Cellular mechanism for spontaneous calcium oscillations in astrocytes.

abstract：AIM:The metabolites of naproxen produced by Cunninghamella species were isolated and identified, and further to compare the similarities between microbial transformation and mammalian metabolism. METHODS:Naproxen was transformed by three strains of Cunninghammella species (Cunninghamella blakeslesna AS 3.153, Cunningh...

journal_title：Acta pharmacologica Sinica

authors： Zhong DF,Sun L,Liu L,Huang HH

更新日期：2003-05-01 00:00:00

abstract：AIM:To explore the action of doxorubicin on vascular smooth muscle cells. METHODS:Isometric tension of denuded or intact thoracic aortic vessels was recorded and [Ca(2+)](i) in isolated aortic smooth muscle cells was measured by using Fluo-3. RESULTS:Doxorubicin induced phasic and tonic contractions in denuded vessel...

journal_title：Acta pharmacologica Sinica

authors： Shen B,Ye CL,Ye KH,Zhuang L,Jiang JH

更新日期：2009-11-01 00:00:00

abstract：AIM:To construct an HEK293 cell line stably expressing human dopamine D1 receptor (D1R). METHODS:cDNA was amplified by RT-PCR using total RNA from human embryo brain tissue as the template. The PCR products were subcloned into the plasmid pcDNA3 and cloned into the plasmid pcDNA3.1. The cloned D1R cDNA was sequenced a...

journal_title：Acta pharmacologica Sinica

authors： Sun WC,Jin L,Cao Y,Wang LZ,Meng F,Zhu XZ

更新日期：2005-01-01 00:00:00

abstract：AIM:To simultaneously investigate the contribution of the alpha 1 chain of collagen type 1 (COL1A1) and alpha2-HS-glycoprotein (AHSG) genes to the variation of bone geometric parameters in both Caucasians and Chinese. METHODS:Six hundred and five Caucasian individuals from 157 nuclear families and 1228 Chinese subject...

journal_title：Acta pharmacologica Sinica

authors： Jiang H,Lei SF,Xiao SM,Chen Y,Sun X,Yang F,Li LM,Wu S,Deng HW

更新日期：2007-03-01 00:00:00

abstract：AIM:To test the hypothesis that PI3K/Akt/eNOS signaling has a protective role in a murine model of ventilation associated lung injury (VALI) through down-regulation of p38 MAPK signaling. METHODS:Male C57BL/J6 (wild-type, WT) or eNOS knockout mice (eNOS(-/-)) were exposed to mechanical ventilation (MV) with low (LV(T)...

journal_title：Acta pharmacologica Sinica

authors： Peng XQ,Damarla M,Skirball J,Nonas S,Wang XY,Han EJ,Hasan EJ,Cao X,Boueiz A,Damico R,Tuder RM,Sciuto AM,Anderson DR,Garcia JG,Kass DA,Hassoun PM,Zhang JT

更新日期：2010-02-01 00:00:00

abstract：:An increasing number of cases of herb-induced liver injury (HILI) have been reported, presenting new clinical challenges. In this study, taking Polygonum multiflorum Thunb (PmT) as an example, we proposed a computational systems toxicology approach to explore the molecular mechanisms of HILI. First, the chemical compo...

journal_title：Acta pharmacologica Sinica

authors： Wang YY,Li J,Wu ZR,Zhang B,Yang HB,Wang Q,Cai YC,Liu GX,Li WH,Tang Y

更新日期：2017-05-01 00:00:00

abstract：AIM:To study in vitro release and in vivo effect of four different types of sustained-release naltrexone microspheres on morphine analgesia. METHODS:Release of naltrexone from four types of biodegradable microspheres was investigated by HPLC. Their antagonist effects on morphine analgesia were observed using mouse hot...

