Abstract:
:Ras homologue enriched in brain (Rheb) is a small GTPase that plays an important role in tuberous sclerosis. Here we present the backbone assignments of activated rRheb in complex with the non-hydrolisable GTP analogue GppNHp. These assignments now provide a basis for the analysis of rRheb's interaction with putative effectors in order to further elucidate the physiological function of this GTPase and its role in the regulation of neuronal cell volume as well as in tuberous sclerosis.
journal_name
Biomol NMR Assignjournal_title
Biomolecular NMR assignmentsauthors
Schwarten M,Berghaus C,Heumann R,Stoll Rdoi
10.1007/s12104-007-9030-3subject
Has Abstractpub_date
2007-07-01 00:00:00pages
105-8issue
1eissn
1874-2718issn
1874-270Xjournal_volume
1pub_type
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