Proteome reference map and regulation network of neonatal rat cardiomyocyte.

abstract：AIM:To compare high K(+ )-induced contraction and optimal resting tension measured by two commonly used techniques of hypertonic and isotonic K(+ ) in aortas with and without adventitial fat from various age rats. METHODS:Three age groups of rats (15, 25, and 62 weeks) were used to prepare thoracic aortic rings in whi...

journal_title：Acta pharmacologica Sinica

authors： Guan YF,Chen RH,Wang P,Qin Y,Su DF,Miao CY

更新日期：2007-05-01 00:00:00

abstract：AIM:To test the hypothesis that PI3K/Akt/eNOS signaling has a protective role in a murine model of ventilation associated lung injury (VALI) through down-regulation of p38 MAPK signaling. METHODS:Male C57BL/J6 (wild-type, WT) or eNOS knockout mice (eNOS(-/-)) were exposed to mechanical ventilation (MV) with low (LV(T)...

journal_title：Acta pharmacologica Sinica

authors： Peng XQ,Damarla M,Skirball J,Nonas S,Wang XY,Han EJ,Hasan EJ,Cao X,Boueiz A,Damico R,Tuder RM,Sciuto AM,Anderson DR,Garcia JG,Kass DA,Hassoun PM,Zhang JT

更新日期：2010-02-01 00:00:00

abstract：AIM:To evaluate retrospectively the association of cytochrome P450 3A (CYP3A) and ATP-binding cassette sub-family B member 1 (ABCB1) gene polymorphisms with the pharmacokinetics of cyclosporine A (CsA) in Chinese renal transplant patients. METHODS:One hundred and twenty-six renal transplant patients were recruited. Bl...

journal_title：Acta pharmacologica Sinica

authors： Meng XG,Guo CX,Feng GQ,Zhao YC,Zhou BT,Han JL,Chen X,Shi Y,Shi HY,Yin JY,Peng XD,Pei Q,Zhang W,Wang G,He M,Liu M,Yang JK,Zhou HH

更新日期：2012-12-01 00:00:00

abstract：:The hypnotic agent propofol is effective for the induction and maintenance of anesthesia. However, recent studies have shown that propofol administration is related to arrhythmias. Propofol displays both pro- and anti-arrhythmic effects in a concentration-dependent manner. Data indicate that propofol can convert supra...

journal_title：Acta pharmacologica Sinica

authors： Liu Q,Kong AL,Chen R,Qian C,Liu SW,Sun BG,Wang LX,Song LS,Hong J

更新日期：2011-06-01 00:00:00

abstract：:The intercellular communication between leukemia cells and bone marrow mesenchymal stem cells (BM-MSCs) plays more important role in chronic myeloid leukemia (CML) than we previously understood. Recently, we found that microvesicles released from human leukemia cell line K562 (K562-MVs) containing BCR-ABL1 mRNA malign...

journal_title：Acta pharmacologica Sinica

authors： Fu FF,Zhu XJ,Wang HX,Zhang LM,Yuan GL,Chen ZC,Li QB

更新日期：2017-11-01 00:00:00

abstract：AIM:To study the effects of the caspase-1 inhibitor Ac-YVAD-CHO on quinolinic acid (QA)-induced apoptosis. METHODS:Rats were pre-treated with intrastriatal infusion of Ac-YVAD-CHO (2-8 microg) before intrastriatal injection of QA (60 nmol). Striatal total proteins, genomic DNA, and nuclear proteins were isolated. The ...

journal_title：Acta pharmacologica Sinica

authors： Cao Y,Gu ZL,Lin F,Han R,Qin ZH

更新日期：2005-02-01 00:00:00

abstract：AIM:FTY720 is a new synthetic immunosuppressive agent which has a unique mechanism of action and induces long-term graft acceptance in rat and dog allotransplantation as prophylactic administration. The present study investigated whether FTY720 was able to rescue ongoing acute rejection of solid organ transplants in a ...

