Oral ofloxacin for infections caused by bacteria resistant to oral antimicrobial agents.


:We conducted an open trial of oral ofloxacin, 400 mg q 12 hr, in the treatment of infections caused by Pseudomonas aeruginosa and other bacteria resistant to traditional oral antibiotics. There were 53 evaluable subjects, 30 having infection of the skin/skin structure, 13 of the respiratory tract, six of bone, and four complicated infections of the genitourinary tract. Most subjects (72%) had previously failed a course of antibiotic therapy for their infections. Ofloxacin therapy was administered an average of 45 days per patient, and was well tolerated. Clinical success was observed in 40 (74%) subjects, with failure in 13 (26%). Responses ranged from 50% success for six lower respiratory tract infections to 100% success for six cases of osteomyelitis. There were 28 P. aeruginosa with 22 Gram-positive and 24 other Gram-negative infections. Of 28 cases in which P. aeruginosa was implicated as a pathogen, 19 (68%) were successfully treated with ofloxacin therapy. Overall, 63 (85%) of 74 pathogens were eradicated. Of the 11 persistent organisms, five were P. aeruginosa in which resistance to ofloxacin emerged during therapy. Our data imply ofloxacin to be effective for infections due to ofloxacin-susceptible organisms other than P. aeruginosa; for this pathogen, ofloxacin therapy is associated with a high degree of failure. If ofloxacin is used for infection due to P. aeruginosa, microbiologic surveillance is necessary for cases that either fail to respond or relapse clinically.


Eron LJ,Gentry LO




Has Abstract


1992-07-01 00:00:00














  • Loop-mediated isothermal amplification (LAMP) for the rapid detection of Mycoplasma genitalium.

    abstract::Mycoplasma genitalium is a sexually transmissible, pathogenic bacterium and a significant cause of nongonococcal urethritis in both men and women. Due to the difficulty of the culture of M. genitalium from clinical samples, the laboratory diagnosis of M. genitalium infection is almost exclusively carried out using nuc...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Edwards T,Burke P,Smalley HB,Gillies L,Longhurst D,Vipond B,Hobbs G

    更新日期:2015-09-01 00:00:00

  • Use of cerebrospinal fluid shunt for the management of elevated intracranial pressure in a patient with active AIDS-related cryptococcal meningitis.

    abstract::Persistently elevated intracranial pressure (ICP) is one of the most accurate predictors of a poor prognosis in patients with AIDS-related cryptococcal meningitis. We present a severe case of persistent cryptococcal meningitis in a patient with advanced AIDS, complicated by elevation of ICP. A ventriculoperitoneal shu...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Mylonakis E,Merriman NA,Rich JD,Flanigan TP,Walters BC,Tashima KT,Mileno MD,van der Horst CM

    更新日期:1999-06-01 00:00:00

  • Treatment of non-life-threatening methicillin-resistant Staphylococcus aureus infections with alternative antimicrobial agents: a 2-year retrospective review.

    abstract::The emergence of methicillin-resistant Staphylococcus aureus (MRSA) infections has created a need for additional antimicrobial options. Patients at the Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, who received alternative (nonvancomycin, nonlinezolid) therapy for MRSA infections from January 2004 to D...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Drekonja DM,Traynor LM,DeCarolis DD,Crossley KB,Johnson JR

    更新日期:2009-02-01 00:00:00

  • Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii.

    abstract::At 24 h, sub-MIC doripenem and levofloxacin showed synergy against 21 of 25 Pseudomonas aeruginosa strains, sub-MIC doripenem and amikacin against 22 isolates, and sub-MIC doripenem and colistin against 19 isolates. Of 25 Acinetobacter baumannii strains, sub-MIC doripenem and levofloxacin showed synergy against 11 str...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Pankuch GA,Seifert H,Appelbaum PC

    更新日期:2010-06-01 00:00:00

  • Diagnostic performance of a new automated heterophile antibody test in adults and children.

    abstract::Epstein-Barr virus serologic profiles were obtained from 618 patients using an automated platform, including the new BioPlex heterophile assay. When compared with 2 IgM viral capsid antigen (VCA) assays and a predicate heterophile assay, the BioPlex heterophile assay was more likely to be associated with serologic pat...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Klutts JS,Wu AH,Smith A,Yen-Lieberman B,Gronowski AM

    更新日期:2008-07-01 00:00:00

  • Molecular epidemiology of KPC-2-producing Enterobacteriaceae (non-Klebsiella pneumoniae) isolated from Brazil.

