Abstract:
BACKGROUND/OBJECTIVES:Carnosic acid (CA), found in rosemary (Rosemarinus officinalis) leaves, is known to exhibit anti-obesity and anti-inflammatory activities. However, whether its anti-inflammatory potency can contribute to the amelioration of obesity has not been elucidated. The aim of the current study was to investigate the effect of CA on Toll-like receptor 4 (TLR4) pathways in the presence of lipopolysaccharide (LPS) in 3T3-L1 adipocytes. MATERIALS/METHODS:3T3-L1 adipocytes were treated with CA (0-20 µM) for 1 h, followed by treatment with LPS for 30 min; mRNA expression of adipokines and protein expression of TLR4-related molecules were then measured. RESULTS:LPS-stimulated 3T3-L1 adipocytes showed elevated mRNA expression of tumor necrosis factor (TNF)-α, interleukin-6, and monocyte chemoattractant protein-1, and CA significantly inhibited the expression of these adipokine genes. LPS-induced up regulation of TLR4, myeloid differentiation factor 88, TNF receptor-associated factor 6, and nuclear factor-κB, as well as phosphorylated extracellular receptor-activated kinase were also suppressed by pre-treatment of 3T3-L1 adipocytes with CA. CONCLUSIONS:Results of this study suggest that CA directly inhibits TLR4-MyD88-dependent signaling pathways and decreases the inflammatory response in adipocytes.
journal_name
Nutr Res Practjournal_title
Nutrition research and practiceauthors
Park MY,Mun STdoi
10.4162/nrp.2014.8.5.516subject
Has Abstractpub_date
2014-10-01 00:00:00pages
516-20issue
5eissn
1976-1457issn
2005-6168journal_volume
8pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:Malnutrition has multiple impacts on surgical success, postoperative complications, duration of hospital stay, and costs, particularly for cancer patients. There are various nutrition risk screening tools available for clinical use. Herein, we aim to determine the most appropriate nutritional risk...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2020.14.1.20
更新日期:2020-02-01 00:00:00
abstract::The most critical point in the assessment of adherence to dietary guidelines is the development of a practical definition for adherence, such as a dietary pattern score. The purpose of this study was to develop the Korean Diet Score (KDS) based on the Korean Food Balance Wheel and to examine the association of KDS wit...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.1.49
更新日期:2013-02-01 00:00:00
abstract::[This retracts the article on p. 507 in vol. 10, PMID: 27698958.]. ...
journal_title:Nutrition research and practice
pub_type: 杂志文章,撤回出版物
doi:10.4162/nrp.2019.13.1.76
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Over the past few decades, Malaysia has been experiencing an increased prevalence of overweight and obesity that threatens the health of Malaysians. Poor dietary intake is one of the major contributors to the development of obesity and many non-communicable diseases. The dietary intakes of adults ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2019.13.2.159
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The NAD+ precursor nicotinamide riboside (NR) is a type of vitamin B3 found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents hearing loss, high-fat diet-induced obesity, Alzheimer's disease, and mitochondrial myopathy. The objective of this s...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2019.13.1.3
更新日期:2019-02-01 00:00:00
abstract::The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, 57.4 ± 13.1 yrs), anthropometric and biochemical parameters such as lipid profiles and LDL partic...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.2.120
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Epithelial-mesenchymal transition (EMT) is involved in not only cancer development and metastasis but also non-cancerous conditions. Hypoxia is one of the proposed critical factors contributing to formation of chronic rhinosinusitis or nasal polyposis. Wheatgrass (Triticum aestivum) has antioxidan...
journal_title:Nutrition research and practice
pub_type: 杂志文章,收录出版
doi:10.4162/nrp.2017.11.2.83
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diet plays an important role in growth and development of children. However, dietary intakes of children living in either rural or urban areas can be influenced by household income. This cross-sectional study examined energy, nutrient and food group intakes of 749 urban children (1-10 years old) b...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2015.9.3.278
更新日期:2015-06-01 00:00:00
abstract::Inadequate dietary intakes and poor health behaviors are of concern among rural residents in Korea. This study is conducted to compare dietary intakes, dietary diversity score (DDS), mean nutrient adequacy ratio (MAR) and health related behaviors by rural, factory and urban areas in Asan. A total of 930 adults (351 me...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2007.1.2.143
更新日期:2007-07-01 00:00:00
abstract::In Korea, chestnut production is increasing each year, but consumption is far below production. We investigated the effect of chestnut extracts on antioxidant activity and anticancer effects. Ethanol extracts of raw chestnut (RCE) or chestnut powder (CPE) had dose-dependent superoxide scavenging activity. Viable numbe...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2011.5.3.185
更新日期:2011-06-01 00:00:00
abstract::Leaf of Sasa borealis, a species of bamboo, has been reported to exhibit anti-hyperglycemic effect. However, its antidiabetic mechanism is not fully understood. In this study, we examined whether an extract of S. borealis activates AMP-activated protein kinase (AMPK) and exerts anti-hyperglycemic effects. Treatment wi...
