Aetiology, comorbidities and cofactors of chronic leg ulcers: retrospective evaluation of 1 000 patients from 10 specialised dermatological wound care centers in Germany.

Abstract:

:Numerous comorbidities and cofactors have been known to influence wound healing processes. In this multicentre study, clinical data of 1 000 patients with chronic leg ulcers from ten specialised dermatological wound care centers were analysed. The patient cohort comprised 567 females and 433 males with an average age of 69·9 years. The wounds persisted on average for 40·8 months and had a mean size of 43·7 cm(2) . Venous leg ulcers represented the most common entity accounting for 51·3% of all chronic wounds, followed by mixed-type ulcers in 12·9% and arterial ulcerations in 11·0% of the patients. Vasculitis was diagnosed in 4·5%, trauma in 3·2%, pyoderma gangrenosum in 2·8%, lymphoedema in 1·7%, neoplasia in 1·0% and delayed post-surgical wound healing in 0·6% of the included patients. In total, 70·5% of patients suffered from arterial hypertension, 45·2% were obese, 27·2% had non-insulin dependent diabetes, and 24·4% dyslipidaemia. Altogether 18·4% suffered from metabolic syndrome. Cofactors and comorbidities of patients with chronic leg ulcers have previously been studied but not in detail. Here, we were able to demonstrate the existence of several potentially relevant cofactors, comorbidities of their associations and geographical distributions, which should be routinely examined in patients with chronic leg ulcers and - if possible - treated.

journal_name

Int Wound J

authors

Jockenhöfer F,Gollnick H,Herberger K,Isbary G,Renner R,Stücker M,Valesky E,Wollina U,Weichenthal M,Karrer S,Kuepper B,Roesch A,Dissemond J

doi

10.1111/iwj.12387

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

821-8

issue

5

eissn

1742-4801

issn

1742-481X

journal_volume

13

pub_type

杂志文章,多中心研究
  • The smart negative pressure (SNaP) wound care system: A case series from Singapore.

    abstract::The Smart Negative Pressure (SNaP) wound care system is a novel device that is single-patient use, ultra-portable, and light weight and does not rely on battery or need recharging. A systematic search was performed on major databases to identify relevant articles including case reports, retrospective case series, and ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13114

    authors: Wee IJY,Mak M,O'Donnell G,Tan J,Chong TT,Tang TY

    更新日期:2019-08-01 00:00:00

  • The detrimental impact of extracellular bacterial proteases on wound healing.

    abstract::In addition to clinical signs of infection (e.g. inflammation, purulence and pain), a microbial count of ≥105 colony-forming units/g has historically been used to define wound infection. However, it is increasingly recognised that, rather than a high bioburden level alone being detrimental to wound healing, it is the ...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12790

    authors: Lindsay S,Oates A,Bourdillon K

    更新日期:2017-12-01 00:00:00

  • High body mass index is a strong predictor of intraoperative acquired pressure injury in spinal surgery patients when prophylactic film dressings are applied: A retrospective analysis prior to the BOSS Trial.

    abstract::We reported the efficacy of soft silicone multilayered foam dressings in preventing intraoperatively acquired pressure injuries (IAPIs) in the prone position using a Relton-Hall frame (BOSS trial). The aim of this study was to clarify the incidence and extract the risk factors for IAPIs in cases in which polyurethane ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13287

    authors: Yoshimura M,Ohura N,Santamaria N,Watanabe Y,Akizuki T,Gefen A

    更新日期:2020-06-01 00:00:00

  • The impact of incisional negative pressure wound therapy on the wound healing process after midline sternotomy.

    abstract::Previous studies have reported that the use of incisional negative pressure wound therapy (INPWT) might reduce the incidence of wound infections, although its mechanism remains unknown. We designed a prospective study to explore the effects of INPWT on different stages of the wound healing process. After meeting the i...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13497

    authors: Rashed A,Csiszar M,Beledi A,Gombocz K

    更新日期:2020-11-25 00:00:00

  • Risk of readmissions, mortality, and hospital-acquired conditions across hospital-acquired pressure injury (HAPI) stages in a US National Hospital Discharge database.

    abstract::Pressure injuries are one of the most common and costly complications occurring in US hospitals. With up to 3 million patients affected each year, hospital-acquired pressure injuries (HAPIs) place a substantial burden on the US healthcare system. In the current study, US hospital discharge records from 9.6 million pat...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13482

    authors: Wassel CL,Delhougne G,Gayle JA,Dreyfus J,Larson B

    更新日期:2020-12-01 00:00:00

  • Science supporting negative pressure wound therapy with instillation.

