Epidermal growth factor-containing wound closure enhances wound healing in non-diabetic and diabetic rats.

Abstract:

BACKGROUND:This study was designed to elucidate the in vivo efficacy of epidermal growth factor (EGF) on wound healing in non diabetic and diabetic rats. METHODS:Ninety-six male Wistar-Albino rats were randomly divided into six groups. Saline-moistened gauze, pure gelatin or EGF in gelatin-microsphere dressings were used in a dermal excision model in both normal and streptomycin-induced diabetic rats. Wound healing was evaluated on day 7 and 14. Reduction in wound area, hydroxypyroline content and tensile strength of the wound were evaluated in each rat. Tissue samples taken from the wounds were examined histopathologically for reepithelialisation, cellular infiltration, number of fibroblasts, granulation and neovascularisation. RESULTS:On day 7, the use of EGF-containing dressing was observed to reduce the wound area better when compared with the other dressings tested. This effect was significant in normal rats rather than diabetic rats. The difference in reduction of wound area did not persist on day 14. No significant effect on hydroxyproline content of the wound was found with EGF-containing dressing in either normal or diabetic rats. There was a statistically significant increase in tensile strength values of EGF-applied non diabetic rats over the 14 day period. An increase in tensile strength was prominent in also EGF-applied diabetic rats on day 14. Histological examination revealed higher histopathologic scores in EGF-applied diabetic and non diabetic rats. CONCLUSION:These findings implicate that use of EGF in gelatin-microsphere dressings improves wound healing both in normal and diabetic rats.

journal_name

Int Wound J

authors

Dogan S,Demirer S,Kepenekci I,Erkek B,Kiziltay A,Hasirci N,Müftüoglu S,Nazikoglu A,Renda N,Dincer UD,Elhan A,Kuterdem E

doi

10.1111/j.1742-481X.2009.00584.x

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

107-15

issue

2

eissn

1742-4801

issn

1742-481X

pii

IWJ584

journal_volume

6

pub_type

杂志文章
  • The operative treatment of pressure wounds: a 10-year experience in flap selection.

    abstract::This study sought to both assist in the selection of flaps for ischial pressure wound re-construction and to evaluate the overall complication rates associated with re-construction. A retrospective medical record review was conducted for 78 patients following the surgical re-construction of an ischial pressure sore. R...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2010.00662.x

    authors: Ahluwalia R,Martin D,Mahoney JL

    更新日期:2010-04-01 00:00:00

  • Cost-effectiveness of treating vascular leg ulcers with UrgoStart(®) and UrgoCell(®) Contact.

    abstract::Although chronic wounds have a high socio-economic impact, data on comparative effectiveness of treatments are rare. UrgoStart(®) is a hydroactive dressing containing a nano-oligosaccharide factor (NOSF). This study aimed at evaluating the cost-effectiveness of this NOSF-containing wound dressing in vascular leg ulcer...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12238

    authors: Augustin M,Herberger K,Kroeger K,Muenter KC,Goepel L,Rychlik R

    更新日期:2016-02-01 00:00:00

  • Enteroatmospheric fistula management by endoscopic gastrostomy PEG tube.

    abstract::Management of small-bowel fistulas which are in an open abdomen and have no soft tissue overlay or a fistula tract involves many complications and challenges. Controlling the local leakage of enteric contents has a central role in the success of medical treatment. There are several methods to deal with fistula dischar...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12726

    authors: Miranda LE,Miranda AC

    更新日期:2017-12-01 00:00:00

  • Case series of use of Manuka honey in leg ulceration.

    abstract::Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Abstract The historical and current literature reports the successful use of honey to manage a diversity of wound aetiologies. However, only in the last 40 years is research on its mode of action and contribution to wound healing being investiga...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-4801.2005.00078.x

    authors: Gethin G,Cowman S

    更新日期:2005-03-01 00:00:00

  • A meta-analysis of interleukin-6 as a valid and accurate index in diagnosing early neonatal sepsis.

    abstract::We aimed to systematically assess the overall value of interleukin 6 (IL-6) in diagnosing neonates with sepsis. A systematic literature search was conducted using the following electronic databases: PubMed, Embase, and Cochrane, to identify eligible studies through the index words updated till November 2018. Cross-sec...