journal_title：Acta pharmacologica Sinica

authors： He GA,Hou HM,Liu XJ

更新日期：2001-06-01 00:00:00

abstract：AIM:Recent evidence shows that cultured mycelium Cordyceps sinensis (CMCS) effectively protects against liver fibrosis in mice. Here, we investigated whether the anti-fibrotic action of CMCS was related to its regulation of the activity of hepatic natural killer (NK) cells in CCl4-treated mice. METHODS:C57BL/6 mice we...

journal_title：Acta pharmacologica Sinica

authors： Peng Y,Huang K,Shen L,Tao YY,Liu CH

更新日期：2016-02-01 00:00:00

abstract：AIM:To evaluate the protective effects of apocynin on "two-hit" injury in rats. METHODS:"Two-hit" injury model of rat was induced by hemorrhagic shock (40 mmHg for 45 min) followed by iv administration of lipopolysaccharide (LPS, 150 microg/kg). Rats were randomized into seven groups: Sham, LPS, hemorrhage, hemorrhage...

journal_title：Acta pharmacologica Sinica

authors： Zhou R,Hu DY,Liu LM,Zhou XW

更新日期：2002-11-01 00:00:00

abstract：AIM:To investigate the effects of diosgenin (Dio), a naturally occurring steroid saponin, on goiter formation in a mouse model of Graves' disease (GD) and the underlying mechanisms. METHODS:Female BALB/c mice were injected with adenovirus expressing the A subunit of thyrotropin receptor to induce GD. The mice were tre...

journal_title：Acta pharmacologica Sinica

authors： Cai H,Wang Z,Zhang HQ,Wang FR,Yu CX,Zhang FX,Gao L,Zhang J,Zhao JJ

更新日期：2014-01-01 00:00:00

abstract：:It was reported that antituberculosis medicines could induce liver damage via oxidative stress. In this study, we investigated the effects of rifampicin (RFP) on the membrane expression of multidrug resistance-associated protein 2 (MRP2) and the relationship between oxidative stress and RFP-induced endocytosis of MRP2...

journal_title：Acta pharmacologica Sinica

authors： Xu BY,Tang XD,Chen J,Wu HB,Chen WS,Chen L

更新日期：2020-01-01 00:00:00

abstract：AIM:Osteopontin (OPN), a multifunctional protein, has been reported to be protoxicant in acetaminophen hepatotoxicity. In this study, the mechanisms underlying the detrimental role of OPN in acetaminophen toxicity were explored. METHODS:Male C57BL/6 (wild-type, WT) and OPN(-/-) mice were administered with acetaminophe...

journal_title：Acta pharmacologica Sinica

authors： He CY,Liang BB,Fan XY,Cao L,Chen R,Guo YJ,Zhao J

更新日期：2012-08-01 00:00:00

abstract：AIM:To study the effects of cimetidine (Cim) on the production of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) by splenocytes in immune-derived aplastic anemic (AA) mice. METHODS:Aplastic anemic mice model was constructed first, and then the splenocytes were induced to secrete IFN gamma and...

journal_title：Acta pharmacologica Sinica

authors： Xia T,Wang QR,Xu YH

更新日期：2001-03-01 00:00:00

abstract：AIM:To investigate the effect of peroxisome proliferator-activated receptor gamma (PPAR gamma ) activation on the growth of rat hepatic stellate cells (HSC) and transforming growth factor beta (TGF-beta)-induced connective tissue growth factor (CTGF) expression. METHODS:After being treated with various amounts of the ...

journal_title：Acta pharmacologica Sinica

authors： Sun K,Wang Q,Huang XH

更新日期：2006-06-01 00:00:00

abstract：:The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer intervention due to their roles in tumor metastasis and angiogenesis. Here, we identified a new selective FGFR inhibitor, C11, and assessed its antitumor activities. C11 was a selective FGFR1 inhibitor ...

journal_title：Acta pharmacologica Sinica

authors： Chen Z,Tong LJ,Tang BY,Liu HY,Wang X,Zhang T,Cao XW,Chen Y,Li HL,Qian XH,Xu YF,Xie H,Ding J

