abstract：:Pre-B-cell leukemia transcription factor 3 (PBX3) is a member of the PBX family and contains a highly conserved homologous domain. PBX3 is involved in the progression of gastric cancer, colorectal cancer, and prostate cancer; however, the detailed mechanism by which it promotes tumor growth remains to be elucidated. H...

journal_title：Acta pharmacologica Sinica

authors： Li WF,Herkilini A,Tang Y,Huang P,Song GB,Miyagishi M,Kasim V,Wu SR

更新日期：2021-02-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) is a severe acute abdominal disease. Recent evidence shows that intestinal homeostasis is essential for the management of acute pancreatitis. Chitosan oligosaccharides (COS) possess antioxidant activity that are effective in treating various inflammatory diseases. In this study we explo...

journal_title：Acta pharmacologica Sinica

authors： Mei QX,Hu JH,Huang ZH,Fan JJ,Huang CL,Lu YY,Wang XP,Zeng Y

更新日期：2021-01-25 00:00:00

abstract：:Herbal and dietary supplements (HDS)-induced liver injury has been a great concern all over the world. Polygonum multiflorum Thunb., a well-known Chinese herbal medicine, is recently drawn increasing attention because of its hepatotoxicity. According to the clinical and experimental studies, P. multiflorum-induced liv...

journal_title：Acta pharmacologica Sinica

authors： Rao T,Liu YT,Zeng XC,Li CP,Ou-Yang DS

更新日期：2021-01-01 00:00:00

abstract：:Immune checkpoint blockade therapy has become a first-line treatment in various cancers. But there are only a small percent of colorectal patients responding to PD-1/PD-L1 blockage immunotherapy. How to increase their treatment efficacy is an urgent and clinically unmet need. It is acknowledged that immunogenic cell d...

journal_title：Acta pharmacologica Sinica

authors： He ZD,Zhang M,Wang YH,He Y,Wang HR,Chen BF,Tu B,Zhu SQ,Huang YZ

更新日期：2020-12-11 00:00:00

abstract：:Aflibercept, as a soluble decoy vascular endothelial growth factor receptor, Which has been used as a first-line monotherapy for cancers. Aflibercept often causes cardiovascular toxicities including hypertension, but the mechanisms underlying aflibercept-induced hypertension remain unknown. In this study we investigat...

journal_title：Acta pharmacologica Sinica

authors： Dong ZC,Wu MM,Zhang YL,Wang QS,Liang C,Yan X,Zou LX,Chen C,Han X,Zhang B,Zhang ZR

更新日期：2020-12-10 00:00:00

abstract：:The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat to global public health. The highly infectious SARS-CoV-2 virus primarily attacks pulmonary tissues and impairs gas exchange leading to acute respir...

journal_title：Acta pharmacologica Sinica

authors： Serebrovska ZO,Chong EY,Serebrovska TV,Tumanovska LV,Xi L

更新日期：2020-12-01 00:00:00

abstract：:Cerebral ischemia/reperfusion (I/R) results in harmful consequences during ischemic stroke, especially the disruption of the blood-brain barrier (BBB), which leads to severe hemorrhagic transformation through aggravation of edema and brain hemorrhage. Our previous study demonstrated that icariside II (ICS II), which i...

journal_title：Acta pharmacologica Sinica

authors： Liu MB,Wang W,Gao JM,Li F,Shi JS,Gong QH

更新日期：2020-12-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have become an essential research platform to study different human diseases once being discovered by Dr. Shinya Yamanaka in 2006. Another breakthrough in biomedical research is the application of CRISPR/Cas9 system for genome editing in mammalian cells. Although numerous studies...

journal_title：Acta pharmacologica Sinica

authors： Geng BC,Choi KH,Wang SZ,Chen P,Pan XD,Dong NG,Ko JK,Zhu H

更新日期：2020-11-01 00:00:00

abstract：:Hepatic fibrosis is a disease characterized by excessive deposition of extracellular matrix (ECM) in the liver. Activation of hepatic stellate cells (HSCs) is responsible for most of ECM production. Oxidative stress and reactive oxygen species (ROS) may be important factors leading to liver fibrosis. NADPH oxidase 4 (...

