Relative concentrations of proton MR visible neurochemicals in gray and white matter in human brain.


:The relative distributions of N-acetylaspartate (NAA) + N-acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed using an automated spectroscopic image processing algorithm, and image segmentation was performed using a supervised technique. Linear regression analysis indicated that the NAA + NAAG (2.01 ppm) and Cr/PCr (3.02 ppm) peaks are greater in gray matter compared with white matter. The large intersubject variation observed in the Cho (3.20 ppm) resonance prevented the assessment of its regional distribution with confidence.


Magn Reson Med


Doyle TJ,Bedell BJ,Narayana PA




Has Abstract


1995-06-01 00:00:00












  • Quantitative measurement of regional lung ventilation using 3He MRI.

    abstract::A new strategy for a quantitative measurement of regional pulmonary ventilation using hyperpolarized helium-3 (3He) MRI has been developed. The method employs the build-up of the signal intensity after a variable number of (3)He breaths. A mathematical model of the signal dynamics is presented, from which the local ve...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Deninger AJ,Månsson S,Petersson JS,Pettersson G,Magnusson P,Svensson J,Fridlund B,Hansson G,Erjefeldt I,Wollmer P,Golman K

    更新日期:2002-08-01 00:00:00

  • Iterative projection onto convex sets for quantitative susceptibility mapping.

    abstract:PURPOSE:Quantitative susceptibility map (QSM) reconstruction is ill posed due to the zero values on the "magic angle cone" that make the maps prone to streaking artifacts. We propose projection onto convex sets (POCS) in the method of steepest descent (SD) for QSM reconstruction. METHODS:Two convex projections, an obj...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Deng W,Boada F,Poser BA,Schirda C,Stenger VA

    更新日期:2015-02-01 00:00:00

  • Free breathing lung T1 mapping using image registration in patients with idiopathic pulmonary fibrosis.

    abstract:PURPOSE:To assess the use of image registration for correcting respiratory motion in free breathing lung T1 mapping acquisition in patients with idiopathic pulmonary fibrosis (IPF). THEORY AND METHODS:The method presented used image registration to synthetic images during postprocessing to remove respiratory motion. S...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Saunders LC,Eaden JA,Bianchi SM,Swift AJ,Wild JM

    更新日期:2020-12-01 00:00:00

  • Simultaneous spin-echo refocusing.

    abstract::A new approach to spin-echo imaging is presented in which the 180 degrees RF pulse refocuses two or more spin-echoes at different positions in the readout period. When simultaneous echo refocusing (SER) is implemented using multiple 180 degrees pulses, an undesirable mixing of stimulated echoes and primary echoes from...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Günther M,Feinberg DA

    更新日期:2005-09-01 00:00:00

  • MRI evaluation of myocardial perfusion without a contrast agent using magnetization transfer.

    abstract::We propose a new magnetic resonance imaging (MRI) technique that is sensitive to myocardial tissue perfusion that obviates the use of an extrinsic contrast agent. Significant advantages of such a technique are that it avoids accumulation of contrast agent when repeated studies are performed on the same subject and tha...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Prasad PV,Burstein D,Edelman RR

    更新日期:1993-08-01 00:00:00

  • Relative indices of water diffusion anisotropy are equivalent in live and formalin-fixed mouse brains.

    abstract::Formalin fixation of tissue is a common laboratory practice. A direct comparison of diffusion tensor imaging (DTI) parameters from mouse brains before (in vivo) and after (ex vivo) formalin fixation is reported herein. Five diffusion indices were examined in a cohort of seven mice: relative anisotropy (RA), directiona...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Sun SW,Neil JJ,Song SK

    更新日期:2003-10-01 00:00:00

  • Multinuclear NMR investigations of probe construction materials at 4.7 T.

    abstract::Since background signal from NMR probes can overwhelm the signal from a sample, the NMR analysis of plastics or machinable ceramics is a prerequisite to their use in probe implementations. The contributions from a variety of materials to proton, fluorine, and carbon NMR spectra are presented. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Babcock EE,Vaughan JT,Lesan B,Nunnally RL

