C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis.

abstract：AIM:To develop a combined population pharmacokinetic model (PPK) to assess the magnitude and variability of exposure to both clozapine and its primary metabolite norclozapine in Chinese patients with refractory schizophrenia via sparse sampling with a focus on the effects of covariates on the pharmacokinetic parameters...

journal_title：Acta pharmacologica Sinica

authors： Li LJ,Shang DW,Li WB,Guo W,Wang XP,Ren YP,Li AN,Fu PX,Ji SM,Lu W,Wang CY

更新日期：2012-11-01 00:00:00

abstract：AIM:To examine the effect of curcumin on oxidative DNA damage and cell apoptosis and injury caused by the reaction of methylglyoxal(MG) with amino acids. METHODS:We used DNA strand breaks to examine the effect of curcumin on oxidative DNA damage. In addition, reactive oxygen species(ROS) formation occurs in MG-treated...

journal_title：Acta pharmacologica Sinica

authors： Chan WH,Wu HJ

更新日期：2006-09-01 00:00:00

abstract：:Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and pathogens. Lf can bi...

journal_title：Acta pharmacologica Sinica

authors： Siqueiros-Cendón T,Arévalo-Gallegos S,Iglesias-Figueroa BF,García-Montoya IA,Salazar-Martínez J,Rascón-Cruz Q

更新日期：2014-05-01 00:00:00

abstract：AIM:Filamin binding LIM protein 1, also known as migfilin, is a skeleton organization protein that binds to mitogen-inducible gene 2 at cell-extracellular matrix adhesions. The aim of this study was to investigate the role of migfilin in cisplatin-induced apoptosis in human glioma cells, to determine the functional dom...

journal_title：Acta pharmacologica Sinica

authors： Fan J,Ou YW,Wu CY,Yu CJ,Song YM,Zhan QM

更新日期：2012-10-01 00:00:00

abstract：AIM:To evaluate retrospectively the association of cytochrome P450 3A (CYP3A) and ATP-binding cassette sub-family B member 1 (ABCB1) gene polymorphisms with the pharmacokinetics of cyclosporine A (CsA) in Chinese renal transplant patients. METHODS:One hundred and twenty-six renal transplant patients were recruited. Bl...

journal_title：Acta pharmacologica Sinica

authors： Meng XG,Guo CX,Feng GQ,Zhao YC,Zhou BT,Han JL,Chen X,Shi Y,Shi HY,Yin JY,Peng XD,Pei Q,Zhang W,Wang G,He M,Liu M,Yang JK,Zhou HH

更新日期：2012-12-01 00:00:00

abstract：AIM:To make a LQT3 model (one form of the long QT syndromes) and to investigate the effect of mexiletine on LQT3. METHODS:Sea anemone toxin (ATX II) was used to produce the LQT3 model. The Effect of mexiletine on LQT3 was performed on single Na channel, action potential, and electrocardiography in guinea pigs. RESULT...

journal_title：Acta pharmacologica Sinica

authors： Wang HW,Zheng YQ,Yang ZF,Li CZ,Liu YM

更新日期：2003-04-01 00:00:00

abstract：:Recent evidence shows that high glucose levels recruit carbohydrate response element-binding protein, which binds the promoter of thioredoxin-interacting protein (txnip), thereby regulating its expression in β-cells. Overexpression of txnip not only induces β-cell apoptosis but also reduces insulin production. Thus, t...

journal_title：Acta pharmacologica Sinica

authors： Li T,Lin GY,Zhong L,Zhou Y,Wang J,Zhu Y,Feng Y,Cai XQ,Liu Q,Nosjean O,Boutin JA,Renard P,Yang DH,Wang MW

更新日期：2017-07-01 00:00:00

abstract：AIM:To examine the in vitro antitumor activity of resveratrol against multiple myeloma (MM) cell lines (RPMI 8226, U266, and KM3), and the mechanisms involved. METHODS:The growth inhibition of resveratrol was determined by 3-(4, 5-dimethyl-2-thiazyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The effect of resve...

journal_title：Acta pharmacologica Sinica

authors： Sun CY,Hu Y,Guo T,Wang HF,Zhang XP,He WJ,Tan H

更新日期：2006-11-01 00:00:00

abstract：:Esophageal cancer is one of the most common types of cancer in the world, and it demonstrates a distinct geographical distribution pattern in China. In the last decade, inducing apoptosis with traditional Chinese medicine (TCM) has become an active area in both fundamental and clinical research on cancer therapy. In t...

journal_title：Acta pharmacologica Sinica

authors： Zhang YS,Shen Q,Li J

更新日期：2016-03-01 00:00:00

abstract：AIM:To study the protective effect of the polypeptide isolated from Chlamys farreri (PCF) on hairless mice skin damaged by ultraviolet A. METHODS:Enzymes and malondialdehyde (MDA) were determined by biochemical methods; the expressions of Bcl-2 protein and NOS protein were examined by immunohistochemical technique. Th...

