Fenoterol, a beta(2)-adrenoceptor agonist, inhibits LPS-induced membrane-bound CD14, TLR4/CD14 complex, and inflammatory cytokines production through beta-arrestin-2 in THP-1 cell line.

abstract：AIM:To investigate whether histidine can enhance the anticonvulsant efficacy of carbamazepine (CBZ) and simultaneously improve the spatial memory impairment induced by transauricular kindled seizures in Sprague-Dawley rats. METHODS:Chronic transauricular kindling was induced by repeated application of initially subcon...

journal_title：Acta pharmacologica Sinica

authors： Li Q,Jin CL,Xu LS,Zhu-Ge ZB,Yang LX,Liu LY,Chen Z

更新日期：2005-11-01 00:00:00

abstract：AIM:Recent studies have shown that constitutive activation of the nuclear factor κB (NF-κB) plays a key role in chronic inflammation and cancers. The aim of this study was to characterize lobolide, a cembrane diterpene, as a drug candidate targeting the NF-κB signaling pathway. METHODS:A HEK 293/NF-κB-Luc stable cell ...

journal_title：Acta pharmacologica Sinica

authors： Lv XF,Chen SH,Li J,Fang JP,Guo YW,Ding K

更新日期：2012-10-01 00:00:00

abstract：AIM:To investigate possible intracellular signal molecules involved in diphenylhydantoin (DPH)-mediated apoptosis of cerebellar granule neurons (CGN) and explore possible molecular mechanisms of neurotoxicity of DPH. METHODS:Fluorescein diacetate (FDA) stain, hochest 33258 stain, and agar gel electrophoresis were used...

journal_title：Acta pharmacologica Sinica

authors： Zhao LZ,Su XW,Huang YJ,Qiu PX,Yan GM

更新日期：2003-06-01 00:00:00

abstract：AIM:Catechol estrogens and 16alpha-hydroxy estrogen are important metabolites that cause carcinogenesis. This study was aimed to stud y the role of cytochrome P450 in estradiol metabolism. METHODS:The estradiol metabolites were determined with HPLC-ECD. Correlation of estradiol metabolites production between cytochrom...

journal_title：Acta pharmacologica Sinica

authors： Cheng ZN,Shu Y,Liu ZQ,Wang LS,Ou-Yang DS,Zhou HH

更新日期：2001-02-01 00:00:00

abstract：:Type 2 diabetes (T2D) and Alzheimer's disease (AD) share several common pathophysiological features. Huperzine A (Hup A), a Lycopodium alkaloid extracted from the Chinese herb moss Huperzia serrata, is a specific and reversible inhibitor of acetylcholinesterase, which is clinically used for the treatment of AD. In thi...

journal_title：Acta pharmacologica Sinica

authors： Wang HY,Wu M,Diao JL,Li JB,Sun YX,Xiao XQ

更新日期：2020-02-01 00:00:00

abstract：AIM:To develop a high-throughput real-time assay based on molecular beacons to monitor the integrase 3'-processing reaction in vitro and apply it to inhibitor screening. METHODS:The recombinant human immunodeficiency virus (HIV)-1 integrase (IN) is incubated with a 38 mer oligonucleotide substrate, a sequence identica...

journal_title：Acta pharmacologica Sinica

authors： He HQ,Ma XH,Liu B,Zhang XY,Chen WZ,Wang CX,Cheng SH

更新日期：2007-06-01 00:00:00

abstract：AIM:To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO). METHODS:Thirty male Wistar rats were randomly divided into 3 groups. Group 1 was the healthy control group, group 2 was the ISO grou...

journal_title：Acta pharmacologica Sinica

authors： Zhang YG,Li YG,Liu BG,Wei RH,Wang DM,Tan XR,Bu DF,Pang YZ,Tang CS

更新日期：2007-01-01 00:00:00

abstract：AIM:To investigate the anticancer mechanism of a methoxyflavanone derivative, WJ9708012, highlighting its role on a crosstalk between endoplasmic reticulum (ER) and mitochondrial stress. METHODS:Cell proliferation was examined using sulforhodamine B assay. Cell-cycle progression, Ca(2+) mobilization and mitochondrial ...

journal_title：Acta pharmacologica Sinica

authors： Kuo TC,Huang WJ,Guh JH

更新日期：2011-01-01 00:00:00

abstract：AIM:To study the protective effect of the polypeptide isolated from Chlamys farreri (PCF) on hairless mice skin damaged by ultraviolet A. METHODS:Enzymes and malondialdehyde (MDA) were determined by biochemical methods; the expressions of Bcl-2 protein and NOS protein were examined by immunohistochemical technique. Th...

journal_title：Acta pharmacologica Sinica

authors： Wang CB,Yao RY,Liu ZT,Zhong WZ,Liu XP,Wang YJ

更新日期：2002-09-01 00:00:00

abstract：:Pulmonary fibrosis may be partially the result of deregulated tissue repair in response to chronic hypoxia. In this study we explored the effects of hypoxia on lung fibroblasts and the effects of neotuberostemonine (NTS), a natural alkaloid isolated from Stemona tuberosa, on activation of fibroblasts in vitro and in v...