journal_title：Acta pharmacologica Sinica

authors： Du JJ,Sun JC,Li N,Li XQ,Sun WY,Wei W

更新日期：2020-10-28 00:00:00

abstract：:DJ-1 is a multifunctional protein associated with cancers and autosomal early-onset Parkinson disease. Besides the well-documented antioxidative stress activity, recent studies show that DJ-1 has deglycation enzymatic activity and anti-ferroptosis effect. It has been shown that DJ-1 forms the homodimerization, which d...

journal_title：Acta pharmacologica Sinica

authors： Jiang L,Chen XB,Wu Q,Zhu HY,Du CY,Ying MD,He QJ,Zhu H,Yang B,Cao J

更新日期：2020-10-06 00:00:00

abstract：:Cerebral edema is a pathological hallmark of various central nervous system (CNS) insults, including traumatic brain injury (TBI) and excitotoxic injury such as stroke. Due to the rigidity of the skull, edema-induced increase of intracranial fluid significantly complicates severe CNS injuries by raising intracranial p...

journal_title：Acta pharmacologica Sinica

authors： Luo ZW,Ovcjak A,Wong R,Yang BX,Feng ZP,Sun HS

更新日期：2020-10-01 00:00:00

abstract：:Sepsis-induced multiple organ dysfunction and inflammatory response are life-threatening symptoms without effective treatment. Fisetin, a dietary flavonoid extracted from berries and family Fabaceae, has displayed neuroprotective and anti-oxidant activities. In this study we investigated whether fisetin exerted a prot...

journal_title：Acta pharmacologica Sinica

authors： Zhang HF,Zhang HB,Wu XP,Guo YL,Cheng WD,Qian F

更新日期：2020-10-01 00:00:00

abstract：:Diabetic nephropathy (DN) is characterized by sterile inflammation with continuous injury and loss of renal inherent parenchyma cells. Podocyte is an essential early injury target in DN. The injury and loss of podocytes are closely associated with proteinuria, the early symptom of renal injury in DN. However, the exac...

journal_title：Acta pharmacologica Sinica

authors： Cheng Q,Pan J,Zhou ZL,Yin F,Xie HY,Chen PP,Li JY,Zheng PQ,Zhou L,Zhang W,Liu J,Lu LM

更新日期：2020-09-23 00:00:00

abstract：:Dry eye disease (DED) is a multifactorial disorder of the tears and ocular surface characterized by manifestations of dryness and irritation. Although the pathogenesis is not fully illuminated, it is recognized that inflammation has a prominent role in the development and deterioration of DED. β-aminoarteether maleate...

journal_title：Acta pharmacologica Sinica

authors： Yang FM,Fan D,Yang XQ,Zhu FH,Shao MJ,Li Q,Liu YT,Lin ZM,Cao SQ,Tang W,He SJ,Zuo JP

更新日期：2020-08-03 00:00:00

abstract：:Cycloastragenol (CAG) is the active form of astragaloside IV isolated from Astragalus Radix, which displays multiple pharmacological effects. Silent information regulator 1 (SIRT1), a class III histone deacetylase, has been shown to play an important role in neuroprotection against cerebral ischemia. In this study, we...

journal_title：Acta pharmacologica Sinica

authors： Li M,Li SC,Dou BK,Zou YX,Han HZ,Liu DX,Ke ZJ,Wang ZF

更新日期：2020-08-01 00:00:00

abstract：:For follicular lymphoma (FL) with grade 1/2, the complete response (CR) rate of the first-line R-CHOP treatment was significantly low. In this study, we assessed the rationality of the administration of rituximab for FL patients with grade 1/2 based on concentration-response relationship analyses. Thus, we conducted a...

