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Identification of estrogen-responsive genes based on the DNA binding properties of estrogen receptors using high-throughput sequencing technology.

Abstract：

:Estrogens are important endocrine hormones that control physiological functions in reproductive organs, and play a pivotal role in the generation and progression of breast cancer. Therapeutic drugs including anti-estrogen and aromatase inhibitors are used to treat patients with breast cancer. The estrogen receptors, ERα and ERβ, function as hormone-dependent transcription factors that directly regulate the expression of their target genes. Therefore, a better understanding of the function and regulation of estrogen-responsive genes provides insight into the gene regulation network associated with breast cancer. Recent technological developments in high-throughput sequencing have enabled the genome-wide identification of estrogen-responsive genes. Further elucidating the estrogen gene cascade is critical for advancements in the diagnosis and treatment of breast cancer.

journal_name

Acta Pharmacol Sin

journal_title

Acta pharmacologica Sinica

authors

Ikeda K,Horie-Inoue K,Inoue S

doi

10.1038/aps.2014.123

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

24-31

issue

1

eissn

1671-4083

issn

1745-7254

pii

aps2014123

journal_volume

36

pub_type

杂志文章,评审

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