journal_title：Acta pharmacologica Sinica

authors： Lv XM,Li MD,Cheng S,Liu BL,Liu K,Zhang CF,Xu XH,Zhang M

更新日期：2018-09-01 00:00:00

abstract：:Fibronectin (FN) is a main component of extracellular matrix (ECM) in most adult tissues. Under pathological conditions, particularly inflammation, wound healing and tumors, an alternatively spliced exon extra domain A (EDA) is included in the FN protein (EDA+FN), which facilitates cellular proliferation, motility, an...

journal_title：Acta pharmacologica Sinica

authors： Wang HC,Wang P,Chen YW,Zhang Y

更新日期：2019-07-01 00:00:00

abstract：:Volatile anesthetics improve postischemic cardiac function and reduce infarction even when administered for only a brief time at the onset of reperfusion. A recent study showed that sevoflurane postconditioning (SPC) attenuated myocardial reperfusion injury, but the underlying mechanisms remain unclear. In this study,...

journal_title：Acta pharmacologica Sinica

authors： Qiao SG,Sun Y,Sun B,Wang A,Qiu J,Hong L,An JZ,Wang C,Zhang HL

更新日期：2019-01-01 00:00:00

abstract：AIM:To discover novel ligands of estrogen receptor (ER) β using pharmacophore mapping and structure-based screening. METHODS:A computer-aided strategy combining pharmacophore mapping and structure-based screening was used to screen the Maybridge and Enamine databases. Yeast two-hybrid (Y2H) assay was used to detect th...

journal_title：Acta pharmacologica Sinica

authors： Chen L,Wu D,Bian HP,Kuang GL,Jiang J,Li WH,Liu GX,Zou SE,Huang J,Tang Y

更新日期：2014-10-01 00:00:00

abstract：:Innovative teaching methodologies in different parts of the world are being practiced since last 3 decades. The aim of this review is to report the transition from traditional to innovative self learning process in Ziauddin Medical University, a new medical institute of Pakistan. Various problems encountered have been...

journal_title：Acta pharmacologica Sinica

authors： Barakzai Q

更新日期：2004-09-01 00:00:00

abstract：:Cysteine-rich peptides from the venom of cone snails (Conus) target a wide variety of different ion channels. One family of conopeptides, the alpha-conotoxins, specifically target different isoforms of nicotinic acetylcholine receptors (nAChRs) found both in the neuromuscular junction and central nervous system. This ...

journal_title：Acta pharmacologica Sinica

authors： Azam L,McIntosh JM

更新日期：2009-06-01 00:00:00

abstract：:With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ul...

journal_title：Acta pharmacologica Sinica

authors： Manov I,Motanis H,Frumin I,Iancu TC

更新日期：2006-03-01 00:00:00

abstract：AIM:To identify a small molecule L655,240 as a novel β-secretase (BACE1) inhibitor and to investigate its effects on β-amyloid (Aβ) generation in vitro. METHODS:Fluorescence resonance energy transfer (FRET) was used to characterize the inhibitory effect of L655,240 on BACE1. Surface plasmon resonance (SPR) technology-...

journal_title：Acta pharmacologica Sinica

authors： Lu Q,Chen WY,Zhu ZY,Chen J,Xu YC,Kaewpet M,Rukachaisirikul V,Chen LL,Shen X

更新日期：2012-12-01 00:00:00

abstract：AIM:It is generally assumed that only unbound drugs can reach the site of action by diffusing across the membranes and exerting pharmacological effects by interacting with receptors. Recent research has shown that the percentage of free drugs may depend on the total drug concentration. The aim of the paper is to verify...

journal_title：Acta pharmacologica Sinica

authors： Kalitynski R,Dawidowicz AL,Poszytek J

更新日期：2006-12-01 00:00:00

abstract：:Hispidulin, a polyphenolic flavonoid extracted from the traditional Chinese medicinal plant S involucrata, exhibits anti-tumor effects in a wide array of human cancer cells, mainly through growth inhibition, apoptosis induction and cell cycle arrest. However, its precise anticancer mechanisms remain unclear. In this s...

journal_title：Acta pharmacologica Sinica

authors： Gao H,Gao MQ,Peng JJ,Han M,Liu KL,Han YT

更新日期：2017-12-01 00:00:00

abstract：AIM:Localized delivery of growth factors has significant potential as a future therapeutic strategy in tissue engineering and regenerative medicine. A nanoparticle vehicle was created and evaluated in this study with the intent to deliver growth factors for periodontal regeneration. METHODS:Novel composite nanoparticl...

journal_title：Acta pharmacologica Sinica

authors： Chen FM,Ma ZW,Dong GY,Wu ZF

更新日期：2009-04-01 00:00:00

abstract：AIM:To investigate the effects of co-delivering IL-6 expressing plasmid pCI-IL-6 on the immunogenicity of the anti-caries DNA vaccine pCIA-P, which encodes the surface protein antigen PAc of Streptococcus mutans. METHODS:Plasmid pCI-IL-6 was constructed by inserting the murine IL-6 gene into the pCI vector. Expression...

