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Susceptibility of clinical isolates of Candida spp. to terconazole and other azole antifungal agents.

Abstract：

:Terconazole is a triazole ketal derivative with potent, broad-spectrum antifungal activity. We investigated the in vitro activity of terconazole, miconazole, and clotrimazole, against 94 clinical isolates of Candida spp.: C. albicans (n = 68), C. tropicalis (n = 18), and C. parapsilosis (n = 8). In vitro susceptibility testing was performed using a broth microdilution method. The minimal inhibitory concentrations of terconazole were less than those of miconazole against C. albicans and C. parapsilosis but higher against C. tropicalis. Terconazole was more active than clotrimazole against C. parapsilosis and less active against C. albicans and C. tropicalis. Terconazole inhibited the uptake of 14C-labeled glucose, leucine, and hypoxanthine into C. albicans and caused the rapid release of intracellular K+. Based on these studies, terconazole has promising anticandidal activity and warrants further in vitro and in vivo investigation.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Pfaller MA,Gerarden T

doi

10.1016/0732-8893(89)90079-5

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

467-71

issue

6

eissn

0732-8893

issn

1879-0070

pii

0732-8893(89)90079-5

journal_volume

12

pub_type

杂志文章

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