Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density.

Abstract:

:The impact of accessory gene regulator (agr) dysfunction and high bacterial density on vancomycin killing and resistance was evaluated among 10 clinical methicillin-resistant Staphylococcus aureus bloodstream isolates using time kill experiments. Under conditions of high inocula and agr dysfunction, vancomycin activity was markedly attenuated, amplifying resistant mutants by 72 h.

authors

Tsuji BT,Harigaya Y,Lesse AJ,Sakoulas G,Mylotte JM

doi

10.1016/j.diagmicrobio.2009.01.028

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

220-4

issue

2

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(09)00049-2

journal_volume

64

pub_type

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