journal_title：Acta pharmacologica Sinica

authors： Liu S,Huang H,Chen RX,Wang Z,Guan YP,Peng C,Fang XJ,Chen ZJ,Guan SX,Zhu X,Ren QG,Yao YY,Huang HB,Huang M,Wang XD,Lin TY

更新日期：2020-07-31 00:00:00

abstract：:The mechanism underlying the resistance of cancer cells to chemotherapeutic drug varies with different cancer cells. Recent evidence shows that lysosomal function is associated with drug resistance of cancer cells. Artesunate, a derivative of artemisinin, displays broad antitumor activity and direct cytotoxicity on va...

journal_title：Acta pharmacologica Sinica

authors： Li Z,Zhu YT,Xiang M,Qiu JL,Luo SQ,Lin F

更新日期：2020-07-23 00:00:00

abstract：:Oral administration of curcumin has been shown to inhibit pulmonary fibrosis (PF) despite its extremely low bioavailability. In this study, we investigated the mechanisms underlying the anti-PF effect of curcumin in focus on intestinal endocrine. In bleomycin- and SiO2-treated mice, curcumin (75, 150 mg· kg-1 per day)...

journal_title：Acta pharmacologica Sinica

authors： Miao YM,Zhang YJ,Qiao SM,Xia YF,Wei ZF,Dai Y

更新日期：2020-07-21 00:00:00

abstract：:Sphingosine-1-phosphate (S1P), the backbone of most sphingolipids, activating S1P receptors (S1PRs) and the downstream G protein signaling has been implicated in chemoresistance. In this study we investigated the role of S1PR2 internalization in 5-fluorouracil (5-FU) resistance in human colorectal cancer (CRC). Clinic...

journal_title：Acta pharmacologica Sinica

authors： Zhang YH,Cui SX,Wan SB,Wu SH,Qu XJ

更新日期：2020-07-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Acta pharmacologica Sinica

authors： Zhong HH,Wang HY,Gao J,Huang YZ,Gao A,Hu XL,Saeed M,Chen BF,Li YP,Yu HJ

更新日期：2020-07-06 00:00:00

abstract：:As the most powerful antigen-presenting cell type, dendritic cells (DCs) can induce potent antigen-specific immune responses in vivo, hence becoming optimal cell population for vaccination purposes. DCs can be derived ex vivo in quantity and manipulated extensively to be endowed with adequate immune-stimulating capaci...

journal_title：Acta pharmacologica Sinica

authors： Gu YZ,Zhao X,Song XR

更新日期：2020-07-01 00:00:00

abstract：:Cancer immunotherapy has received extensive attention due to its ability to activate the innate or adaptive immune systems of patients to combat tumors. Despite a few clinical successes, further endeavors are still needed to tackle unresolved issues, including limited response rates, development of resistance, and imm...

journal_title：Acta pharmacologica Sinica

authors： Sun B,Hyun H,Li LT,Wang AZ

更新日期：2020-07-01 00:00:00

abstract：:Central nervous system (CNS) disorders represent a broad spectrum of brain ailments with short- and long-term disabilities, and nanomedicine-based approaches provide a new therapeutic approach to treating CNS disorders. A variety of potential drugs have been discovered to treat several neuronal disorders; however, the...

journal_title：Acta pharmacologica Sinica

authors： Hanif S,Muhammad P,Chesworth R,Rehman FU,Qian RJ,Zheng M,Shi BY

更新日期：2020-07-01 00:00:00

abstract：:Natural compound valepotriate exhibits inhibitory activity against a number of cancers, but the effect of valepotriate against pancreatic cancer is unclear, and the structure-activity relationship of valepotriate has not been characterized. In this study, we performed a structure-based similarity search and found 16 h...

journal_title：Acta pharmacologica Sinica

authors： Yan YY,Shi KY,Teng F,Chen J,Che JX,Dong XW,Lin NM,Zhang B

更新日期：2020-06-01 00:00:00

abstract：:Etimicin (ETM), a fourth-generation aminoglycosides (AGs), is now widely clinically used in China due to its high efficacy and low toxicity. However, the mechanisms underlying its low nephrotoxicity and ototoxicity remain unclear. In the present study we compared the antibacterial and toxicity profiles of etimicin, ge...