journal_title：Acta pharmacologica Sinica

authors： Wang MH,Milekhin V,Zhang H,Huang HZ

更新日期：2003-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disease characterized by motor impairment and progressive loss of dopamine (DA) neurons. At present, the acute application of neurotoxic drugs such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are commonly used to simulate ...

journal_title：Acta pharmacologica Sinica

authors： Guo CH,Cao T,Zheng LT,Waddington JL,Zhen XC

更新日期：2020-04-01 00:00:00

abstract：AIM:To develop a high-throughput real-time assay based on molecular beacons to monitor the integrase 3'-processing reaction in vitro and apply it to inhibitor screening. METHODS:The recombinant human immunodeficiency virus (HIV)-1 integrase (IN) is incubated with a 38 mer oligonucleotide substrate, a sequence identica...

journal_title：Acta pharmacologica Sinica

authors： He HQ,Ma XH,Liu B,Zhang XY,Chen WZ,Wang CX,Cheng SH

更新日期：2007-06-01 00:00:00

abstract：:In this brief review we summarize the current fndings relative to the discovery of a small peptide ligand, phoenixin (PNX). Using a bioinformatic approach, two novel peptides PNX-14 and PNX-20 containing 14 and 20 amino acids, respectively, were isolated from diverse tissues including the brain, heart, lung and stomac...

journal_title：Acta pharmacologica Sinica

authors： Lyu RM,Cowan A,Zhang Y,Chen YH,Dun SL,Chang JK,Dun NJ,Luo JJ

更新日期：2018-05-01 00:00:00

abstract：AIM:to investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation. METHODS:the denervated and innervated skeletal muscle cells were examined on days 1, 4, 7, 14, 21, and 28 after denervation. Individual denervated and innervated cells were prepared from the...

journal_title：Acta pharmacologica Sinica

authors： WANG H,YANG B,HAN GW,LI ST

更新日期：2010-12-01 00:00:00

abstract：:The revolutionary induced pluripotent stem cell (iPSC) technology provides a new path for cell replacement therapies and drug screening. Patient-specific iPSCs and subsequent differentiated cells manifesting disease phenotypes will finally position human disease pathology at the core of drug discovery. Cells used to t...

journal_title：Acta pharmacologica Sinica

authors： Zhang R,Zhang LH,Xie X

更新日期：2013-06-01 00:00:00

abstract：AIM:Matrine is an alkaloid from Sophora alopecuroides L, which has shown a variety of pharmacological activities and potential therapeutic value in cardiovascular diseases. In this study we examined the protective effects of matrine against diabetic cardiomyopathy (DCM) in rats. METHODS:Male SD rats were injected with...

journal_title：Acta pharmacologica Sinica

authors： Liu ZW,Wang JK,Qiu C,Guan GC,Liu XH,Li SJ,Deng ZR

更新日期：2015-03-01 00:00:00

abstract：AIM:To investigate whether atorvastatin can promote formation of neurites in cultured cortical neurons and the signaling mechanisms responsible for this effect. METHODS:Cultured rat cerebral cortical neurons were incubated with atorvastatin (0.05-10 μmol/L) for various lengths of time. For pharmacological experiments,...

journal_title：Acta pharmacologica Sinica

authors： Jin Y,Sui HJ,Dong Y,Ding Q,Qu WH,Yu SX,Jin YX

更新日期：2012-07-01 00:00:00

abstract：AIM:To simultaneously investigate the contribution of the alpha 1 chain of collagen type 1 (COL1A1) and alpha2-HS-glycoprotein (AHSG) genes to the variation of bone geometric parameters in both Caucasians and Chinese. METHODS:Six hundred and five Caucasian individuals from 157 nuclear families and 1228 Chinese subject...