    abstract::In Brazil, since 2009, there has been an ever increasing widespread of the bla(KPC-2) gene, mainly in Klebsiella pneumoniae. This study aims to assess the molecular epidemiology and genetic background of this gene in Enterobacteriaceae (non-K. pneumoniae) species from 9 Brazilian states between 2009 and 2011. Three hu...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Tavares CP,Pereira PS,Marques Ede A,Faria C Jr,de Souza Mda P,de Almeida R,Alves Cde F,Asensi MD,Carvalho-Assef AP

    更新日期:2015-08-01 00:00:00

  • Mycetoma of the scalp due to Microsporum canis: hystopathologic, mycologic, and immunogenetic features in a 6-year-old girl.

    abstract::Dermatophytic mycetoma is an extremely rare subcutaneous mycosis. Here, we report the case of a 6-year-old girl with clinical, histologic, and mycologic findings consistent with a mycetoma of the scalp caused by Microsporum canis. To our knowledge, this is the first report showing the immunologic and immunogenetic fea...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Chiapello LS,Dib MD,Nuncira CT,Nardelli L,Vullo C,Collino C,Abiega C,Cortes PR,Spesso MF,Masih DT

    更新日期:2011-05-01 00:00:00

  • The E-Test as an epidemiologic tool.

    abstract::A comparison was made of the discriminating power of the E-Test and conventional methods to distinguish different bacterial strains harboring plasmid-mediated extended-spectrum beta-lactamases. The E-Test provided quantitative data comparable to those of a broad range of concentrations in the agar dilution method, but...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Baquero F,Cantón R,Martinez-Beltrán J,Bolmström A

    更新日期:1992-07-01 00:00:00

  • Comparison of Gram and Kopeloff stains in the diagnosis of bacterial vaginosis in pregnancy.

    abstract::Bacterial vaginosis (BV) is commonly diagnosed by using the Nugent score, a semiquantitative scoring system to evaluate bacterial morphotypes on Gram stain of vaginal secretions. Some authors have suggested using the Kopeloff modification of the Gram stain. Asymptomatic BV in pregnancy has been associated with adverse...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Libman MD,Kramer M,Platt R,Montreal Prematurity Study Group.

    更新日期:2006-03-01 00:00:00

  • Bartonella quintana-induced apoptosis inhibition of human endothelial cells is associated with p38 and SAPK/JNK modulation and with stimulation of mitosis.

    abstract::Previous studies demonstrated that live Bartonella quintana often induces angioproliferative lesions in humans. It modulates endothelial cell apoptotic and inflammatory patterns, thus inducing a very early overexpression of caspase 8 and Apaf-1 and increasing mRNA production of TNF-alpha, interleukin-8, and E-selectin...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Liberto MC,Matera G,Lamberti AG,Barreca GS,Focà D,Quirino A,Soria MR,Focà A

    更新日期:2004-11-01 00:00:00

  • Comparison of a conventional and nested PCR for diagnostic confirmation and genotyping of Orientia tsutsugamushi.

    abstract::A nested polymerase chain reaction (PCR) targeting the 56-kDa antigen gene is currently the most commonly used molecular technique for confirmation of scrub typhus and genotyping of Orientia tsutsugamushi. In this study, we have compared the commonly used nested PCR (N-PCR) with a single-step conventional PCR (C-PCR) ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Janardhanan J,Prakash JA,Abraham OC,Varghese GM

    更新日期:2014-05-01 00:00:00

  • Effect of 10 minutes heat treatment on HIV antibody testing from alternate testing sites.

    abstract::One hundred and thirty-five sera were tested for the presence of antibody to human immunodeficiency virus (HIV) by enzyme immunoassay (EIA) with the Abbott Diagnostics HTLV-III test before and after heating at 56 degrees C for 10 min. Only one serum specimen was repeatedly reactive after heating when compared with the...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Markowski MA,Coard JG,Griffith B,Mayo DR

    更新日期:1988-04-01 00:00:00

  • Differentiation of Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides and Haemophilus species in gram-stained direct smears.

    abstract::The accuracy of examination of the Gram-stained direct smear to classify presumptively Gram-negative rods into three morphotype groups, that is, (a) Enteric bacteria, (b) Pseudomonas, and (c) Bacteroides or Haemophilus, was evaluated. Randomly selected clinical strains (4-9) each of Escherichia coli, Klebsiella pneumo...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Bartlett RC,Mazens-Sullivan MF,Lerer TJ

    更新日期:1991-05-01 00:00:00

  • Clinically expedient reporting of rapid diagnostic test information.

    abstract::With the development of rapid diagnostic tests in the clinical microbiology laboratory has come an awareness of the importance of rapid results reporting. Clearly, the potential clinical impact of rapid diagnostic tests is dependent on expeditious reporting. Traditional manual reporting systems are encumbered by the n...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Doern GV