    更新日期:1990-03-01 00:00:00

  • Tuning and amplification strategies for intravascular imaging coils.

    abstract::The manufacturing of intravascular imaging coils poses several challenges. Due to their size, it can be difficult to incorporate local matching networks and signal amplifiers. The goal of this study is to investigate tuning and amplification strategies for intravascular coils and to assess the signal-to-noise benefits...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Yak N,Anderson KJ,Wright GA

    更新日期:2012-11-01 00:00:00

  • Dual-polarity slice-GRAPPA for concurrent ghost correction and slice separation in simultaneous multi-slice EPI.

    abstract:PURPOSE:A ghost correction strategy for Simultaneous Multi-Slice (SMS) EPI methods that provides improved ghosting artifact reduction compared to conventional methods is presented. Conventional Nyquist ghost correction methods for SMS-EPI rely on navigator data that contain phase errors from all slices in the simultane...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hoge WS,Setsompop K,Polimeni JR

    更新日期:2018-10-01 00:00:00

  • Echo-planar time course MRI of cat brain oxygenation changes.

    abstract::When deoxygenated, blood behaves as an effective susceptibility contrast agent. Changes in brain oxygenation can be monitored using gradient-echo echo-planar imaging. With this technique, difference images also demonstrate that blood oxygenation is increased during periods of recovery from respiratory challenge. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Turner R,Le Bihan D,Moonen CT,Despres D,Frank J

    更新日期:1991-11-01 00:00:00

  • Free-breathing diffusion tensor MRI of the whole left ventricle using second-order motion compensation and multitasking respiratory motion correction.

    abstract:PURPOSE:We aimed to develop a novel free-breathing cardiac diffusion tensor MRI (DT-MRI) approach, M2-MT-MOCO, capable of whole left ventricular coverage that leverages second-order motion compensation (M2) diffusion encoding and multitasking (MT) framework to efficiently correct for respiratory motion (MOCO). METHODS...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Nguyen CT,Christodoulou AG,Coll-Font J,Ma S,Xie Y,Reese TG,Mekkaoui C,Lewis GD,Bi X,Sosnovik DE,Li D

    更新日期:2020-11-30 00:00:00

  • A ranking of diffusion MRI compartment models with in vivo human brain data.

    abstract:PURPOSE:Diffusion magnetic resonance imaging (MRI) microstructure imaging provides a unique noninvasive probe into tissue microstructure. The technique relies on biophysically motivated mathematical models, relating microscopic tissue features to the magnetic resonance (MR) signal. This work aims to determine which com...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Ferizi U,Schneider T,Panagiotaki E,Nedjati-Gilani G,Zhang H,Wheeler-Kingshott CA,Alexander DC

    更新日期:2014-12-01 00:00:00

  • Biexponential longitudinal relaxation in white matter: Characterization and impact on T1 mapping with IR-FSE and MP2RAGE.

    abstract:PURPOSE:Magnetization transfer in white matter (WM) causes biexponential relaxation, but most quantitative T1 measurements fit data assuming monoexponential relaxation. The resulting monoexponential T1 estimate varies based on scan parameters and represents a source of variation between studies, especially at high fiel...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Rioux JA,Levesque IR,Rutt BK

    更新日期:2016-06-01 00:00:00

  • Out-and-in spiral spectroscopic imaging in rat brain at 7 T.

    abstract::With standard spectroscopic imaging, high spatial resolution is achieved at the price of a large number of phase-encoding steps, leading to long acquisition times. Fast spatial encoding methods reduce the minimum total acquisition time. In this article, a k-space scanning scheme using a continuous series of growing an...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hiba B,Faure B,Lamalle L,Décorps M,Ziegler A

    更新日期:2003-12-01 00:00:00

  • T2 relaxation-time mapping in healthy and diseased skeletal muscle using extended phase graph algorithms.

