Abstract:
:Collision-activated dissociation and electron-transfer dissociation (ETD) each produce spectra containing unique features. Though several database search algorithms (e.g. SEQUEST, MASCOT, and Open Mass Spectrometry Search Algorithm) have been modified to search ETD data, this consists chiefly of the ability to search for c- and z(*)-ions; additional ETD-specific features are often unaccounted for and may hinder identification. Removal of these features via spectral processing increased total search sensitivity by approximately 20% for both human and yeast data sets; unique peptide identifications increased by approximately 17% for the yeast data sets and approximately 16% for the human data set.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Good DM,Wenger CD,Coon JJdoi
10.1002/pmic.200900570subject
Has Abstractpub_date
2010-01-01 00:00:00pages
164-7issue
1eissn
1615-9853issn
1615-9861journal_volume
10pub_type
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