journal_title：Acta pharmacologica Sinica

authors： Jiang H,Lei SF,Xiao SM,Chen Y,Sun X,Yang F,Li LM,Wu S,Deng HW

更新日期：2007-03-01 00:00:00

abstract：:Saw palmetto extract (SPE), an extract from the ripe berries of the American dwarf palm, has been widely used as a therapeutic remedy for urinary dysfunction due to benign prostatic hyperplasia (BPH) in Europe. Numerous mechanisms of action have been proposed for SPE, including the inhibition of 5alpha-reductase. Toda...

journal_title：Acta pharmacologica Sinica

authors： Suzuki M,Ito Y,Fujino T,Abe M,Umegaki K,Onoue S,Noguchi H,Yamada S

更新日期：2009-03-01 00:00:00

abstract：AIM:To explore the possible association of different polymorphic forms of human alpha-estrogen receptor (ER-alpha) and aryl hydrocarbon receptor gene (Ahr) with the risk to senile dementia in farmers in Shanghai suburb. METHODS:Senile dementia patients (n=52) were examined for ER-alpha and Ahr gene polymorphism genoty...

journal_title：Acta pharmacologica Sinica

authors： Lin GF,Ma QW,Zhang DS,Zha YL,Lou KJ,Shen JH

更新日期：2003-07-01 00:00:00

abstract：AIM:(-)Stepholidine (SPD) is an active ingredient of the Chinese herb Stephania intermedia, which binds to the dopamine D(1) and D(2) like receptors. Biochemical, electrophysiological and behavioural experiments have provided strong evidence that SPD is both a D(1) and a D(2) antagonist, which could make SPD a unique a...

journal_title：Acta pharmacologica Sinica

authors： Ellenbroek BA,Zhang XX,Jin GZ

更新日期：2006-09-01 00:00:00

abstract：AIM:To establish a population pharmacokinetics (PPK) model for lamotrigine (LTG) in Chinese children with epilepsy in order to formulate an individualized dosage guideline. METHODS:LTG steady-state plasma concentration data from therapeutic drug monitoring (TDM) were collected retrospectively from 284 patients, with a...

journal_title：Acta pharmacologica Sinica

authors： He DK,Wang L,Qin J,Zhang S,Lu W,Li L,Zhang JM,Bao WQ,Song XQ,Liu HT

更新日期：2012-11-01 00:00:00

abstract：AIM:To investigate the molecular mechanism and signaling pathway by which fenoterol, a beta(2)-adrenergic receptor (beta(2)-AR) agonist, produces anti-inflammatory effects. METHODS:THP-1, a monocytic cell line, was used to explore the mechanism of beta(2)-AR stimulation in LPS-induced secretion of inflammatory cytokin...

journal_title：Acta pharmacologica Sinica

authors： Wang W,Xu M,Zhang YY,He B

更新日期：2009-11-01 00:00:00

abstract：:Contact inhibition and its disruption of vascular smooth muscle cells (VSMCs) are important cellular events in vascular diseases. But the underlying molecular mechanisms are unclear. In this study we investigated the roles of microRNAs (miRNAs) in the contact inhibition and its disruption of VSMCs and the molecular me...

journal_title：Acta pharmacologica Sinica

authors： Sun YY,Qin SS,Cheng YH,Wang CY,Liu XJ,Liu Y,Zhang XL,Zhang W,Zhan JX,Shao S,Bian WH,Luo BH,Lu DF,Yang J,Wang CH,Zhang CX

更新日期：2018-05-01 00:00:00

abstract：AIM:To investigate the effects of different muscarinic receptor (M) subtypes in the spinal cord on the scores of naloxone-precipitated morphine-withdrawal symptoms and the changes of nNOS expression in locus coeruleus (LC). METHODS:nNOS immunohistochemistry, intrathecal injection (it), and antisense oligonucleotides (...

journal_title：Acta pharmacologica Sinica

authors： Chou WB,Zeng YM,Duan SM,Zhou WH,Gu J,Yang GD

更新日期：2002-08-01 00:00:00

abstract：AIM:To develop and validate a novel precolumn derivatization method for the quantitative determination and pharmacokinetic application of acetylshikonin in macaque monkeys by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). METHODS:2-Mercaptoethanol was added to the blood sample a...

