The nested graft acts by inducing the process of de-senescence of the fibroblasts in chronic venous ulcers.

Abstract:

:Senescent fibroblasts, which are present in chronic ulcers, are the reason for the wound becoming chronic. In this study, we introduce full-thickness micro skin grafts in the ulcer, a surgical technique known as a 'nested graft', which gave encouraging results leading to complete wound healing in all patients. The assessment of fibroblast cultures taken from the wound before and after treatment and comparison with fibroblasts from healthy skin showed that the fibroblasts taken from the ulcer after the nested graft treatment acquire morpho-functional characteristics overlapping those of fibroblasts from healthy skin. This surgical approach is, therefore, able to lead to the healing of chronic ulcers through the de-senescence of the fibroblasts.

journal_name

Int Wound J

authors

Gualdi G,Crotti S,Monari P,Calzavara-Pinton P,Vitali M,Baronio M,Lougaris V

doi

10.1111/iwj.12415

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1104-1110

issue

6

eissn

1742-4801

issn

1742-481X

journal_volume

13

pub_type

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