Prevalence of Coronary Artery Disease Risk Factors and Metabolic Syndrome in Children with Heart Disease.

Abstract:

:Children with acquired and congenital heart disease (CHD) are increasingly surviving to adulthood. Our aim was to determine the prevalence of coronary artery disease (CAD) risk factors in children at known risk for early CAD or with severe CHD. We recruited children (8-19 years) at risk for early CAD-Kawasaki disease (KD, N = 36) and coarctation (69) or severe CHD: > 1 cardiopulmonary bypass surgery (60), single ventricle (15), prosthetic valves (13). Anthropometric measurements, blood pressure, and fasting lipid data were compared with summaries from National Health and Nutrition Examination Survey (NHANES) publications (1999-2012). Relative risk (RR) ratios were calculated based on age classification and pooled to obtain overall RR. Of 174 subjects, 106 were male (61%) and 138 (79%) had CHD. Compared to NHANES data, hypertension and low HDL were higher in the study cohort [RR 11.7 (CI 6.34-21.6), p < 0.001; and 1.79 (CI 1.36-2.35). p < 0.001] and obesity and elevated total cholesterol were lower [RR 0.59 (CI 0.37-0.96), p = 0.03; and 0.42 (CI 0.19-0.95), p = 0.04]. Elevated non-HDL was similar between groups. Age category had similar RR for all CAD risk factors. Eight subjects had metabolic syndrome. Risk factors were similar between KD versus CHD subgroups. Both coarctation and non-coarctation subjects had increased RR for hypertension. Hypertension is the most common risk factor for children at risk of early CAD and severe CHD. Metabolic syndrome is rare. These patients should be screened and treated for hypertension and current recommendations for universal lipid screening are adequate for follow-up.

journal_name

Pediatr Cardiol

journal_title

Pediatric cardiology

authors

Ware AL,Young PC,Weng C,Presson AP,Minich LL,Menon SC

doi

10.1007/s00246-017-1750-2

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

261-267

issue

2

eissn

0172-0643

issn

1432-1971

pii

10.1007/s00246-017-1750-2

journal_volume

39

pub_type

杂志文章
  • Transcatheter management of subtotal cor triatriatum sinister: a rare anomaly.

    abstract::Subtotal cor triatriatum sinister (partially divided left atrium) is characterized by a membrane dividing the left atrium into two portions: a dorsal accessory proximal chamber that receives part of the pulmonary venous return and a small restrictive defect in the membrane that obstructs blood flow from the accessory ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-008-9205-4

    authors: Sivakumar K,Satish R,Tailor K,Coelho R

    更新日期:2008-07-01 00:00:00

  • Nitric oxide in the evaluation of congenital heart disease with pulmonary hypertension: factors related to nitric oxide response.

    abstract::Inhaled nitric oxide (NO) has been used in the preoperative evaluation of patients with congenital heart disease and pulmonary hypertension. The purpose of this study was to characterize responses in pulmonary vascular resistance (PVR) to oxygen and increasing doses of NO during cardiac catheterization and to determin...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-004-0767-5

    authors: Cannon BC,Feltes TF,Fraley JK,Grifka RG,Riddle EM,Kovalchin JP

    更新日期:2005-09-01 00:00:00

  • Successful modified Fontan procedure in an adolescent after left pneumonectomy.

    abstract::We performed a Waterston's anastomosis on a patient with complicated tricuspid atresia when she was two months of age. At age 14 years she required left pneumonectomy for massive, idiopathic hemoptysis. Four months after the pneumonectomy we substituted a modified Fontan anastomosis for the Waterston anastomosis. Rest...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02238530

    authors: Danilowicz D,Langsner A,Colvin SB

    更新日期:1991-07-01 00:00:00

  • Growth of an atrial septal defect: missing the window for transcatheter closure.

    abstract::We describe a patient diagnosed with a small atrial septal defect (3-4 mm) that had grown to 24 mm in diameter over a six-year period. Timing of transcatheter intervention may be affected by growth of the atrial septal defect and this reports the first case of an atrial septal defect outgrowing the possibility of tran...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-001-0068-1

    authors: Tortoriello TA,McMahon C,Kovalchin JP,Bricker JT,Grifka RG

    更新日期:2002-09-01 00:00:00

  • Warfarin anticoagulation after congenital heart surgery at a large children's hospital.

    abstract::Management of warfarin in pediatric patients remains a clinical challenge. Warfarin may be administered after congenital heart surgery, and the risks of morbidity can be high. Currently, no data exist to describe the initiation of warfarin and the risk factors for morbidity in post-congenital heart surgery patients. T...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0351-3

    authors: Lowry AW,Moffett BS,Moodie D,Knudson JD

    更新日期:2012-12-01 00:00:00

  • Magnesium Lowers the Incidence of Postoperative Junctional Ectopic Tachycardia in Congenital Heart Surgical Patients: Is There a Relationship to Surgical Procedure Complexity?