    abstract:PURPOSE:Multi-echo spin-echo (MSE) transverse relaxometry mapping using multi-component models is used to study disease activity in neuromuscular disease by assessing the T2 of the myocytic component (T2water ). Current extended phase graph algorithms are not optimized for fat fractions above 50% and the effects of ina...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Keene KR,Beenakker JM,Hooijmans MT,Naarding KJ,Niks EH,Otto LAM,van der Pol WL,Tannemaat MR,Kan HE,Froeling M

    更新日期:2020-11-01 00:00:00

  • Design and evaluation of quantitative MRI phantoms to mimic the simultaneous presence of fat, iron, and fibrosis in the liver.

    abstract:PURPOSE:To design, construct, and evaluate quantitative MR phantoms that mimic MRI signals from the liver with simultaneous control of three parameters: proton-density fat fraction (PDFF), R 2 ∗ ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Zhao R,Hamilton G,Brittain JH,Reeder SB,Hernando D

    更新日期:2021-02-01 00:00:00

  • Trajectory optimization based on the signal-to-noise ratio for spatial encoding with nonlinear encoding fields.

    abstract:PURPOSE:Multiple nonlinear gradient fields offer many potential benefits for spatial encoding including reduced acquisition time, fewer artefacts and region-specific imaging, although designing a suitable trajectory for such a setup is difficult. This work aims to optimize encoding trajectories for multiple nonlinear g...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Layton KJ,Kroboth S,Jia F,Littin S,Yu H,Zaitsev M

    更新日期:2016-07-01 00:00:00

  • SAR comparison between CASL and pCASL at high magnetic field and evaluation of the benefit of a dedicated labeling coil.

    abstract:PURPOSE:To investigate the heating induced by (pseudo)-continuous arterial spin labeling ((p)CASL) sequences in vivo at 9.4T and to evaluate the benefit of a dedicated labeling coil. METHODS:Temperature was measured continuously in the brain, neck, and rectum of 9 rats with fiber-optic temperature probes while running...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hirschler L,Collomb N,Voiron J,Köhler S,Barbier EL,Warnking JM

    更新日期:2020-01-01 00:00:00

  • The Rician distribution of noisy MRI data.

    abstract::The image intensity in magnetic resonance magnitude images in the presence of noise is shown to be governed by a Rician distribution. Low signal intensities (SNR < 2) are therefore biased due to the noise. It is shown how the underlying noise can be estimated from the images and a simple correction scheme is provided ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Gudbjartsson H,Patz S

    更新日期:1995-12-01 00:00:00

  • Oxygen-sensitive contrast in blood for steady-state free precession imaging.

    abstract::Steady-state free precession (SSFP) methods have gained widespread recognition for their ability to provide fast scans at high signal-to-noise ratio. This paper demonstrates that such methods are also capable of reflecting functional information, particularly blood oxygenation state. It is well known that SSFP signals...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Dharmakumar R,Hong J,Brittain JH,Plewes DB,Wright GA

    更新日期:2005-03-01 00:00:00

  • Stream function optimization for gradient coil design.

    abstract::This work presents a method applied to the design of short self-shielded gradient coils of cylindrical geometry. The method uses a hybrid technique that combines the simulated annealing and target field methods to optimize the standard stream functions. The optimized stream functions were parameterized using a few deg...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Tomasi D

    更新日期:2001-03-01 00:00:00

  • Echo-time reduction for submillimeter resolution imaging with a 3D phase encode time reduced acquisition method.

    abstract::To achieve optimal image quality and highest spatial resolution for inner ear imaging with a 3D gradient echo sequence, it is necessary to minimize susceptibility dephasing effects by using very short TE. Fractional RF pulses and echoes can yield short TE for moderate spatial resolution; however, for voxel size of les...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Ying K,Schmalbrock P,Clymer B

