Abstract：
:The response to warfarin is highly variable among individuals and such variability is likely to have some genetic basis. We evaluted the effect of VKORC1 polymorphisms on warfarin response among Japanese, taking advantage of its unique population structure in which CYP2C9 *2 and *3 alleles are relatively rare. Thirty-one patients (12-34 years old; median, 22) on warfarin were recruited from a pediatric cardiology clinic. Genotyping of the C>T polymorphism at position 1173 in intron 1 of VKORC1 revealed that 26 patients (84%) were T/T homozygotes at nucleotide 1173, whereas 5 (16%) were C/T heterozygotes. Complete linkage disequilibrium was observed between the 1173C > T polymorphism and another polymorphism, the 3730G > A, in the 3' untranslated region. The C/T heterozyogtes at the 1173C > T polymorphism tended to require more warfarin than the T/T homozygotes, when adjusted for international normalized ratio (p = 0.003). Both the 1173C > T polymorphism and the 3730G > A polymorphism are likely to be inert from a functional standpoint. Rather, based on the complete linkage disequilibrium between 1173C > T and 3730G > A polymorphisms, we suspect that the actual change that defines the relative resistance to warfarin may be present in the proximity of these two polymorphisms.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Kosaki K,Yamaghishi C,Sato R,Semejima H,Fuijita H,Tamura K,Maeyama K,Yamagishi H,Sugaya A,Dodo H,Tanigawara Y,Takahashi Tdoi
10.1007/s00246-005-1150-xsubject
Has Abstractpub_date
2006-11-01 00:00:00pages
685-8issue
6eissn
0172-0643issn
1432-1971journal_volume
27pub_type
杂志文章abstract：:Conotruncal heart defect is a complex form of congenital heart disease and usually has a poor prognosis. Although previous studies have identified several missense variants in GATA4 gene that may cause CTD, it remains unclear whether they are involved in CTD pathogenesis because the study population was limited. The a...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1542-0
更新日期：2017-03-01 00:00:00
abstract：:The nuclear cross-sectional area of the muscular fibers from a series of myocardial bridges was analyzed and compared to both the adjacent and underlying myocardial fibers. The series came from 12 hearts of children, ranging in age from 24 h to 2 years, with diverse forms of congenital heart disease, which caused left...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02238364
更新日期：1990-10-01 00:00:00
abstract：:We report our findings in the microscopic examination of the conduction system in four infants with glycogen storage disease, one of whom had adequate electrophysiologic studies. The electrophysiologic studies in the latter case showed P-A and A-H intervals at the lower limits of normal, but the H-V interval was just ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02265613
更新日期：1982-01-01 00:00:00
abstract：:Children and adolescents with congenital heart disease often do not have the opportunity, inclination, or education to participate in safe and effective exercise. The consequences of this behavioral pattern affect not only cardiopulmonary parameters, but also psychosocial factors, especially when lack of participation...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02413-z
更新日期：2020-12-01 00:00:00
abstract：:There has been substantial controversy regarding treatment of congenital heart defects in infants with trisomies 13 and 18. Most reports have focused on surgical outcomes versus expectant treatment, and rarely there has been an effort to consolidate existing evidence into a more coherent way to help clinicians with de...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-020-02444-6
更新日期：2020-10-01 00:00:00
abstract：:The treatment of recurrent supraventricular tachycardia in a 3-week-old infant is described. Multiple doses of adenosine were used successfully to convert the dysrhythmia, without adverse effects or apparent tachyphylaxis. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900222
更新日期：1997-11-01 00:00:00
abstract：:This study aimed to clarify the characteristics of pulmonary arterial resistance (Rp)-compliance (Cp) coupling in individuals with Down syndrome (DS), who have increased risks of pulmonary arterial hypertension (PAH). We performed cardiac catheterization before and after corrective surgery in 85 DS infants and 85 cont...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02080-9