    abstract::A new method (V.A.C.ULTA Therapy System, KCI USA, Inc., San Antonio, TX) combines the benefits of negative pressure wound therapy (NPWT; V.A.C. Therapy, KCI USA, Inc.) with regulated, periodic instillation of user-selected topical wound solutions (V.A.C. VeraFlo Therapy, KCI USA, Inc.). In simulated wound model studie...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12171

    authors: Rycerz AM,Allen D,Lessing MC

    更新日期:2013-12-01 00:00:00

  • Podiatrist care and outcomes for patients with diabetes and foot ulcer.

    abstract::We examined whether outcomes of care (amputation and hospitalisation) among patients with diabetes and foot ulcer differ between those who received pre-ulcer care from podiatrists and those who did not. Adult patients with diabetes and a diagnosis of a diabetic foot ulcer were found in the MarketScan Databases, 2005-2...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12021

    authors: Gibson TB,Driver VR,Wrobel JS,Christina JR,Bagalman E,DeFrancis R,Garoufalis MG,Carls GS,Gatwood J

    更新日期:2014-12-01 00:00:00

  • An integrated experimental-computational study of the microclimate under dressings applied to intact weight-bearing skin.

    abstract::Pressure ulcers (PUs) are one of the most prevalent adverse events in acute and chronic care. The root aetiological cause of PUs is sustained cell and tissue deformations, which triggers a synergistic tissue damage cascade that accelerates over relatively short time periods. Changes in skin microclimate conditions are...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13309

    authors: Schwartz D,Gefen A

    更新日期:2020-06-01 00:00:00

  • Contact sensitivity in patients with venous leg ulcer: A multi-centric Indian study.

    abstract::Venous leg ulcers are the most common form of non-healing leg ulcers. They are subjected to treatments such as topical medications, dressings, and compression therapies. This can lead to exposure to a number of allergens with subsequent sensitisation and contact dermatitis of the regional skin. This may contribute to ...

    journal_title:International wound journal

    pub_type: 杂志文章,多中心研究

    doi:10.1111/iwj.12905

    authors: Rai R,Shenoy MM,Viswanath V,Sarma N,Majid I,Dogra S

    更新日期:2018-08-01 00:00:00

  • The clinical dynamic changes of macrophage phenotype and function in different stages of human wound healing and hypertrophic scar formation.

    abstract::The pathogenesis of hypertrophic scar (HS) is still poorly understood. Macrophages, especially the polarisation of that to M1 or M2, play a pivotal role in control of the degree of scar formation. Profiling of macrophage phenotypes in human specimens during long-term period of wound healing and HS formation may provid...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13041

    authors: Chen L,Wang J,Li S,Yu Z,Liu B,Song B,Su Y

    更新日期:2019-04-01 00:00:00

  • The impact of skin calcinosis on digital ulcers in patients with SSc: clinical and prognostic stratification using the "wound bed score".

    abstract::Digital ulcers (DUs) represent one of the major burdens for patients with systemic sclerosis (SSc), especially when associated with skin calcinosis (SC). The aim of this work is to evaluate the impact of SC in DUs of patients with SSc for clinical characteristics and prognosis assessed by the wound bed score (WBS). We...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13467

    authors: Barsotti S,Venturini V,Di Battista M,Janowska A,Dini V,Della Rossa A,Mosca M

    更新日期:2020-12-01 00:00:00

  • No need for biopsies: comparison of three sample techniques for wound microbiota determination.

    abstract::The aim of the study was to compare three sampling techniques used in routine diagnostics to identify the microbiota in chronic venous leg ulcers. A total of 46 patients with persisting venous leg ulcers were included in the study. At inclusion, swab, biopsy and filter paper pad samples were collected. After 4 weeks, ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2011.00883.x

    authors: Gjødsbøl K,Skindersoe ME,Christensen JJ,Karlsmark T,Jørgensen B,Jensen AM,Klein BM,Sonnested MK,Krogfelt KA

    更新日期:2012-06-01 00:00:00

  • Use of prophylactic silicone adhesive dressings for maintaining skin integrity in intensive care unit patients: A randomised controlled trial.

    abstract::The aims of this randomised controlled study were to determine whether the application of silicone adhesive dressings with standard preventive care would reduce the impairment of skin integrity and to evaluate the subepidermal moisture (SEM) value in anatomical locations to predict impairment of skin integrity. Of the...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/iwj.13028

    authors: Lee YJ,Kim JY,Shin WY

    更新日期:2019-03-01 00:00:00

  • Prediction and monitoring the therapeutic response of chronic dermal wounds.

