Two ligands for a GPCR, proton vs lysolipid.

abstract：:Contact inhibition and its disruption of vascular smooth muscle cells (VSMCs) are important cellular events in vascular diseases. But the underlying molecular mechanisms are unclear. In this study we investigated the roles of microRNAs (miRNAs) in the contact inhibition and its disruption of VSMCs and the molecular me...

journal_title：Acta pharmacologica Sinica

authors： Sun YY,Qin SS,Cheng YH,Wang CY,Liu XJ,Liu Y,Zhang XL,Zhang W,Zhan JX,Shao S,Bian WH,Luo BH,Lu DF,Yang J,Wang CH,Zhang CX

更新日期：2018-05-01 00:00:00

abstract：:Emerging evidence demonstrates that a c-Met antibody-drug conjugate (ADC) has superior efficacy and safety profiles compared with those of currently available small molecules or antibody inhibitors for the treatment of c-Met-overexpressing cancers. Here we described both the in vitro and in vivo efficacies of SHR-A140...

journal_title：Acta pharmacologica Sinica

authors： Yang CY,Wang L,Sun X,Tang M,Quan HT,Zhang LS,Lou LG,Gou SH

更新日期：2019-07-01 00:00:00

abstract：AIM:Matrine is an alkaloid from Sophora alopecuroides L, which has shown a variety of pharmacological activities and potential therapeutic value in cardiovascular diseases. In this study we examined the protective effects of matrine against diabetic cardiomyopathy (DCM) in rats. METHODS:Male SD rats were injected with...

journal_title：Acta pharmacologica Sinica

authors： Liu ZW,Wang JK,Qiu C,Guan GC,Liu XH,Li SJ,Deng ZR

更新日期：2015-03-01 00:00:00

abstract：AIM:To test whether carbachol can influence endothelial barrier dysfunction induced by tumor necrosis factor (TNF)-α and whether the alpha 7 nicotinic receptor can mediate this process. METHODS:Rat cardiac microvascular endothelial cells were exposed to carbachol followed by TNF-α treatment in the presence or the abse...

journal_title：Acta pharmacologica Sinica

authors： Li YZ,Liu XH,Rong F,Hu S,Sheng ZY

更新日期：2010-10-01 00:00:00

abstract：AIM:To investigate the modulatory effect of CJZ3, a lomerizine derivative, on P-glycoprotein (P-gp) function in rat brain microvessel endothelial cells (RBMEC). METHODS:RBMEC were isolated and cultured in Dulbecco modified Eagle medium/F12 (1:1) medium, and the amount of intracellular rhodamine 123 (Rh123) was determi...

journal_title：Acta pharmacologica Sinica

authors： Ji BS,He L,Li XQ,Liu GQ

更新日期：2006-04-01 00:00:00

abstract：:Esophageal cancer is one of the most common types of cancer in the world, and it demonstrates a distinct geographical distribution pattern in China. In the last decade, inducing apoptosis with traditional Chinese medicine (TCM) has become an active area in both fundamental and clinical research on cancer therapy. In t...

journal_title：Acta pharmacologica Sinica

authors： Zhang YS,Shen Q,Li J

更新日期：2016-03-01 00:00:00

abstract：AIM:The role of caveolin-1 (Cav-1) in angiogenesis remains poorly understood. The endothelial nitric oxide (NO) synthase (eNOS), a caveolin-interacting protein, was demonstrated to play a predominant role in vascular endothelial growth factor (VEGF) -induced angiogenesis. The purpose of our study was to examine the rol...

journal_title：Acta pharmacologica Sinica

authors： Pan YM,Yao YZ,Zhu ZH,Sun XT,Qiu YD,Ding YT

更新日期：2006-12-01 00:00:00

abstract：AIM:To study the effect of nomegestrol acetate, a new synthetic progesterone on granulosa cells' viability and steroidogenesis function. METHODS:Granulosa cells were cultured in McCoy's 5A medium. Trypan blue stain was used to measure viable cells. FSH and testosterone were added to stimulate the steroid secretion. Sp...

journal_title：Acta pharmacologica Sinica

authors： Qian LH,Yang B,Leng Y,Cao L,Gu ZP

更新日期：2001-01-01 00:00:00

abstract：AIM:To construct a recombinant adenovirus that can express human spermidine/ spermine N1-acetyltransferase (SSAT) and detect its inhibitory effect on colorectal cancer cell growth in vitro. METHODS:A 516 bp cDNA of SSAT was amplified and cloned into a pGL3-hTERT plasmid. The pGL3-hTERT-SSAT recombinant was digested, a...

journal_title：Acta pharmacologica Sinica

authors： Sun H,Liu B,Yang YP,Xu CX,Yan YF,Wang W,Liu XX

更新日期：2008-05-01 00:00:00

abstract：:Abnormal growth of the intimal layer of blood vessels (neointima formation) contributes to the progression of atherosclerosis and in-stent restenosis. Recent evidence shows that the 18-kDa translocator protein (TSPO), a mitochondrial membrane protein, is involved in diverse cardiovascular diseases. In this study we in...

