Investigating the effect of age on platelet ultrastructure using transmission electron microscopy.

Abstract:

:In the present study, the age- and sex-related differences in platelet ultrastructure were investigated using transmission electron microscopy (TEM). A total of 15 healthy volunteers were grouped according to age, with 5 people in each of the following groups: young group (25-45 years), middle-aged group (46-65 years), and old-aged group (> 65 years). In the TEM micrographs, the internal components, specifically the α-granules, dense granules, and lysosomal granules, of 20 platelets were counted for each group. Two-way analysis of variance of age and sex variance was used to compare the results. The ultrastructure of the platelets in the old-aged group was observed to be quite different from those of the young and middle-aged groups. Specifically, with ageing, the platelet membrane becomes more irregular in shape and non-smooth, and multiple platelet membrane ruptures are observed. Furthermore, the pseudopodia and protuberances become more numerous and slender, and the number of α-granules is significantly reduced. These morphological changes indicate that ageing may affect the function of platelets, which in turn affects the efficacy of platelet concentrates. Thus, the effects of age should be considered when using platelet concentrates prepared from elderly autologous blood.

journal_name

Int Wound J

authors

Tian J,Cheng LH,Cui X,Lei XX,Tang JB,Cheng B

doi

10.1111/iwj.13214

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1457-1463

issue

6

eissn

1742-4801

issn

1742-481X

journal_volume

16

pub_type

杂志文章
  • Segmental ulcerative vasculitis: a cutaneous manifestation of Takayasu's arteritis.

    abstract::A 16-year-old girl with pyoderma gangrenosum (PG)-like skin lesions on the extremities, trunk and face developed Takayasu's arteritis (TA; pulseless disease). After 3 years under maintenance cyclosporin A therapy, the patient developed an ischaemic cerebral accident. Severe obstruction of both subclavian and left caro...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-4801.2005.00103.x

    authors: Dourmishev AL,Serafimova DK,Vassileva SG,Dourmishev LA,Schwartz RA

    更新日期:2005-12-01 00:00:00

  • The effect of non-thermal atmospheric pressure plasma application on wound healing after gingivectomy.

    abstract::Recent studies have indicated the potential benefits of Non-thermal atmospheric pressure plasma (NTAPP) as a novel therapeutic approach. The purpose of the current study was thus to assess the effect of NTAPP on gingival wound healing. Fifteen patients with bilaterally symmetrical gingival hyperplasia were included in...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13379

    authors: Kusakci-Seker B,Demirayak-Akdemir M

    更新日期:2020-10-01 00:00:00

  • Laser Doppler flowmetry assessment of peristernal perfusion after cardiac surgery: beneficial effect of negative pressure therapy.

    abstract::Negative pressure therapy has been successfully applied to clean, closed incisions in patients at high-risk for wound complications. Using laser Doppler flowmetry, we evaluated peristernal perfusion after cardiac surgery via median sternotomy, assessing the influence of mammary artery harvesting and the impact of nega...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2010.00743.x

    authors: Atkins BZ,Tetterton JK,Petersen RP,Hurley K,Wolfe WG

    更新日期:2011-02-01 00:00:00

  • Alcohol consumption does not increase the risk of surgical wound complications in breast cancer patients.

    abstract::Alcohol consumption, despite influencing several organic processes, has been scarcely studied regarding the risk of developing surgical wound complications after surgical breast cancer treatment. The aim of this study was to analyse the association between alcohol consumption and the development of surgical wound comp...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13455

    authors: de Menezes RF,Bergmann A,Thuler LCS

    更新日期:2020-12-01 00:00:00

  • Taking the pressure off in the Emergency Department: evaluation of the prophylactic application of a low shear, soft silicon sacral dressing on high risk medical patients.

    abstract::Pressure injuries are key clinical indicators of care standard. In Australia, pressure injuries increase length of hospital stay by 4.31 and cost $285 million annually. This pilot study examined the effectiveness of sacral dressing in reducing the prevalence of pressure injuries in older, high-risk patients. A non ran...

    journal_title:International wound journal

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1742-481X.2012.01025.x

    authors: Cubit K,McNally B,Lopez V

    更新日期:2013-10-01 00:00:00

  • Efficacy of hydrosurgical debridement and nanocrystalline silver dressings for infection prevention in type II and III open injuries.