    abstract::A significant proportion of chronic wounds fail to heal in response to treatment of underlying pathologies combined with good wound care practice. Current prognostic tests to identify these wounds rely on the use of algorithms based on clinically measurable parameters such as wound dimensions and wound duration. Venou...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-4801.2006.00212.x

    authors: Moore K,McCallion R,Searle RJ,Stacey MC,Harding KG

    更新日期:2006-06-01 00:00:00

  • Nicorandil: from ulcer to fistula into adjacent organs.

    abstract::Nicorandil is an original vasodilatator used to control angina by decreasing cardiac preload and afterload. Since 1997, many reports of single or multiple nicorandil-induced ulcerations have been published. To date, eight cases of nicorandil-induced fistula into adjacent organs have been described. The pathogeneses of...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2012.00966.x

    authors: Trechot P,Petitpain N,Guy C,Pinzano A,Javot L,Schmutz JL,Marie B,Barbaud A

    更新日期:2013-04-01 00:00:00

  • How precise is the evaluation of chronic wounds by health care professionals?

    abstract::Chronic wounds are a growing challenge for physicians and health insurance agencies. The burden of affected patients is enormous, because of pain but also because of long-lasting therapies and dependence on nursing services. In other areas of medicine, computer-based diagnostics is established, yet, accurate wound doc...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2007.00334.x

    authors: Stremitzer S,Wild T,Hoelzenbein T

    更新日期:2007-06-01 00:00:00

  • Use of Cellutome for the healing of venous or mixed ulcers.

    abstract::Venous or mixed ulcers are common and invalidating. Cutaneous transplants may be necessary if conventional treatment is ineffective. We evaluated the performance of Cellutome in promoting the healing of venous or mixed ulcers 2 months after grafting. This was a retrospective, multi-centric, descriptive study of patien...

    journal_title:International wound journal

    pub_type: 杂志文章,多中心研究

    doi:10.1111/iwj.12966

    authors: Vinceneux Talvande B,Carvalho Lallement P,Safa G,Journet Tollhupp J,Lembelembe JP,Blaise S,Maillard H

    更新日期:2018-12-01 00:00:00

  • Evolution or revolution? Adapting to complexity in wound management.

    abstract::Wound clinics are seeing an increase in the number of 'complex' wounds, which arise as the result of the interaction between multiple coexisting systemic pathologies, environmental factors and local wound factors. These complex wounds require an approach to diagnosis and management that can encapsulate all these facto...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-481X.2007.00329.x

    authors: Harding K,Gray D,Timmons J,Hurd T

    更新日期:2007-06-01 00:00:00

  • Comparative effectiveness of the SNaP™ Wound Care System.

    abstract::Diabetic lower extremity wounds cause substantial burden to healthcare systems, costing tens of thousands of dollars per episode. Negative pressure wound therapy (NPWT) devices have been shown to be cost-effective at treating these wounds, but the traditional devices use bulky electrical pumps that require a durable m...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2011.00775.x

    authors: Hutton DW,Sheehan P

    更新日期:2011-04-01 00:00:00

  • Effects of pH-neutral, super-oxidised solution on human dermal fibroblasts in vitro.

    abstract::For the past 20 years, super-oxidised solutions (SOSs) have been shown to be potent antimicrobials and disinfectants via oxidative damage. However, the potential toxicity of SOSs on eukaryotic cells has not been documented in vitro. This is relevant because oxygen and chlorine reactive species may possibly induce agei...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2007.00331.x

    authors: González-Espinosa D,Pérez-Romano L,Guzmán-Soriano B,Arias E,Bongiovanni CM,Gutiérrez AA

    更新日期:2007-09-01 00:00:00

  • Porcine acellular dermal matrix (PADM) vascularises after exposure in open necrotic wounds seen after complex hernia repair.

    abstract::Biological alternatives to synthetic meshes are increasingly utilised in complex abdominal wall reconstruction. There is a lack of evidence demonstrating that non-cross-linked porcine acellular dermal matrix vascularizes and integrates with human tissue in suboptimal wound conditions. We aimed to evaluate these proper...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12558

    authors: Gowda AU,Chang SM,Chopra K,Matthews JA,Sabino J,Stromberg JA,Zahiri HR,Pinczewski J,Holton LH 3rd,Silverman RP,Singh DP

    更新日期:2016-10-01 00:00:00

  • Bacterial inhibition efficiency of prilocaine and bupivacaine.

