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Embryonic stem cell application in drug discovery.

Abstract：

:Embryonic stem (ES) cells and their differentiated progeny offer tremendous potential for regenerative medicine, even in the field of drug discovery. There is an urgent need for clinically relevant assays that make use of ES cells because of their rich biological utility. Attention has been focused on small molecules that allow the precise manipulation of cells in vitro, which could allow researchers to obtain homogeneous cell types for cell-based therapies and discover drugs for stimulating the regeneration of endogenous cells. Such therapeutics can act on target cells or their niches in vivo to promote cell survival, proliferation, differentiation, and homing. In the present paper, we reviewed the use of ES cell models for high-throughput/content drug screening and toxicity assessment. In addition, we examined the role of stem cells in large pharmaceutical companies' R&D and discussed a novel subject, nicheology, in stem cell-related research fields.

journal_name

Acta Pharmacol Sin

journal_title

Acta pharmacologica Sinica

authors

Lou YJ,Liang XG

doi

10.1038/aps.2010.194

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

152-9

issue

2

eissn

1671-4083

issn

1745-7254

pii

aps2010194

journal_volume

32

pub_type

杂志文章,评审

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