journal_title：Acta pharmacologica Sinica

authors： Yao L,Zhang JW,Chen B,Cai MM,Feng D,Wang QZ,Wang XY,Sun JG,Zheng YW,Wang GJ,Zhou F

更新日期：2020-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disease characterized by motor impairment and progressive loss of dopamine (DA) neurons. At present, the acute application of neurotoxic drugs such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are commonly used to simulate ...

journal_title：Acta pharmacologica Sinica

authors： Guo CH,Cao T,Zheng LT,Waddington JL,Zhen XC

更新日期：2020-04-01 00:00:00

abstract：:Propofol is a commonly used intravenous anesthetic agent, which has been found to affect cell survival and proliferation especially in early life. Our previous studies show that propofol-induced neurodegeneration and neurogenesis are closely associated with cell autophagy. In the present study we explored the roles of...

journal_title：Acta pharmacologica Sinica

authors： Xu ZD,Wang Y,Liang G,Liu ZQ,Ma WH,Chu CT,Wei HF

更新日期：2020-03-01 00:00:00

abstract：:Type 2 diabetes (T2D) and Alzheimer's disease (AD) share several common pathophysiological features. Huperzine A (Hup A), a Lycopodium alkaloid extracted from the Chinese herb moss Huperzia serrata, is a specific and reversible inhibitor of acetylcholinesterase, which is clinically used for the treatment of AD. In thi...

journal_title：Acta pharmacologica Sinica

authors： Wang HY,Wu M,Diao JL,Li JB,Sun YX,Xiao XQ

更新日期：2020-02-01 00:00:00

abstract：:Breast cancer resistance protein (BCRP) is one of ATP-binding cassette (ABC) transporters in brain microvessel endothelial cells that transport their substrates from brain to blood, thus limiting substrates to crossing into brain through blood-brain barrier. Our previous works show that bile duct ligation (BDL) impair...

journal_title：Acta pharmacologica Sinica

authors： Qin YY,Xu P,Wu T,Qian CQ,Fan YL,Gen DH,Zhu L,Kong WM,Yang HY,Xu F,Yang YT,Liu L,Liu XD

更新日期：2020-02-01 00:00:00

abstract：:Cocaine is one of the most abused illicit drugs worldwide. It is well known that the dopamine (DA) transporter is its major target; but cocaine also acts on other targets including nicotinic acetylcholine receptors (nAChRs). In this study, we investigated the effects of cocaine on a special subtype of neuronal nAChR, ...

journal_title：Acta pharmacologica Sinica

authors： Ma ZG,Jiang N,Huang YB,Ma XK,Brek Eaton J,Gao M,Chang YC,Lukas RJ,Whiteaker P,Neisewander J,Wu J

更新日期：2020-02-01 00:00:00

abstract：:Abnormal growth of the intimal layer of blood vessels (neointima formation) contributes to the progression of atherosclerosis and in-stent restenosis. Recent evidence shows that the 18-kDa translocator protein (TSPO), a mitochondrial membrane protein, is involved in diverse cardiovascular diseases. In this study we in...

journal_title：Acta pharmacologica Sinica

authors： Wu LP,Gong ZF,Wang H,Zhou ZS,Zhang MM,Liu C,Ren HM,Yang J,Han Y,Zeng CY

更新日期：2020-01-01 00:00:00

abstract：:It was reported that antituberculosis medicines could induce liver damage via oxidative stress. In this study, we investigated the effects of rifampicin (RFP) on the membrane expression of multidrug resistance-associated protein 2 (MRP2) and the relationship between oxidative stress and RFP-induced endocytosis of MRP2...

journal_title：Acta pharmacologica Sinica

authors： Xu BY,Tang XD,Chen J,Wu HB,Chen WS,Chen L

更新日期：2020-01-01 00:00:00

abstract：:Monoclonal antibodies are believed to be magic bullets and hold great potential for lots of biological process. About 100 μg of mAb109 was expressed in 5 × 106 cells after 10 days' immunization. 64Cu-NOTA-mAb109 was synthesized with the specific activity of 0.74 MBq/μg and high in vitro stability. The binding affinity...

