Abstract:
:Senescent fibroblasts, which are present in chronic ulcers, are the reason for the wound becoming chronic. In this study, we introduce full-thickness micro skin grafts in the ulcer, a surgical technique known as a 'nested graft', which gave encouraging results leading to complete wound healing in all patients. The assessment of fibroblast cultures taken from the wound before and after treatment and comparison with fibroblasts from healthy skin showed that the fibroblasts taken from the ulcer after the nested graft treatment acquire morpho-functional characteristics overlapping those of fibroblasts from healthy skin. This surgical approach is, therefore, able to lead to the healing of chronic ulcers through the de-senescence of the fibroblasts.
journal_name
Int Wound Jjournal_title
International wound journalauthors
Gualdi G,Crotti S,Monari P,Calzavara-Pinton P,Vitali M,Baronio M,Lougaris Vdoi
10.1111/iwj.12415subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1104-1110issue
6eissn
1742-4801issn
1742-481Xjournal_volume
13pub_type
杂志文章,评审abstract::Necrobiosis lipoidica is a rare granulomatous disorder of the skin. In up to 30% of the affected patients it can lead to ulcerations, which can impair the quality of life and are also very difficult to treat. Its pathogenesis is not fully understood. Only few studies focussing on necrobiosis lipoidica can be found, bu...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12159
更新日期:2015-10-01 00:00:00
abstract::This data review reports the results of 15 patients who were treated with Vacuum-Assisted Closure (VAC) negative pressure therapy system in addition to the timed, intermittent delivery of an instilled topical solution for management of their complex, infected wounds. Prospective data for 15 patients treated with negat...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2007.00423.x
更新日期:2008-06-01 00:00:00
abstract::This is a prospective study with the aim to determine specific patterns of burn wound bacterial colonisation and antimicrobial resistance profiles. There is a high incidence of infections and septicaemia in post-burn patients, which, in turn, are associated with high morbidity and mortality, a fact that compelled us t...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12588
更新日期:2017-02-01 00:00:00
abstract::Recurrence of breast cancer is a predominant fear for patients who were treated for breast cancer. Acute and late dermatologic effects of radiotherapy are not uncommon and could have similar characteristics to breast cancer recurrence. Thus, it is important to highlight key differences between the clinical and histolo...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13350
更新日期:2020-08-01 00:00:00
abstract::Current embodiments of negative pressure wound therapy (NPWT) create a hermetically sealed chamber at the surface of the body using polyurethane foam connected to a vacuum pump, which is then covered by a flexible adhesive drape. Commercially available NPWT systems routinely use flexible polyethylene films that have a...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12589
更新日期:2017-02-01 00:00:00
abstract::Management of small-bowel fistulas which are in an open abdomen and have no soft tissue overlay or a fistula tract involves many complications and challenges. Controlling the local leakage of enteric contents has a central role in the success of medical treatment. There are several methods to deal with fistula dischar...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12726
更新日期:2017-12-01 00:00:00
abstract::The prognosis of stage I pressure ulcers cannot be predicted; therefore, nursing interventions for preventing their deterioration have not been clearly established. This study describes the clinical course of stage I pressure ulcers and prospectively investigates the factors related to their deterioration. Thirty-one ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2006.00267.x
更新日期:2006-12-01 00:00:00
abstract::Enzymatic debridement with collagenase is a technique that is commonly used in clinical practice. This systematic review examines the effect of collagenase on all kinds of wounds, compared to an alternative therapy, on wound healing, wound bed characteristics, cost-effectiveness and the occurrence of adverse events. W...
journal_title:International wound journal
pub_type: 杂志文章,meta分析,评审
doi:10.1111/iwj.12760
更新日期:2017-12-01 00:00:00
abstract::Chronic wounds are a significant problem in Australia. The health care-related costs of chronic wounds in Australia are considerable, equivalent to more than AUD $3.5 billion, approximately 2% of national health care expenditure. Chronic wounds can also have a significant negative impact on the health-related quality ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12996
更新日期:2019-02-01 00:00:00
abstract::An understanding of risk factors associated with mortality among pressure ulcer patients can inform prognostic counselling and treatment plans. This retrospective cohort study examined associations of comorbid illness, demographic characteristics and laboratory values with 90-day and 90- to 180-day mortality in adult ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2012.01032.x
更新日期:2014-02-01 00:00:00
abstract::Pressure ulcers (PUs) are one of the most prevalent adverse events in acute and chronic care. The root aetiological cause of PUs is sustained cell and tissue deformations, which triggers a synergistic tissue damage cascade that accelerates over relatively short time periods. Changes in skin microclimate conditions are...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13309
更新日期:2020-06-01 00:00:00
abstract::Prevention and treatment of bacterial colonised/infected wounds are critical. Many commercially available silver dressings claim broad-spectrum bactericidal activity over days and are indicated for serious conditions including burns and ulcers. However, there is no peer-reviewed literature available for many newer dre...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2010.00705.x
更新日期:2010-10-01 00:00:00
abstract::Breast cancer is a serious disease in women. We estimated the global technical success rate and complication rates of percutaneous vacuum-assisted breast biopsy (VABB). PubMed, Embase, Web of Science, and Scopus databases were retrieved up to July 2018 to find studies in which technical success rate and complication r...
