Abstract:
:Zinc is an essential trace element required for bone formation, however not much has been clarified yet for its role in osteoblast. We hypothesized that zinc would increase osteogenetic function in osteoblasts. To test this, we investigated whether zinc treatment enhances bone formation by stimulating osteoblast proliferation, bone marker protein alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells. MC3T3-E1 cells were cultured and treated with various concentrations of zinc (0, 1, 3, 15, 25 uM) along with a normal osteogenic medium (OSM) as control for 1, 5, 10 days. As measured by MTT assay for mitochondrial metabolic activity, cell proliferation was stimulated even at low zinc treatment (1-3 µM) compared to OSM, and it was stimulated in a zinc concentration-dependent manner during 5 and 10 days, with the most pronounced effect at 15 and 25 uM Zn. Cellular (synthesized) alkaline phosphatase (ALP) activity was increased in a zinc concentration-dependent manner, so did medium (secreted) ALP activity. Cellular collagen concentration was increased by zinc as time went by, therefore with the maximum zinc stimulatory effect in 10 days, and medium collagen concentration showed the same pattern even on 1 and 5 day. This zinc stimulatory effect of collagen synthesis was observed in cell matrix collagen staining. The study results imply that zinc can increase osteogenic effect by stimulating cell proliferation, ALP activity and collagen synthesis in osteoblastic cells.
journal_name
Nutr Res Practjournal_title
Nutrition research and practiceauthors
Seo HJ,Cho YE,Kim T,Shin HI,Kwun ISdoi
10.4162/nrp.2010.4.5.356subject
Has Abstractpub_date
2010-10-01 00:00:00pages
356-61issue
5eissn
1976-1457issn
2005-6168journal_volume
4pub_type
杂志文章abstract:BACKGROUND/OBJECTIVE:It is expected that dairy products such as cheeses, which are the main source of cholesterol and saturated fat, may lead to the development or increase the risk of cardiovascular and metabolic diseases; however, the results of different studies are inconsistent. This study was conducted to assess t...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.3.336
更新日期:2014-06-01 00:00:00
abstract::Leaf of Sasa borealis, a species of bamboo, has been reported to exhibit anti-hyperglycemic effect. However, its antidiabetic mechanism is not fully understood. In this study, we examined whether an extract of S. borealis activates AMP-activated protein kinase (AMPK) and exerts anti-hyperglycemic effects. Treatment wi...
journal_title:Nutrition research and practice
pub_type: 杂志文章,收录出版
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journal_title:Nutrition research and practice
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更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:We examined dietary fat intake and the major food sources by young children in Korea. SUBJECTS/METHODS:A total of 1,041 children aged 1-5 years were identified from the 2013-2015 Korea National Health and Nutrition Examination Survey. Data on total fat and fatty acid intake were obtained by a sin...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.4.324
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Carnosic acid (CA), found in rosemary (Rosemarinus officinalis) leaves, is known to exhibit anti-obesity and anti-inflammatory activities. However, whether its anti-inflammatory potency can contribute to the amelioration of obesity has not been elucidated. The aim of the current study was to inves...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.5.516
更新日期:2014-10-01 00:00:00
abstract::Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was me...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.6.505
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Malnutrition has multiple impacts on surgical success, postoperative complications, duration of hospital stay, and costs, particularly for cancer patients. There are various nutrition risk screening tools available for clinical use. Herein, we aim to determine the most appropriate nutritional risk...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2020.14.1.20
更新日期:2020-02-01 00:00:00
abstract::The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, 57.4 ± 13.1 yrs), anthropometric and biochemical parameters such as lipid profiles and LDL partic...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.2.120
更新日期:2012-04-01 00:00:00
abstract::Resistance training (RT) is associated with reduced risk of low grade inflammation related diseases, such as cardiovascular disease and type 2 diabetes. The majority of the data studying cytokines and exercise comes from endurance exercise. In contrast, evidence establishing a relationship between RT and inflammation ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.4.259
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Despite the importance of a low-iodine diet (LID) for thyroid cancer patients preparing for radioactive iodine (RAI) therapy, few studies have evaluated dietary intake during LID. This study evaluated the amount of dietary iodine intake and its major food sources during a typical diet and during L...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.2.167
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:This cross-sectional study assessed household food security status and determined its association with diet quality and weight status among indigenous women from the Mah Meri tribe in Peninsular Malaysia. SUBJECTS/METHODS:The Radimer/Cornell Hunger and Food Insecurity Instrument and the Malaysian...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.2.135
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Obesity-induced steatohepatitis accompanied by activated hepatic macrophages/Kupffer cells facilitates the progression of hepatic fibrinogenesis and exacerbates metabolic derangements such as insulin resistance. Heme oxyganase-1 (HO-1) modulates tissue macrophage phenotypes and thus is implicated ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.6.623
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The objective of the study was to provide useful insights into plain water intake of Korean adults according to life style, anthropometric, and dietary characteristics. SUBJECTS/METHODS:The data from the 2008-2010 Korea National Health and Nutrition Examination Survey were used. The subjects were...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.5.580
更新日期:2014-10-01 00:00:00
