Abstract:
:Cardiac involvement of Duchenne and Becker muscular dystrophies (DMD/BMD) is the most common cause of fatal outcomes. It is still unclear whether some DMD/BMD gene mutations might be predictive of cardiac involvement. In this study, we provide a comprehensive overview on genotypes of cardiac disease in DMD/BMD. We systematically searched the PubMed/Medline, EMBASE and Cochrane electronic databases. Search results were filtered to include only human studies, English language and all dates up to August 2019. We summarized and extensively reviewed all studies that passed the selection criteria and performed a meta-analysis on key genotype parameters of cardiac disease in DMD/BMD. Of 3450 articles scanned, we included 18 studies from 9 regions in the meta-analysis. The pooled studies included 2661 DMD/BMD patients and 1324 DMD/BMD patients with cardiac disease. The most common mutation type was exon deletion, with a pooled frequency of 90% (P < 0.01). In DMD/BMD patients with cardiac dysfunction, a higher frequency of involvement of exons 45 and 46 was found in DMD/BMD patients with cardiac dysfunction. This might be predictive of cardiac involvement in patients with DMD/BMD.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Zhou H,Fu M,Mao B,Yuan Ldoi
10.1007/s00246-020-02470-4subject
Has Abstractpub_date
2020-10-09 00:00:00eissn
0172-0643issn
1432-1971pii
10.1007/s00246-020-02470-4pub_type
杂志文章abstract::Left atrial tumor, diagnosed as myxoma at first investigation, was later demonstrated to be a malignant fibrosarcoma with myxoid change. Myxoma should be diagnosed and managed carefully because of its wide range of histopathologic features. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010218
更新日期:2001-05-01 00:00:00
abstract::A retrospective study of children dying with active varicella revealed 11 of 17 cases who had unsuspected interstitial myocarditis at the time of their death. In addition, a prospective study of 6 children, consecutively admitted to the hospital with active varicella, were evaluated for evidence of cardiac dysfunction...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02082333
更新日期:1982-01-01 00:00:00
abstract::After surgical repair of an aortic coarctation a term infant presented with severe pulmonary hypertension and cyanosis unresponsive to treatment including extracorporeal membrane oxygenation. The atypical clinical course became apparent once the accompanying diagnosis of congenital alveolar capillary dysplasia with mi...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-007-9063-5
更新日期:2008-01-01 00:00:00
abstract::Atherosclerotic cardiovascular disease (CVD), a leading cause of death globally, has origins in childhood. Major risk factors include family history of premature CVD, dyslipidemia, diabetes mellitus, and hypertension. Lipoprotein (a) [Lp(a)], an inherited lipoprotein, is associated with premature CVD, but its impact o...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-1927-3
更新日期:2018-12-01 00:00:00
abstract::Magnetocardiographic mapping was performed on a 2-year-old boy who suffered from the Wolff-Parkinson-White syndrome in association with a complex congenital heart defect. The pre-excitation site was determined noninvasively from the measured cardiac magnetic fields. The location was in the same anatomic region as foun...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02310333
更新日期:1995-01-01 00:00:00
abstract::Electrocardiograms (heart rate, QRS voltage, QRS axis in the frontal plane. Q-Tc interval) echocardiograms [left ventricular fractional shortening (LVFS); preejection period (PEP); PEP/left ventricular ejection time (PEP/LVET) ratio; end-diastolic left ventricular free wall and interventricular septum thickness; prese...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02238495
更新日期:1991-01-01 00:00:00
abstract::Little has been published about specific problems that may occur during long-distance transports of newborn cardiac patients. During a 4-year period after centralization of pediatric heart surgery in Sweden, 286 transports were prospectively investigated. A majority (77.3%) of the transports were carried out by nonspe...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010254
更新日期:2001-09-01 00:00:00
abstract::Children with acquired and congenital heart disease (CHD) are increasingly surviving to adulthood. Our aim was to determine the prevalence of coronary artery disease (CAD) risk factors in children at known risk for early CAD or with severe CHD. We recruited children (8-19 years) at risk for early CAD-Kawasaki disease ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-017-1750-2
