Negative pressure wound therapy with instillation: a pilot study describing a new method for treating infected wounds.

Abstract:

:This data review reports the results of 15 patients who were treated with Vacuum-Assisted Closure (VAC) negative pressure therapy system in addition to the timed, intermittent delivery of an instilled topical solution for management of their complex, infected wounds. Prospective data for 15 patients treated with negative pressure wound therapy (NPWT)-instillation was recorded and analysed. Primary endpoints were compared to a retrospective control group of 15 patients treated with our institution's standard moist wound-care therapy. Culture-specific systemic antibiotics were prescribed as per specific patient need in both groups. All data were checked for normality of distribution and equality of variance and appropriate parametric and non parametric analyses were conducted. Compared with the standard moist wound-care therapy control group, patients in the NPWT-instillation group required fewer days of treatment (36.5 +/- 13.1 versus 9.9 +/- 4.3 days, P < 0.001), cleared of clinical infection earlier (25.9 +/- 6.6 versus 6.0 +/- 1.5 days, P < 0.001), had wounds close earlier (29.6 +/- 6.5 versus 13.2 +/- 6.8 days, P < 0.001) and had fewer in-hospital stay days (39.2 +/- 12.1 versus 14.7 +/- 9.2 days, P < 0.001). In this pilot study, NPWT instillation showed a significant decrease in the mean time to bioburden reduction, wound closure and hospital discharge compared with traditional wet-to-moist wound care. Outcomes from this study analysis suggest that the use of NPWT instillation may reduce cost and decrease inpatient care requirements for these complex, infected wounds.

journal_name

Int Wound J

authors

Gabriel A,Shores J,Heinrich C,Baqai W,Kalina S,Sogioka N,Gupta S

doi

10.1111/j.1742-481X.2007.00423.x

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

399-413

issue

3

eissn

1742-4801

issn

1742-481X

pii

IWJ423

journal_volume

5

pub_type

杂志文章
  • The role of Inadine in wound care: a consensus document.

    abstract::Iodine-based products are antibacterial. The small iodine molecular size is ideally suited to treat surface critical colonisation. Inadine is a 10% povidone iodine dressing with the equivalent of 1% available iodine that is easily extracted from the viscose backing by serum or exudate. The use of hydrophilic polyethyl...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12602

    authors: Sibbald RG,Elliott JA

    更新日期:2017-04-01 00:00:00

  • Chronic oedema/lymphoedema: under-recognised and under-treated.

    abstract::Even though it is estimated that at least 300 000 people in Canada may be affected by chronic oedema/lymphoedema, recognition of the seriousness of this chronic disease in health care is scarce. Lymphoedema affects up to 70% of breast and prostate cancer patients, substantially increasing their postoperative medical c...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12224

    authors: Keast DH,Despatis M,Allen JO,Brassard A

    更新日期:2015-06-01 00:00:00

  • TIME management by medicinal larvae.

    abstract::Wound bed preparation (WBP) is an integral part of the care programme for chronic wounds. The acronym TIME is used in the context of WBP and describes four barriers to healing in chronic wounds; namely, dead Tissue, Infection and inflammation, Moisture imbalance and a non-migrating Edge. Larval debridement therapy (LD...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12457

    authors: Pritchard DI,Čeřovský V,Nigam Y,Pickles SF,Cazander G,Nibbering PH,Bültemann A,Jung W

    更新日期:2016-08-01 00:00:00

  • Evaluation of a new foam to increase skin hydration of the foot in type 2 diabetes: a pilot study.

    abstract::The aim of the present study was to evaluate the efficacy of a new product (Neuropad repair foam(®)) in promoting skin hydration of the foot in type 2 diabetes. Included in this study were 20 type 2 diabetic patients (10 men, mean age 61·40 ± 2·44 years). Patients applied Neuropad repair foam(®) on the plantar aspect ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2011.00786.x

    authors: Papanas N,Papazoglou D,Papatheodorou K,Maltezos E

    更新日期:2011-06-01 00:00:00

  • Comparison of the efficacy and safety of povidone-iodine foam dressing (Betafoam), hydrocellular foam dressing (Allevyn), and petrolatum gauze for split-thickness skin graft donor site dressing.

    abstract::We evaluated the efficacy and safety of a povidone-iodine (PVP-I) foam dressing (Betafoam) for donor site dressing versus a hydrocellular foam dressing (Allevyn) and petrolatum gauze. This prospective Phase 4 study was conducted between March 2016 and April 2017 at eight sites in Korea. A total of 106 consenting patie...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13043

    authors: Pak CS,Park DH,Oh TS,Lee WJ,Jun YJ,Lee KA,Oh KS,Kwak KH,Rhie JW

    更新日期:2019-04-01 00:00:00

  • Infection in neuro-muscular scoliosis deformity correction.