journal_title：Acta pharmacologica Sinica

authors： Wang CB,Yao RY,Liu ZT,Zhong WZ,Liu XP,Wang YJ

更新日期：2002-09-01 00:00:00

abstract：:Cardiac amyloidosis (CA) comprises a heterogeneous group of medical conditions affecting the myocardium. It presents with proteinaceous infiltration with variable degrees of severity, prevalence and evolution. Despite this heterogeneity, erroneous protein folding is the common pathophysiologic process, yielding the fo...

journal_title：Acta pharmacologica Sinica

authors： Luciani M,Troncone L,Monte FD

更新日期：2018-07-01 00:00:00

abstract：AIM:To investigate the effect of ectogenesis unsaturated fatty acid on carbachol-induced muscarinic current (ICCh) and its mechanism. METHODS:Using the whole-cell patch-clamp technique, ICCh was recorded in single smooth muscle cell isolated from the antral circular smooth muscles of guinea-pig stomach. RESULTS:Arach...

journal_title：Acta pharmacologica Sinica

authors： Cui YF,Jin H,Guo HS,Li L,Yu YC,Xu WX

更新日期：2003-03-01 00:00:00

abstract：:Etimicin (ETM), a fourth-generation aminoglycosides (AGs), is now widely clinically used in China due to its high efficacy and low toxicity. However, the mechanisms underlying its low nephrotoxicity and ototoxicity remain unclear. In the present study we compared the antibacterial and toxicity profiles of etimicin, ge...

journal_title：Acta pharmacologica Sinica

authors： Yao L,Zhang JW,Chen B,Cai MM,Feng D,Wang QZ,Wang XY,Sun JG,Zheng YW,Wang GJ,Zhou F

更新日期：2020-06-01 00:00:00

abstract：AIM:To investigate the effects of pravastatin, a potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on impaired endothelium-dependent relaxation induced by lysophosphatidylcholine (LPC), the major component of oxidized low-density lipoprotein, in rat thoracic aorta. METHODS:Both the endotheliu...

journal_title：Acta pharmacologica Sinica

authors： Deng HF,Xiong Y

更新日期：2005-01-01 00:00:00

abstract：AIM:The substrate cocktail is frequently used to evaluate cytochrome P450 (CYP) enzyme-mediated drug interactions and potential interactions among the probe substrates. Here, we re-optimized the substrate cocktail method to increase the reliability and accuracy of screening for candidate compounds and expanded the meth...

journal_title：Acta pharmacologica Sinica

authors： Chen ZH,Zhang SX,Long N,Lin LS,Chen T,Zhang FP,Lv XQ,Ye PZ,Li N,Zhang KZ

更新日期：2016-05-01 00:00:00

abstract：:Recepteur d'origine nantais (RON) belongs to a subfamily of receptor tyrosine kinases (RTK) with unique expression patterns and biological activities. RON is activated by a serum-derived growth factor macrophage stimulating protein (MSP). The RON gene transcription is essential for embryonic development and critical i...

journal_title：Acta pharmacologica Sinica

authors： Wang MH,Yao HP,Zhou YQ

更新日期：2006-06-01 00:00:00

abstract：:As autophagy is involved in cell growth, survival, development and death, impaired autophagic flux has been linked to a variety of human pathophysiological processes, including neurodegeneration, cancer, myopathy, cardiovascular and immune-mediated disorders. There is a growing need to identify and quantify the status...

journal_title：Acta pharmacologica Sinica

authors： Zhang XJ,Chen S,Huang KX,Le WD

更新日期：2013-05-01 00:00:00

abstract：:The mechanism underlying the resistance of cancer cells to chemotherapeutic drug varies with different cancer cells. Recent evidence shows that lysosomal function is associated with drug resistance of cancer cells. Artesunate, a derivative of artemisinin, displays broad antitumor activity and direct cytotoxicity on va...

journal_title：Acta pharmacologica Sinica

authors： Li Z,Zhu YT,Xiang M,Qiu JL,Luo SQ,Lin F

更新日期：2020-07-23 00:00:00

abstract：AIM:To evaluate single-dose and multiple-dose pharmacokinetics of cytotoxic T-lymphocyte-associated antigen 4 fusion protein (CTLA4Ig) in healthy volunteers and patients with rheumatoid arthritis (RA). METHODS:The clinical trials included two phase I open studies: study 1 was an open-label dose-escalation study in 27 ...

journal_title：Acta pharmacologica Sinica

authors： Ma Y,Lin BR,Lin B,Hou S,Qian WZ,Li J,Tan M,Ma J,Li BH,Wang H,Wen AD,Guo YJ

更新日期：2009-03-01 00:00:00

abstract：AIM:It is generally assumed that only unbound drugs can reach the site of action by diffusing across the membranes and exerting pharmacological effects by interacting with receptors. Recent research has shown that the percentage of free drugs may depend on the total drug concentration. The aim of the paper is to verify...

