Abstract:
:For the past 20 years, super-oxidised solutions (SOSs) have been shown to be potent antimicrobials and disinfectants via oxidative damage. However, the potential toxicity of SOSs on eukaryotic cells has not been documented in vitro. This is relevant because oxygen and chlorine reactive species may possibly induce ageing and irreversible cellular dysfunctions that eventually produce cell death. The present study investigates the cytotoxicity and oxidative stress induced by a novel, pH-neutral SOS (i.e. Microcyn, MCN) on young, primary diploid - human dermal fibroblast (HDF) cultures. For this purpose, hydrogen peroxide (HP) was used as a positive control of oxidative damage. When these solutions were used at concentrations indicated for wound care (i.e. undiluted MCN or 880 mM HP), HP was significantly more toxic than MCN. After 5 and 30 minutes of exposure, cell viability was 38% and 5%, respectively, in 880 mM HP-treated cells versus 75% and 70% in MCN-treated populations, respectively. HP induced both apoptosis and necrosis, whereas MCN induced only necrosis. Genotoxic and ageing studies were then conducted at sublethal HP concentrations as previously reported in the literature. Cellular DNA and RNA were partially degraded only in HDFs exposed to 500 microM HP for 30 minutes but not in those exposed to undiluted MCN. At this same concentration, HP induced the formation of 8-hydroxy-2'deoxyguanosine adducts in HDFs but this effect was neither observed in control- nor observed in MCN-treated cells. HDFs were further exposed to 5 microM HP or 10% MCN for 1 month. The expression of senescence-associated-beta-galactosidase was only significantly elevated in cells chronically exposed to 5 microM HP. Altogether, these results show that MCN is significantly less cytotoxic than antiseptic HP concentrations (i.e. 880 mM) and that, in vitro, it does not induce genotoxicity or accelerated ageing.
journal_name
Int Wound Jjournal_title
International wound journalauthors
González-Espinosa D,Pérez-Romano L,Guzmán-Soriano B,Arias E,Bongiovanni CM,Gutiérrez AAdoi
10.1111/j.1742-481X.2007.00331.xsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
241-50issue
3eissn
1742-4801issn
1742-481Xpii
IWJ331journal_volume
4pub_type
杂志文章abstract::Surgical patients are at risk of developing a perioperative pressure injury (ORPI) during surgery. Accurate assessment and prompt implementation of prevention strategies or treatment of ORPI are dependent on knowledge and skills of operating room (OR) nurses. The study examined the knowledge and attitude of OR nurses ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13295
更新日期:2020-04-01 00:00:00
abstract::Breast cancer is a serious disease in women. We estimated the global technical success rate and complication rates of percutaneous vacuum-assisted breast biopsy (VABB). PubMed, Embase, Web of Science, and Scopus databases were retrieved up to July 2018 to find studies in which technical success rate and complication r...
journal_title:International wound journal
pub_type: 杂志文章,meta分析
doi:10.1111/iwj.13224
更新日期:2019-12-01 00:00:00
abstract::A sandwich graft was applied to the debrided cortical bone layer of the tibia in the case of a 72-year-old male patient with full-thickness necrotic burn injury. The combined graft consisted of a dermal template material and autologous split thickness skin graft. After application, the graft was found totally accepted...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-4801.2006.00175.x
更新日期:2006-03-01 00:00:00
abstract::Pre-tibial lacerations are complex wounds affecting a primarily aged population, with poor healing and a potentially significant impact on social well-being. Management of these wounds has changed little in 20 years, despite significant advances in wound care. A retrospective observational study was undertaken to obse...
journal_title:International wound journal
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1742-481X.2011.00884.x
更新日期:2012-06-01 00:00:00
abstract::Wound chronification and opportunistic infections stand as major factors leading to lower extremities amputations in diabetes. The molecular mechanisms underlying diabetic's torpid healing have not been elucidated. We present the case of a female diabetic patient that after a plantar abscess surgical drainage, tight g...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2012.12000.x
更新日期:2013-04-01 00:00:00
abstract::The aim of this systematic review was to determine the supporting evidence for the clinical use of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting. Two authors searched three databases (Ovid Medline, Ovid Embase and The Cochrane Library) for relevant English language art...
journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/iwj.12469
更新日期:2016-08-01 00:00:00
abstract::This is a prospective study with the aim to determine specific patterns of burn wound bacterial colonisation and antimicrobial resistance profiles. There is a high incidence of infections and septicaemia in post-burn patients, which, in turn, are associated with high morbidity and mortality, a fact that compelled us t...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12588
更新日期:2017-02-01 00:00:00
abstract::A 6-month-old Caucasian baby is described with a postaxial polydactyly of the letf foot. Radiographic examination revealed the accessory digit was composed of soft tissue, some with a tiny osseous element, originated from around the metatarsophalangeal joint, defined by floating type (FT). The parents had consistent d...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12700
更新日期:2017-10-01 00:00:00
abstract::Wound dehiscence is a surgical complication caused by the application of opposing and distracting forces tending to pull apart the suture line. In recent years, a novel negative pressure surgical management system has been developed to prevent surgical wound complications. This system creates a closed environment that...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12040
更新日期:2015-02-01 00:00:00
abstract::This prospective, non comparative study evaluated the safety and effectiveness of an adhesive gelling foam dressing in pressure ulcer management. Twenty-three subjects with exuding pressure ulcers were recruited from seven centres in the USA and Canada. Study treatment included an adhesive gelling foam dressing, optio...
journal_title:International wound journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1742-481X.2007.00428.x
更新日期:2008-03-01 00:00:00
abstract::The aim of this study was to investigate the relationship between perioperative corticosteroids administration and the incidence of pressure ulcers (PUs) in cardiovascular surgical patients. A retrospective analysis was performed on data from consecutive patients who had cardiac surgery in 2012. Univariate and multiva...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12168
更新日期:2015-10-01 00:00:00
abstract::Chronic non-healing wounds are a burden in the Long-Term Care (LTC) sector, increasing costs, morbidity, and mortality and causing pain and suffering. The objective of this LTC Innovation pilot was to test the value of a promising new neuromuscular stimulation device in elevating the experience and satisfaction of the...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13027
更新日期:2019-02-01 00:00:00
abstract::In recent years, oxidative stress and free radicals have been implicated in impaired wound healing. Grape (Vitis vinifera) seed extract (GSE) possesses anti-inflammatory and antioxidant properties. The present study was undertaken to assess the potential activity of grape seed hydroalcoholic extract in wound healing i...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2011.00833.x
更新日期:2011-10-01 00:00:00
abstract::Pressure injuries are one of the most common and costly complications occurring in US hospitals. With up to 3 million patients affected each year, hospital-acquired pressure injuries (HAPIs) place a substantial burden on the US healthcare system. In the current study, US hospital discharge records from 9.6 million pat...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13482
更新日期:2020-12-01 00:00:00
abstract::A longitudinal observational study on a convenience sample was conducted between 4 January and 31 December of 2010 to evaluate clinical outcomes that occur when a new Interprofessional Diabetes Foot Ulcer Team (IPDFUT) helps in the management of diabetes-related foot ulcers (DFUs) in patients living in a small urban c...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12119
更新日期:2015-08-01 00:00:00
abstract::We present a new surgical modification to allow propeller perforator flaps to cover pressure sores at various locations. We used a propeller perforator flap concept based on the detection of newly formed perforator vessels located 1 cm from the wound margin and stimulated by the chronic inflammation process. Between J...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12783
更新日期:2017-12-01 00:00:00
abstract::The Smart Negative Pressure (SNaP) wound care system is a novel device that is single-patient use, ultra-portable, and light weight and does not rely on battery or need recharging. A systematic search was performed on major databases to identify relevant articles including case reports, retrospective case series, and ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13114
更新日期:2019-08-01 00:00:00
abstract::The critical problem of post-burn depigmentation is the lacking normal melanocytes. Auto-skin grafting and autologous non-cultured epidermal cell suspension have been used to improve the appearance. However, a large amount of skin graft is required of donor sites in the former method, while the latter method is though...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12577
更新日期:2017-02-01 00:00:00
abstract::We demonstrate sodium pyruvate (NaPy) pre-treatment as a successful approach for pressure ulcer (PU) prevention by averting their aetiological origin-cell-level damage and death by large, sustained mechanical loads. We evaluated the NaPy pre-treatment effect on permeability changes in the cell's plasma membrane (PM) f...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13173
更新日期:2019-10-01 00:00:00
abstract::The aim of the study was to compare three sampling techniques used in routine diagnostics to identify the microbiota in chronic venous leg ulcers. A total of 46 patients with persisting venous leg ulcers were included in the study. At inclusion, swab, biopsy and filter paper pad samples were collected. After 4 weeks, ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2011.00883.x
更新日期:2012-06-01 00:00:00
abstract::Immunosuppressive therapy is increasingly being used in clinical practice and has been shown to affect wound healing to varying degrees. This article looks at the effects of the newer immunosuppressive agents on wound healing. It is shown that wound healing is impaired via different mechanisms. Some of the animal and ...
journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/j.1742-481X.2012.00950.x
更新日期:2013-02-01 00:00:00
abstract::Senescent fibroblasts, which are present in chronic ulcers, are the reason for the wound becoming chronic. In this study, we introduce full-thickness micro skin grafts in the ulcer, a surgical technique known as a 'nested graft', which gave encouraging results leading to complete wound healing in all patients. The ass...
journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/iwj.12415
更新日期:2016-12-01 00:00:00
abstract::We reported the efficacy of soft silicone multilayered foam dressings in preventing intraoperatively acquired pressure injuries (IAPIs) in the prone position using a Relton-Hall frame (BOSS trial). The aim of this study was to clarify the incidence and extract the risk factors for IAPIs in cases in which polyurethane ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13287
更新日期:2020-06-01 00:00:00
abstract::We report a 53-year-old farmer who developed subcutaneous and cerebral masses 24 years after penetrating trauma during a tropic storm. Computed tomography scans, magnetic resonance imaging and histopathology disclosed actinomycetoma, a disease that rarely develops after trauma and is only occasionally seen with intrac...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2008.00456.x
更新日期:2008-12-01 00:00:00
abstract::This retrospective study compared the clinical outcomes of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by Vacuum-Assisted Therapy(®) (V.A.C.(®) Therapy, KCI Licensing Inc., San Antonio, TX) to non-NPWT/ROCF conventional therapy (CT) in split-thickness skin graft (STSG) surv...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2010.00728.x
更新日期:2010-12-01 00:00:00
abstract::Leg ulcer management is complex, time-consuming and of high socio-economic importance. Data on cost-of-illness in leg ulcer care are sparse. The objective of this study was to evaluate the cost-of-illness in leg ulcer treatment in the metropolitan area of Hamburg. About 147 institutions involved in wound care particip...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2012.01089.x
更新日期:2014-06-01 00:00:00
abstract::The World Health Assembly declared 2020, the International Year of the Nurse and the Midwife. Recent editorials and commentaries support the leading role of nurses and midwives as frontline caregivers emphasizing the need to invest in the nursing workforce worldwide to meet global health needs. Today nurses are also l...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13492
更新日期:2020-12-01 00:00:00
abstract::This study developed a measuring instrument of pressure-injury risk assessment competence for nursing education adopting theoretical procedures based on competence structuration to support the psychometric quality. The objective of this study is testing the psychometric properties of the instrument using simulation st...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13311
更新日期:2020-06-01 00:00:00
abstract::Major sickle cell disease syndrome (SCD) is a set of potentially serious and disabling constitutional haemoglobin pathologies characterised by chronic haemolysis and vaso-occlusion phenomena. If expression takes the form of acute vaso-occlusive crisis, SCD is currently considered to be a chronic systemic pathology, pr...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13115
更新日期:2019-08-01 00:00:00
abstract::The purpose of this project was to evaluate associations of increasing diabetic foot surgery stage with postoperative outcome. This project, designed as a retrospective cohort model, was conducted at three large, urban referral-based diabetic foot clinics. The investigators abstracted medical records from 180 patients...
journal_title:International wound journal
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1742-481X.2006.00236.x
更新日期:2006-09-01 00:00:00