Abstract：
:Nocardiosis occurs in both immunocompromised and immunocompetent patients. We aimed to assess how its characteristics differ depending on patients' immune status. Of a total of 54 patients with culture-proven nocardiosis diagnosed over 13 years, 18 (33%) were immunocompetent. Half of immunocompetent patients had chronic lung disease and were not receiving systemic corticosteroid. There were no significant differences in clinical, radiographic, and microbiologic characteristics, and treatment outcomes according to immune status, except that pulmonary cavitation (47% vs. 8%) and coexisting infections (17% vs. 0%) were more frequent in immunocompromised hosts. Nocardia farcinica, the most commonly identified isolates at the species level (51%), was highly susceptible to trimethoprim-sulfamethoxazole (100%) and highly resistant to ceftriaxone (94%). Nocardiosis should be considered in differential diagnosis of pneumonia, brain abscess, or soft tissue infection that does not respond to conventional antibiotic therapy such as ceftriaxone, regardless of whether the patient is immunocompromised or not.
journal_name
Diagn Microbiol Infect Disjournal_title
Diagnostic microbiology and infectious diseaseauthors
Kim YK,Sung H,Jung J,Yu SN,Lee JY,Kim SH,Choi SH,Kim YS,Woo JH,Lee SO,Chong YPdoi
10.1016/j.diagmicrobio.2016.05.004subject
Has Abstractpub_date
2016-08-01 00:00:00pages
482-7issue
4eissn
0732-8893issn
1879-0070pii
S0732-8893(16)30126-2journal_volume
85pub_type
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journal_title：Diagnostic microbiology and infectious disease
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