更新日期：2019-04-01 00:00:00
abstract：:Long-term ECG is widely used in diagnosis and assessment of many cardiac symptoms which may be caused by dangerous arrhythmias that sometimes can be difficult to document. The PocketECG system is a new technological solution for a long-term, noninvasive, continuous and real-time ECG monitoring that provides automatic ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1534-0
更新日期：2017-03-01 00:00:00
abstract：:Overweight and obesity rates have risen dramatically in the United States, with subsequent detrimental comorbidity risks. The rates for obesity among children with congenital and acquired heart disease have rarely been reported. A retrospective cross-sectional study was conducted to determine the prevalence of overwei...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-0049-y
更新日期：2012-01-01 00:00:00
abstract：:The most common modes of medical education for congenital heart disease (CHD) rely heavily on 2-dimensional imaging. Three-dimensional (3D) printing technology allows for the creation of physical cardiac models that can be used for teaching trainees. 3D printed cardiac models were created for the following lesions: pu...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02146-8
更新日期：2019-08-01 00:00:00
abstract：:The aim of this study is to evaluate the relationship between maternal single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine (HCY) level and offspring congenital heart diseases (CHDs). 338 mothers with offspring CHDs as case group and 306 mothers of normal ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02449-1
更新日期：2020-11-21 00:00:00
abstract：:This study aimed to assess the technical aspects of atrial septal defect (ASD) closure using the Amplatzer septal occluder (ASO) and the Gore Helex septal occluder (GHSO) for infants weighing less than 8 kg and to determine the safety, effectiveness, and near-to-intermediate-term outcome of the closure. The Mid-Atlant...
journal_title：Pediatric cardiology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00246-014-0905-7
更新日期：2014-10-01 00:00:00
abstract：:Congenital heart disease (CHD) is the most common congenital anomaly, affecting 1 % of live births. The field of pediatric cardiology has witnessed major advances over the past 25 years triggered by research initiatives focusing on CHD. However, large disparities exist in research capabilities between Arab developing ...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-012-0466-6
更新日期：2013-02-01 00:00:00
abstract：:This study was performed to evaluate the hemodynamic status of children admitted to the intensive care unit, using suprasternal and transesophageal Doppler ultrasound, and to establish a suitable noninvasive technique to monitor trends in cardiac output in critically ill children. Twenty children were studied over a p...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-001-0014-2
更新日期：2002-01-01 00:00:00
abstract：:Coronary artery anatomy represents a challenging and, often, determining predictor of outcome in an arterial switch operation (ASO). Impact of specific coronary artery variants, such as single, intramural and inverted, on time-related events following ASO, is, yet, to be determined. We sought to compare early and late...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1543-z
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:In 2017, the AHA published revised guidelines for the diagnosis of Kawasaki disease (KD). In the absence of compelling data supporting or refuting the utility of lack of tapering (LT) and perivascular brightness (PB), expert panel consensus removed LT and PB from consideration. We hypothesize that LT and PB ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-1971-z
更新日期：2019-01-01 00:00:00
abstract：:The aim of this study was to evaluate by Doppler echocardiography whether administration of transdermal nitroglycerin (NTG) to children with congestive heart failure could modify mitral flow velocity profile with redistribution of left ventricular filling to late diastole, suggesting preload reduction of the left vent...
