Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats.

abstract：AIM:Probucol, an anti-hyperlipidemic drug, has been reported to exert antitumor activities at various stages of tumor initiation, promotion and progression. In this study we examined whether the drug affected glioma cell growth in vitro and the underlying mechanisms. METHODS:Human glioma U87 and glioblastoma SF295 cel...

journal_title：Acta pharmacologica Sinica

authors： Jiang YS,Lei JA,Feng F,Liang QM,Wang FR

更新日期：2014-12-01 00:00:00

abstract：AIM:To examine the effects of β3-adrenoceptor (β3-AR) activation on atherosclerotic plaque development in ApoE(-/-) mice. METHODS:Thirty six week-old male ApoE(-/-) mice on a high-fat diet were treated with atorvastatin (10 mg·kg(-1)·d(-1), po), BRL37344 (β3-AR agonist, 1.65 or 3.30 μg/kg, ip, twice a week) or SR52390...

journal_title：Acta pharmacologica Sinica

authors： Wang ZH,Li YF,Guo YQ

更新日期：2013-09-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have become an essential research platform to study different human diseases once being discovered by Dr. Shinya Yamanaka in 2006. Another breakthrough in biomedical research is the application of CRISPR/Cas9 system for genome editing in mammalian cells. Although numerous studies...

journal_title：Acta pharmacologica Sinica

authors： Geng BC,Choi KH,Wang SZ,Chen P,Pan XD,Dong NG,Ko JK,Zhu H

更新日期：2020-11-01 00:00:00

abstract：AIM:High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play pivotal roles in vascular inflammation and atherosclerosis. The aim of this study was to determine whether the HMGB1-RAGE axis was involved in the actions of simvastatin on vascular inflammation and atheroscler...

journal_title：Acta pharmacologica Sinica

authors： Liu M,Yu Y,Jiang H,Zhang L,Zhang PP,Yu P,Jia JG,Chen RZ,Zou YZ,Ge JB

更新日期：2013-06-01 00:00:00

abstract：:Estrogens are important endocrine hormones that control physiological functions in reproductive organs, and play a pivotal role in the generation and progression of breast cancer. Therapeutic drugs including anti-estrogen and aromatase inhibitors are used to treat patients with breast cancer. The estrogen receptors, E...

journal_title：Acta pharmacologica Sinica

authors： Ikeda K,Horie-Inoue K,Inoue S

更新日期：2015-01-01 00:00:00

abstract：AIM:To study the expressions of vascular endothelial growth factor (VEG F), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), Tie-1, and Tie-2 in C57BL/6 mouse brain after permanent focal cerebral ischemia. METHODS:The mRNA levels of VEGF, Ang-1, Ang-2, Tie-1, and Tie-2 were measured by semiquantitative reverse transcri...

journal_title：Acta pharmacologica Sinica

authors： Wang RG,Zhu XZ

更新日期：2002-05-01 00:00:00

abstract：:Embryonic stem (ES) cells and their differentiated progeny offer tremendous potential for regenerative medicine, even in the field of drug discovery. There is an urgent need for clinically relevant assays that make use of ES cells because of their rich biological utility. Attention has been focused on small molecules ...

journal_title：Acta pharmacologica Sinica

authors： Lou YJ,Liang XG

更新日期：2011-02-01 00:00:00

abstract：AIM:To examine the interactions of allopregnanolone and phenobarbital for the protection against seizures. METHODS:The protective activity of allopregnanolone and/or phenobarbital against seizures was studied in the C57 mice, using the maximal electroshock seizure (MES) test. The modulations by allopregnanolone and/or...

journal_title：Acta pharmacologica Sinica

authors： Lu YQ,Yu R

更新日期：2001-04-01 00:00:00

abstract：AIM:To investigate the effects of 3,4,4'-trihydroxy-trans-stilbene (3,4,4'-THS), an analogue of resveratrol, on human non-small-cell lung cancer (NSCLC) cells in vitro. METHODS:Cell viability of NSCLC A549 cells was determined by MTT assay. Cell apoptosis was evaluated using flow cytometry and TUNEL assay. Cell necros...

journal_title：Acta pharmacologica Sinica

authors： Zhang L,Dai F,Sheng PL,Chen ZQ,Xu QP,Guo YQ

更新日期：2015-10-01 00:00:00

abstract：:Resibufogenin (RBG) is a single compound isolated from Chansu, a traditional Chinese medicine obtained from the skin venom gland of the toad. Formulations of Chansu have been widely applied in China, Japan, and other Asian countries for a long time and are currently used as alternative medicines. However, there have b...