    abstract::Magnesium sulfate was given to pediatric cardiac surgical patients during cardiopulmonary bypass period in an attempt to reduce the occurrence of postoperative junctional ectopic tachycardia (PO JET). We reviewed our data to evaluate the effect of magnesium on the occurrence of JET and assess a possible relationship b...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-015-1141-5

    authors: He D,Sznycer-Taub N,Cheng Y,McCarter R,Jonas RA,Hanumanthaiah S,Moak JP

    更新日期:2015-08-01 00:00:00

  • Effect of ventriculotomy on right-ventricular remodeling in hypoplastic left heart syndrome: a histopathological and echocardiography correlation study.

    abstract::The objective of this study was to compare histopathological changes in hypoplastic left heart syndrome right ventricles (RV) of patients undergoing Sano and modified Blalock-Taussig (MBT) shunt and correlate them with echocardiographic findings. Myocardial tissue samples were obtained from hearts with Sano or MBT shu...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0462-x

    authors: Menon SC,Erickson LK,McFadden M,Miller DV

    更新日期:2013-02-01 00:00:00

  • Prognosis in fetal tetralogy of Fallot.

    abstract::The outcome in a series of 23 cases of tetralogy of Fallot diagnosed prenatally was compared to published figures for this condition when (a) identified postnatally or (b) treated surgically. There was a marked difference in the survival between these groups, with the highest mortality (75%) occurring when the diagnos...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF00788220

    authors: Allan LD,Sharland GK

    更新日期:1992-01-01 00:00:00

  • Myopericarditis associated with varicella zoster virus infection.

    abstract::Acute myopericarditis is a major cause of acquired heart disease worldwide in pediatric patients. Various viruses have been reported as the etiology, of which varicella zoster virus was first reported in 1953. However, since nationwide administration of the varicella vaccine, reports of varicella-associated myopericar...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-009-9637-5

    authors: Kao KL,Yeh SJ,Chen CC

    更新日期:2010-07-01 00:00:00

  • Assessment of regional atrial function in patients with hypertrophic cardiomyopathies using tissue Doppler imaging.

    abstract:BACKGROUND:This study applied tissue Doppler imaging and color tissue Doppler imaging to study atrial function changes in patients with hypertrophic cardiomyopathy (HCM). The profile of the segmental atrial velocities and the strain rate were determined and compared with those of normal matched control subjects. METHO...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-007-9112-0

    authors: Telagh R,Hui W,Abd El Rahman M,Berger F,Lange PE,Abdul-Khaliq H

    更新日期:2008-03-01 00:00:00

  • Myocardial Oxidative Stress in Infants Undergoing Cardiac Surgery.

    abstract::Cardiac surgery for congenital heart disease often necessitates a period of myocardial ischemia during cardiopulmonary bypass and cardioplegic arrest, followed by reperfusion after aortic cross-clamp removal. In experimental models, myocardial ischemia-reperfusion is associated with significant oxidative stress and ve...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-016-1345-3

    authors: Sznycer-Taub N,Mackie S,Peng YW,Donohue J,Yu S,Aiyagari R,Charpie J

    更新日期:2016-04-01 00:00:00

  • Ventricular inversion and tricuspid atresia (VITA complex): long survival without surgical treatment.

    abstract::Five patients with ventricular inversion, corrected transposition of the great arteries, and atresia of the left-sided atrioventricular (tricuspid) valve have been observed. Three patients died in infancy, two had large interatrial communications, one with an early stage of arterial-type hypertensive pulmonary vascula...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02310996

    authors: Tazelaar HD,Moore GW,Hutchins GM

    更新日期:1986-01-01 00:00:00

  • Progression of Vasculopathy in Young Individuals with Turner Syndrome.

    abstract::Vasculopathy has been identified in young individuals with Turner syndrome (TS). No studies in young individuals with TS have investigated whether this vasculopathy progresses over time. The objective of this study is to describe the changes in vasculopathy over time in a cohort of young individuals with TS. Repeat ul...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-020-02505-w

    authors: Blunden CE,Urbina EM,Lawson SA,Gutmark-Little I,Shah AS,Khoury PR,Backeljauw PF

    更新日期:2020-11-26 00:00:00

  • Plasma B-type natriuretic peptides in children with cardiovascular diseases.

