Sequence-specific 1H, 13C, and 15N backbone assignment of the activated 21 kDa GTPase rRheb.

Abstract:

:Ras homologue enriched in brain (Rheb) is a small GTPase that plays an important role in tuberous sclerosis. Here we present the backbone assignments of activated rRheb in complex with the non-hydrolisable GTP analogue GppNHp. These assignments now provide a basis for the analysis of rRheb's interaction with putative effectors in order to further elucidate the physiological function of this GTPase and its role in the regulation of neuronal cell volume as well as in tuberous sclerosis.

journal_name

Biomol NMR Assign

authors

Schwarten M,Berghaus C,Heumann R,Stoll R

doi

10.1007/s12104-007-9030-3

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

105-8

issue

1

eissn

1874-2718

issn

1874-270X

journal_volume

1

pub_type

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