    abstract::This study aimed to demonstrate the antibacterial effects of bupivacaine and prilocaine on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. In our study, the in vitro antimicrobial effects of 20 mg/mL prilocaine and 5 mg/mL bupivacaine were tested against a S. aureus American-type culture collectio...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.13180

    authors: Kesici S,Demirci M,Kesici U

    更新日期:2019-10-01 00:00:00

  • Implementation of a successful electronic wound documentation system in rural Victoria, Australia: a subject of collaboration and community engagement.

    abstract::To describe the steps needed for a successful implementation of an e-health programme (the Mobile Wound Care system) in rural Victoria, Australia and to provide recommendations for future e-health initiatives. Wound care is a major burden on the health care system. Optimal wound care was found to be impeded by issues ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12041

    authors: Khalil H,Cullen M,Chambers H,Steers N,Walker J

    更新日期:2014-06-01 00:00:00

  • The nested graft acts by inducing the process of de-senescence of the fibroblasts in chronic venous ulcers.

    abstract::Senescent fibroblasts, which are present in chronic ulcers, are the reason for the wound becoming chronic. In this study, we introduce full-thickness micro skin grafts in the ulcer, a surgical technique known as a 'nested graft', which gave encouraging results leading to complete wound healing in all patients. The ass...

    journal_title:International wound journal

    pub_type: 杂志文章,评审

    doi:10.1111/iwj.12415

    authors: Gualdi G,Crotti S,Monari P,Calzavara-Pinton P,Vitali M,Baronio M,Lougaris V

    更新日期:2016-12-01 00:00:00

  • The impact of providing product funding for compression bandaging and medical footwear on compression use, wound healing and quality of life.

    abstract::A study conducted in an Australian home nursing service sought to ascertain whether the provision of funding for compression bandaging and medical footwear would impact on compression therapy use, wound healing and quality of life (QoL) among people with venous leg ulcers. Clients (n = 120) were randomly allocated to ...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1742-481X.2011.00908.x

    authors: Kapp S,Miller C,Elder K

    更新日期:2012-10-01 00:00:00

  • An unusual lesion on the chest wall.

    abstract::Osteoradionecrosis is an exceptional complication after the treatment of breast carcinoma. We report here a 63-year-old woman who presented with osteoradionecrosis of the sternum 17 years after initial treatment for breast cancer. Difficulty in diagnosing the lesion and its management is discussed. ...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-4801.2004.00037.x

    authors: Pandey M,Chandramohan KN,Mathew A

    更新日期:2004-06-01 00:00:00

  • A simple concept for covering pressure sores: wound edge-based propeller perforator flap.

    abstract::We present a new surgical modification to allow propeller perforator flaps to cover pressure sores at various locations. We used a propeller perforator flap concept based on the detection of newly formed perforator vessels located 1 cm from the wound margin and stimulated by the chronic inflammation process. Between J...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12783

    authors: Kelahmetoglu O,Van Landuyt K,Yagmur C,Sommeling CE,Keles MK,Tayfur V,Simsek T,Demirtas Y,Guneren E

    更新日期:2017-12-01 00:00:00

  • Bacteriotherapy with Lactobacillus plantarum in burns.

    abstract::Bacterial colonisation and infection remain the major causes of delayed healing and graft rejection following burns. Topical treatment is necessary to reduce the incidence of burn wound infection. Silver sulphadiazine (SD-Ag) is an often used microbicidal agent. However, this treatment produces adverse reactions and s...

    journal_title:International wound journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1742-481X.2008.00577.x

    authors: Peral MC,Martinez MA,Valdez JC

    更新日期:2009-02-01 00:00:00

  • The operative treatment of pressure wounds: a 10-year experience in flap selection.

    abstract::This study sought to both assist in the selection of flaps for ischial pressure wound re-construction and to evaluate the overall complication rates associated with re-construction. A retrospective medical record review was conducted for 78 patients following the surgical re-construction of an ischial pressure sore. R...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/j.1742-481X.2010.00662.x

    authors: Ahluwalia R,Martin D,Mahoney JL

    更新日期:2010-04-01 00:00:00

  • Effective management of patients with diabetes foot ulcers: outcomes of an Interprofessional Diabetes Foot Ulcer Team.

    abstract::A longitudinal observational study on a convenience sample was conducted between 4 January and 31 December of 2010 to evaluate clinical outcomes that occur when a new Interprofessional Diabetes Foot Ulcer Team (IPDFUT) helps in the management of diabetes-related foot ulcers (DFUs) in patients living in a small urban c...

    journal_title:International wound journal

    pub_type: 杂志文章

    doi:10.1111/iwj.12119

    authors: Ogrin R,Houghton PE,Thompson GW

    更新日期:2015-08-01 00:00:00