Abstract:
:Bases, nucleosides, nucleotides, and polynucleotides were exposed to chemically generated singlet oxygen to determine whether the species oxidized paralleled those oxidized in photodynamic reactions. In neutral or basic aqueous solution guanine, guanosine, deoxyguanosine, guanylic acid, deoxyguanylic acid, thymine, and uracil reacted with singlet oxygen. Since these compounds are oxidized in photodynamic processes, this study provides further evidence that singlet oxygen is the active intermediate in the photodynamic oxidation of nucleic acid constituents. Dienophilic attack by singlet oxygen is considered to be a plausible mechanism in these reactions.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Hallett FR,Hallett BP,Snipes Wdoi
10.1016/S0006-3495(70)86303-2subject
Has Abstractpub_date
1970-04-01 00:00:00pages
305-15issue
4eissn
0006-3495issn
1542-0086pii
S0006-3495(70)86303-2journal_volume
10pub_type
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