journal_title：Acta pharmacologica Sinica

authors： Kalitynski R,Dawidowicz AL,Poszytek J

更新日期：2006-12-01 00:00:00

abstract：AIM:To investigate the blood pressure (BP), baroreflex sensitivity (BRS), and organ damage in hybrids of spontaneously hypertensive rats and Sprague-Dawley rats. METHODS:Spontaneously hypertensive rats and Sprague-Dawley rats were crossbred, and the F1 hybrids were inbred randomly to produce an F2 generation. At the a...

journal_title：Acta pharmacologica Sinica

authors： Xie HH,Shen FM,Miao CY,Su DF

更新日期：2005-09-01 00:00:00

abstract：AIM:Recent studies have shown that constitutive activation of the nuclear factor κB (NF-κB) plays a key role in chronic inflammation and cancers. The aim of this study was to characterize lobolide, a cembrane diterpene, as a drug candidate targeting the NF-κB signaling pathway. METHODS:A HEK 293/NF-κB-Luc stable cell ...

journal_title：Acta pharmacologica Sinica

authors： Lv XF,Chen SH,Li J,Fang JP,Guo YW,Ding K

更新日期：2012-10-01 00:00:00

abstract：:Hydrogen sulfide (H2S), which is well known traditionally as a toxic gas, has been proven to be produced endogenously by 3 enzymes in mammalian tissues and plays important roles in physiological and pathophysiological conditions. In the central nervous system, H2S functions as not only a neuromodulator, but also a neu...

journal_title：Acta pharmacologica Sinica

authors： Chen CQ,Xin H,Zhu YZ

更新日期：2007-11-01 00:00:00

abstract：AIM:To study the effect of Huangqi Jianzhong Tang in reducing fatigue improvement in athletes. METHODS:Twelve athletes were randomly separated into a control group, whose members were administered with placebos, and the experimental group, whose members were administered with Huangqi Jianzhong Tang. During the eight w...

journal_title：Acta pharmacologica Sinica

authors： Chen KT,Su CH,Hsin LH,Su YC,Su YP,Lin JG

更新日期：2002-08-01 00:00:00

abstract：AIM:To develop a robust, cell-based, high-content screening (HCS) assay based on receptor internalization for the identification of novel modulators of the epidermal growth factor receptor (EGFR). METHODS:Agonist-induced receptor internalization is part of the signaling cascade of EGFR. Fluorescent-tagged epidermal gr...

journal_title：Acta pharmacologica Sinica

authors： Wang J,Xie X

更新日期：2007-10-01 00:00:00

abstract：AIM:To examine the effects of β3-adrenoceptor (β3-AR) activation on atherosclerotic plaque development in ApoE(-/-) mice. METHODS:Thirty six week-old male ApoE(-/-) mice on a high-fat diet were treated with atorvastatin (10 mg·kg(-1)·d(-1), po), BRL37344 (β3-AR agonist, 1.65 or 3.30 μg/kg, ip, twice a week) or SR52390...

journal_title：Acta pharmacologica Sinica

authors： Wang ZH,Li YF,Guo YQ

更新日期：2013-09-01 00:00:00

abstract：AIM:To investigate the stereoselective metabolism of propafenone (PPF) by human liver CYP3A4. METHODS:A chiral and an achiral HPLC were combined to determine the enantiomer of PPF in S9 incubates prepared from transgenic Chinese hamster CHL cells lines expressing CYP3A4. The time-dependent study was performed using in...

journal_title：Acta pharmacologica Sinica

authors： Zhou Q,Yao TW,Yu YN,Zeng S

更新日期：2001-10-01 00:00:00

abstract：AIM:To examine the therapeutic effects and underlying mechanisms of DZ2002, a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor, on lupus-prone female NZB×NZW F1 (NZB/W F1) mice. METHODS:Female NZB/W F1 mice were treated orally with DZ2002 (0.5 mg·kg(-1)·d(-1)) for 11 weeks, and the proteinuria level and...

journal_title：Acta pharmacologica Sinica

authors： He SJ,Lin ZM,Wu YW,Bai BX,Yang XQ,He PL,Zhu FH,Tang W,Zuo JP

更新日期：2014-02-01 00:00:00

abstract：AIM:To explore the alteration of endogenous metabolites and identify potential biomarkers using metabolomic profiling with gas chromatography coupled a time-of-flight mass analyzer (GC/TOF-MS) in a rat model of estrogen-deficiency-induced obesity. METHODS:Twelve female Sprague-Dawley rats six month of age were either ...

journal_title：Acta pharmacologica Sinica

authors： Ma B,Zhang Q,Wang GJ,A JY,Wu D,Liu Y,Cao B,Liu LS,Hu YY,Wang YL,Zheng YY

更新日期：2011-02-01 00:00:00

abstract：AIM:To investigate the expression of c-Met in peritoneal free cancer cells isolated from human gastric cancer ascites, and its relationship to peritoneal dissemination of gastric cancer. METHODS:Peritoneal free cancer cells (PFCCs) were isolated from ascites specimens of gastric cancer patients. c-Met expression in PF...

journal_title：Acta pharmacologica Sinica

authors： Wang XL,Chen XM,Fang JP,Yang CQ

更新日期：2012-04-01 00:00:00