更新日期:2018-02-01 00:00:00
abstract::Children with congenital heart defects often demonstrate a reduced capacity for exercise, even after surgical intervention. Forty subjects, with various heart defects, completed a 5-year study to evaluate the impact of a postoperative training program on their physical exercise capacity. All of the patients were signi...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02238841
更新日期:1990-07-01 00:00:00
abstract::Thrombus formation in the native aortic root is a rare but potentially life-threatening complication in patients with hypoplastic left heart syndrome. The native aortic root in these patients serves as a conduit for the retrograde filling of the coronary arteries. Thrombus in this location could result in myocardial i...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-005-1274-z
更新日期:2006-05-01 00:00:00
abstract::Maximal oxygen consumption (VO2max) is the "gold standard" by which to assess functional capacity; however, it is effort dependent. VO2@RER1.0 is defined when VO2 = VCO2. Between December 22, 1997 and November 9, 2004, 305 pediatric subjects underwent cycle ergometer cardiopulmonary exercise testing, exercised to exha...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-009-9544-9
更新日期:2010-01-01 00:00:00
abstract::Tricuspid valve malformation is a rare congenital heart disease. Prenatal diagnosis of Ebstein's anomaly (EA) and tricuspid valve dysplasia (TVD) is associated with high mortality. There are conflicting reports concerning accurate prognostication after diagnosis in utero. The aim of our study was to assess prognostic ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0355-z
更新日期:2012-12-01 00:00:00
abstract::A varying degree of impairment of ventricular performance is observed over the long-term after surgery for a congenital heart defect (CHD). Impaired ventricular performance has been shown to be of prognostic value for increased risk of cardiovascular events in adult CHD patients. This emphasizes the importance of deli...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00246-013-0802-5
更新日期:2014-01-01 00:00:00
abstract::Natriuretic peptides (NP) are released from the heart in response to pressure and volume overload. The biologic properties of NPs include counterregulation of the rennin-angiotensin-aldosterone pathway and a decrease in sympathetic tone resulting in diuresis, natriuresis, and vasodilation. Natriuretic peptides help to...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00246-010-9758-x
更新日期:2010-11-01 00:00:00
abstract::Digoxin has been an effective treatment for fetal supraventricular tachycardia (SVT), but second-line therapy remains more controversial. Thirty-seven cases of fetal SVT were identified that received digoxin as first-line therapy. Seventeen fetuses (46%) converted to and maintained normal sinus rhythm. Flecainide was ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010279
更新日期:2001-11-01 00:00:00
abstract::To reveal the association between DNMT1 polymorphisms and congenital heart disease (CHD) in child patients, a total of 224 CHD child patients as well as 199 healthy individuals were enrolled in the present study. The DNA was extracted from whole blood, and four SNPs including rs16999593, rs2228612, rs2288349 and rs104...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-015-1093-9
更新日期:2015-06-01 00:00:00
abstract::Two patients (one girl, one boy) with Kartagener syndrome (situs inversus, bronchiectasis, sinusitis), despite pulmonary problems and associated congenital cardiac anomalies, were operated on at the ages of 4 years and 7 years, respectively. They had had previous palliative treatment at the age of 3 months and 1.3 yea...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469900115
更新日期:1997-01-01 00:00:00
abstract::Thrombocytopenia can be a real challenge during cardiac surgery in children with cyanotic congenital heart disease. This report describes a 7-year-old girl with d-transposition of the great arteries, ventricular septal defect, pulmonary hypertension, chronic thrombocytopenia, polycythemia, and chronic renal impairment...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0570-7
更新日期:2013-01-01 00:00:00
abstract::Accessory atrioventricular pathways (AP) are the most common substrate for paroxysmal supraventricular tachycardia in infants and small children. Up-to-date data on AP ablation in infants and small children are limited. The aim of the present study was to gain additional insight into radiofrequency (RF) catheter ablat...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-016-1365-z
更新日期:2016-06-01 00:00:00