    abstract::Natriuretic peptides (NP) are released from the heart in response to pressure and volume overload. The biologic properties of NPs include counterregulation of the rennin-angiotensin-aldosterone pathway and a decrease in sympathetic tone resulting in diuresis, natriuresis, and vasodilation. Natriuretic peptides help to...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00246-010-9758-x

    authors: Das BB

    更新日期:2010-11-01 00:00:00

  • Failure of balloon dilatation in mid-cavity obstruction of the systemic venous atrium after the Mustard operation.

    abstract::Mid-cavity obstruction of the systemic venous atrium developed after the Mustard operation in a child with transposition of the great arteries. Balloon dilatation (BD) was performed twice, to a maximum theoretical transverse diameter of 18 mm. Each time obstruction was initially relieved, but recurred within months. T...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02076341

    authors: Waldman JD,Waldman J,Jones MC

    更新日期:1983-04-01 00:00:00

  • Double-outlet single ventricle and an abdominal vascular mass: in utero diagnosis with pathological confirmation.

    abstract::A fetal echocardiographic scan was performed when routine prenatal ultrasound screening failed to identify four cardiac chambers. The scan showed a single ventricle with an associated circoid varicosity. Because of these anomalies, amniocentesis was suggested and trisomy 18 confirmed. The presence of major cardiac str...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF00794843

    authors: Duncan WJ,George D,Ezzat W,Wallace K,Van den Beuken B

    更新日期:1993-01-01 00:00:00

  • Acute occlusion of a simple aortic coarctation presenting as abdominal angina.

    abstract::A 9-year-old boy whose past history was remarkable for a heart murmur was diagnosed with abdominal angina due to acute occlusion of a simple coarctation of the aorta. Using a single cross-clamp, we accomplished an end-to-end anastomosis after resection of the coarctation. Paradoxical hypertension and abdominal angina ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-002-0381-3

    authors: Ingu A,Morikawa M,Fuse S,Abe T

    更新日期:2003-09-01 00:00:00

  • Right Ventricular Pressure Overload and Pathophysiology of Growing Porcine Biomodel.

    abstract::The primary objective was to create a clinically relevant model of right ventricular hypertension and to study right ventricular myocardial pathophysiology in growing organism. The secondary objective was to analyse the effect of oral enoximone (phosphodiesterase inhibitor) therapy on right ventricular haemodynamic pa...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-016-1463-y

    authors: Kobr J,Slavik Z,Uemura H,Saeed I,Furck A,Pizingerová K,Fremuth J,Tonar Z

    更新日期:2016-12-01 00:00:00

  • The Significance of Crochetage on the R wave of an Electrocardiogram for the Early Diagnosis of Pediatric Secundum Atrial Septal Defect.

    abstract::The purpose of this study was to test the hypothesis that the incidence of crochetage on the R wave in inferior limb leads can be used for the diagnosis of pediatric secundum atrial septal defect (ASD). Two hundred fifty-six children with secundum ASD (case cohort) and 256 age- and gender-matched children without hear...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-018-1857-0

    authors: Shen L,Liu J,Li JK,Xu M,Yuan L,Zhang GQ,Wang JY,Huang YJ

    更新日期:2018-06-01 00:00:00

  • Cor triatiratum dexter: a rare cause of isolated right atrial enlargement.

    abstract::Cor triatriatum sinistrum (division of the left atrium) is a recognized clinical and surgical entity. Division of the right atrium, also known as cor triatriatum dexter, is an extremely rare congenital abnormality in which persistence of the right valve of the embryonic systemic sinus venosus divides the right atrium ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0443-0

    authors: Choudhary D,Sivasankaran S,Venkateshwaran S,Sasidharan B

    更新日期:2013-01-01 00:00:00

  • Balloon dilation and surgical valvotomy comparison in non-critical congenital aortic valve stenosis.

    abstract::Percutaneous balloon aortic valvoplasty (BAV) and surgical aortic valvotomy (SAV) are palliative procedures in patients with non-critical congenital valve stenosis. The aim of the study was to evaluate long-term BAV and SAV results after up to 24 years of follow-up. From 1987 to 2013, 74 consecutive interventions were...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-014-1056-6

    authors: Prijic SM,Vukomanovic VA,Stajevic MS,Bjelakovic BB,Zdravkovic MD,Sehic IN,Kosutic JLj

    更新日期:2015-03-01 00:00:00

  • Neonatal pulmonary artery thrombosis presenting as persistent pulmonary hypertension of the newborn.

    abstract::Pulmonary artery thrombosis in neonates occurs rarely. This report describes the case of a term infant with a pulmonary artery thrombosis presenting as persistent pulmonary hypertension of the newborn. The risk factors identified in the case included maternal diabetes and heterozygous factor V Leiden deficiency. The p...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-008-9349-2

    authors: Sawyer T,Antle A,Studer M,Thompson M,Perry S,Mahnke CB

    更新日期:2009-05-01 00:00:00

  • Ventricular Arterial Coupling: A Novel Echocardiographic Risk Factor for Disease Progression in Pediatric Dilated Cardiomyopathy.

