Abstract:
BACKGROUND/OBJECTIVES:The number of diabetic patients has recently shown a rapid increase, and delayed wound healing is a major clinical complication in diabetes. In this study, the wound healing effect of Hominis placenta (HP) treatment was investigated in normal and streptozotocin-induced diabetic mice. MATERIALS/METHODS:Four full thickness wounds were created using a 4 mm biopsy punch on the dorsum. HP was injected subcutaneously at the middle region of the upper and lower wounds. Wounds were digitally photographed and wound size was measured every other day until the 14th day. Wound closure rate was analyzed using CANVAS 7SE software. Wound tissues were collected on days 2, 6, and 14 after wounding for H/E, immunohistochemistry for FGF2, and Masson's trichrome staining for collagen study. RESULTS:Significantly faster wound closure rates were observed in the HP treated group than in normal and diabetes control mice on days 6 and 8. Treatment with HP resulted in reduced localization of inflammatory cells in wounded skin at day 6 in normal mice and at day 14 in diabetic mice (P < 0.01). Expression of fibroblast growth factor (FGF) 2 showed a significant increase in the HP treated group on day 14 in both normal (P < 0.01) and diabetic mice (P < 0.05). In addition, HP treated groups showed a thicker collagen layer than no treatment groups, which was remarkable on the last day, day 14, in both normal and diabetic mice. CONCLUSIONS:Taken together, HP treatment has a beneficial effect on acceleration of cutaneous wound healing via regulation of the entire wound healing process, including inflammation, proliferation, and remodeling.
journal_name
Nutr Res Practjournal_title
Nutrition research and practiceauthors
Park JY,Lee J,Jeong M,Min S,Kim SY,Lee H,Lim Y,Park HJdoi
10.4162/nrp.2014.8.4.404subject
Has Abstractpub_date
2014-08-01 00:00:00pages
404-9issue
4eissn
1976-1457issn
2005-6168journal_volume
8pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:Overproduction of nitric oxide (NO) by the inducible nitric oxide synthase (iNOS) enzyme can cause inflammation. Cyclooxygenase-2 (COX-2) is also involved in the inflammatory response through regulation of nuclear factor-kappa B (NF-κB). Areca catechu is one of the known fruit plants of the Palmac...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.3.267
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (Samdasoo™), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, ser...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.2.165
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:It is expected that dairy products such as cheeses, which are the main source of cholesterol and saturated fat, may lead to the development or increase the risk of cardiovascular and metabolic diseases; however, the results of different studies are inconsistent. This study was conducted to assess t...
journal_title:Nutrition research and practice
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doi:10.4162/nrp.2014.8.3.336
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:A higher frequency of family meals is associated with good dietary habits in young people. This study focused on the relationships of family meal frequency with food neophobia and personality traits in adolescents. SUBJECTS/METHOD:For this purpose, we administered a survey to 495 middle school students in S...
journal_title:Nutrition research and practice
pub_type: 杂志文章
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abstract:BACKGROUND/OBJECTIVES:Folic acid supplementation before pregnancy is known to reduce the risk of neural tube defects. The purposes of this study were to investigate the awareness, knowledge, and use of folic acid supplements along with their associated factors among non-pregnant Korean women of childbearing age. SUBJE...
journal_title:Nutrition research and practice
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doi:10.4162/nrp.2018.12.1.78
更新日期:2018-02-01 00:00:00
abstract::This study was conducted to investigate nutrient consumption by Korean adults in various places. To accomplish this, we used the 1998-2009 Korea National Health and Nutrition Examination Survey (KNHANES). Subjects of this investigation were over 19 years and the study included 37,160 people. The meals were categorized...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.1.81
更新日期:2014-02-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 已发布勘误
doi:10.4162/nrp.2015.9.2.213
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abstract:BACKGROUND/OBJECTIVES:Although a lot of effort has been put into increasing fruit and vegetable intakes in preschool children, vegetable intake in this group is still low. This study investigated whether nutrition education focusing on fruit and vegetable intakes can affect preschoolers' fruit and vegetable intakes as ...
journal_title:Nutrition research and practice
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abstract:BACKGROUND/OBJECTIVES:The NAD+ precursor nicotinamide riboside (NR) is a type of vitamin B3 found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents hearing loss, high-fat diet-induced obesity, Alzheimer's disease, and mitochondrial myopathy. The objective of this s...
journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
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abstract::Synurus deltoides (Aiton) Nakai, belonging to the Compositae family, is an edible plant widely distributed in Northeast Asia. In this study, we examined the mechanisms underlying the immunomodulative effects of the ethanol extract of S. deltoides (SDE). The SDE extract strongly down-regulated the mRNA expression of th...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.1.11
更新日期:2014-02-01 00:00:00
abstract::Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was me...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.6.505
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Iron deficiency in early life is associated with developmental problems, which may persist until later in life. The question of whether iron repletion after developmental iron deficiency could restore iron homeostasis is not well characterized. In the present study, we investigated the changes of ...
journal_title:Nutrition research and practice
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abstract::The objective of this study was to evaluate the inhibitory activity of natural products, against growth of Escherichia coli (ATCC 25922) and Salmonella typhimurium (KCCM 11862). Chitosan, epigallocatechin gallate (EGCG), and garlic were used as natural bioactives for antibacterial activity. The testing method was carr...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2007.1.4.273
更新日期:2007-01-01 00:00:00
abstract::Resistance training (RT) is associated with reduced risk of low grade inflammation related diseases, such as cardiovascular disease and type 2 diabetes. The majority of the data studying cytokines and exercise comes from endurance exercise. In contrast, evidence establishing a relationship between RT and inflammation ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.4.259
更新日期:2010-08-01 00:00:00
abstract::This study was performed to investigate effects of Chlorella vulgaris on lipid metabolism in rats fed high fat diet. Sixty 6-week-old male Wistar rats were divided into two groups; normal diet group and high fat diet group, then the rats in each group were further divided into three subgroups and fed 0%, 5% and 10% (w...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2008.2.4.204
更新日期:2008-01-01 00:00:00
abstract::In Korea, chestnut production is increasing each year, but consumption is far below production. We investigated the effect of chestnut extracts on antioxidant activity and anticancer effects. Ethanol extracts of raw chestnut (RCE) or chestnut powder (CPE) had dose-dependent superoxide scavenging activity. Viable numbe...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2011.5.3.185
更新日期:2011-06-01 00:00:00
abstract::Taurine supplementation has been shown to have a beneficial effect on femur bone mineral content in ovariectomized rats. It therefore seemed desirable to find out whether the beneficial effect of taurine on ovariectomized rats fed calcium deficient diet could also be reproduced. Forty female Sprague-Dawley rats were d...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2009.3.2.108
更新日期:2009-07-01 00:00:00
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journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
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更新日期:2016-06-01 00:00:00
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journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
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更新日期:2017-06-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Nutrition research and practice
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abstract:BACKGROUND/OBJECTIVES:Despite the importance of a low-iodine diet (LID) for thyroid cancer patients preparing for radioactive iodine (RAI) therapy, few studies have evaluated dietary intake during LID. This study evaluated the amount of dietary iodine intake and its major food sources during a typical diet and during L...
journal_title:Nutrition research and practice
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更新日期:2016-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM). This study evaluated the effect of vitamin D supplementation on metabolic indices and hs-C-reactive protein (CRP) levels in GDM patients. SUBJECTS/METHODS:The study was a randomized, placebo-controlled, doub...
journal_title:Nutrition research and practice
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更新日期:2016-06-01 00:00:00
abstract::Korean raspberry, Rubus coreanus Miquel (RCM), contains high concentrations of phenolic compounds, which prevent oxidative stress. To determine the effect of RCM on antioxidant capacity in humans, we assessed in vivo lipid oxidation and antioxidant enzyme activities from plasma in 15 healthy men. The subjects ingested...
journal_title:Nutrition research and practice
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abstract::The abnormal content of blood lipids often results in metabolic diseases, such as hyperlipidemia and obesity. Many agents, including natural sources from traditional food, have been developed to regulate the blood lipid contents. In this study, we examined the anti-hyperlipidemic activity of Rhynchosia nulubilis seeds...
journal_title:Nutrition research and practice
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abstract::This study investigated the effect of physical training and oxidative stress on the antioxidative activity and on plasma lipid profile. Forty eight rats were given either a physical training or no training for 4 weeks and were then subdivided into 3 groups: before-exercise (BE); during-exercise (DE); after-exercise (A...
journal_title:Nutrition research and practice
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
abstract::Dietary inorganic sulfur is the minor component in our diet, but some studies suggested that inorganic sulfur is maybe effective to treat cancer related illness. Therefore, this study aims to examine the effects of inorganic sulfur on cell proliferation and gene expression in MDA-MB-231 human breast cancer cells. MDA-...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.2.89
更新日期:2013-04-01 00:00:00