Abstract:
:To reveal the association between DNMT1 polymorphisms and congenital heart disease (CHD) in child patients, a total of 224 CHD child patients as well as 199 healthy individuals were enrolled in the present study. The DNA was extracted from whole blood, and four SNPs including rs16999593, rs2228612, rs2288349 and rs10420321 were selected for the gene polymorphism investigation via ligase detection reaction (LDR) assay. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to assess the strength of the association. rs16999593 was associated with the CHD under the heterozygous (CT vs TT: OR 0.62; 95 % CI 0.41-0.95; p = 0.03), dominant (CT + CC vs TT: OR 0.63; 95 % CI 0.42-0.95; p = 0.03), and allele models (C vs T: OR 0.07; 95 % CI 0.50-1.00; p = 0.05). rs2228612 was related with the CHD under the heterozygous (AG vs AA: OR 0.42; 95 % CI 0.27-0.65; p = 0.0001), homozygous (GG vs AA: OR 0.43; 95 % CI 0.240-0.77; p = 0.004), dominant (AG + GG vs AA: OR 0.42; 95 % CI 0.28-0.64; p < 0.0001), and allele models (G vs A: OR 0.62; 95 % CI 0.47-0.82; p = 0.0007). rs10420321 correlated with the CHD only under the recessive model (GG vs AG + AA: OR 0.61; 95 % CI 0.37-1.01, p = 0.05). However, no significant association between the rs2288349 polymorphisms and the risk of CHD was observed (p > 0.05). DNMT1 polymorphisms might contribute to the risk of CHD, especially rs16999593 and rs2228612.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Wang F,Zhou S,Wang Y,Wang L,Zhou J,Wang H,Li C,Chang Mdoi
10.1007/s00246-015-1093-9subject
Has Abstractpub_date
2015-06-01 00:00:00pages
906-11issue
5eissn
0172-0643issn
1432-1971journal_volume
36pub_type
杂志文章abstract::Noninvasive measurement of cardiac output (CO) and particularly stroke volume (SV) remain difficult but potentially valuable. These variables can be particularly challenging to measure in children with congenital heart disease (CHD). Impedance cardiography (IC) is a technique shown to be accurate in measuring SV in ad...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-016-1456-x
更新日期:2016-12-01 00:00:00
abstract::The slope of the relation between the unadjusted QT interval and heart rate during the face immersion test has been reported to be useful as an index for predicting an abnormal lengthening of the QT interval for children with nonfamilial long QT syndrome. Our goals were to determine whether we can replace the slope of...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-001-0034-y
更新日期:2002-03-01 00:00:00
abstract::There is a higher incidence of sudden death in patients with Rett syndrome than individuals in the general population. Previous studies have implicated cardiac dysautonomia and a long QT interval as causative factors. Because carnitine plays a critical role in cellular metabolism and may have beneficial effects on car...