journal_title：Pediatric cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002460010144
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to investigate the associations between clinical factors and cardiac function as measured by pressure-volume loops (PVLs) in a pediatric heart transplant cohort. METHODS:Patients (age < 20 years) who underwent heart transplantation presenting for a clinically indicated catheter...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-017-1758-7
更新日期：2018-02-01 00:00:00
abstract：:Maintaining patency of the ductus arteriosus pending surgical intervention can be critical to the survival of the neonate with ductal dependent congenital heart disease. Spontaneously delayed ductal closure has been observed clinically and experimentally in newborns with critical pulmonic stenosis. Infants with ductal...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02263445
更新日期：1987-01-01 00:00:00
abstract：:Transient complete heart block (TCHB) is defined as complete interruption of atrioventricular conduction (AVC) after cardiac surgery followed by return of conduction. This study aimed to assess the risk for the development of late complete heart block (LCHB) after recovery of TCHB and to examine the electrocardiograph...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0595-y
更新日期：2013-04-01 00:00:00
abstract：:This report aims to summarize and evaluate the efficacy and experience of reintervention for children with postoperative pulmonary venous restenosis. Clinical data from 61 patients with postoperative pulmonary venous restenosis who underwent reintervention at Shanghai Children's Medical Center (SCMC) from September 20...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02098-z
更新日期：2019-06-01 00:00:00
abstract：:Systemic candidiasis developed in a seven-week-old premature baby after 6 weeks treatment with antibiotics for suspected septicemia. At that time the echocardiogram showed a dense layer of echoes posteriorly to the anterior tricuspid leaflet during atrial systole. The diagnosis of Candida endocarditis with vegetations...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02281007
更新日期：1983-01-01 00:00:00
abstract：:Previous studies have evaluated left ventricular dimensions in children using two-dimensional echocardiography, but there is little information on gender differences and on the longitudinal development of the dimensions of the left ventricle. Our objective was to assess, by two-dimensional echocardiography, the normal...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02505207
更新日期：1996-05-01 00:00:00
abstract：:A patient with pulmonary valve stenosis associated with pseudohypertrophic muscular dystrophy is reported. The anomalies were detected by two-dimensional echocardiography and elevated serum enzymes, conformed by right ventriculography and muscles biopsy. The association between these two pathologies is unknown. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-001-0051-x
更新日期：2002-03-01 00:00:00
abstract：:Many different types of potassium channels with various functions exist in pulmonary artery smooth muscle cells, contributing to many physiological actions and pathological conditions. The deep involvement of these channels in the onset and exacerbation of pulmonary arterial hypertension (PAH) also continues to be rev...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-016-1491-7
更新日期：2017-01-01 00:00:00
abstract：:Right ventricular (RV) pacing can be associated with impairment of left ventricular (LV) function due to electrical dyssynchrony and myocardial remodeling (Janousek et al. in J Cardiovasc Electrophysiol 15:470-474, 2004). RV-pacing induced ventricular dysfunction is reversible by techniques such as biventricular pacin...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-017-1629-2
更新日期：2017-08-01 00:00:00
abstract：:A 2100-g neonate underwent a two-ventricular surgical repair of a right ventricle-dominant unbalanced atrioventricular septal defect associated with the heterotaxy syndrome and sinus node dysfunction. Postoperative congestive heart failure persisted despite bradycardia management by temporary ventricular pacing. Spect...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900446
更新日期：1999-05-01 00:00:00
abstract：:Sinus node disease is a problem encountered in patients after the Mustard surgery, requiring a pacemaker implantation. The knowledge of the complexity anatomy is crucial because of the possible challenges associated with this procedure. We report a case of a 24-year-old woman presented with symptomatic bradycardia, in...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1155-z
更新日期：2015-08-01 00:00:00
abstract：:The primary objective was to create a clinically relevant model of right ventricular hypertension and to study right ventricular myocardial pathophysiology in growing organism. The secondary objective was to analyse the effect of oral enoximone (phosphodiesterase inhibitor) therapy on right ventricular haemodynamic pa...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1463-y
更新日期：2016-12-01 00:00:00
abstract：:Angiotensin-converting enzyme inhibitors (ACEi) are commonly used for pediatric cardiology patients. However, studies examining their safety for neonates with cardiac disease are scarce. The current study aimed to test the hypothesis that ACEi-mediated nephrotoxicity occurs in neonates and may be underappreciated in t...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0813-2
更新日期：2014-03-01 00:00:00