journal_title：Acta pharmacologica Sinica

authors： Wu LP,Gong ZF,Wang H,Zhou ZS,Zhang MM,Liu C,Ren HM,Yang J,Han Y,Zeng CY

更新日期：2020-01-01 00:00:00

abstract：AIM:The aim of this study was to study the effects of compound FLZ, a novel cyclic derivative of squamosamide from Annona glabra, on brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element-binding protein (CREB) signaling and neuronal apoptosis in the hippocampus of the amylo...

journal_title：Acta pharmacologica Sinica

authors： Li N,Liu GT

更新日期：2010-03-01 00:00:00

abstract：:Aspirin (ASA) is a cardioprotective drug with anti-cardiac fibrosis action in vivo. This study was aimed to clarify the anti-cardiac fibrosis action of ASA and the underlying mechanisms. Two heart injury models (injection of isoproterenol and ligation of the left anterior descending branch) were used in mice to induce...

journal_title：Acta pharmacologica Sinica

authors： Liu PP,Liu HH,Sun SH,Shi XX,Yang WC,Su GH,Zhao J

更新日期：2017-04-01 00:00:00

abstract：AIM:The substrate cocktail is frequently used to evaluate cytochrome P450 (CYP) enzyme-mediated drug interactions and potential interactions among the probe substrates. Here, we re-optimized the substrate cocktail method to increase the reliability and accuracy of screening for candidate compounds and expanded the meth...

journal_title：Acta pharmacologica Sinica

authors： Chen ZH,Zhang SX,Long N,Lin LS,Chen T,Zhang FP,Lv XQ,Ye PZ,Li N,Zhang KZ

更新日期：2016-05-01 00:00:00

abstract：AIM:To investigate whether nimesulide could suppress tumor growth and induce apoptosis in implanted hepatoma mice and to explore the molecular mechanisms. METHODS:Male mice received nimesulide 10 mg/kg, 20 mg/kg, and 40 mg/kg ig daily for 21 d. Electron microscopy (EM), flow cytometry (FCM), DNA ladder, radioimmunoass...

journal_title：Acta pharmacologica Sinica

authors： Li XH,Li JJ,Zhang HW,Sun P,Zhang YL,Cai SH,Ren XD

更新日期：2003-10-01 00:00:00

abstract：AIM:To acquire the specific RNA aptamers inhibiting human red blood cell (RBC) acetylcholinesterase (AChE). METHODS:Systematic evolution of ligands by exponential enrichment (SELEX) aptamer against human red blood cell membrane AChE was selected by microtiter plate method in vitro. The specifity binding to AChE was de...

journal_title：Acta pharmacologica Sinica

authors： Zhang XM,Shao NS,Chi MG,Sun MJ

更新日期：2003-07-01 00:00:00

abstract：AIM:To study the expressions of vascular endothelial growth factor (VEG F), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), Tie-1, and Tie-2 in C57BL/6 mouse brain after permanent focal cerebral ischemia. METHODS:The mRNA levels of VEGF, Ang-1, Ang-2, Tie-1, and Tie-2 were measured by semiquantitative reverse transcri...

journal_title：Acta pharmacologica Sinica

authors： Wang RG,Zhu XZ

更新日期：2002-05-01 00:00:00

abstract：AIM:To investigate the pharmacokinetic profile and tissue distribution of a novel phosphodiesterase type 5 inhibitor, 5-ethyl-2-{5-[4-(2-hydroxy-ethyl)-piperazine-1-sulfonyl]-2-propoxy-phenyl}-7-propyl-3,5-dihydro-pyrrolo(3,2-d)pyrimidin-4-one (SK-3530), in rats after administration of the (14)C-labeled compound. METH...

journal_title：Acta pharmacologica Sinica

authors： Yoo HH,Kim NS,Im GJ,Kim DH

更新日期：2007-08-01 00:00:00

abstract：AIM:To examine the protective effect of propofol in renal ischemia/reperfusion (I/R) injury and the role of heme oxygenase-1 (HO-1) in this process. METHODS:Sprague-Dawley rats were randomly divided into 3 groups: (i) sham-operated group; (ii) I/R group; and (iii) propofol group. Bilateral renal warm ischemia for 45 m...

journal_title：Acta pharmacologica Sinica

authors： Wang HH,Zhou HY,Chen CC,Zhang XL,Cheng G

更新日期：2007-08-01 00:00:00

abstract：AIM:To determine whether mycophenolate mofetil (MMF) has beneficial effects on refractory idiopathic thrombocytopenic purpura (ITP) and the corresponding cellular mechanism. METHODS:Twenty refractory ITP patients resistant to corticosteroid and/or splenectomy and chemical therapy were given MMF 1.5-2.0 g/d orally for ...

journal_title：Acta pharmacologica Sinica

authors： Zhang WG,Ji L,Cao XM,Chen YX,He AL,Liu J,Zhao WH,Zou SP

更新日期：2005-05-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles (MVs) are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNA...