    journal_title:International wound journal

    pub_type: 杂志文章,meta分析

    doi:10.1111/iwj.13079

    authors: Sun B,Liang LF,Li J,Yang D,Zhao XB,Zhang KG

    更新日期:2019-04-01 00:00:00

  • Use of prophylactic silicone adhesive dressings for maintaining skin integrity in intensive care unit patients: A randomised controlled trial.

    abstract::The aims of this randomised controlled study were to determine whether the application of silicone adhesive dressings with standard preventive care would reduce the impairment of skin integrity and to evaluate the subepidermal moisture (SEM) value in anatomical locations to predict impairment of skin integrity. Of the...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/iwj.13028

    authors: Lee YJ,Kim JY,Shin WY

    更新日期:2019-03-01 00:00:00

  • Diabetic foot ulcers and ethnicity in Tanzania: a contrast between African and Asian populations.

    abstract::To characterise the role of ethnicity in the occurrence of foot ulcer disease in persons with diabetes, we analysed prospectively collected data for persons attending the diabetes clinic at Muhimbili National Hospital (MNH), Dar es Salaam, Tanzania. A case was defined as any adult presenting to MNH with an ulcer at or...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2008.00578.x

    authors: Abbas ZG,Lutale JK,Archibald LK

    更新日期:2009-04-01 00:00:00

  • The economics of pressure relieving surfaces: an illustrative case study of the impact of high-specification surfaces on hospital finances.

    abstract::Pressure ulcers are associated with a significant economic burden that, in many cases, is recognised as being avoidable. The effectiveness of pressure relieving surfaces is well documented and acknowledged in clinical guidelines on the prevention and management of pressure ulcers. Whilst pressure relieving surfaces ar...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2009.00647.x

    authors: Trueman P,Whitehead SJ

    更新日期:2010-02-01 00:00:00

  • Cold immersion recovery responses in the diabetic foot with neuropathy.

    abstract::The aim of this article was to investigate the effectiveness of testing cold immersion recovery responses in the diabetic foot with neuropathy using a contact thermography system based on thermochromic liquid crystals. A total of 81 subjects with no history of diabetic foot ulceration were assigned to neuropathy, non ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2008.00454.x

    authors: Bharara M,Viswanathan V,Cobb JE

    更新日期:2008-10-01 00:00:00

  • The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting: a systematic review of the literature.

    abstract::The aim of this systematic review was to determine the supporting evidence for the clinical use of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting. Two authors searched three databases (Ovid Medline, Ovid Embase and The Cochrane Library) for relevant English language art...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12469

    authors: Goodwin NS,Spinks A,Wasiak J

    更新日期:2016-08-01 00:00:00

  • Prognosis of stage I pressure ulcers and related factors.

    abstract::The prognosis of stage I pressure ulcers cannot be predicted; therefore, nursing interventions for preventing their deterioration have not been clearly established. This study describes the clinical course of stage I pressure ulcers and prospectively investigates the factors related to their deterioration. Thirty-one ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2006.00267.x

    authors: Sato M,Sanada H,Konya C,Sugama J,Nakagami G

    更新日期:2006-12-01 00:00:00

  • Comparison of tissue damage, cleansing and cross-contamination potential during wound cleansing via two methods: lavage and negative pressure wound therapy with instillation.

    abstract::The use of lavage was compared to negative pressure wound therapy (NPWT) with instillation (NPWTi) to assess extent of soft tissue damage, debris removal and environmental cross-contamination susceptibility in three distinct models. Scanning electron microscopy in an ex vivo model showed increased visible tissue traum...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2012.01073.x

    authors: Allen D,LaBarbera LA,Bondre IL,Lessing MC,Rycerz AM,Kilpadi DV,Collins BA,Perkins J,McNulty AK

    更新日期:2014-04-01 00:00:00

  • The use of a surgical incision management system on vascular surgery incisions: a pilot study.

    abstract::Health care-associated infections in hospitals, including surgical site infections, contribute significantly to morbidity as well as mortality. Surgical incision management (SIM) using negative pressure wound therapy (Prevena™ Incision Management System, Kinetic Concepts, Inc., San Antonio, TX, USA) is designed to cov...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12261

    authors: Weir G

    更新日期:2014-06-01 00:00:00

  • Implementation of a successful electronic wound documentation system in rural Victoria, Australia: a subject of collaboration and community engagement.