journal_title:Pediatric cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00246-005-0784-z
更新日期:2005-09-01 00:00:00
abstract::A 9-year-old boy whose past history was remarkable for a heart murmur was diagnosed with abdominal angina due to acute occlusion of a simple coarctation of the aorta. Using a single cross-clamp, we accomplished an end-to-end anastomosis after resection of the coarctation. Paradoxical hypertension and abdominal angina ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-002-0381-3
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:The aim of this article is to examine the frequency, timing of formation of aneurysm of the ventricular membranous septum (AVMS), and prognosis in patients with a perimembranous ventricular septal defect (VSD). PATIENTS:One hundred forty-eight patients were diagnosed with a perimembranous VSD within 90 days...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-003-0572-6
更新日期:2004-07-01 00:00:00
abstract::Rheumatic heart disease (RHD) is an inflammatory disease that develops following streptococcal infections. IL10 helps to balance immune responses to pathogens. IL10 polymorphisms have been associated with RHD, although results remain inconclusive. Our aim was to investigate the association between IL10 polymorphisms a...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-015-1245-y
更新日期:2016-01-01 00:00:00
abstract::A 6-year-old girl presented with respiratory distress. Chest radiographs exhibited calcifications in the mediastinum. Further imaging revealed extensive cardiac calcifications on computed tomography of the chest. The laboratory parameters were consistent with findings of secondary hyperparathyroidism. Detailed review ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0765-7
更新日期:2005-07-01 00:00:00
abstract::Coronary artery fistula (CAF) is a rare congenital anomaly that can be complicated by endocarditis, myocardial infarction, or coronary aneurysms. This article reviews the clinical characteristics and surgical outcome of 10 patients with CAF in Rajae Heart Center. From 1990 to 2000, 10 patients (age, 6 months to 15 yea...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0656-y
更新日期:2005-07-01 00:00:00
abstract::In this report, we describe a case of coarctation of the aorta, congenital aortic stenosis with bicuspid valve, and supravalvar aortic stenosis with left coronary artery ostial stenosis. The child underwent staged treatment using a hybrid approach employing both surgical and interventional cardiology methods. A single...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010164
更新日期:2001-01-01 00:00:00
abstract::Maintaining patency of the ductus arteriosus pending surgical intervention can be critical to the survival of the neonate with ductal dependent congenital heart disease. Spontaneously delayed ductal closure has been observed clinically and experimentally in newborns with critical pulmonic stenosis. Infants with ductal...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02263445
更新日期:1987-01-01 00:00:00
abstract::In adult heart failure (HF) patients, a higher ventricular arterial (VA) coupling ratio measured non-invasively is associated with worse HF prognosis and response to treatment. There are no data regarding the relationship of VA coupling to outcome in pediatric dilated cardiomyopathy (DCM) patients. We investigated the...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-2021-6
更新日期:2019-02-01 00:00:00
abstract::In the classic scimitar syndrome, a pulmonary vein draining all or part of the right lung enters the inferior vena cava. A variant is described with the same roentgenographic appearance, but with drainage of the anomalous pulmonary vein into both the inferior vena cava and the left atrium; the atrial septum was intact...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02079472
更新日期:1987-01-01 00:00:00
abstract::Cardiac involvement of Duchenne and Becker muscular dystrophies (DMD/BMD) is the most common cause of fatal outcomes. It is still unclear whether some DMD/BMD gene mutations might be predictive of cardiac involvement. In this study, we provide a comprehensive overview on genotypes of cardiac disease in DMD/BMD. We sys...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02470-4
更新日期:2020-10-09 00:00:00
abstract::Management of warfarin in pediatric patients remains a clinical challenge. Warfarin may be administered after congenital heart surgery, and the risks of morbidity can be high. Currently, no data exist to describe the initiation of warfarin and the risk factors for morbidity in post-congenital heart surgery patients. T...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0351-3
更新日期:2012-12-01 00:00:00
abstract::We describe two cases of left-side pulmonary vein obstruction observed after the arterial switch operation (Jatene) for D-transposition of the great arteries. This appears to be related to left-sided pulmonary vein obstruction occurring coincidently with D-transposition of the great arteries, rather than a consequence...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469900180
更新日期:1997-07-01 00:00:00
abstract::The outcome of children born with cyanotic congenital heart disease has markedly improved over the years. Follow up is recommended for most post-operated cases as complications may occur over long term. One of the complications is the development of ventricular dysfunction, often seen after a successful Fontan surgery...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0531-1
更新日期:2013-04-01 00:00:00