    更新日期:1995-01-01 00:00:00

  • Echo-planar imaging of the human fetus in utero.

    abstract::We have demonstrated that echo-planar imaging can be used to produce high-quality snapshot images of the human fetus in utero in a fraction of a second. These images are free of motional artifact or blurring and allow detailed depiction of fetal structures in normal and pathological pregnancies. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Stehling MK,Mansfield P,Ordidge RJ,Coxon R,Chapman B,Blamire A,Gibbs P,Johnson IR,Symonds EM,Worthington BS

    更新日期:1990-02-01 00:00:00

  • Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment.

    abstract::A method for volume selective proton spectroscopy is presented based on a multiecho sequence with short refocusing interval tcp. It is demonstrated, that by appropriate choice of tcp on the order of 4-6 ms, signals from overlapping multiplets like the glutamine and glutamate (Glu/Gln) resonances in spectra of the huma...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Hennig J,Thiel T,Speck O

    更新日期:1997-06-01 00:00:00

  • A controllable susceptibility marker for passive device tracking.

    abstract:PURPOSE:To design and demonstrate a new susceptibility-based tracking device with an artifact that can be mechanically turned on and off, thus permitting tracking and imaging at the device tip with limited artifact. METHODS:The magnetic susceptibilities of readily obtainable grades of titanium and graphite were measur...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Dominguez-Viqueira W,Karimi H,Lam WW,Cunningham CH

    更新日期:2014-07-01 00:00:00

  • Combined dynamic contrast-enhanced liver MRI and MRA using interleaved variable density sampling.

    abstract:PURPOSE:To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent. METHODS:An interleaved variable density (IVD) undersampling pattern was implemented i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Salmani Rahimi M,Korosec FR,Wang K,Holmes JH,Motosugi U,Bannas P,Reeder SB

    更新日期:2015-03-01 00:00:00

  • Simultaneous quantitative mapping of conductivity and susceptibility using a double-echo ultrashort echo time sequence: Example using a hematoma evolution study.

    abstract:PURPOSE:The primary purpose of this study is to propose a method for the simultaneous quantitative three-dimensional (3D) mapping of conductivity and susceptibility using double-echo ultrashort echo time (UTE) imaging. The secondary purpose is to investigate the changes of these properties over time during in vitro hem...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Gho SM,Shin J,Kim MO,Kim DH

    更新日期:2016-07-01 00:00:00

  • Cellular imaging and texture analysis distinguish differences in cellular dynamics in mouse brain tumors.

    abstract:PURPOSE:The heterogeneous tumor cell population and dynamic microenvironment within a tumor lead to regional variations in cell proliferation, migration, and differentiation. In this work, MRI and optical projection tomography were used to examine and compare the redistribution of a cellular label in two mouse glioma m...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Gazdzinski LM,Nieman BJ

    更新日期:2014-04-01 00:00:00

  • Mapping of regional lung microstructural parameters using hyperpolarized 129 Xe dissolved-phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease.

    abstract:PURPOSE:To develop a novel technique for voxel-based mapping of lung microstructural parameters using hyperpolarized 129 Xe dissolved-phase MR imaging during saturation recovery. METHODS:A pulse sequence using a highly undersampled stack-of-stars trajectory was developed, and low-rank plus sparse matrix decomposition ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章


    authors: Kern AL,Gutberlet M,Voskrebenzev A,Klimeš F,Rotärmel A,Wacker F,Hohlfeld JM,Vogel-Claussen J

    更新日期:2019-04-01 00:00:00

  • Present clinical status of magnetic resonance imaging.

    abstract::Magnetic resonance imaging has achieved clinical importance and has become the primary tool in the investigation of head, spinal cord, pelvis, cancellous bone, pericardium (with gating), gallbladder, lymph node masses, and very soon, in the evaluation of joints. In many areas, particularly with respiratory and ECG gat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,评审


    authors: Margulis AR,Fisher MR

    更新日期:1985-08-01 00:00:00