    abstract::To describe the steps needed for a successful implementation of an e-health programme (the Mobile Wound Care system) in rural Victoria, Australia and to provide recommendations for future e-health initiatives. Wound care is a major burden on the health care system. Optimal wound care was found to be impeded by issues ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12041

    authors: Khalil H,Cullen M,Chambers H,Steers N,Walker J

    更新日期:2014-06-01 00:00:00

  • Podiatrist care and outcomes for patients with diabetes and foot ulcer.

    abstract::We examined whether outcomes of care (amputation and hospitalisation) among patients with diabetes and foot ulcer differ between those who received pre-ulcer care from podiatrists and those who did not. Adult patients with diabetes and a diagnosis of a diabetic foot ulcer were found in the MarketScan Databases, 2005-2...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12021

    authors: Gibson TB,Driver VR,Wrobel JS,Christina JR,Bagalman E,DeFrancis R,Garoufalis MG,Carls GS,Gatwood J

    更新日期:2014-12-01 00:00:00

  • Pain and trauma in negative pressure wound therapy: a review.

    abstract::Negative pressure wound therapy (NPWT) is considered an effective wound treatment, but there are a number of issues that need to be addressed for improvements to be made. This review aimed to explore the literature relating to the pain and skin trauma that may be experienced during NPWT. A literature search was carrie...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12059

    authors: Upton D,Andrews A

    更新日期:2015-02-01 00:00:00

  • Infection in neuro-muscular scoliosis deformity correction.

    abstract::Assess the outcome of a standardised protocol for the treatment of post-operative wound infection in patients undergoing deformity correction for neuro-muscular scoliosis (NMS). Retrospective review of 443 consecutive patients with a minimum 18 months' follow-up, following a primary posterior deformity correction for ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13332

    authors: Haleem S,Edwin J,Bashir MA,Soltani S,Nadarajah R,Kieser DC

    更新日期:2020-06-01 00:00:00

  • Cushing's syndrome and chronic venous ulceration--a clinical challenge.

    abstract::Cushing's syndrome is a condition caused by high levels of glucocorticoids, or most commonly as a result of prolonged exposure to exogenous steroids. Clinical features include diabetes, hypertension, obesity, skin atrophy, immune suppression and delayed wound healing. We report a patient with iatrogenic Cushing's synd...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2010.00746.x

    authors: Biswas M,Gibby O,Ivanova-Stoilova T,Harding K

    更新日期:2011-02-01 00:00:00

  • Comparing the reported burn conditions for different severity burns in porcine models: a systematic review.

    abstract::There are many porcine burn models that create burns using different materials (e.g. metal, water) and different burn conditions (e.g. temperature and duration of exposure). This review aims to determine whether a pooled analysis of these studies can provide insight into the burn materials and conditions required to c...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12786

    authors: Andrews CJ,Cuttle L

    更新日期:2017-12-01 00:00:00

  • Effects of pH-neutral, super-oxidised solution on human dermal fibroblasts in vitro.

    abstract::For the past 20 years, super-oxidised solutions (SOSs) have been shown to be potent antimicrobials and disinfectants via oxidative damage. However, the potential toxicity of SOSs on eukaryotic cells has not been documented in vitro. This is relevant because oxygen and chlorine reactive species may possibly induce agei...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2007.00331.x

    authors: González-Espinosa D,Pérez-Romano L,Guzmán-Soriano B,Arias E,Bongiovanni CM,Gutiérrez AA

    更新日期:2007-09-01 00:00:00

  • Segmental ulcerative vasculitis: a cutaneous manifestation of Takayasu's arteritis.

    abstract::A 16-year-old girl with pyoderma gangrenosum (PG)-like skin lesions on the extremities, trunk and face developed Takayasu's arteritis (TA; pulseless disease). After 3 years under maintenance cyclosporin A therapy, the patient developed an ischaemic cerebral accident. Severe obstruction of both subclavian and left caro...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-4801.2005.00103.x

    authors: Dourmishev AL,Serafimova DK,Vassileva SG,Dourmishev LA,Schwartz RA

    更新日期:2005-12-01 00:00:00

  • Autologous platelet-rich plasma for healing chronic venous leg ulcers: Clinical efficacy and potential mechanisms.

    abstract::The overall quality of evidence of autologous platelet-rich plasma (PRP) for treating chronic wounds remains low. While further well-designed clinical studies are clearly required to convincingly demonstrate the efficacy of autologous PRP in improved healing of venous leg ulcers (VLUs) and other chronic wounds, there ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13098

    authors: Weller CD,Gardiner EE,Arthur JF,Southey M,Andrews RK

    更新日期:2019-06-01 00:00:00

  • Cost-of-illness of leg ulcers in the community.

