation in image quality due to selective averaging of phase-encoding lines in Fourier transform MRI.

    abstract::The properties of the image noise for selective averaging of phase-encoding lines have been investigated. For a given acquisition time, selective averaging results in a signal-to-noise ratio penalty compared to averaging all lines equally. In addition, selective averaging yields a non uniform distribution of noise cha...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910190115

    authors: Mugler JP 3rd

    更新日期:1991-05-01 00:00:00

  • A numerical approach to non-circular birdcage RF coil optimization: verification with a fourth-order coil.

    abstract::It is demonstrated that birdcage resonators, satisfying conditions of quadrature operation and radiofrequency field homogeneity, can be realized in practice on formers of non-circular cross section described by an equation of the form (x/a)n + (y/b)n = 1 where a and b are constants and n > or = 2 is an integer. Using ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199906)41:6<1180::aid-mrm1

    authors: Riauka TA,De Zanche NF,Thompson R,Vermeulen FE,Capjack CE,Allen PS

    更新日期:1999-06-01 00:00:00

  • Quantitative proton magnetic resonance spectroscopy of the human cervical spinal cord at 3 Tesla.

    abstract::Cervical spinal cord spectroscopy has the potential to add metabolic information to spinal cord MRI and improve the clinical evaluation and research investigation of spinal cord diseases, such as multiple sclerosis (MS) and intraspinal tumors. However, in vivo proton MR spectroscopy ((1)H-MRS) of the spinal cord is di...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21113

    authors: Marliani AF,Clementi V,Albini-Riccioli L,Agati R,Leonardi M

    更新日期:2007-01-01 00:00:00

  • Single-shot, three-dimensional "non-echo" localization method for in vivo NMR spectroscopy.

    abstract::Metabolite signals with short T(1) or T(2) are difficult to localize with full sensitivity. This limitation was overcome with the development and implementation of a single-shot, complete three-dimensional "non-echo" localization method with reduced sensitivity to spatial B(1) variation, which is suitable for measurin...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200009)44:3<387::aid-mrm8>3.0.co

    authors: Choi IY,Tkác I,Gruetter R

    更新日期:2000-09-01 00:00:00

  • 1H NMR relaxation measurements of human tissues in situ by spatially resolved spectroscopy.

    abstract::Spatially resolved spectroscopy (SPARS) is a method for obtaining high-resolution NMR spectra of well-defined volumes of human tissues in situ. This method was combined with the Carr-Purcell-Meiboom-Gill multiple-echo sequence for T2, and with inversion recovery for T1 relaxation measurements. Relaxation times obtaine...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910040504

    authors: Luyten PR,Anderson CM,den Hollander JA

    更新日期:1987-05-01 00:00:00

  • Carbon-13 "magic-angle" sample-spinning nuclear magnetic resonance studies of human myelin, and model membrane systems.

    abstract::We have obtained high-field (11.7 Tesla), high-resolution carbon-13 solid-state "magic-angle" sample-spinning nuclear magnetic resonance (NMR) spectra of a variety of phospholipids, sphingolipids, myelin and white matter samples, resolving and assigning over 40 resonances in the spectra of human and bovine myelin. The...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290204

    authors: Husted C,Montez B,Le C,Moscarello MA,Oldfield E

    更新日期:1993-02-01 00:00:00

  • Measurement of 129Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema.

    abstract::Hyperpolarized noble gas ((3)He and (129)Xe) apparent diffusion coefficient (ADC) measurements have shown remarkable sensitivity to microstructural (i.e., alveolar) changes in the lung, particularly emphysema. The ADC of hyperpolarized noble gases depends strongly on the diffusion time (Δ), and (3)He ADC has been show...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24224

    authors: Boudreau M,Xu X,Santyr GE

    更新日期:2013-01-01 00:00:00

  • The effect of realistic geometries on the susceptibility-weighted MR signal in white matter.

    abstract:PURPOSE:To investigate the effect of realistic microstructural geometry on the susceptibility-weighted MR signal in white matter (WM), with application to demyelination. METHODS:Previous work has modeled susceptibility-weighted signals under the assumption that axons are cylindrical. In this study, we explored the imp...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26689

    authors: Xu T,Foxley S,Kleinnijenhuis M,Chen WC,Miller KL

    更新日期:2018-01-01 00:00:00

  • Real-time interactive MRI-guided cardiac surgery: aortic valve replacement using a direct apical approach.

    abstract::Minimally invasive cardiac surgery requires arresting and emptying of the heart, which compromises visualization of the surgical field. In this feasibility study a novel surgical procedure is demonstrated in which real-time MRI is used to guide the placement of a prosthetic aortic valve in the beating heart via direct...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21044

    authors: McVeigh ER,Guttman MA,Lederman RJ,Li M,Kocaturk O,Hunt T,Kozlov S,Horvath KA

    更新日期:2006-11-01 00:00:00

  • Multislice and multicoil phase-sensitive inversion-recovery imaging.

    abstract::Phase-sensitive inversion-recovery (PSIR) imaging may provide enhanced T(1) contrast. However, clinical implementation of PSIR imaging is hindered because image reconstruction with this method often lacks robustness and requires manual intervention, particularly for data acquired in multiple slices and with phased-arr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20414

    authors: Ma J

    更新日期:2005-04-01 00:00:00

  • Flow-suppressed hyperpolarized 13 C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T.