journal_title：Acta pharmacologica Sinica

authors： Xie JT,Dey L,Wu JA,Lowell TK,Yuan CS

更新日期：2001-04-01 00:00:00

abstract：:Hydrogen sulfide (H2S), which is well known traditionally as a toxic gas, has been proven to be produced endogenously by 3 enzymes in mammalian tissues and plays important roles in physiological and pathophysiological conditions. In the central nervous system, H2S functions as not only a neuromodulator, but also a neu...

journal_title：Acta pharmacologica Sinica

authors： Chen CQ,Xin H,Zhu YZ

更新日期：2007-11-01 00:00:00

abstract：:Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of tumors, inflammation and other diseases in traditional Chinese medicine. Compound Kushen Injection (CKI) is a mixture of natural compounds extracted from Kushen and Baituling (Rhizoma Smilacis Glabrae). The main principles of CKI are m...

journal_title：Acta pharmacologica Sinica

authors： Wang W,You RL,Qin WJ,Hai LN,Fang MJ,Huang GH,Kang RX,Li MH,Qiao YF,Li JW,Li AP

更新日期：2015-06-01 00:00:00

abstract：:The chemokine receptor CCR5 is an important anti-HIV (human immunodeficiency virus) drug target owning to its pivotal role in HIV-1 viral entry as a co-receptor. Here, we present a 2.9 Å resolution crystal structure of CCR5 bound to PF-232798, a second-generation oral CCR5 antagonist currently in phase II clinical tri...

journal_title：Acta pharmacologica Sinica

authors： Zhu Y,Zhao YL,Li J,Liu H,Zhao Q,Wu BL,Yang ZL

更新日期：2019-04-01 00:00:00

abstract：:Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and they perform as key regulators in cell-to-cell communication in normal as well as diseased states. EVs contain natural cargo molecules, such as miRNA, mRNA and proteins, and transfer these functional cargos to neighboring cells or ...

journal_title：Acta pharmacologica Sinica

authors： Samanta S,Rajasingh S,Drosos N,Zhou Z,Dawn B,Rajasingh J

更新日期：2018-04-01 00:00:00

abstract：:Recently, two different chemicals have been matched as ligands with the same G-protein-coupled receptor (GPCR). Double-pairing of OGR1 family GPCRs with proton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs. Second, whether modulation of a GPCR by two chemicals could be ...

journal_title：Acta pharmacologica Sinica

authors： Im DS

更新日期：2005-12-01 00:00:00

abstract：:Cardiac amyloidosis (CA) comprises a heterogeneous group of medical conditions affecting the myocardium. It presents with proteinaceous infiltration with variable degrees of severity, prevalence and evolution. Despite this heterogeneity, erroneous protein folding is the common pathophysiologic process, yielding the fo...

journal_title：Acta pharmacologica Sinica

authors： Luciani M,Troncone L,Monte FD

更新日期：2018-07-01 00:00:00

abstract：:Cerebral ischemia/reperfusion (I/R) results in harmful consequences during ischemic stroke, especially the disruption of the blood-brain barrier (BBB), which leads to severe hemorrhagic transformation through aggravation of edema and brain hemorrhage. Our previous study demonstrated that icariside II (ICS II), which i...

journal_title：Acta pharmacologica Sinica

authors： Liu MB,Wang W,Gao JM,Li F,Shi JS,Gong QH

更新日期：2020-12-01 00:00:00

abstract：AIM:Breviscapine isolated from the Chinese herb Erigeron breviscapus (Vant) Hand-Mazz is widely used to treat cardiovascular and cerebrovascular diseases. The aim of this study was to improve the pharmacokinetic profiles of breviscapine using nanostructured lipid carrier based on an ionic complex formation. METHODS:Br...

journal_title：Acta pharmacologica Sinica

authors： Li M,Zheng Y,Shan FY,Zhou J,Gong T,Zhang ZR

更新日期：2013-08-01 00:00:00

abstract：:An early intervention using biomarkers to predict acute myocardial infarction (AMI) will effectively reduce global heart attack incidence, particularly among high-risk patients with type 2 diabetes mellitus (T2DM). This study attempted to identify potential biomarkers by detecting changes in the levels of plasma prote...

journal_title：Acta pharmacologica Sinica

authors： Rahim MAA,Rahim ZHA,Ahmad WAW,Bakri MM,Ismail MD,Hashim OH

更新日期：2018-07-01 00:00:00

abstract：AIM:To investigate whether histidine can enhance the anticonvulsant efficacy of carbamazepine (CBZ) and simultaneously improve the spatial memory impairment induced by transauricular kindled seizures in Sprague-Dawley rats. METHODS:Chronic transauricular kindling was induced by repeated application of initially subcon...