    更新日期:1986-03-01 00:00:00

  • Impact of AmpC overexpression on outcomes of patients with Pseudomonas aeruginosa bacteremia.

    abstract::AmpC overexpression (AmpC++) is a significant mechanism of beta-lactam resistance in Pseudomonas aeruginosa, but its impact on clinical outcomes is not well established. To examine the influence of AmpC++ on clinical outcomes of patients with P. aeruginosa bacteremia, we screened all bloodstream P. aeruginosa isolates...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Tam VH,Chang KT,Schilling AN,LaRocco MT,Genty LO,Garey KW

    更新日期:2009-03-01 00:00:00

  • Evaluation of a new real-time reverse transcription polymerase chain reaction assay for detection of norovirus in fecal specimens.

    abstract::A new real-time reverse transcription polymerase chain reaction (RT-PCR) assay, the AccuPower Norovirus Real-time RT-PCR Kit, was evaluated in detection of human norovirus in stool specimens. Studies for detection limit, dynamic range, reproducibility, and cross-reactivity were performed. A total of 281 fecal specimen...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Hyun J,Kim HS,Kim HS,Lee KM

    更新日期:2014-01-01 00:00:00

  • Pharmacodynamic profiling of cefepime in plasma and cerebrospinal fluid of hospitalized patients with external ventriculostomies.

    abstract::Population pharmacokinetic (PK) modeling and Monte Carlo simulation (MCS) were used to describe the pharmacodynamic profile of cefepime in the both plasma and cerebrospinal fluid (CSF). Plasma and CSF cefepime data were obtained from a PK study of 7 hospitalized patients with external ventricular drains. Concentration...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Lodise TP Jr,Rhoney DH,Tam VH,McKinnon PS,Drusano GL

    更新日期:2006-03-01 00:00:00

  • Serological response to plasmid-encoded antigens in children and adults with shigellosis.

    abstract::The immunological response to plasmid-encoded antigens of virulent Shigella was determined in Thai children less than 4 yr of age and in Thai adults by immunoblot analysis and ELISA. Forty-two percent (8/19) of Thai children and 4% (1/22) of Thai adults with shigellosis developed a greater than or equal to 4-fold rise...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Echeverria P,Hanchalay S,Taylor DN

    更新日期:1988-06-01 00:00:00

  • Comparison of the microbiological characteristics and virulence factors of ST131 and non-ST131 clones among extended-spectrum β-lactamase-producing Escherichia coli causing bacteremia.

    abstract::We evaluated the molecular epidemiology and microbiological characteristics of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) isolates that cause bacteremia in Korean hospitals, focusing especially on ST131. Our data suggest that ST131 isolates possessed more virulence traits and showed more multid...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章,多中心研究


    authors: Cha MK,Kang CI,Kim SH,Cho SY,Ha YE,Wi YM,Chung DR,Peck KR,Song JH,Korean Network for Study on Infectious Diseases (KONSID).

    更新日期:2016-02-01 00:00:00

  • Multi-laboratory evaluation of the rapid genoserotyping array (SGSA) for the identification of Salmonella serovars.

    abstract::Salmonella serotyping is an essential first step for identification of isolates associated with disease outbreaks. The Salmonella genoserotyping array (SGSA) is a microarray-based alternative to standard serotyping designed to rapidly identify 57 of the most commonly reported serovars through detection of the genes en...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Yoshida C,Lingohr EJ,Trognitz F,MacLaren N,Rosano A,Murphy SA,Villegas A,Polt M,Franklin K,Kostic T,OIE Reference Laboratory for Salmonellosis.,Austrian Agency for Health and Food Safety.,Kropinski AM,Card RM

    更新日期:2014-11-01 00:00:00

  • The isolation of nonpolio enteroviruses from serum.

    abstract::Enteroviruses were isolated from 14 of 31 frozen serum specimens obtained from hospitalized patients with enterovirus infection, which had been previously documented by recovery of virus from stool, throat, or cerebrospinal fluid (CSF). Virus was detected in 71% of the positive sera within 3 days of specimen inoculati...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Prather SL,Jenista JA,Menegus MA

    更新日期:1984-09-01 00:00:00

  • Assessment of ceftaroline fosamil in the treatment of community-acquired bacterial pneumonia due to Streptococcus pneumoniae: insights from two randomized trials.

    abstract::Ceftaroline fosamil resulted in higher cure rates than ceftriaxone in patients with community-acquired bacterial pneumonia in 2 randomized trials (FOCUS 1 and FOCUS 2). The present analysis examines the subgroup of patients with Streptococcus pneumoniae infection to determine whether the apparent difference in cure ra...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Shorr AF,Kollef M,Eckburg PB,Llorens L,Friedland HD