    abstract::Assess the outcome of a standardised protocol for the treatment of post-operative wound infection in patients undergoing deformity correction for neuro-muscular scoliosis (NMS). Retrospective review of 443 consecutive patients with a minimum 18 months' follow-up, following a primary posterior deformity correction for ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13332

    authors: Haleem S,Edwin J,Bashir MA,Soltani S,Nadarajah R,Kieser DC

    更新日期:2020-06-01 00:00:00

  • Epidermal growth factor-containing wound closure enhances wound healing in non-diabetic and diabetic rats.

    abstract:BACKGROUND:This study was designed to elucidate the in vivo efficacy of epidermal growth factor (EGF) on wound healing in non diabetic and diabetic rats. METHODS:Ninety-six male Wistar-Albino rats were randomly divided into six groups. Saline-moistened gauze, pure gelatin or EGF in gelatin-microsphere dressings were u...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2009.00584.x

    authors: Dogan S,Demirer S,Kepenekci I,Erkek B,Kiziltay A,Hasirci N,Müftüoglu S,Nazikoglu A,Renda N,Dincer UD,Elhan A,Kuterdem E

    更新日期:2009-04-01 00:00:00

  • The impact of providing product funding for compression bandaging and medical footwear on compression use, wound healing and quality of life.

    abstract::A study conducted in an Australian home nursing service sought to ascertain whether the provision of funding for compression bandaging and medical footwear would impact on compression therapy use, wound healing and quality of life (QoL) among people with venous leg ulcers. Clients (n = 120) were randomly allocated to ...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1742-481X.2011.00908.x

    authors: Kapp S,Miller C,Elder K

    更新日期:2012-10-01 00:00:00

  • Biomarkers in post-reperfusion syndrome after acute lower limb ischaemia.

    abstract::Ischaemia reperfusion (I/R) injury refers to tissue damage caused when blood supply returns to the tissue after a period of ischaemia. Matrix metalloproteinases (MMPs), neutrophil gelatinase-associated lipocalin (NGAL) and cytokines are biomarkers involved in several vascular complications. The aim of this study was t...

    journal_title:International wound journal

    pub_type: 杂志文章,多中心研究

    doi:10.1111/iwj.12392

    authors: de Franciscis S,De Caridi G,Massara M,Spinelli F,Gallelli L,Buffone G,Caliò FG,Butrico L,Grande R,Serra R

    更新日期:2016-10-01 00:00:00

  • Effects of immunosuppressive therapy on wound healing.

    abstract::Immunosuppressive therapy is increasingly being used in clinical practice and has been shown to affect wound healing to varying degrees. This article looks at the effects of the newer immunosuppressive agents on wound healing. It is shown that wound healing is impaired via different mechanisms. Some of the animal and ...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-481X.2012.00950.x

    authors: Bootun R

    更新日期:2013-02-01 00:00:00

  • What should be the antibiotic prescription protocol for burn patients admitted in the department of burns, plastic and reconstructive surgery.

    abstract::This is a prospective study with the aim to determine specific patterns of burn wound bacterial colonisation and antimicrobial resistance profiles. There is a high incidence of infections and septicaemia in post-burn patients, which, in turn, are associated with high morbidity and mortality, a fact that compelled us t...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12588

    authors: Mir MA,Khurram MF,Khan AH

    更新日期:2017-02-01 00:00:00

  • Epidermal growth factor in clinical practice - a review of its biological actions, clinical indications and safety implications.

    abstract::Chemotaxis, mitogenesis, motogenesis and cytoprotection are common cellular events involved in both tumourigenesis and tissue repair, which appear amplified upon growth factors exposure. Epidermal growth factor (EGF) promotes these events in epithelial and mesenchymal cells through the binding to a specific tyrosine k...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-481X.2009.00622.x

    authors: Berlanga-Acosta J,Gavilondo-Cowley J,López-Saura P,González-López T,Castro-Santana MD,López-Mola E,Guillén-Nieto G,Herrera-Martinez L

    更新日期:2009-10-01 00:00:00

  • Cushing's syndrome and chronic venous ulceration--a clinical challenge.

    abstract::Cushing's syndrome is a condition caused by high levels of glucocorticoids, or most commonly as a result of prolonged exposure to exogenous steroids. Clinical features include diabetes, hypertension, obesity, skin atrophy, immune suppression and delayed wound healing. We report a patient with iatrogenic Cushing's synd...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2010.00746.x

    authors: Biswas M,Gibby O,Ivanova-Stoilova T,Harding K

    更新日期:2011-02-01 00:00:00

  • Using image J to document healing in ulcers of the foot in diabetes.

