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Identification of CTX-M beta-lactamases in Escherichia coli from hospitalized patients and residents of long-term care facilities.

Abstract：

:Bacteria harboring CTX-M extended-spectrum beta-lactamases (ESBLs) have been identified worldwide, with most reports coming from regions outside North America. We have identified CTX-M enzymes in 31% of ESBL-positive Escherichia coli isolates from our hospital and more than half (53%) of the isolates from associated long-term care facilities. Approximately 3/4 of all CTX-M-bearing isolates were from urine specimens, with a predominance of CTX-M-15. A large proportion of such isolates were nonsusceptible to levofloxacin, trimethoprim/sulfamethoxazole, and all beta-lactam antimicrobials with the exception of the carbapenems, requiring carbapenem therapy for acute urinary tract infection or urinary tract-related sepsis. CTX-M beta-lactamases have emerged within our location, and detection of bacteria harboring these enzymes in the clinical microbiology laboratory remains problematic because molecular methods are needed for their identification.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Urban C,Mariano N,Bradford PA,Tuckman M,Segal-Maurer S,Wehbeh W,Grenner L,Colon-Urban R,Johnston B,Johnson JR,Rahal JJ

doi

10.1016/j.diagmicrobio.2009.11.012

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

402-6

issue

4

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(09)00474-X

journal_volume

66

pub_type

杂志文章

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