    更新日期:2013-03-01 00:00:00

  • Leukocytoclastic vasculitis complicating Klebsiella pneumoniae bacteremia.

    abstract::A 79-year old woman, with a history of hypertension, presented with clinical features of congestive heart failure, fever, a purpuric rash, and left lower quadrant abdominal tenderness. Contrast computed tomography scan of the abdomen showed features of acute diverticulitis, and blood culture was subsequently positive ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Lum PN,Woo PC,Wong SS,Yuen K

    更新日期:2000-08-01 00:00:00

  • Rapid urine antigen testing for Streptococcus pneumoniae in adults with community-acquired pneumonia: clinical use and barriers.

    abstract::Streptococcus pneumoniae (pneumococcus) is the most common bacterial etiology of community-acquired pneumonia (CAP) in adults, a leading cause of death. The majority of pneumococcal CAP is diagnosed by blood culture, which likely underestimates the burden of disease. The 2007 CAP guidelines recommend routine use of th...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Harris AM,Beekmann SE,Polgreen PM,Moore MR

    更新日期:2014-08-01 00:00:00

  • Antifungal susceptibility of 1000 Candida bloodstream isolates to 5 antifungal drugs: results of a multicenter study conducted in São Paulo, Brazil, 1995-2003.

    abstract::We evaluated all Candida sp. bloodstream isolates obtained from patients admitted to 4 tertiary care hospitals between 1995 and 2003 in the city of São Paulo, Brazil. Susceptibility to amphotericin B, 5-fluorocytosine, fluconazole (FCZ), itraconazole (ITZ), and voriconazole (VCZ) was determined using the Clinical Labo...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章,多中心研究


    authors: da Matta DA,de Almeida LP,Machado AM,Azevedo AC,Kusano EJ,Travassos NF,Salomão R,Colombo AL

    更新日期:2007-04-01 00:00:00

  • Relevance of autoantibody detection to the rapid diagnosis of brucellosis.

    abstract::The rose bengal test is often used for rapid diagnosis of human brucellosis in endemic areas. However, autoantibodies have never been investigated as a reason for false-positive or false-negative results. Therefore, the aim of this study was to show the effect of autoantibody detection on the rapid diagnosis of human ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Yumuk Z,Afacan G,Calişkan S,Irvem A,Arslan U

    更新日期:2007-07-01 00:00:00

  • Susceptibility of multiply resistant Haemophilus influenzae to newer antimicrobial agents.

    abstract::One hundred and six isolates of Haemophilus influenzae from a national antimicrobial surveillance study demonstrated resistance to two or more of 10 primary antimicrobial agents by mechanisms other than or in addition to beta-lactamase. Of particular note were strains multiply resistant to ampicillin (by beta-lactamas...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Jorgensen JH,Doern GV,Thornsberry C,Preston DA,Redding JS,Maher LA,Tubert T

    更新日期:1988-01-01 00:00:00

  • Trends in frequency and susceptibilities of Candida glabrata bloodstream isolates at a university hospital.

    abstract::The frequency of isolation and antifungal susceptibility patterns to fluconazole and itraconazole were determined for 166 Candida glabrata isolates causing bloodstream infection at a single institution from 1995-2000. Findings demonstrated a trend of increasing resistance to itraconazole among the isolates, but no tre...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Baddley JW,Smith AM,Moser SA,Pappas PG

    更新日期:2001-03-01 00:00:00

  • A cocktail of affinity-purified antibodies reactive with diagnostically useful mycobacterial antigens ES-31, ES-43, and EST-6 for detecting the presence of Mycobacterium tuberculosis.

    abstract::A cocktail of affinity-purified antibodies against diagnostically useful Mycobacterium tuberculosis H37Ra excretory-secretory protein antigens ES-31, ES-43, and EST-6 was explored for detection of circulating free and immune-complexed (IC) antigen in sera of patients with confirmed tuberculosis (TB) by sandwich enzyme...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Harinath BC,Kumar S,Roy SS,Hirudkar S,Upadhye V,Shende N

    更新日期:2006-05-01 00:00:00

  • Susceptibility of clinical isolates of Candida spp. to terconazole and other azole antifungal agents.

    abstract::Terconazole is a triazole ketal derivative with potent, broad-spectrum antifungal activity. We investigated the in vitro activity of terconazole, miconazole, and clotrimazole, against 94 clinical isolates of Candida spp.: C. albicans (n = 68), C. tropicalis (n = 18), and C. parapsilosis (n = 8). In vitro susceptibilit...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Pfaller MA,Gerarden T

    更新日期:1989-11-01 00:00:00