    abstract::The aim of the study was to assess the reliability of measuring the cross-sectional area of diabetic foot ulcers using Image J software. The inter- and intra-rater reliability of ulcer area measures were assessed using digital images of acetate tracings of ulcers of the foot affecting 31 participants in an off-loading...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/iwj.12769

    authors: Jeffcoate WJ,Musgrove AJ,Lincoln NB

    更新日期:2017-12-01 00:00:00

  • Nurses are research leaders in skin and wound care.

    abstract::The World Health Assembly declared 2020, the International Year of the Nurse and the Midwife. Recent editorials and commentaries support the leading role of nurses and midwives as frontline caregivers emphasizing the need to invest in the nursing workforce worldwide to meet global health needs. Today nurses are also l...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13492

    authors: Gethin G,Probst S,Weller C,Kottner J,Beeckman D

    更新日期:2020-12-01 00:00:00

  • The relationship between pressure injury complication and mortality risk of older patients in follow-up: A systematic review and meta-analysis.

    abstract::Pressure injuries (PIs) have now become a common complication of the elderly patients. Some studies have observed that pressure injuries may increase mortality, but this area of evidence has not been evaluated and summarised. The aim of this study was to compare the mortality of patients with pressure injuries and tho...

    journal_title:International wound journal

    pub_type: 杂志文章,meta分析

    doi:10.1111/iwj.13243

    authors: Song YP,Shen HW,Cai JY,Zha ML,Chen HL

    更新日期:2019-12-01 00:00:00

  • The efficacy of maggot debridement therapy--a review of comparative clinical trials.

    abstract::Over the last decade, maggot debridement therapy (MDT) has been recognized by many clinicians as a potential adjunct to conventional therapy, and many patients with non healing, chronic ulcers have been treated. Numerous case reports and case series have described the successful use of MDT in a variety of ulcers. Howe...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-481X.2011.00919.x

    authors: Zarchi K,Jemec GB

    更新日期:2012-10-01 00:00:00

  • Ultrasonography effectiveness of the vibration vs cryotherapy added to an eccentric exercise protocol in patients with chronic mid-portion Achilles tendinopathy: A randomised clinical trial.

    abstract::Tendinopathy is a very common disease in the general population as well as in athletes. The aim of the present study was to examine the tendon thickness and cross-sectional area (CSA) in subjects with chronic mid-portion Achilles tendinopathy (AT) who engaged in either an eccentric exercise (EE) programme with vibrati...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/iwj.13074

    authors: Romero-Morales C,Javier Martín-Llantino P,Calvo-Lobo C,Palomo-López P,López-López D,Fernández-Carnero J,Rodríguez-Sanz D

    更新日期:2019-04-01 00:00:00

  • Using a muscle pump activator device to stimulate healing for non-healing lower leg wounds in long-term care residents.

    abstract::Chronic non-healing wounds are a burden in the Long-Term Care (LTC) sector, increasing costs, morbidity, and mortality and causing pain and suffering. The objective of this LTC Innovation pilot was to test the value of a promising new neuromuscular stimulation device in elevating the experience and satisfaction of the...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13027

    authors: Harris C,Ramage D,Boloorchi A,Vaughan L,Kuilder G,Rakas S

    更新日期:2019-02-01 00:00:00

  • Evaluating antimicrobial efficacy of new commercially available silver dressings.

    abstract::Prevention and treatment of bacterial colonised/infected wounds are critical. Many commercially available silver dressings claim broad-spectrum bactericidal activity over days and are indicated for serious conditions including burns and ulcers. However, there is no peer-reviewed literature available for many newer dre...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2010.00705.x

    authors: Cavanagh MH,Burrell RE,Nadworny PL

    更新日期:2010-10-01 00:00:00

  • Evaluation of vacuum-assisted closure in patients with wound complications following tumour surgery.

    abstract::Covering the reconstructed area with a healthy soft-tissue envelope is a major challenge after limb-sparing surgery in patients with malignant bone and soft-tissue tumours. Negative pressure wound therapy (NPWT) of open wounds hastens healing and minimises the requirement for complex reconstructive soft-tissue surgery...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12318

    authors: Mermerkaya U,Bekmez S,Alkan E,Ayvaz M,Tokgozoglu M

    更新日期:2016-06-01 00:00:00

  • The clinical experience for treating post-burn depigmentation with tiny epidermal particles graft.