journal_title：Acta pharmacologica Sinica

authors： Zhu H,Liu TL,Liu CH,Wang J,Zhang H,Dong B,Shen J,Zhao CK,Li ZF,Cheng Z,Yang Z

更新日期：2020-01-01 00:00:00

abstract：:Midbrain dopaminergic (DA) neurons are governed by an endogenous cholinergic system, originated in the mesopontine nuclei. Nicotine hijacks nicotinic acetylcholine receptors (nAChRs) and interferes with physiological function of the cholinergic system. In this review, we describe the anatomical organization of the cho...

journal_title：Acta pharmacologica Sinica

authors： Xiao C,Zhou CY,Jiang JH,Yin C

更新日期：2020-01-01 00:00:00

abstract：:Excessive and abnormal vessel growth plays a critical role in the pathogenesis of many diseases, such as cancer. Angiogenesis is one of the hallmarks of cancer growth, invasion, and metastasis. Discovery of novel antiangiogenic agents would provide new insights into the mechanisms of angiogenesis, as well as potential...

journal_title：Acta pharmacologica Sinica

authors： Liu B,Cui LS,Zhou B,Zhang LL,Liu ZH,Zhang L

更新日期：2019-11-01 00:00:00

abstract：:Autophagy, a form of cellular self-digestion by lysosome, is associated with various disease processes including cancers, and modulating autophagy has shown promise in the treatment of various malignancies. A number of natural products display strong antitumor activity, yet their mechanisms of action remain unclear. T...

journal_title：Acta pharmacologica Sinica

authors： Jiang SL,Guan YD,Chen XS,Ge P,Wang XL,Lao YZ,Xiao SS,Zhang Y,Yang JM,Xu XJ,Cao DS,Cheng Y

更新日期：2019-07-01 00:00:00

abstract：:Fibronectin (FN) is a main component of extracellular matrix (ECM) in most adult tissues. Under pathological conditions, particularly inflammation, wound healing and tumors, an alternatively spliced exon extra domain A (EDA) is included in the FN protein (EDA+FN), which facilitates cellular proliferation, motility, an...

journal_title：Acta pharmacologica Sinica

authors： Wang HC,Wang P,Chen YW,Zhang Y

更新日期：2019-07-01 00:00:00

abstract：:Emerging evidence demonstrates that a c-Met antibody-drug conjugate (ADC) has superior efficacy and safety profiles compared with those of currently available small molecules or antibody inhibitors for the treatment of c-Met-overexpressing cancers. Here we described both the in vitro and in vivo efficacies of SHR-A140...

journal_title：Acta pharmacologica Sinica

authors： Yang CY,Wang L,Sun X,Tang M,Quan HT,Zhang LS,Lou LG,Gou SH

更新日期：2019-07-01 00:00:00

abstract：:The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer intervention due to their roles in tumor metastasis and angiogenesis. Here, we identified a new selective FGFR inhibitor, C11, and assessed its antitumor activities. C11 was a selective FGFR1 inhibitor ...

journal_title：Acta pharmacologica Sinica

authors： Chen Z,Tong LJ,Tang BY,Liu HY,Wang X,Zhang T,Cao XW,Chen Y,Li HL,Qian XH,Xu YF,Xie H,Ding J

更新日期：2019-06-01 00:00:00

abstract：:Astragaloside IV (AsIV) is an active saponin extracted from Astragalus membranaceus, which has shown cardioprotective effects in a number of experimental animals. In this study we investigated the molecular mechanisms by which AsIV attenuated the myocardial ischemia reperfusion (MI/R)-induced injury in vitro and in vi...

journal_title：Acta pharmacologica Sinica

authors： Yin B,Hou XW,Lu ML

更新日期：2019-05-01 00:00:00