更新日期：2019-06-01 00:00:00

abstract：:Recent evidence shows that dopamine D2-like receptor (D2DR) antagonists, such as trifluoperazine and thioridazine, are effective for cancer therapy and inhibition of cancer stem-like cells (CSCs). In this study, we investigated the anti-cancer effects of combination therapy of dexamethasone (DEX) and sulpiride (SUL), ...

journal_title：Acta pharmacologica Sinica

authors： Li J,Yao QY,Xue JS,Wang LJ,Yuan Y,Tian XY,Su H,Wang SY,Chen WJ,Lu W,Zhou TY

更新日期：2017-09-01 00:00:00

abstract：AIM:To study the effect of chloroquine on the expression of human clotting factor IX (hFIX) in mice. METHODS:Hydrodynamics-based naked DNA plasmid administration was performed by tail vein injection of 10 microg of pCMV- hFIX and chloroquine (0, 100, 200, and 500 micromol/L) in 2.2 mL of Ringer's solution within 6-7 s...

journal_title：Acta pharmacologica Sinica

authors： Chen HY,Zhu HZ,Lu B,Xu X,Yao JH,Shen Q,Xue JL

更新日期：2004-05-01 00:00:00

abstract：:Binding of a neurotransmitter to its ionotropic receptor opens a distantly located ion channel, a process termed allosteric activation. Here we review recent advances in the molecular mechanism by which the cys-loop receptors are activated with emphasis on the best studied nicotinic acetylcholine receptors (nAChRs). W...

journal_title：Acta pharmacologica Sinica

authors： Chang YC,Wu W,Zhang JL,Huang Y

更新日期：2009-06-01 00:00:00

abstract：AIM:To investigate the effects of the cardiotonic steroid, ouabain, on cardiac differentiation of murine embyronic stem cells (mESCs). METHODS:Cardiac differentiation of murine ESCs was enhanced by standard hanging drop method in the presence of ouabain (20 μmol/L) for 7 d. The dissociated ES derived cardiomyocytes we...

journal_title：Acta pharmacologica Sinica

authors： Lee YK,Ng KM,Lai WH,Man C,Lieu DK,Lau CP,Tse HF,Siu CW

更新日期：2011-01-01 00:00:00

abstract：:Human enterovirus 71 (EV71) is the primary causative agent of recent large-scale outbreaks of hand, foot, and mouth disease (HFMD) in Asia. Currently, there are no drugs available for the prevention and treatment of HFMD. In this study, we compared the anti-EV71 activities of three natural compounds, rheum emodin, art...

journal_title：Acta pharmacologica Sinica

authors： Zhong T,Zhang LY,Wang ZY,Wang Y,Song FM,Zhang YH,Yu JH

更新日期：2017-03-01 00:00:00

abstract：AIM:To study the changes and mechanisms of protein-tyrosine kinase (PTK) and protein-tyrosine phosphatase (PTP) activities in the hippocamal synaptosome following cerebral ischemia/reperfusion (I/R) in gerbil. METHODS:Transient (15 min) global ischemia was produced by bilateral carotid artery occlusion. Total PTK and ...

journal_title：Acta pharmacologica Sinica

authors： Pei L,Li Y,Yan JZ,Zhang GY,Cui ZC,Zhu ZM

更新日期：2000-08-01 00:00:00

abstract：AIM:To study the effect of nomegestrol acetate, a new synthetic progesterone on granulosa cells' viability and steroidogenesis function. METHODS:Granulosa cells were cultured in McCoy's 5A medium. Trypan blue stain was used to measure viable cells. FSH and testosterone were added to stimulate the steroid secretion. Sp...

