Abstract:
:Chemotaxis, mitogenesis, motogenesis and cytoprotection are common cellular events involved in both tumourigenesis and tissue repair, which appear amplified upon growth factors exposure. Epidermal growth factor (EGF) promotes these events in epithelial and mesenchymal cells through the binding to a specific tyrosine kinase receptor. In experimental oncology settings, EGF does not initiate malignant transformation but exhibits 'tumour promotion'. These observations have raised doubts on the clinical use of EGF despite solid demonstrations of efficacy in experimental conditions and clinical trials. The results of a Pubmed and Bioline investigation on EGF clinical uses and preclinical safety data are presented here. EGF topical administration has been used since 1989 to enhance the healing process of a variety of peripheral tissues wounds (16 clinical reports), as well as its intravenous, oral and rectal administration for gastrointestinal damages (11 clinical reports). EGF therapeutic efficacy and excellent tolerability seem demonstrated. Lack of long-term adverse effects is highlighted in those studies with 6, 12 and 24 months of patients follow-up. Although post-treatment follow-up may fall short for malignant growth, there are no reports on evidences linking EGF clinical use with cancer. A multicentre, nationwide survey in Cuba, 15 years after randomly using silver sulphadiazine with EGF or not in burn victims yielded that cancer incidence was comparable between EGF-treated and control subjects and that such incidence rate does not differ from the age-matched national incidence for those 15-year period. All the animal species subjected to long-term EGF systemic administration exhibit dose-dependent and reversible epithelial organs hyperplasia with no changes in cells phenotypic differentiation. Histotypic pre-malignant markers were not identified. The results emerged from co-carcinogenesis studies and from transgenic mice over-expressing EGF are conflicting and indicate that EGF overexposure, either innate or postnatal, may not be sufficient to transform cells. The ability of EGF to heal injured tissues in life-threatening scenarios or to assist in preventing physical and social disability advocates for its clinical use under a rational medical risk/benefit balance.
journal_name
Int Wound Jjournal_title
International wound journalauthors
Berlanga-Acosta J,Gavilondo-Cowley J,López-Saura P,González-López T,Castro-Santana MD,López-Mola E,Guillén-Nieto G,Herrera-Martinez Ldoi
10.1111/j.1742-481X.2009.00622.xsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
331-46issue
5eissn
1742-4801issn
1742-481Xpii
IWJ622journal_volume
6pub_type
杂志文章,评审abstract::This study developed a measuring instrument of pressure-injury risk assessment competence for nursing education adopting theoretical procedures based on competence structuration to support the psychometric quality. The objective of this study is testing the psychometric properties of the instrument using simulation st...
journal_title:International wound journal
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
abstract::Wound complications following arterial surgery in the groin are relatively common and can result in significant morbidity and mortality. Vascularised muscle flaps (VMF) may be used as an adjunct to aid healing, either to manage complications or prophylactically. This series describes 46 patients who received sartorius...
journal_title:International wound journal
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abstract::The aims of this randomised controlled study were to determine whether the application of silicone adhesive dressings with standard preventive care would reduce the impairment of skin integrity and to evaluate the subepidermal moisture (SEM) value in anatomical locations to predict impairment of skin integrity. Of the...
journal_title:International wound journal
pub_type: 杂志文章,随机对照试验
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abstract::Recurrence of breast cancer is a predominant fear for patients who were treated for breast cancer. Acute and late dermatologic effects of radiotherapy are not uncommon and could have similar characteristics to breast cancer recurrence. Thus, it is important to highlight key differences between the clinical and histolo...
journal_title:International wound journal
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journal_title:International wound journal
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journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2007.00331.x
更新日期:2007-09-01 00:00:00
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journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/j.1742-481X.2008.00436.x
更新日期:2008-06-01 00:00:00
abstract::Subcutaneous mastectomy, the first step in sexual reassignment surgery of female-to-male transsexuals, is associated with high rates of complication and revision surgery. Also, conventional electrosurgery and the associated thermal tissue damage may compromise outcome. This retrospective randomised clinical study eval...
journal_title:International wound journal
pub_type: 杂志文章
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journal_title:International wound journal
pub_type: 杂志文章,评审
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journal_title:International wound journal
pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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journal_title:International wound journal
pub_type:
doi:10.1111/j.1742-481X.2012.00978.x
更新日期:2012-08-01 00:00:00
abstract::The World Health Assembly declared 2020, the International Year of the Nurse and the Midwife. Recent editorials and commentaries support the leading role of nurses and midwives as frontline caregivers emphasizing the need to invest in the nursing workforce worldwide to meet global health needs. Today nurses are also l...
journal_title:International wound journal
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
abstract::Even though it is estimated that at least 300 000 people in Canada may be affected by chronic oedema/lymphoedema, recognition of the seriousness of this chronic disease in health care is scarce. Lymphoedema affects up to 70% of breast and prostate cancer patients, substantially increasing their postoperative medical c...
journal_title:International wound journal
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/iwj.12664
更新日期:2016-09-01 00:00:00
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journal_title:International wound journal
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:International wound journal
pub_type: 杂志文章
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更新日期:2020-11-25 00:00:00
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journal_title:International wound journal
pub_type: 杂志文章,随机对照试验
doi:10.1111/iwj.12160
更新日期:2015-06-01 00:00:00
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journal_title:International wound journal
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:International wound journal
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journal_title:International wound journal
pub_type: 杂志文章,评审
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journal_title:International wound journal
pub_type: 杂志文章
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journal_title:International wound journal
pub_type: 杂志文章
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abstract::Breast cancer is a serious disease in women. We estimated the global technical success rate and complication rates of percutaneous vacuum-assisted breast biopsy (VABB). PubMed, Embase, Web of Science, and Scopus databases were retrieved up to July 2018 to find studies in which technical success rate and complication r...
journal_title:International wound journal
pub_type: 杂志文章,meta分析
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更新日期:2019-12-01 00:00:00
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journal_title:International wound journal
pub_type: 杂志文章,随机对照试验
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更新日期:2012-08-01 00:00:00
abstract::For nearly two decades, Negative Pressure Wound Therapy (NPWT) has been used for temporary wound coverage as well as wound bed preparation. The addition of instillation and dwell time as an adjunct to NPWT (NPWTi-d) enables wound bed cleaning and improved wound bed granulation. Thirty patients with different types of ...
journal_title:International wound journal
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更新日期:2020-12-01 00:00:00
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journal_title:International wound journal
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journal_title:International wound journal
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journal_title:International wound journal
pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00