    abstract:PURPOSE:To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification of hyperpolarized 13 C chemical shift imaging (CSI) of mouse liver at 9.4 T. METHODS:The trade-off between the amount of flow suppression using bipolar gradients and T2* effect from static spins was ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26578

    authors: Lee H,Lee J,Joe E,Yang S,Song JE,Choi YS,Wang E,Joo CG,Song HT,Kim DH

    更新日期:2017-11-01 00:00:00

  • Effects of imaging gradients in sequences with varying longitudinal storage time-Case of diffusion exchange imaging.

    abstract:PURPOSE:To illustrate the potential bias caused by imaging gradients in correlation MRI sequences using longitudinal magnetization storage (LS) and examine the case of filter exchange imaging (FEXI) yielding maps of the apparent exchange rate (AXR). METHODS:The effects of imaging gradients in FEXI were observed on yea...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26856

    authors: Lasič S,Lundell H,Topgaard D,Dyrby TB

    更新日期:2018-04-01 00:00:00

  • A magnetic shield for large-bore, high field magnets.

    abstract::An effective shield for the dc fringing fields produced by a large-bore, high field magnet intended for imaging and in vivo spectroscopy is presented. While limiting the extent of fringe fields, the shield has little effect on the homogeneity of the central field of the magnet. The effect of institutional safety polic...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910020506

    authors: Ewing JR,Timms W,Williams JE,Welch KM

    更新日期:1985-10-01 00:00:00

  • Metabolic assessment of a migraine model using relaxation-enhanced 1 H spectroscopy at ultrahigh field.

    abstract:PURPOSE:This study evaluates biochemical imbalances in a rat model that reflects dysfunctional pathways in migraine. The high sensitivity and spectral dispersion available to 1 H MRS at 21.1 T expands metabolic profiling in this migraine model to include lactate (Lac), taurine (Tau), aspartate, and Gly-a mixture of gly...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26811

    authors: Abad N,Rosenberg JT,Roussel T,Grice DC,Harrington MG,Grant SC

    更新日期:2018-03-01 00:00:00

  • Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI.

    abstract::Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI-based 3He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vivo mouse lungs. The technique yiel...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22737

    authors: Wang W,Nguyen NM,Yablonskiy DA,Sukstanskii AL,Osmanagic E,Atkinson JJ,Conradi MS,Woods JC

    更新日期:2011-03-01 00:00:00

  • Repeatability and variability of myocardial perfusion imaging techniques in mice: Comparison of arterial spin labeling and first-pass contrast-enhanced MRI.

    abstract:PURPOSE:Preclinical imaging of myocardial blood flow (MBF) can elucidate molecular mechanisms underlying cardiovascular disease. We compared the repeatability and variability of two methods, first-pass MRI and arterial spin labeling (ASL), for imaging MBF in mice. METHODS:Quantitative perfusion MRI in mice was perform...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25769

    authors: Naresh NK,Chen X,Moran E,Tian Y,French BA,Epstein FH

    更新日期:2016-06-01 00:00:00

  • Relative concentrations of proton MR visible neurochemicals in gray and white matter in human brain.

    abstract::The relative distributions of N-acetylaspartate (NAA) + N-acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed using an automated sp...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910330603

    authors: Doyle TJ,Bedell BJ,Narayana PA

    更新日期:1995-06-01 00:00:00

  • Impact of transcytolemmal water exchange on estimates of tissue microstructural properties derived from diffusion MRI.

    abstract:PURPOSE:To investigate the influence of transcytolemmal water exchange on estimates of tissue microstructural parameters derived from diffusion MRI using conventional PGSE and IMPULSED methods. METHODS:Computer simulations were performed to incorporate a broad range of intracellular water life times τin (50-∞ ms), cel...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26309

    authors: Li H,Jiang X,Xie J,Gore JC,Xu J

    更新日期:2017-06-01 00:00:00

  • Estimates of systolic and diastolic myocardial blood flow by dynamic contrast-enhanced MRI.

    abstract::Myocardial blood flow varies during the cardiac cycle in response to pulsatile changes in epicardial circulation and cyclical variation in myocardial tension. First-pass assessment of myocardial perfusion by dynamic contrast-enhanced MRI is one of the most challenging applications of MRI because of the spatial and tem...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22538

    authors: Radjenovic A,Biglands JD,Larghat A,Ridgway JP,Ball SG,Greenwood JP,Jerosch-Herold M,Plein S

    更新日期:2010-12-01 00:00:00

  • Electrocardiogram acquisition during MR examinations for patient monitoring and sequence triggering.

    abstract::We have developed a method for measuring the electrocardiogram (ECG) continuously during MR examinations. In contrast to ECG acquisition by wires, our new method is to amplify and convert the ECG into an optical signal directly above the patient's heart. The optical signal is transmitted out of the magnet bore by opti...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320416

    authors: Felblinger J,Lehmann C,Boesch C

    更新日期:1994-10-01 00:00:00

  • Recovery of the rodent brain after cardiac arrest: a functional MRI study.

    abstract::Recovery of the cerebral cortex after 10 min of cardiac arrest was studied in rat using noninvasive MRI techniques. The apparent diffusion coefficient (ADC) of brain water was imaged to document reversal of the metabolic impairment. Perfusion-weighted imaging and blood oxygen level dependent (BOLD) imaging were perfor...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910390516

    authors: Schmitz B,Bock C,Hoehn-Berlage M,Kerskens CM,Böttiger BW,Hossmann KA

    更新日期:1998-05-01 00:00:00