journal_title：Acta pharmacologica Sinica

authors： Li Q,Jin CL,Xu LS,Zhu-Ge ZB,Yang LX,Liu LY,Chen Z

更新日期：2005-11-01 00:00:00

abstract：AIM:To study the effect of chronic insulin treatment on insulin post-receptor signaling transduction and whether the effects of metformin are transmitted throughout the cascade of insulin signaling intermediates in a human hepatoma cell line (Hep G2). METHODS:Hep G2 cells were incubated in serum free media containing ...

journal_title：Acta pharmacologica Sinica

authors： Yuan L,Ziegler R,Hamann A

更新日期：2003-01-01 00:00:00

abstract：AIM:To study the effect of gum mastic, a natural resin, on the proliferation of androgen-independent prostate cancer PC-3 cells, and further investigate the mechanisms involved in this regulatory system, taking nuclear factor kappaB (NF-kappaB) signal as the target. METHODS:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltet...

journal_title：Acta pharmacologica Sinica

authors： He ML,Li A,Xu CS,Wang SL,Zhang MJ,Gu H,Yang YQ,Tao HH

更新日期：2007-03-01 00:00:00

abstract：AIM:To characterize the in vitro bioactivities of rhodanine derivatives as novel peroxisome proliferator-activated receptor (PPAR) gamma modulators, based on a hit (SH00012671) identified during high-throughput screening (HTS) of a diverse synthetic compound library, and to preliminarily elucidate the structure-activit...

journal_title：Acta pharmacologica Sinica

authors： Liu Q,Zhang YY,Lu HL,Li QY,Zhou CH,Wang MW

更新日期：2007-12-01 00:00:00

abstract：:In an effort to develop effective alternative strategies that increase the therapeutic efficacy and minimize the systemic toxicity of chemotherapeutic agents, more efforts are being directed towards the investigation of dietary supplements and other phytotherapeutic agents for their synergistic efficacy in combination...

journal_title：Acta pharmacologica Sinica

authors： Raina K,Agarwal R

更新日期：2007-09-01 00:00:00

abstract：AIM:Chinese medicine CGA formula consists of polysaccharide from Cordyceps sinensis mycelia (CS-PS), gypenosides and amygdalin, which is derived from Fuzheng Huayu (FZHY) capsule for treating liver fibrosis. In this study we attempted to confirm the therapeutic effects of CGA formula in dimethylnitrosamine (DMN)-induce...

journal_title：Acta pharmacologica Sinica

authors： Li XM,Peng JH,Sun ZL,Tian HJ,Duan XH,Liu L,Ma X,Feng Q,Liu P,Hu YY

更新日期：2016-06-01 00:00:00

abstract：AIM:to investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation. METHODS:the denervated and innervated skeletal muscle cells were examined on days 1, 4, 7, 14, 21, and 28 after denervation. Individual denervated and innervated cells were prepared from the...

journal_title：Acta pharmacologica Sinica

authors： WANG H,YANG B,HAN GW,LI ST

更新日期：2010-12-01 00:00:00

abstract：AIM:To investigate the effect of ectogenesis unsaturated fatty acid on carbachol-induced muscarinic current (ICCh) and its mechanism. METHODS:Using the whole-cell patch-clamp technique, ICCh was recorded in single smooth muscle cell isolated from the antral circular smooth muscles of guinea-pig stomach. RESULTS:Arach...

journal_title：Acta pharmacologica Sinica

authors： Cui YF,Jin H,Guo HS,Li L,Yu YC,Xu WX

更新日期：2003-03-01 00:00:00

abstract：AIM:To study the regulation of monoamine oxidase-B (MAO-B) activity and imidazoline receptors (I-R) during long term treatment of morphine. METHODS:MAO-B activity was detected by high performance liquid chromatography; I-R was detected by [3H]idazoxan binding test. RESULTS:Idazoxan and morphine inhibited whole brain ...

journal_title：Acta pharmacologica Sinica

authors： Su RB,Li J,Li X,Qin BY

更新日期：2001-07-01 00:00:00

abstract：AIM:To study the effects of cimetidine (Cim) on the production of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) by splenocytes in immune-derived aplastic anemic (AA) mice. METHODS:Aplastic anemic mice model was constructed first, and then the splenocytes were induced to secrete IFN gamma and...

journal_title：Acta pharmacologica Sinica

authors： Xia T,Wang QR,Xu YH

更新日期：2001-03-01 00:00:00

abstract：AIM:To explore the anti-diabetic effects of berberine and its influence on insulin secretion. METHODS:Impaired glucose tolerance rats induced by iv injection of streptozotocin 30 mg/kg were treated with berberine 187.5 and 562.5 mg/kg while fed with high fat laboratory chow. After rats were treated for 4 weeks, oral g...

journal_title：Acta pharmacologica Sinica

authors： Leng SH,Lu FE,Xu LJ

更新日期：2004-04-01 00:00:00