journal_title：Acta pharmacologica Sinica

authors： Su LK,Yu F,Li ZF,Zeng C,Xu QA,Fan MW

更新日期：2014-05-01 00:00:00

abstract：AIM:To examine the therapeutic effects and underlying mechanisms of DZ2002, a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor, on lupus-prone female NZB×NZW F1 (NZB/W F1) mice. METHODS:Female NZB/W F1 mice were treated orally with DZ2002 (0.5 mg·kg(-1)·d(-1)) for 11 weeks, and the proteinuria level and...

journal_title：Acta pharmacologica Sinica

authors： He SJ,Lin ZM,Wu YW,Bai BX,Yang XQ,He PL,Zhu FH,Tang W,Zuo JP

更新日期：2014-02-01 00:00:00

abstract：AIM:To investigate the effects of deferiprone on doxorubicin-induced cardiotoxicity and determine its protection on cardiac contractility in vivo at tissue level. METHODS:Spontaneously-beating isolated atria from rats were pretreated with deferiprone for 10 min at 1.2 mmol/L or 0.3 mmol/L, respectively before co-incub...

journal_title：Acta pharmacologica Sinica

authors： Xu LJ,Jin L,Pan H,Zhang AZ,Wei G,Li PP,Lu WY

更新日期：2006-10-01 00:00:00

abstract：:The therapeutic outcome of chemotherapy is severely limited by intrinsic or acquired drug resistance, the most common causes of chemotherapy failure. In the past few decades, advancements in nanotechnology have provided alternative strategies for combating tumor drug resistance. Drug-loaded nanoparticles (NPs) have se...

journal_title：Acta pharmacologica Sinica

authors： Liu JP,Wang TT,Wang DG,Dong AJ,Li YP,Yu HJ

更新日期：2017-01-01 00:00:00

abstract：AIM:To determine the active ingredient of Niuchangchih (Antrodia camphorata) responsible for its anti-inflammatory effects and the relevant molecular mechanisms. METHODS:Five major antcins (A, B, C, H, and K) were isolated from fruiting bodies of Niuchangchih. Structural similarity between the antcins and 2 glucocorti...

journal_title：Acta pharmacologica Sinica

authors： Chen YC,Liu YL,Li FY,Chang CI,Wang SY,Lee KY,Li SL,Chen YP,Jinn TR,Tzen JT

更新日期：2011-07-01 00:00:00

abstract：AIM:To evaluate single-dose and multiple-dose pharmacokinetics of cytotoxic T-lymphocyte-associated antigen 4 fusion protein (CTLA4Ig) in healthy volunteers and patients with rheumatoid arthritis (RA). METHODS:The clinical trials included two phase I open studies: study 1 was an open-label dose-escalation study in 27 ...

journal_title：Acta pharmacologica Sinica

authors： Ma Y,Lin BR,Lin B,Hou S,Qian WZ,Li J,Tan M,Ma J,Li BH,Wang H,Wen AD,Guo YJ

更新日期：2009-03-01 00:00:00

abstract：AIM:To investigate the effect and mechanism of morphine on purine nucleotide catabolism. METHODS:The rat model of morphine dependence and withdrawal and rat C6 glioma cells in culture were used. Concentrations of uric acid in the plasma were measured by the uricase-rap method, adenosine deaminase (ADA) and xanthine ox...

journal_title：Acta pharmacologica Sinica

authors： Liu C,Liu JK,Kan MJ,Gao L,Fu HY,Zhou H,Hong M

更新日期：2007-08-01 00:00:00

abstract：AIM:To investigate the effects of small interfering RNA of cyclooxygenase-2 (COX-2) on the proliferation and apoptosis of human multiple myeloma RPMI8226 cells and its relation with the Bcl-2 family in vitro. METHODS:Transcription and expression of COX-2 in human myeloma RPMI8226 cells were checked by RT-PCR and Weste...

journal_title：Acta pharmacologica Sinica

authors： Li QB,Chen ZC,You Y,Zou P

更新日期：2007-07-01 00:00:00

abstract：AIM:To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. METHODS:Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed wi...

journal_title：Acta pharmacologica Sinica

authors： Fan LH,Tian HY,Ma AQ,Hu Z,Huo JH,Cao YX

更新日期：2008-10-01 00:00:00

abstract：AIM:To investigate the effect of 7-hydroxystaurosporine (UCN-01), a selective protein kinase C (PKC) inhibitor, on cell growth, migration, and invasion in invasive human glioblastoma U-87MG cells. METHODS:PKC activity was determined based on the PKC-catalyzed transfer of the (32)P-phosphate group from [g-(32)P]ATP int...

journal_title：Acta pharmacologica Sinica

authors： Meng QH,Zhou LX,Luo JL,Cao JP,Tong J,Fan SJ

更新日期：2005-04-01 00:00:00