journal_title：Acta pharmacologica Sinica

authors： Qian LH,Yang B,Leng Y,Cao L,Gu ZP

更新日期：2001-01-01 00:00:00

abstract：AIM:To examine whether the cell growth inhibitory effect of the combination of baicalin and baicalein is related to apoptosis. Moreover, to determine whether the expression of some apoptosis-related proteins is regulated by the ERK/p38 MAPK pathway. METHODS:Cell viability was measured using a 3-(4,5-dimethylthiazol-2-...

journal_title：Acta pharmacologica Sinica

authors： Zhou QM,Wang S,Zhang H,Lu YY,Wang XF,Motoo Y,Su SB

更新日期：2009-12-01 00:00:00

abstract：AIM:To investigate the protective effects of hydrogen sulfide (H2S) against inflammation, oxidative stress and apoptosis in a rat model of resuscitated hemorrhagic shock. METHODS:Hemorrhagic shock was induced in adult male SD rats by drawing blood from the femoral artery for 10 min. The mean arterial pressure was main...

journal_title：Acta pharmacologica Sinica

authors： Xu DQ,Gao C,Niu W,Li Y,Wang YX,Gao CJ,Ding Q,Yao LN,Chai W,Li ZC

更新日期：2013-12-01 00:00:00

abstract：AIM:To evaluation the doxorubicin (DOX)-loaded pH-sensitive polymeric micelle release from tumor blood vessels into tumor interstitium using an animal vessel visibility model, the so-called dorsal skin-fold window chamber model. METHODS:DOX-loaded pH-sensitive polyHis-b-PEG micelles and DOX-loaded pH-insensitive PLLA-...

journal_title：Acta pharmacologica Sinica

authors： Jin ZH,Jin MJ,Jiang CG,Yin XZ,Jin SX,Quan XQ,Gao ZG

更新日期：2014-06-01 00:00:00

abstract：AIM:The interaction of anthracycline anticancer drugs with chromatin, nucleosomes and histone H1 has been extensively studied. In the present study, for the first time, we have investigated the binding of anthracycline antibiotic, daunomycin, to free and cross-linked thymus core histones (CL-core) in solution and in th...

journal_title：Acta pharmacologica Sinica

authors： Rabbani A,Abdosamadi S,Sari-Saraf N

更新日期：2007-05-01 00:00:00

abstract：:The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat to global public health. The highly infectious SARS-CoV-2 virus primarily attacks pulmonary tissues and impairs gas exchange leading to acute respir...

journal_title：Acta pharmacologica Sinica

authors： Serebrovska ZO,Chong EY,Serebrovska TV,Tumanovska LV,Xi L

更新日期：2020-12-01 00:00:00

abstract：AIM:To investigate the effects of chronic ethanol intake on the locomotor activity and the levels of calcium/calmodulin-dependent protein kinase IV (CaM kinase IV) in the nucleus accumbens (NAc) of rats. Simultaneously, the effects of nonselective opioid antagonist (naloxone) on the CaM kinase IV expression in the NAc ...

journal_title：Acta pharmacologica Sinica

authors： Li J,Bian WL,Xie GQ,Cui SZ,Wu ML,Li YH,Que LL,Yuan XR

更新日期：2008-06-01 00:00:00

abstract：AIM:Using sparse data of valproate (VPA) serum concentrations to build a population pharmacokinetic (PPK) model of VPA in Chinese children with epilepsy and to predict serum concentrations for new patients using a Bayesian approach. METHODS:Two hundred epileptic children, whose VPA serum concentrations were collected,...

journal_title：Acta pharmacologica Sinica

authors： Jiang DC,Wang L

更新日期：2004-12-01 00:00:00

abstract：AIM:Experimental studies found that cinacalcet (CINA) markedly attenuated vascular calcification in uremic rats, but its underlying mechanisms are still largely unknown. Recent evidence have demonstrated that endothelial cells (ECs) participate in ectopic calcification in part by mediating endothelial-to-mesenchymal tr...

journal_title：Acta pharmacologica Sinica

authors： Wu M,Tang RN,Liu H,Pan MM,Liu BC

更新日期：2016-11-01 00:00:00