abstract::This report describes the case of a 29-day-old infant with Kawasaki's disease who presented in extremis with multiple coronary aneurysms and coronary thromboses, myocardial ischemia, and congestive heart failure. The infant successfully underwent emergent coronary thrombolysis with tissue plasminogen activator. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-010-9781-y
更新日期:2010-11-01 00:00:00
abstract::A 5-year-old boy born with a congenital heart defect had insertion of an epicardial pacemaker that was found on routine evaluation to have been displaced into the rectovesical pouch. He underwent transvenous insertion of another pacemaker, and the displaced pacemaker was successfully retrieved by laparoscopy without i...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-011-9972-1
更新日期:2011-12-01 00:00:00
abstract::Sudden cardiac death in young competitive athletes is tragic and usually due to unsuspected cardiovascular disease. Screening programs for athletes remain debatable, and restriction of athletes from sports can have physical, emotional, and legal ramifications. In this article, we review the epidemiology of the more co...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00246-012-0170-6
更新日期:2012-03-01 00:00:00
abstract::Azygos continuation of inferior venacava (IVC) is well known in association with interrupted IVC. We report azygos connection of uninterrupted IVC in a young child with complex univentricular heart. This peculiar anatomy was made suitable for univentricular repair by combining percutaneous device closure of prehepatic...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-010-9802-x
更新日期:2011-01-01 00:00:00
abstract::To examine factors associated with low high-density lipoprotein cholesterol (HDL-C) levels among middle school children. HDL-C levels were the primary outcome of interest. A total of 1,104 middle-school children (mean age 11.6 years, 51.2% female) were included in this analysis, of whom 177 (16%) had an HDL-C level ≤4...
journal_title:Pediatric cardiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00246-013-0814-1
更新日期:2014-03-01 00:00:00
abstract::The epidemiologic data for pediatric hypertrophic cardiomyopathy (HCM) needs to be periodically updated as diagnostic techniques and management strategies improve. Herein, the incidence, prevalence, and mortality rates of pediatric HCM in a population-based treatment system are described. Patients aged ≤ 17 years and ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02472-2
更新日期:2020-10-03 00:00:00
abstract:OBJECTIVES:The aim of this article is to examine the frequency, timing of formation of aneurysm of the ventricular membranous septum (AVMS), and prognosis in patients with a perimembranous ventricular septal defect (VSD). PATIENTS:One hundred forty-eight patients were diagnosed with a perimembranous VSD within 90 days...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-003-0572-6
更新日期:2004-07-01 00:00:00
abstract::Various surgical techniques have been proposed for the repair of supravalvular pulmonary stenosis (SVPS) in pediatric populations. Whereas growth potential should be promised, excessive expansion under the presence of undiminished high pulmonary arterial pressure should be avoided. The authors applied all-autologous t...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-013-0698-0
更新日期:2013-10-01 00:00:00
abstract::Once a mainstay in the treatment of neonates with d-transposition of the great arteries (d-TGA), the application of balloon atrial septostomy (BAS) in the d-TGA population has become more selective. Currently, there is no clear evidence for or against a selective BAS strategy. The aims of this single-center retrospect...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02520-x
更新日期:2021-01-25 00:00:00
abstract::In our institute, 1100 patients with a history of Kawasaki disease have been catheterized for selective coronary arteriography. Their age at examination ranged from four months to 13 years. Coronary artery lesions (CAL) were found in 262 patients. As far as the type of the CAL was concerned, occlusion was noted in 20 ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02315475
更新日期:1986-01-01 00:00:00
abstract::We describe two cases of left-side pulmonary vein obstruction observed after the arterial switch operation (Jatene) for D-transposition of the great arteries. This appears to be related to left-sided pulmonary vein obstruction occurring coincidently with D-transposition of the great arteries, rather than a consequence...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469900180
更新日期:1997-07-01 00:00:00