    abstract::The critical problem of post-burn depigmentation is the lacking normal melanocytes. Auto-skin grafting and autologous non-cultured epidermal cell suspension have been used to improve the appearance. However, a large amount of skin graft is required of donor sites in the former method, while the latter method is though...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12577

    authors: Chen B,Xu M,Li B

    更新日期:2017-02-01 00:00:00

  • Alcohol consumption does not increase the risk of surgical wound complications in breast cancer patients.

    abstract::Alcohol consumption, despite influencing several organic processes, has been scarcely studied regarding the risk of developing surgical wound complications after surgical breast cancer treatment. The aim of this study was to analyse the association between alcohol consumption and the development of surgical wound comp...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13455

    authors: de Menezes RF,Bergmann A,Thuler LCS

    更新日期:2020-12-01 00:00:00

  • Effective management of patients with diabetes foot ulcers: outcomes of an Interprofessional Diabetes Foot Ulcer Team.

    abstract::A longitudinal observational study on a convenience sample was conducted between 4 January and 31 December of 2010 to evaluate clinical outcomes that occur when a new Interprofessional Diabetes Foot Ulcer Team (IPDFUT) helps in the management of diabetes-related foot ulcers (DFUs) in patients living in a small urban c...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12119

    authors: Ogrin R,Houghton PE,Thompson GW

    更新日期:2015-08-01 00:00:00

  • Negative-pressure wound dressings to secure split-thickness skin grafts in the perineum.

    abstract::Several researches have shown that negative-pressure wound dressings can secure split-thickness skin grafts and improve graft survival. However, in anatomically difficult body regions such as the perineum it is questionable whether these dressings have similar beneficial effects. In this study, we evaluated the effect...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2012.01078.x

    authors: Lee KT,Pyon JK,Lim SY,Mun GH,Oh KS,Bang SI

    更新日期:2014-04-01 00:00:00

  • Risk factors for 90-day and 180-day mortality in hospitalised patients with pressure ulcers.

    abstract::An understanding of risk factors associated with mortality among pressure ulcer patients can inform prognostic counselling and treatment plans. This retrospective cohort study examined associations of comorbid illness, demographic characteristics and laboratory values with 90-day and 90- to 180-day mortality in adult ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2012.01032.x

    authors: Flattau A,Blank AE

    更新日期:2014-02-01 00:00:00

  • Vacuum-assisted closure therapy combined with bi-pectoral muscle flap for the treatment of deep sternal wound infections.

    abstract::Deep sternal wound infection (DSWI) is a fatal complication after median sternotomy. This study was to assess the effect of vacuum-assisted closure (VAC) combined with bi-pectoral muscle advancement flap therapy on rehabilitation for the treatment of DSWI. Fifty-two patients with DSWI underwent treatment of VAC and bi...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13277

    authors: Wang C,Zhang J,Liu Z

    更新日期:2020-04-01 00:00:00

  • Laser Doppler flowmetry assessment of peristernal perfusion after cardiac surgery: beneficial effect of negative pressure therapy.

    abstract::Negative pressure therapy has been successfully applied to clean, closed incisions in patients at high-risk for wound complications. Using laser Doppler flowmetry, we evaluated peristernal perfusion after cardiac surgery via median sternotomy, assessing the influence of mammary artery harvesting and the impact of nega...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2010.00743.x

    authors: Atkins BZ,Tetterton JK,Petersen RP,Hurley K,Wolfe WG

    更新日期:2011-02-01 00:00:00

  • The influence on wound contraction and fluid evacuation of a rigid disc inserted to protect exposed organs during negative pressure wound therapy.

    abstract::The use of a rigid disc as a barrier between the wound bed and the wound filler during negative pressure wound therapy (NPWT) has been suggested to prevent damage to exposed organs. However, it is important to determine that the effects of NPWT, such as wound contraction and fluid removal, are maintained during treatm...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2011.00805.x

    authors: Anesäter E,Roupé KM,Robertsson P,Borgquist O,Torbrand C,Ingemansson R,Lindstedt S,Malmsjö M

    更新日期:2011-08-01 00:00:00

  • Cost-effectiveness of treating vascular leg ulcers with UrgoStart(®) and UrgoCell(®) Contact.

    abstract::Although chronic wounds have a high socio-economic impact, data on comparative effectiveness of treatments are rare. UrgoStart(®) is a hydroactive dressing containing a nano-oligosaccharide factor (NOSF). This study aimed at evaluating the cost-effectiveness of this NOSF-containing wound dressing in vascular leg ulcer...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12238

    authors: Augustin M,Herberger K,Kroeger K,Muenter KC,Goepel L,Rychlik R

    更新日期:2016-02-01 00:00:00