Abstract：
:Digoxin has been an effective treatment for fetal supraventricular tachycardia (SVT), but second-line therapy remains more controversial. Thirty-seven cases of fetal SVT were identified that received digoxin as first-line therapy. Seventeen fetuses (46%) converted to and maintained normal sinus rhythm. Flecainide was used in 13/15 patients requiring second-line therapy; 12/13 (92%) converted to sinus rhythm. Of seven hydropic fetuses, five required second-line therapy and were then successfully converted with flecainide. The improved efficacy of flecainide was statistically significant with a p value <0.01. Complete follow-up was available in 13 digoxin-treated and in 12 second-line therapy infants. Prolonged or multiple drug therapy for postnatal arrhythmia management was required in 3/13 (23%) patients in the digoxin group and in 8/12 (67%) patients requiring second-line therapy. This demonstrated a correlation between the need for second-line fetal therapy and more complex postnatal management with a p value of 0.003. Digoxin remains an effective first-line therapy in the treatment of fetal SVT. Flecainide is an effective second-line therapy, especially in the face of fetal hydrops. Use of second-line therapy in fetal SVT is a predictor of complex postnatal course, and these patients should be followed more closely.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Ebenroth ES,Cordes TM,Darragh RKdoi
10.1007/s002460010279subject
Has Abstractpub_date
2001-11-01 00:00:00pages
483-7issue
6eissn
0172-0643issn
1432-1971journal_volume
22pub_type
杂志文章abstract：:Inferior sinus venosus defects (SVDs) are rare imperfections located in the inferior portion of the atrial septum, leading to an overriding inferior vena cava (IVC) and an interatrial connection. These defects have increased risk of anomalous pulmonary venous return (PAPVR) and often are confused with secundum atrial ...
journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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pub_type： 杂志文章,评审
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journal_title：Pediatric cardiology
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更新日期：2013-02-01 00:00:00
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更新日期：2013-01-01 00:00:00
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journal_title：Pediatric cardiology
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更新日期：2006-11-01 00:00:00
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pub_type： 杂志文章,多中心研究
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journal_title：Pediatric cardiology
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更新日期：1988-01-01 00:00:00
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journal_title：Pediatric cardiology
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