    abstract::In adult heart failure (HF) patients, a higher ventricular arterial (VA) coupling ratio measured non-invasively is associated with worse HF prognosis and response to treatment. There are no data regarding the relationship of VA coupling to outcome in pediatric dilated cardiomyopathy (DCM) patients. We investigated the...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-018-2021-6

    authors: Capone CA,Lamour JM,Lorenzo J,Tria B,Ye K,Hsu DT,Mahgerefteh J

    更新日期:2019-02-01 00:00:00

  • Delayed contrast enhancement magnetic resonance imaging in congenital aortic stenosis.

    abstract::We report a case of a 12-year-old boy with severe congenital aortic stenosis in whom magnetic resonance imaging (MRI) with delayed contrast enhancement demonstrated extensive subendocardial hyperenhancement within the left ventricle. The hyperenhancement was confirmed to be subendocardial infarct and fibrosis by histo...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-005-5891-3

    authors: La Salvia EA,Gilkeson RC,Dahms BB,Siwik E

    更新日期:2006-05-01 00:00:00

  • Early and mid-term results of the arterial switch operation in patients with intramural coronary artery.

    abstract::Intramural coronary artery is known to be a risk factor for early death after an arterial switch operation (ASO). We evaluated the early and mid-term results of ASO for patients with intramural coronary artery. From September 2008 to March 2012, seven patients with an intramural coronary artery underwent ASO at our ho...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-014-0968-5

    authors: Chen X,Cui H,Chen W,Yang S,Cui Y,Xia Y,Ma L

    更新日期:2015-01-01 00:00:00

  • Ventricular performance after surgery for a congenital heart defect as assessed using advanced echocardiography: from doppler flow to 3D echocardiography and speckle-tracking strain imaging.

    abstract::A varying degree of impairment of ventricular performance is observed over the long-term after surgery for a congenital heart defect (CHD). Impaired ventricular performance has been shown to be of prognostic value for increased risk of cardiovascular events in adult CHD patients. This emphasizes the importance of deli...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00246-013-0802-5

    authors: Klitsie LM,Roest AA,Blom NA,ten Harkel AD

    更新日期:2014-01-01 00:00:00

  • Outcomes after "unroofing" of a myocardial bridge of the left anterior descending coronary artery in children with hypertrophic cardiomyopathy.

    abstract::The importance of myocardial bridging of a coronary artery in the setting of hypertrophic cardiomyopathy is controversial, although we have previously reported an association with myocardial ischemia and sudden death in children. We report five symptomatic children in whom symptoms or evidence of myocardial ischemia r...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-003-0576-2

    authors: Downar J,Williams WG,McDonald C,Wigle ED,McCrindle BW

    更新日期:2004-07-01 00:00:00

  • Coarctation of the aorta, aortic valvar stenosis, and supravalvar aortic stenosis with left coronary artery ostial stenosis: management using a staged hybrid approach.

    abstract::In this report, we describe a case of coarctation of the aorta, congenital aortic stenosis with bicuspid valve, and supravalvar aortic stenosis with left coronary artery ostial stenosis. The child underwent staged treatment using a hybrid approach employing both surgical and interventional cardiology methods. A single...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s002460010164

    authors: Goel P,Madhu Sankar N,Rajan S,Cherian KM

    更新日期:2001-01-01 00:00:00

  • Routine Detection of Atrial Fibrillation/Flutter Predicts a Worse Outcome in a Cohort of Tetralogy of Fallot Patients During 23 Years of Follow-Up.

    abstract::Atrial flutter/fibrillation (AFL/AF) is a late complication in adults with repaired tetralogy of Fallot (TOF). Its effects on long-term prognosis are not fully understood. We evaluate the impact of AFL/AF in adults with repaired TOF on global mortality and unplanned hospitalizations during follow-up, and the predictor...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-019-02106-2

    authors: de Castilhos GM,Ley ALG,Daudt NS,Horowitz ESK,Leiria TLL

    更新日期:2019-06-01 00:00:00

  • Feasibility and Efficacy of Defatted Human Milk in the Treatment for Chylothorax After Cardiac Surgery in Infants.

    abstract::Chylothorax is a well-described complication after cardiothoracic surgery in children. Medical nutritional therapy for chylothorax includes medium-chain triglyceride (MCT) formulas and reduction in enteral long-chain triglyceride intake to reduce chyle production. Human milk is usually eliminated from the diet of infa...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-016-1393-8

    authors: Fogg KL,DellaValle DM,Buckley JR,Graham EM,Zyblewski SC

    更新日期:2016-08-01 00:00:00