abstract::This study investigated the effect of physical training and oxidative stress on the antioxidative activity and on plasma lipid profile. Forty eight rats were given either a physical training or no training for 4 weeks and were then subdivided into 3 groups: before-exercise (BE); during-exercise (DE); after-exercise (A...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2007.1.1.14
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The number of diabetic patients has recently shown a rapid increase, and delayed wound healing is a major clinical complication in diabetes. In this study, the wound healing effect of Hominis placenta (HP) treatment was investigated in normal and streptozotocin-induced diabetic mice. MATERIALS/ME...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.4.404
更新日期:2014-08-01 00:00:00
abstract::Forty guinea pigs were divided into four groups and fed 0.04% cholesterol based control diet, plus 0.05% simvastatin, and statin plus 0.1% CoQ10 or 10% Ardisia Japonica Blume (AJB) leave powder for 4 weeks. Plasma total cholesterol levels decreased significantly in all groups fed the statin-containing diet compared wi...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.5.414
更新日期:2012-10-01 00:00:00
abstract::Dietary inorganic sulfur is the minor component in our diet, but some studies suggested that inorganic sulfur is maybe effective to treat cancer related illness. Therefore, this study aims to examine the effects of inorganic sulfur on cell proliferation and gene expression in MDA-MB-231 human breast cancer cells. MDA-...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.2.89
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Isoflavones are widely believed to be beneficial to human health, in relation to their antioxidant potentials. Exercise can cause an imbalance between reactive oxygen species (ROS) and antioxidants. This study was conducted in order to investigate the ability of isoflavones in amelioration of oxid...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.6.618
更新日期:2014-12-01 00:00:00
abstract::The Framingham risk score (FRS) has been used to assess the risk of a cardiovascular event and to identify patients for risk factor modifications. Therefore, the purpose of this study was to evaluate the relationship of the FRS with dietary intake and inflammatory biomarkers. We conducted a cross-sectional study of 18...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.3.246
更新日期:2012-06-01 00:00:00
abstract::The purpose of this study was to investigate the diet of children under the government-funded meal support program. The 143 children (67 boys and 76 girls) participated in this study among 4(th)-6(th) elementary school students receiving free lunches during the summer vacation of 2007 and living in Gwanak-gu, Seoul, K...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.6.515
更新日期:2010-12-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2011.5.1.73
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:This study examined the effect of nutrition labeling formats on parents' food choices for their children at different restaurant types. SUBJECTS/METHODS:An online survey was conducted with 1,980 parents of children aged 3-12 years. Participants were randomly assigned to fast food or family restau...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.3.243
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Most consumers are able to recognize allergenic foods. However, the frequency of checking such foods is reportedly low, resulting in higher prevalence of food-related allergic reactions in Korea compared to other countries. Thus, this study was performed to investigate the overall perception of al...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.4.424
更新日期:2016-08-01 00:00:00
abstract::The purpose of this study was to investigate the effect of soybean on blood glucose and lipid concentrations, and antioxidant enzyme activity in type 2 diabetes mellitus (DM) patients. We divided patients into two groups and fed them, respectively, a basal diet (control group) and a basal diet with 69 g/d of soybean (...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2008.2.3.152
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To compare five indices of adherence to the Mediterranean Diet (MD) among adults living in the Mediterranean region. SUBJECTS/METHODS:A total of 100 healthy Lebanese adults aged between 18 and 65 years. Face-to-face interviews to collect sociodemographic and medical information, to take anthropom...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2019.13.4.333
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Telomere length is a useful biomarker for determining general aging status. Some studies have reported an association between alcohol consumption and telomere length in a general population; however, it is unclear whether the alcohol flush reaction, which is an alcohol-related trait predominantly ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2017.11.4.334
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Over the past few decades, Malaysia has been experiencing an increased prevalence of overweight and obesity that threatens the health of Malaysians. Poor dietary intake is one of the major contributors to the development of obesity and many non-communicable diseases. The dietary intakes of adults ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2019.13.2.159
更新日期:2019-04-01 00:00:00
abstract::Dietary sodium intake is considered one of the major causal factors for hypertension. Thus, to control the increase of blood pressure and reduce the risk of hypertension-related clinical complications, a reduction in sodium intake is recommended. The present study aimed at determining the association of dietary sodium...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.3.192
更新日期:2013-06-01 00:00:00
abstract::The rapid rise in the incidence of obesity has emerged as one of the most pressing global public health issues in recent years. The underlying etiological causes of obesity, whether behavioral, environmental, genetic, or a combination of several of them, have not been completely elucidated. The obesity epidemic has be...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2011.5.3.253
更新日期:2011-06-01 00:00:00
abstract::The objectives of this study were to examine the association between dietary factors and underweight and overweight adult Vietnamese living in the rural areas of Vietnam. A cross-sectional study of 497 Vietnamese aged 19 to 60 years (204 males, 293 females) was conducted in rural areas of Haiphong, Vietnam. The subjec...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.3.235
更新日期:2010-06-01 00:00:00