journal_title：Acta pharmacologica Sinica

authors： Sun DX,Tian HF,Meng ZY,Du A,Yuan D,Gu RL,Wu ZN,Dou GF

更新日期：2008-12-01 00:00:00

abstract：AIM:To examine the protective effect of propofol in renal ischemia/reperfusion (I/R) injury and the role of heme oxygenase-1 (HO-1) in this process. METHODS:Sprague-Dawley rats were randomly divided into 3 groups: (i) sham-operated group; (ii) I/R group; and (iii) propofol group. Bilateral renal warm ischemia for 45 m...

journal_title：Acta pharmacologica Sinica

authors： Wang HH,Zhou HY,Chen CC,Zhang XL,Cheng G

更新日期：2007-08-01 00:00:00

abstract：AIM:We have shown that a combination of ligustrazine and berberine produces more effective inhibition on platelet activation and inflammatory reactions in rat acute myocardial infarction compared with either agent alone. In this study we evaluated the beneficial effects of a combination of ligustrazine and berberine in...

journal_title：Acta pharmacologica Sinica

authors： Zhang Y,Ma XJ,Guo CY,Wang MM,Kou N,Qu H,Mao HM,Shi DZ

更新日期：2016-04-01 00:00:00

abstract：:Autophagy, a form of cellular self-digestion by lysosome, is associated with various disease processes including cancers, and modulating autophagy has shown promise in the treatment of various malignancies. A number of natural products display strong antitumor activity, yet their mechanisms of action remain unclear. T...

journal_title：Acta pharmacologica Sinica

authors： Jiang SL,Guan YD,Chen XS,Ge P,Wang XL,Lao YZ,Xiao SS,Zhang Y,Yang JM,Xu XJ,Cao DS,Cheng Y

更新日期：2019-07-01 00:00:00

abstract：:Alzheimer's disease (AD), a progressive degenerative disorder, is characterized by the presence of amyloid deposits, neurofibrillary tangles and neuron loss. Emerging evidence indicates that antioxidants could be useful either for the prevention or treatment of AD. It has been shown that melatonin is a potent antioxid...

journal_title：Acta pharmacologica Sinica

authors： Cheng Y,Feng Z,Zhang QZ,Zhang JT

更新日期：2006-02-01 00:00:00

abstract：AIM:Tolsultazolamide, a novel carbonic anhydrase inhibitor, is designed for the prophylaxis and treatment of acute mountain sickness. The aim of this study was to investigate the pharmacokinetics, tissue distribution, and excretion characteristics of tolsultazolamide and the sex difference in pharmacokinetics in rats. ...

journal_title：Acta pharmacologica Sinica

authors： Wang JD,Shi YP,Yin J,Pan ZY,Cui WY,Zhang YF,Wang H

更新日期：2014-02-01 00:00:00

abstract：AIM:To determine whether basophils expressed human leucocyte antigen (HLA) class II molecules. METHODS:Basophils in umbilical cord blood were separated and purified with methods of density gradient centrifugation and immunomagnetic microbeads. The isolated basophils were cultured in RPMI-1640 plus 10 % fetal calf seru...

journal_title：Acta pharmacologica Sinica

authors： Xie ML,Wu YG

更新日期：2002-07-01 00:00:00

abstract：AIM:To study the effects of tanshinone IIA (TIIA) on lipopolysaccharide (LPS)-induced acute lung injury in mice and the underlying mechanisms. METHODS:Mice were injected with LPS (10 mg/kg, i.p.), then treated with TIIA (10 mg/kg, i.p.). Seven hours after LPS injection, the lungs were collected for histological study....

journal_title：Acta pharmacologica Sinica

authors： Xu M,Cao FL,Zhang YF,Shan L,Jiang XL,An XJ,Xu W,Liu XZ,Wang XY

更新日期：2015-02-01 00:00:00