    abstract::The aim of this study was to retrospectively evaluate the clinical and culture-positive infection rates of open Gustilo/Anderson type II and III fractures using a protocol nanocrystalline silver wound dressing and hydrosurgical debridement. Retrospective case series through chart review on all type II and III open fra...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2011.00822.x

    authors: Keen JS,Desai PP,Smith CS,Suk M

    更新日期:2012-02-01 00:00:00

  • A meta-analysis of interleukin-6 as a valid and accurate index in diagnosing early neonatal sepsis.

    abstract::We aimed to systematically assess the overall value of interleukin 6 (IL-6) in diagnosing neonates with sepsis. A systematic literature search was conducted using the following electronic databases: PubMed, Embase, and Cochrane, to identify eligible studies through the index words updated till November 2018. Cross-sec...

    journal_title:International wound journal

    pub_type: 杂志文章,meta分析

    doi:10.1111/iwj.13079

    authors: Sun B,Liang LF,Li J,Yang D,Zhao XB,Zhang KG

    更新日期:2019-04-01 00:00:00

  • Pain and trauma in negative pressure wound therapy: a review.

    abstract::Negative pressure wound therapy (NPWT) is considered an effective wound treatment, but there are a number of issues that need to be addressed for improvements to be made. This review aimed to explore the literature relating to the pain and skin trauma that may be experienced during NPWT. A literature search was carrie...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12059

    authors: Upton D,Andrews A

    更新日期:2015-02-01 00:00:00

  • Role of acellular dermal matrix allograft in minimal invasive coverage of deep burn wound with bone exposed--case report and histological evaluation.

    abstract::A sandwich graft was applied to the debrided cortical bone layer of the tibia in the case of a 72-year-old male patient with full-thickness necrotic burn injury. The combined graft consisted of a dermal template material and autologous split thickness skin graft. After application, the graft was found totally accepted...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-4801.2006.00175.x

    authors: Gáspár K,Erdei I,Péter Z,Dezsö B,Hunyadi J,Juhász I

    更新日期:2006-03-01 00:00:00

  • Nicorandil: from ulcer to fistula into adjacent organs.

    abstract::Nicorandil is an original vasodilatator used to control angina by decreasing cardiac preload and afterload. Since 1997, many reports of single or multiple nicorandil-induced ulcerations have been published. To date, eight cases of nicorandil-induced fistula into adjacent organs have been described. The pathogeneses of...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2012.00966.x

    authors: Trechot P,Petitpain N,Guy C,Pinzano A,Javot L,Schmutz JL,Marie B,Barbaud A

    更新日期:2013-04-01 00:00:00

  • Evaluating antimicrobial efficacy of new commercially available silver dressings.

    abstract::Prevention and treatment of bacterial colonised/infected wounds are critical. Many commercially available silver dressings claim broad-spectrum bactericidal activity over days and are indicated for serious conditions including burns and ulcers. However, there is no peer-reviewed literature available for many newer dre...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2010.00705.x

    authors: Cavanagh MH,Burrell RE,Nadworny PL

    更新日期:2010-10-01 00:00:00

  • Negative pressure wound therapy with instillation and dwell time (NPWTi-d) with V. A. C. VeraFlo in traumatic, surgical, and chronic wounds-A helpful tool for decontamination and to prepare successful reconstruction.

    abstract::For nearly two decades, Negative Pressure Wound Therapy (NPWT) has been used for temporary wound coverage as well as wound bed preparation. The addition of instillation and dwell time as an adjunct to NPWT (NPWTi-d) enables wound bed cleaning and improved wound bed granulation. Thirty patients with different types of ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13462

    authors: Diehm YF,Loew J,Will PA,Fischer S,Hundeshagen G,Ziegler B,Gazyakan E,Kneser U,Hirche C

    更新日期:2020-12-01 00:00:00

  • Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study.

    abstract::Non healing diabetic foot ulcers and the resulting potential amputations present significant costs to the health care system and reduce patient quality of life. The goal of diabetic foot ulcer treatment is to obtain wound closure as expeditiously as possible. The use of platelet-rich plasma (PRP) to enhance wound heal...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1742-481X.2011.00797.x

    authors: Saad Setta H,Elshahat A,Elsherbiny K,Massoud K,Safe I

    更新日期:2011-06-01 00:00:00

  • An unusual presentation of postaxial polydactyly of the foot.

    abstract::A 6-month-old Caucasian baby is described with a postaxial polydactyly of the letf foot. Radiographic examination revealed the accessory digit was composed of soft tissue, some with a tiny osseous element, originated from around the metatarsophalangeal joint, defined by floating type (FT). The parents had consistent d...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12700

    authors: López-López D,Becerro-de-Bengoa-Vallejo R,Losa-Iglesias ME,Bautista Casasnovas AL

