Oral beta-lactams in the treatment of acute bacterial rhinosinusitis.

Abstract:

:Acute bacterial rhinosinusitis (ABRS) is a well-known complication of viral upper respiratory tract infection and is associated with a significant socioeconomic burden. Difficulties in diagnosis, a substantial spontaneous resolution rate, and growing concerns regarding antimicrobial resistance make the proper management of ABRS quite challenging. Treatment guidelines have been developed, taking into account the major bacterial pathogens, rates of antimicrobial resistance, spontaneous resolution rates, and pharmacokinetic and pharmacodynamic considerations. Optimal choices for initial treatment of ABRS in patients without prior antibacterial exposure include the oral beta-lactam agents amoxicillin/clavulanate, cefdinir, cefpodoxime, and cefuroxime. Clinicians are encouraged to consider the local pathogen distribution and rates of antibacterial resistance in selecting therapy for ABRS.

authors

Hadley JA,Pfaller MA

doi

10.1016/j.diagmicrobio.2006.11.018

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

47S-54S

issue

3 Suppl

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(06)00474-3

journal_volume

57

pub_type

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