Abstract:
:Carbonic anhydrase (CA) is a thoroughly studied enzyme. Its primary role is the rapid interconversion of carbon dioxide and bicarbonate in the cells, where carbon dioxide is produced, and in the lungs, where it is released from the blood. At the same time, it regulates pH homeostasis. The inhibitory function of sulfonamides on CA was discovered some 80 years ago. There are numerous physiological-therapeutic conditions in which inhibitors of carbonic anhydrase have a positive effect, such as glaucoma, or act as diuretics. With the realization that several isoenzymes of carbonic anhydrase are associated with the development of several types of cancer, such as brain and breast cancer, the development of inhibitor drugs specific to those enzyme forms has exploded. We would like to highlight the breadth of research on the enzyme as well as draw the attention to some problems in recent published work on inhibitor discovery.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Jonsson BH,Liljas Adoi
10.1016/j.bpj.2020.08.020subject
Has Abstractpub_date
2020-10-06 00:00:00pages
1275-1280issue
7eissn
0006-3495issn
1542-0086pii
S0006-3495(20)30668-8journal_volume
119pub_type
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