abstract::The clinical and pathological features of primary pulmonary artery sarcoma in two children are reported. The first patient presented with right ventricular outflow obstruction and underwent successful surgical resection of his tumor. The second patient developed cardiac arrest following a relatively short period of sy...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02078416
更新日期:1988-01-01 00:00:00
abstract::Combination of right and left ventricular outflow tracts obstruction is extremely rare. Neonates with combined aortic stenosis (AS) and pulmonary stenosis (PS) present in critical condition and required urgent treatment. The management approach is not well defined. We report five female neonates with combined AS and P...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-014-1000-9
更新日期:2014-12-01 00:00:00
abstract::Severe atrioventricular valve (AVV) or semilunar valve (SLV) regurgitation in the setting of a single ventricle physiology may proceed to valve replacement if repair strategies fail. Outcome data for these children are limited. We present transplant-free survival of a case series of children with single ventricle phys...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-019-02234-9
更新日期:2020-01-01 00:00:00
abstract::Vitamin D has anti-inflammatory properties, and deficiency is prevalent in children. There is a paucity of data regarding vitamin D status and its correlation with low-grade inflammation and vasculature. We prospectively enrolled 25 children, 9-11 years old (13 male); 21 obese. Eight atherosclerosis-promoting risk fac...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-015-1162-0
更新日期:2015-10-01 00:00:00
abstract::To evaluate the feasibility of implementing a pulse oximetry screening protocol at a city of mild elevation with a specific focus on the false-positive screening rate. Pulse oximetry screening was performed according to the proposed guidelines endorsed by the American Academy of Pediatrics at a center in Tucson, AZ, a...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-013-0716-2
更新日期:2013-01-01 00:00:00
abstract::Natriuretic peptides (NP) are released from the heart in response to pressure and volume overload. The biologic properties of NPs include counterregulation of the rennin-angiotensin-aldosterone pathway and a decrease in sympathetic tone resulting in diuresis, natriuresis, and vasodilation. Natriuretic peptides help to...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00246-010-9758-x
更新日期:2010-11-01 00:00:00
abstract::The response to warfarin is highly variable among individuals and such variability is likely to have some genetic basis. We evaluted the effect of VKORC1 polymorphisms on warfarin response among Japanese, taking advantage of its unique population structure in which CYP2C9 *2 and *3 alleles are relatively rare. Thirty-...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-005-1150-x
更新日期:2006-11-01 00:00:00
abstract::Serum troponin (Tn) is often elevated in viral myocarditis; however, its prognostic significance is unknown. We tested the hypothesis that abnormal serum Tn is associated with mortality in children hospitalized with myocarditis. We retrospectively studied data from six large children's hospitals participating in the P...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-1871-2
更新日期:2018-08-01 00:00:00
abstract::Magnesium sulfate was given to pediatric cardiac surgical patients during cardiopulmonary bypass period in an attempt to reduce the occurrence of postoperative junctional ectopic tachycardia (PO JET). We reviewed our data to evaluate the effect of magnesium on the occurrence of JET and assess a possible relationship b...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-015-1141-5
更新日期:2015-08-01 00:00:00
abstract::Aortic atresia and interrupted aortic arch is a rare cardiac combination. Review of the literature revealed nine cases. We present two patients with this combination and the additional finding of quadricuspid pulmonary valves, one of which was severely stenotic. In the latter patient, an aortopulmonary window was pres...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0754-x
更新日期:2005-07-01 00:00:00
abstract::We report our experience with asymptomatic valvar aortic stenosis diagnosed during infancy. During the period between November 1, 1986 and October 31, 1992 a total of 13 infants were diagnosed with asymptomatic aortic stenosis, 5 of whom showed rapid progression over the first 2 years of life. Two of these asymptomati...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469900105
更新日期:1997-01-01 00:00:00
abstract::In our institute, 1100 patients with a history of Kawasaki disease have been catheterized for selective coronary arteriography. Their age at examination ranged from four months to 13 years. Coronary artery lesions (CAL) were found in 262 patients. As far as the type of the CAL was concerned, occlusion was noted in 20 ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02315475
更新日期:1986-01-01 00:00:00
abstract::This retrospective study aimed to determine the superior vena cava (SVC) and left innominate vein (INV) normative cross-sectional area in children noninvasively using age as a predictor and also to compare the correlation of the area measured with the diameter on multidetector computed tomography (MDCT). Analysis of t...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-014-0893-7
更新日期:2014-08-01 00:00:00
abstract::Acute myopericarditis is a major cause of acquired heart disease worldwide in pediatric patients. Various viruses have been reported as the etiology, of which varicella zoster virus was first reported in 1953. However, since nationwide administration of the varicella vaccine, reports of varicella-associated myopericar...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-009-9637-5
更新日期:2010-07-01 00:00:00