journal_title:International wound journal
pub_type: 杂志文章,meta分析
doi:10.1111/iwj.13224
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:This study was designed to elucidate the in vivo efficacy of epidermal growth factor (EGF) on wound healing in non diabetic and diabetic rats. METHODS:Ninety-six male Wistar-Albino rats were randomly divided into six groups. Saline-moistened gauze, pure gelatin or EGF in gelatin-microsphere dressings were u...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2009.00584.x
更新日期:2009-04-01 00:00:00
abstract::Leg ulcer management is complex, time-consuming and of high socio-economic importance. Data on cost-of-illness in leg ulcer care are sparse. The objective of this study was to evaluate the cost-of-illness in leg ulcer treatment in the metropolitan area of Hamburg. About 147 institutions involved in wound care particip...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2012.01089.x
更新日期:2014-06-01 00:00:00
abstract::Although platelet gel is considered one of the most popular tools in the treatment of chronic ulcers, current consensus on its use is not unanimous. A prospective randomised trial was carried out at the Plastic Surgery Unit of the 'Salvatore Maugeri' Foundation Hospital of Pavia (Italy). The study involved 13 patients...
journal_title:International wound journal
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1742-481X.2010.00671.x
更新日期:2010-06-01 00:00:00
abstract::Randomised clinical trials (RCTs) to evaluate diabetic foot wound therapies have systematically eliminated large acute wounds from evaluation, focusing only on smaller chronic wounds. The purpose of this study was to evaluate the proportion and rate of wound healing in acute and chronic wounds after partial foot amput...
journal_title:International wound journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1742-481X.2006.00270.x
更新日期:2007-03-01 00:00:00
abstract::Combinations of various treatment modalities were shown to be more effective than monotherapy when treating hypertrophic scars and keloids. This study was conducted to assess the effectiveness of combination therapy with non-ablative fractional laser and intralesional steroid injection. From May 2015 to June 2017, a t...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13213
更新日期:2019-12-01 00:00:00
abstract::Numerous comorbidities and cofactors have been known to influence wound healing processes. In this multicentre study, clinical data of 1 000 patients with chronic leg ulcers from ten specialised dermatological wound care centers were analysed. The patient cohort comprised 567 females and 433 males with an average age ...
journal_title:International wound journal
pub_type: 杂志文章,多中心研究
doi:10.1111/iwj.12387
更新日期:2016-10-01 00:00:00
abstract::In May 2011, an international panel of wound care experts from multiple disciplines convened to develop this document to summarise the evolution of negative pressure wound therapy (NPWT) technology devices over the past 15 years, specifically concentrating on the V.A.C.(®) Therapy (KCI USA, Inc., San Antonio, TX) fam...
journal_title:International wound journal
pub_type:
doi:10.1111/j.1742-481X.2012.00978.x
更新日期:2012-08-01 00:00:00
abstract::Chronic non-healing wounds are a burden in the Long-Term Care (LTC) sector, increasing costs, morbidity, and mortality and causing pain and suffering. The objective of this LTC Innovation pilot was to test the value of a promising new neuromuscular stimulation device in elevating the experience and satisfaction of the...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13027
更新日期:2019-02-01 00:00:00
abstract::Wound chronification and opportunistic infections stand as major factors leading to lower extremities amputations in diabetes. The molecular mechanisms underlying diabetic's torpid healing have not been elucidated. We present the case of a female diabetic patient that after a plantar abscess surgical drainage, tight g...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2012.12000.x
更新日期:2013-04-01 00:00:00
abstract::The aim of this study was to retrospectively evaluate the clinical and culture-positive infection rates of open Gustilo/Anderson type II and III fractures using a protocol nanocrystalline silver wound dressing and hydrosurgical debridement. Retrospective case series through chart review on all type II and III open fra...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2011.00822.x
更新日期:2012-02-01 00:00:00
abstract::Pressure ulcers are associated with a significant economic burden that, in many cases, is recognised as being avoidable. The effectiveness of pressure relieving surfaces is well documented and acknowledged in clinical guidelines on the prevention and management of pressure ulcers. Whilst pressure relieving surfaces ar...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2009.00647.x
更新日期:2010-02-01 00:00:00
abstract::Assess the outcome of a standardised protocol for the treatment of post-operative wound infection in patients undergoing deformity correction for neuro-muscular scoliosis (NMS). Retrospective review of 443 consecutive patients with a minimum 18 months' follow-up, following a primary posterior deformity correction for ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13332
更新日期:2020-06-01 00:00:00
abstract::Ischaemia reperfusion (I/R) injury refers to tissue damage caused when blood supply returns to the tissue after a period of ischaemia. Matrix metalloproteinases (MMPs), neutrophil gelatinase-associated lipocalin (NGAL) and cytokines are biomarkers involved in several vascular complications. The aim of this study was t...
journal_title:International wound journal
pub_type: 杂志文章,多中心研究
doi:10.1111/iwj.12392
更新日期:2016-10-01 00:00:00
abstract::Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Abstract The historical and current literature reports the successful use of honey to manage a diversity of wound aetiologies. However, only in the last 40 years is research on its mode of action and contribution to wound healing being investiga...
journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/j.1742-4801.2005.00078.x
更新日期:2005-03-01 00:00:00
abstract::The use of a rigid disc as a barrier between the wound bed and the wound filler during negative pressure wound therapy (NPWT) has been suggested to prevent damage to exposed organs. However, it is important to determine that the effects of NPWT, such as wound contraction and fluid removal, are maintained during treatm...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2011.00805.x
更新日期:2011-08-01 00:00:00
abstract::A 6-month-old Caucasian baby is described with a postaxial polydactyly of the letf foot. Radiographic examination revealed the accessory digit was composed of soft tissue, some with a tiny osseous element, originated from around the metatarsophalangeal joint, defined by floating type (FT). The parents had consistent d...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12700
更新日期:2017-10-01 00:00:00
abstract::Surgical site infections are the most common nosocomial infections in surgical patients. The preventable and the unmodifiable risk factors for deep sternal wound infections (DSWI) have been amply assessed in the literature. The aim of this review was to describe the results of the numerous published studies to describ...
journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/j.1742-481X.2011.00896.x
更新日期:2012-08-01 00:00:00