    更新日期:2017-10-01 00:00:00

  • Use of Cellutome for the healing of venous or mixed ulcers.

    abstract::Venous or mixed ulcers are common and invalidating. Cutaneous transplants may be necessary if conventional treatment is ineffective. We evaluated the performance of Cellutome in promoting the healing of venous or mixed ulcers 2 months after grafting. This was a retrospective, multi-centric, descriptive study of patien...

    journal_title:International wound journal

    pub_type: 杂志文章,多中心研究

    doi:10.1111/iwj.12966

    authors: Vinceneux Talvande B,Carvalho Lallement P,Safa G,Journet Tollhupp J,Lembelembe JP,Blaise S,Maillard H

    更新日期:2018-12-01 00:00:00

  • High body mass index is a strong predictor of intraoperative acquired pressure injury in spinal surgery patients when prophylactic film dressings are applied: A retrospective analysis prior to the BOSS Trial.

    abstract::We reported the efficacy of soft silicone multilayered foam dressings in preventing intraoperatively acquired pressure injuries (IAPIs) in the prone position using a Relton-Hall frame (BOSS trial). The aim of this study was to clarify the incidence and extract the risk factors for IAPIs in cases in which polyurethane ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13287

    authors: Yoshimura M,Ohura N,Santamaria N,Watanabe Y,Akizuki T,Gefen A

    更新日期:2020-06-01 00:00:00

  • The influence on wound contraction and fluid evacuation of a rigid disc inserted to protect exposed organs during negative pressure wound therapy.

    abstract::The use of a rigid disc as a barrier between the wound bed and the wound filler during negative pressure wound therapy (NPWT) has been suggested to prevent damage to exposed organs. However, it is important to determine that the effects of NPWT, such as wound contraction and fluid removal, are maintained during treatm...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2011.00805.x

    authors: Anesäter E,Roupé KM,Robertsson P,Borgquist O,Torbrand C,Ingemansson R,Lindstedt S,Malmsjö M

    更新日期:2011-08-01 00:00:00

  • Podiatrist care and outcomes for patients with diabetes and foot ulcer.

    abstract::We examined whether outcomes of care (amputation and hospitalisation) among patients with diabetes and foot ulcer differ between those who received pre-ulcer care from podiatrists and those who did not. Adult patients with diabetes and a diagnosis of a diabetic foot ulcer were found in the MarketScan Databases, 2005-2...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12021

    authors: Gibson TB,Driver VR,Wrobel JS,Christina JR,Bagalman E,DeFrancis R,Garoufalis MG,Carls GS,Gatwood J

    更新日期:2014-12-01 00:00:00

  • Association of diabetic foot care and amputation rates in Germany.

    abstract::Podologists are nurses who care for the diabetic foot (orthotics, offloading devices, blisters, calluses, treatment of fungus infection and patient education). In contrast to podiatrists, they are not qualified to perform any surgical treatment or wound care. We analysed whether there is an association between the dec...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12347

    authors: Kröger K,Moysidis T,Feghaly M,Schäfer E,Bufe A,Initiative Chronische Wunden e.V., Germany.

    更新日期:2016-10-01 00:00:00

  • Bacteriotherapy with Lactobacillus plantarum in burns.

    abstract::Bacterial colonisation and infection remain the major causes of delayed healing and graft rejection following burns. Topical treatment is necessary to reduce the incidence of burn wound infection. Silver sulphadiazine (SD-Ag) is an often used microbicidal agent. However, this treatment produces adverse reactions and s...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1742-481X.2008.00577.x

    authors: Peral MC,Martinez MA,Valdez JC

    更新日期:2009-02-01 00:00:00

  • What should be the antibiotic prescription protocol for burn patients admitted in the department of burns, plastic and reconstructive surgery.

    abstract::This is a prospective study with the aim to determine specific patterns of burn wound bacterial colonisation and antimicrobial resistance profiles. There is a high incidence of infections and septicaemia in post-burn patients, which, in turn, are associated with high morbidity and mortality, a fact that compelled us t...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12588

    authors: Mir MA,Khurram MF,Khan AH

    更新日期:2017-02-01 00:00:00

  • Cold immersion recovery responses in the diabetic foot with neuropathy.