journal_title：Acta pharmacologica Sinica

authors： Zhang W,Chen S,Liu ML

更新日期：2018-01-01 00:00:00

abstract：AIM:Gemcitabine has been increasingly prescribed for the treatment of gallbladder cancer. However, the response rate is low. The aim of this study is to determine whether icariin, a flavonoid isolated from Epimedi herba, could potentiate the antitumor activity of gemcitabine in gallbladder cancer. METHODS:Human gallbl...

journal_title：Acta pharmacologica Sinica

authors： Zhang DC,Liu JL,Ding YB,Xia JG,Chen GY

更新日期：2013-02-01 00:00:00

abstract：AIM:To investigate the antidepressant-like effects of a novel 5-HT3 receptor antagonist N-(benzo[d]thiazol-2-yl)-3-methoxyquinoxalin-2-carboxamide (6z) in acute and chronic murine models of depression. METHODS:5-HT3 receptor antagonism was examined in guinea pig ileum in vitro. A tail suspension test (TST) was used as...

journal_title：Acta pharmacologica Sinica

authors： Gupta D,Radhakrishnan M,Kurhe Y,Thangaraj D,Prabhakar V,Kanade P

更新日期：2014-12-01 00:00:00

abstract：AIM:Pim-2 is a short-lived serine/threonine kinase, which plays a key role in metastasis of breast cancer through persistent activation of STAT3. Although the crystal structure of Pim-2 has been reported, but thus far no specific Pim-2-targeted compounds have been reported. In this study, we identified a novel Pim-2 in...

journal_title：Acta pharmacologica Sinica

authors： Zhao YQ,Yin YQ,Liu J,Wang GH,Huang J,Zhu LJ,Wang JH

更新日期：2016-09-01 00:00:00

abstract：AIM:To evaluate the pharmacokinetic characteristics of L-valyl-ara-C, a peptidomimetic prodrug of ara-C. METHODS:After the synthesis of L-valyl-ara-C, the in vitro stability of L-valyl-ara-C was examined in various biological media. Plasma pharmacokinetic profiles of ara-C and L-valyl-ara-C were also evaluated in rats...

journal_title：Acta pharmacologica Sinica

authors： Cheon EP,Han HK

更新日期：2007-02-01 00:00:00

abstract：AIM:To investigate the anticancer mechanism of a methoxyflavanone derivative, WJ9708012, highlighting its role on a crosstalk between endoplasmic reticulum (ER) and mitochondrial stress. METHODS:Cell proliferation was examined using sulforhodamine B assay. Cell-cycle progression, Ca(2+) mobilization and mitochondrial ...

journal_title：Acta pharmacologica Sinica

authors： Kuo TC,Huang WJ,Guh JH

更新日期：2011-01-01 00:00:00

abstract：AIM:To determine the Ca2+ source and cellular mechanisms of spontaneous Ca2+ oscillations in hippocampal astrocytes. METHODS:The cultured cells were loaded with Fluo-4 AM, the indicator of intracellular Ca2+, and the dynamic Ca2+ transients were visualized with confocal laser-scanning microscopy. RESULTS:The spontane...

journal_title：Acta pharmacologica Sinica

authors： Wang TF,Zhou C,Tang AH,Wang SQ,Chai Z

更新日期：2006-07-01 00:00:00

abstract：:As autophagy is involved in cell growth, survival, development and death, impaired autophagic flux has been linked to a variety of human pathophysiological processes, including neurodegeneration, cancer, myopathy, cardiovascular and immune-mediated disorders. There is a growing need to identify and quantify the status...

journal_title：Acta pharmacologica Sinica

authors： Zhang XJ,Chen S,Huang KX,Le WD

更新日期：2013-05-01 00:00:00

abstract：AIM:To investigate the effect of incorporation of an isoleucine zipper (IZ) motif into CD40 on binding activity of CD40 for the CD40 ligand (CD40L). METHODS:Prokaryotic expression vectors for 2 soluble CD40 derivatives, shCD40His and shCD40IZ containing an IZ domain, were constructed and expressed in Escherichia coli....

journal_title：Acta pharmacologica Sinica

authors： He XH,Xu LH,Liu Y

更新日期：2006-03-01 00:00:00

abstract：AIM:To determine propofol concentration in the cerebral spinal fluid (CSF) of neurosurgical patients and carry out a preliminary population pharmacodynamic study. METHODS:Twenty-seven elective neurosurgical patients (12 men and 15 women) aged 17-74 years received propofol in a bolus dose of 2 mg/kg for 5 min and an in...

journal_title：Acta pharmacologica Sinica

authors： Li YH,Wu FS,Xu JG

更新日期：2006-05-01 00:00:00

abstract：:Innovative teaching methodologies in different parts of the world are being practiced since last 3 decades. The aim of this review is to report the transition from traditional to innovative self learning process in Ziauddin Medical University, a new medical institute of Pakistan. Various problems encountered have been...

journal_title：Acta pharmacologica Sinica

authors： Barakzai Q

更新日期：2004-09-01 00:00:00