Sasa borealis extract exerts an antidiabetic effect via activation of the AMP-activated protein kinase.

Abstract:

:Leaf of Sasa borealis, a species of bamboo, has been reported to exhibit anti-hyperglycemic effect. However, its antidiabetic mechanism is not fully understood. In this study, we examined whether an extract of S. borealis activates AMP-activated protein kinase (AMPK) and exerts anti-hyperglycemic effects. Treatment with the S. borealis extract increased insulin signaling and phosphorylation of AMPK and stimulated the expression of its downstream targets, including PPARα, ACO, and CPT-1 in C2C12 cells and PPARα in HepG2 cells. However, inhibition of AMPK activation attenuated insulin signaling and prevented the stimulation of AMPK target genes. The S. borealis extract increased glucose uptake in C2C12 cells and suppressed expression of the gluconeogenic gene, PEPCK in HepG2 cells. The extract significantly reduced blood glucose and triglyceride levels in STZ-induced diabetic mice. The extract enhanced AMPK phosphorylation and increased Glut-4 expression in the skeletal muscle of the mice. These findings demonstrated that the S. borealis extract exerts its anti-hyperglycemic effect through activation of AMPK and enhancement of insulin signaling.

journal_name

Nutr Res Pract

authors

Nam JS,Chung HJ,Jang MK,Jung IA,Park SH,Cho SI,Jung MH

doi

10.4162/nrp.2013.7.1.15

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

15-21

issue

1

eissn

1976-1457

issn

2005-6168

journal_volume

7

pub_type

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