    abstract::The aim of this article was to investigate the effectiveness of testing cold immersion recovery responses in the diabetic foot with neuropathy using a contact thermography system based on thermochromic liquid crystals. A total of 81 subjects with no history of diabetic foot ulceration were assigned to neuropathy, non ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2008.00454.x

    authors: Bharara M,Viswanathan V,Cobb JE

    更新日期:2008-10-01 00:00:00

  • Understanding factors influencing venous leg ulcer guideline implementation in Australian primary care.

    abstract::The aim of this study was to gain a better understanding of the venous leg ulcer (VLU) management in primary health care settings located in Melbourne metropolitan and rural Victoria, Australia. We explored health professionals' perspective on the use of the Australian and New Zealand Venous Leg Ulcer Clinical Practic...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13334

    authors: Weller CD,Richards C,Turnour L,Team V

    更新日期:2020-06-01 00:00:00

  • Case series of use of Manuka honey in leg ulceration.

    abstract::Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Abstract The historical and current literature reports the successful use of honey to manage a diversity of wound aetiologies. However, only in the last 40 years is research on its mode of action and contribution to wound healing being investiga...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-4801.2005.00078.x

    authors: Gethin G,Cowman S

    更新日期:2005-03-01 00:00:00

  • Comparing the reported burn conditions for different severity burns in porcine models: a systematic review.

    abstract::There are many porcine burn models that create burns using different materials (e.g. metal, water) and different burn conditions (e.g. temperature and duration of exposure). This review aims to determine whether a pooled analysis of these studies can provide insight into the burn materials and conditions required to c...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12786

    authors: Andrews CJ,Cuttle L

    更新日期:2017-12-01 00:00:00

  • A case series and a review of the literature on foreign modelling agent reaction: an emerging problem.

    abstract::Foreign modelling agent reactions (FMAR) are the result of the injection of unapproved high-viscosity fluids with the purpose of cosmetic body modelling. Its consequences lead to ulceration, disfigurement and even death, and it has reached epidemic proportions in several regions of the world. We describe a series of p...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12643

    authors: Martínez-Villarreal AA,Asz-Sigall D,Gutiérrez-Mendoza D,Serena TE,Lozano-Platonoff A,Sanchez-Cruz LY,Toussaint-Caire S,Domínguez-Cherit J,López-García LA,Cárdenas-Sánchez A,Contreras-Ruiz J

    更新日期:2017-06-01 00:00:00

  • Enzymatic debridement with collagenase in wounds and ulcers: a systematic review and meta-analysis.

    abstract::Enzymatic debridement with collagenase is a technique that is commonly used in clinical practice. This systematic review examines the effect of collagenase on all kinds of wounds, compared to an alternative therapy, on wound healing, wound bed characteristics, cost-effectiveness and the occurrence of adverse events. W...

    journal_title:International wound journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/iwj.12760

    authors: Patry J,Blanchette V

    更新日期:2017-12-01 00:00:00

  • Multiple subcutaneous haematomas of the legs causing skin necrosis in an elderly patient affected by corticosteroid-induced skin atrophy: Case report and review of literature.

    abstract::Corticosteroid-induced skin atrophy (CISA) consists of a thinning of the skin and subcutaneous tissues, representing the natural consequence of a prolonged glucocorticosteroids use, both systemic as well as topical. It is characterised by the loss of elasticity and skin thickness, associated with an increased skin fra...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13312

    authors: Vallini V,Rinaldi E,Mangano L,Modesti L,Ghelardini P,Roberts AT,Grazi G

    更新日期:2020-06-01 00:00:00

  • The impact of incisional negative pressure wound therapy on the wound healing process after midline sternotomy.

    abstract::Previous studies have reported that the use of incisional negative pressure wound therapy (INPWT) might reduce the incidence of wound infections, although its mechanism remains unknown. We designed a prospective study to explore the effects of INPWT on different stages of the wound healing process. After meeting the i...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13497

    authors: Rashed A,Csiszar M,Beledi A,Gombocz K

    更新日期:2020-11-25 00:00:00

  • Porcine acellular dermal matrix (PADM) vascularises after exposure in open necrotic wounds seen after complex hernia repair.

    abstract::Biological alternatives to synthetic meshes are increasingly utilised in complex abdominal wall reconstruction. There is a lack of evidence demonstrating that non-cross-linked porcine acellular dermal matrix vascularizes and integrates with human tissue in suboptimal wound conditions. We aimed to evaluate these proper...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12558

    authors: Gowda AU,Chang SM,Chopra K,Matthews JA,Sabino J,Stromberg JA,Zahiri HR,Pinczewski J,Holton LH 3rd,Silverman RP,Singh DP

    更新日期:2016-10-01 00:00:00