journal_title:Nutrition research and practice
pub_type: 杂志文章,收录出版
doi:10.4162/nrp.2013.7.1.15
更新日期:2013-02-01 00:00:00
abstract::The purposes of this study were to determine phenolic compounds and to evaluate antioxidant activities of plums (Soldam, Oishiwase and Formosa). Soldam contains the highest amount of total phenolics among cultivars (Formosa: 4.0%, Oishiwase: 3.3%, Soldam: 6.4% for total phenolic) as well as the total flavonoids of whi...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.4.277
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Although a lot of effort has been put into increasing fruit and vegetable intakes in preschool children, vegetable intake in this group is still low. This study investigated whether nutrition education focusing on fruit and vegetable intakes can affect preschoolers' fruit and vegetable intakes as ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.6.521
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Despite the importance of a low-iodine diet (LID) for thyroid cancer patients preparing for radioactive iodine (RAI) therapy, few studies have evaluated dietary intake during LID. This study evaluated the amount of dietary iodine intake and its major food sources during a typical diet and during L...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.2.167
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Obesity-induced steatohepatitis accompanied by activated hepatic macrophages/Kupffer cells facilitates the progression of hepatic fibrinogenesis and exacerbates metabolic derangements such as insulin resistance. Heme oxyganase-1 (HO-1) modulates tissue macrophage phenotypes and thus is implicated ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.6.623
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (Samdasoo™), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, ser...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.2.165
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Increased consumption of instant noodles has recently been reported to be positively associated with obesity and cardiometabolic syndrome in South Korea, which has the highest per capita instant noodle consumption worldwide. This study aimed to investigate the association between instant noodle co...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2017.11.3.232
更新日期:2017-06-01 00:00:00
abstract::In this study, the protective effects of EGCG on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced oxidative cell death in catecholaminergic PC12 cells, the in vitro model of Parkinson's disease, were investigated. Treatment with L-DOPA at concentrations higher than 150 µM caused cytotoxicity in PC12 cells, as determined ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.4.249
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The type of sweet snack incorporated into an energy-restricted diet (ERD) may produce differential effects on metabolic improvements associated with body weight (BW) loss. This study compared effects of incorporating either twice daily energy-controlled dark chocolate snacks plus once daily sugar-...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.6.695
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Serum ferritin levels are significantly increased after menopause and greatly affect women's health. The aim of this study was to investigate the dietary and non-dietary factors associated with high ferritin levels in postmenopausal women. SUBJECTS/METHODS:Among adult women in 2010-2012, qualifie...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.1.81
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Iron deficiency in early life is associated with developmental problems, which may persist until later in life. The question of whether iron repletion after developmental iron deficiency could restore iron homeostasis is not well characterized. In the present study, we investigated the changes of ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2015.9.6.613
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Isoflavones are widely believed to be beneficial to human health, in relation to their antioxidant potentials. Exercise can cause an imbalance between reactive oxygen species (ROS) and antioxidants. This study was conducted in order to investigate the ability of isoflavones in amelioration of oxid...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.6.618
更新日期:2014-12-01 00:00:00
abstract::Synurus deltoides (Aiton) Nakai, belonging to the Compositae family, is an edible plant widely distributed in Northeast Asia. In this study, we examined the mechanisms underlying the immunomodulative effects of the ethanol extract of S. deltoides (SDE). The SDE extract strongly down-regulated the mRNA expression of th...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.1.11
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM). This study evaluated the effect of vitamin D supplementation on metabolic indices and hs-C-reactive protein (CRP) levels in GDM patients. SUBJECTS/METHODS:The study was a randomized, placebo-controlled, doub...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.3.328
更新日期:2016-06-01 00:00:00
abstract::The objectives of this study were to examine the association between dietary factors and underweight and overweight adult Vietnamese living in the rural areas of Vietnam. A cross-sectional study of 497 Vietnamese aged 19 to 60 years (204 males, 293 females) was conducted in rural areas of Haiphong, Vietnam. The subjec...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.3.235
更新日期:2010-06-01 00:00:00
abstract::Taurine supplementation has been shown to have a beneficial effect on femur bone mineral content in ovariectomized rats. It therefore seemed desirable to find out whether the beneficial effect of taurine on ovariectomized rats fed calcium deficient diet could also be reproduced. Forty female Sprague-Dawley rats were d...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2009.3.2.108
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:This study investigates correlations between circulating microRNAs (miRNAs) and obesity-related parameters among young women (aged 20-30 years old) in Korea. SUBJECTS/METHODS:We analyzed TaqMan low density arrays (TLDAs) of circulating miRNAs in 9 lean (body mass index [BMI] < 25 kg/m2) and 15 ob...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2020.14.4.412
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Folic acid supplementation before pregnancy is known to reduce the risk of neural tube defects. The purposes of this study were to investigate the awareness, knowledge, and use of folic acid supplements along with their associated factors among non-pregnant Korean women of childbearing age. SUBJE...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.1.78
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Although the association of body mass index (BMI) with metabolic syndrome (MetS) is well documented, there is little knowledge on the independent and joint associations of BMI and physical activity with MetS risk based on a continuous scoring system. This study was designed to explore the effect o...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2015.9.4.404
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:A higher frequency of family meals is associated with good dietary habits in young people. This study focused on the relationships of family meal frequency with food neophobia and personality traits in adolescents. SUBJECTS/METHOD:For this purpose, we administered a survey to 495 middle school students in S...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.4.476
更新日期:2014-08-01 00:00:00