    abstract::Leg ulcer management is complex, time-consuming and of high socio-economic importance. Data on cost-of-illness in leg ulcer care are sparse. The objective of this study was to evaluate the cost-of-illness in leg ulcer treatment in the metropolitan area of Hamburg. About 147 institutions involved in wound care particip...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2012.01089.x

    authors: Augustin M,Brocatti LK,Rustenbach SJ,Schäfer I,Herberger K

    更新日期:2014-06-01 00:00:00

  • Biomarkers in post-reperfusion syndrome after acute lower limb ischaemia.

    abstract::Ischaemia reperfusion (I/R) injury refers to tissue damage caused when blood supply returns to the tissue after a period of ischaemia. Matrix metalloproteinases (MMPs), neutrophil gelatinase-associated lipocalin (NGAL) and cytokines are biomarkers involved in several vascular complications. The aim of this study was t...

    journal_title:International wound journal

    pub_type: 杂志文章,多中心研究

    doi:10.1111/iwj.12392

    authors: de Franciscis S,De Caridi G,Massara M,Spinelli F,Gallelli L,Buffone G,Caliò FG,Butrico L,Grande R,Serra R

    更新日期:2016-10-01 00:00:00

  • The influence of different sizes and types of wound fillers on wound contraction and tissue pressure during negative pressure wound therapy.

    abstract::Negative pressure wound therapy (NPWT) contracts the wound and alters the pressure in the tissue of the wound edge, which accelerates wound healing. The aim of this study was to examine the effect of the type (foam or gauze) and size (small or large) of wound filler for NPWT on wound contraction and tissue pressure. N...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2011.00790.x

    authors: Anesäter E,Borgquist O,Hedström E,Waga J,Ingemansson R,Malmsjö M

    更新日期:2011-08-01 00:00:00

  • Leg ulcer induced by hydroxycarbamide in sickle cell disease: What is the therapeutic impact?

    abstract::Major sickle cell disease syndrome (SCD) is a set of potentially serious and disabling constitutional haemoglobin pathologies characterised by chronic haemolysis and vaso-occlusion phenomena. If expression takes the form of acute vaso-occlusive crisis, SCD is currently considered to be a chronic systemic pathology, pr...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13115

    authors: Soya E,Makowski C,Blaise S

    更新日期:2019-08-01 00:00:00

  • Negative pressure surgical management after pathological scar surgical excision: a first report.

    abstract::Wound dehiscence is a surgical complication caused by the application of opposing and distracting forces tending to pull apart the suture line. In recent years, a novel negative pressure surgical management system has been developed to prevent surgical wound complications. This system creates a closed environment that...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12040

    authors: Bollero D,Malvasio V,Catalano F,Stella M

    更新日期:2015-02-01 00:00:00

  • Effect of low-thermal dissection device versus conventional electrocautery in mastectomy for female-to-male transgender patients.

    abstract::Subcutaneous mastectomy, the first step in sexual reassignment surgery of female-to-male transsexuals, is associated with high rates of complication and revision surgery. Also, conventional electrosurgery and the associated thermal tissue damage may compromise outcome. This retrospective randomised clinical study eval...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13382

    authors: Schlosshauer T,Kiehlmann M,Riener MO,Rothenberger J,Sader R,Rieger UM

    更新日期:2020-10-01 00:00:00

  • Using image J to document healing in ulcers of the foot in diabetes.

    abstract::The aim of the study was to assess the reliability of measuring the cross-sectional area of diabetic foot ulcers using Image J software. The inter- and intra-rater reliability of ulcer area measures were assessed using digital images of acetate tracings of ulcers of the foot affecting 31 participants in an off-loading...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/iwj.12769

    authors: Jeffcoate WJ,Musgrove AJ,Lincoln NB

    更新日期:2017-12-01 00:00:00

  • Using a muscle pump activator device to stimulate healing for non-healing lower leg wounds in long-term care residents.

    abstract::Chronic non-healing wounds are a burden in the Long-Term Care (LTC) sector, increasing costs, morbidity, and mortality and causing pain and suffering. The objective of this LTC Innovation pilot was to test the value of a promising new neuromuscular stimulation device in elevating the experience and satisfaction of the...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13027

    authors: Harris C,Ramage D,Boloorchi A,Vaughan L,Kuilder G,Rakas S

    更新日期:2019-02-01 00:00:00